Published in J Exp Med on September 16, 2002
Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer (2009) 12.92
Class I PI3K in oncogenic cellular transformation. Oncogene (2008) 3.90
The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood (2011) 3.87
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science (2013) 3.33
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
PI3K signalling: the path to discovery and understanding. Nat Rev Mol Cell Biol (2012) 3.11
The follicular versus marginal zone B lymphocyte cell fate decision. Nat Rev Immunol (2009) 2.80
Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling. Cancer Discov (2014) 2.79
Peripheral B cell subsets. Curr Opin Immunol (2008) 2.60
Control systems and decision making for antibody production. Nat Immunol (2010) 2.60
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol (2009) 2.29
The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A (2006) 2.23
Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med (2003) 2.16
The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development. Sci Signal (2010) 2.15
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. Nat Rev Cancer (2015) 2.10
Signaling by the phosphoinositide 3-kinase family in immune cells. Annu Rev Immunol (2013) 2.09
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers. Proc Natl Acad Sci U S A (2007) 1.98
Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma. Clin Cancer Res (2015) 1.81
PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans. Blood (2010) 1.76
New insights into pre-BCR and BCR signalling with relevance to B cell malignancies. Nat Rev Immunol (2013) 1.66
Phase I study of the anti-CD40 humanized monoclonal antibody lucatumumab (HCD122) in relapsed chronic lymphocytic leukemia. Leuk Lymphoma (2012) 1.57
PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances. Biochem J (2012) 1.56
Coming full circle: 70 years of chronic lymphocytic leukemia cell redistribution, from glucocorticoids to inhibitors of B-cell receptor signaling. Blood (2012) 1.45
Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K. Trends Immunol (2007) 1.38
Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival. Blood (2005) 1.36
The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation. J Exp Med (2008) 1.34
Essential function for the GTPase TC21 in homeostatic antigen receptor signaling. Nat Immunol (2009) 1.30
Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation. Curr Opin Immunol (2011) 1.28
Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils. Eur J Immunol (2008) 1.25
Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling. Nat Rev Immunol (2013) 1.18
Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2. Mol Cell Biol (2004) 1.17
Rho GTPase Cdc42 is essential for B-lymphocyte development and activation. Blood (2009) 1.17
PI3K: from the bench to the clinic and back. Curr Top Microbiol Immunol (2010) 1.16
PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes. PLoS One (2012) 1.16
Phosphatidylinositol 3-kinase: the oncoprotein. Curr Top Microbiol Immunol (2010) 1.14
3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. Mol Cell Biol (2006) 1.13
Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood (2009) 1.13
PI3Ks in lymphocyte signaling and development. Curr Top Microbiol Immunol (2010) 1.12
Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies. Front Immunol (2012) 1.12
Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals. BMC Cell Biol (2006) 1.11
Lipid signaling in T-cell development and function. Cold Spring Harb Perspect Biol (2010) 1.08
Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells. PLoS One (2009) 1.06
The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades. J Exp Med (2004) 1.05
Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs. Chem Biol (2010) 1.05
Abnormal hematopoiesis in Gab2 mutant mice. Blood (2007) 1.04
Molecular pathways: targeting phosphoinositide 3-kinase p110-delta in chronic lymphocytic leukemia. Clin Cancer Res (2012) 1.03
Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion. J Cell Biol (2010) 1.03
Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation. Blood (2007) 1.00
T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. Blood (2007) 1.00
Context-specific BAFF-R signaling by the NF-κB and PI3K pathways. Cell Rep (2013) 0.99
Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1. Cell Cycle (2013) 0.98
The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases. Open Rheumatol J (2012) 0.97
Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation. J Biol Chem (2008) 0.96
B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. J Immunol (2008) 0.96
Differential role of reactive oxygen species in the activation of mitogen-activated protein kinases and Akt by key receptors on B-lymphocytes: CD40, the B cell antigen receptor, and CXCR4. J Cell Commun Signal (2007) 0.95
The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions. Front Immunol (2012) 0.95
S1PR2 links germinal center confinement and growth regulation. Immunol Rev (2012) 0.93
PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus. Diabetes (2012) 0.93
Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. Arthritis Rheum (2009) 0.92
A novel regulatory mechanism links PLCγ1 to PDK1. J Cell Sci (2012) 0.91
All PI3Kinase signaling is not mTOR: dissecting mTOR-dependent and independent signaling pathways in T cells. Front Immunol (2012) 0.91
Deletion of PI3K-p85alpha gene impairs lineage commitment, terminal maturation, cytokine generation and cytotoxicity of NK cells. Genes Immun (2008) 0.91
Receptor crosstalk: reprogramming B cell receptor signalling to an alternate pathway results in expression and secretion of the autoimmunity-associated cytokine, osteopontin. J Intern Med (2009) 0.90
p110δ PI3 kinase pathway: emerging roles in cancer. Front Oncol (2013) 0.89
Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond. Immunology (2007) 0.88
Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity. Blood (2016) 0.86
Foxo1 regulates marginal zone B-cell development. Eur J Immunol (2010) 0.86
Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization. Nat Commun (2015) 0.86
Syk mediates BCR- and CD40-signaling integration during B cell activation. Immunobiology (2010) 0.86
Phosphoinositide 3-kinase signalling regulates early development and developmental haemopoiesis. J Cell Sci (2007) 0.85
Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets. Platelets (2005) 0.85
Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation. Proc Natl Acad Sci U S A (2012) 0.85
Lymphocyte signaling: beyond knockouts. Nat Immunol (2009) 0.83
Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia. Evid Based Complement Alternat Med (2012) 0.81
S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness. Evid Based Complement Alternat Med (2011) 0.81
Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction. Mol Cell Biol (2006) 0.81
Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase. Biochem Soc Trans (2007) 0.81
PI3Kδ inhibition augments the efficacy of rapamycin in suppressing proliferation of Epstein-Barr virus (EBV)+ B cell lymphomas. Am J Transplant (2013) 0.81
PI3Kδ and primary immunodeficiencies. Nat Rev Immunol (2016) 0.81
Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression. J Exp Med (2012) 0.80
Interaction of Ras with p110γ is required for thymic β-selection in the mouse. J Immunol (2011) 0.80
Primary immunoglobulin repertoire development: time and space matter. Curr Opin Immunol (2015) 0.79
Inducible IL10(+) suppressor B cells inhibit CNS inflammation and T helper 17 polarization. Mol Ther (2012) 0.79
Study on improving the selectivity of compounds that inhibit two PI3Ks (gamma and delta). J Mol Model (2006) 0.79
Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy. Cancer Discov (2016) 0.79
Biochanin a, a phytoestrogenic isoflavone with selective inhibition of phosphodiesterase 4, suppresses ovalbumin-induced airway hyperresponsiveness. Evid Based Complement Alternat Med (2011) 0.79
Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis. World J Gastroenterol (2014) 0.78
Constitutive AKT activation in follicular lymphoma. BMC Cancer (2014) 0.78
Signaling via class IA Phosphoinositide 3-kinases (PI3K) in human, breast-derived cell lines. PLoS One (2013) 0.78
Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK. Exp Mol Med (2011) 0.78
Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio. J Biomed Sci (2011) 0.78
The PI3K pathway in B cell metabolism. Crit Rev Biochem Mol Biol (2016) 0.78
Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors. ACS Med Chem Lett (2016) 0.77
Nck, a missing adaptor between the B-cell receptor complex and the BCAP/PI3K/Akt pathway. Cell Mol Immunol (2013) 0.77
Hesperidin-3'-o-methylether is more potent than hesperidin in phosphodiesterase inhibition and suppression of ovalbumin-induced airway hyperresponsiveness. Evid Based Complement Alternat Med (2012) 0.77
Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer. Nat Commun (2017) 0.76
Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies. Front Immunol (2014) 0.76
Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice. J Biol Chem (2014) 0.76
Phosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+ T Cell Responses during Acute Viral and Intracellular Bacterial Infections. J Immunol (2016) 0.76
Cellular survival: a play in three Akts. Genes Dev (1999) 17.05
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods (1991) 16.64
Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc Natl Acad Sci U S A (1997) 7.42
Marginal-zone B cells. Nat Rev Immunol (2002) 4.87
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science (1999) 4.77
Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat Immunol (2000) 4.57
Impaired Fas response and autoimmunity in Pten+/- mice. Science (1999) 4.25
Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature (1995) 4.10
Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase. EMBO J (1996) 3.41
The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L). Mol Cell Biol (2000) 3.34
Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase. J Biol Chem (1999) 3.17
P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci U S A (1997) 3.09
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J (1998) 3.09
Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm Genome (2002) 2.79
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science (1996) 2.71
Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity (1995) 2.69
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science (1999) 2.56
Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells. J Biol Chem (1999) 2.43
SHIP modulates immune receptor responses by regulating membrane association of Btk. Immunity (1998) 2.39
Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex. Mol Cell Biol (1999) 2.39
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem (1997) 2.37
Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation. EMBO J (1998) 2.36
Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis. J Cell Biol (2001) 2.28
A comparison of fluorescent Ca2+ indicator properties and their use in measuring elementary and global Ca2+ signals. Cell Calcium (2000) 2.21
Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation. Nat Immunol (2001) 2.03
Antibody regulation of B cell development. Nat Immunol (2000) 2.00
Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages. Nat Cell Biol (1999) 1.96
Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling. Proc Natl Acad Sci U S A (1992) 1.95
Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. Nat Immunol (2002) 1.92
The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. J Exp Med (1998) 1.88
Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1998) 1.84
CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science (1993) 1.80
Phosphoinositide 3-kinase in immunological systems. Semin Immunol (2002) 1.67
Xid-like phenotypes: a B cell signalosome takes shape. Immunity (2000) 1.60
Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2. J Exp Med (1994) 1.45
Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes. J Immunol (1992) 1.43
Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function. J Biol Chem (1997) 1.43
A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice. J Exp Med (2000) 1.42
Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med (2002) 1.36
Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP). J Exp Med (2000) 1.34
BLNK mediates Syk-dependent Btk activation. Proc Natl Acad Sci U S A (2001) 1.32
PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals. Cell (1998) 1.29
Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling. J Biol Chem (2001) 1.28
Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk. J Biol Chem (2001) 1.27
Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. J Exp Med (1997) 1.25
Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling. J Biol Chem (2001) 1.19
CD1high B cells: a population of mixed origin. Eur J Immunol (1999) 1.10
Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase. J Immunol (1999) 1.09
p110beta and p110delta phosphatidylinositol 3-kinases up-regulate Fc(epsilon)RI-activated Ca2+ influx by enhancing inositol 1,4,5-trisphosphate production. J Biol Chem (2001) 1.04
Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases. Eur J Immunol (2000) 1.02
Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products. J Biol Chem (2000) 1.02
In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies. Proc Natl Acad Sci U S A (1999) 0.98
Signal transduction pathways that regulate the fate of B lymphocytes. Adv Immunol (1999) 0.97
Cd19-dependent activation of Akt kinase in B-lymphocytes. J Biol Chem (2001) 0.96
Vav and the B cell signalosome. Nat Immunol (2001) 0.93
Antigen-receptor cross-linking and lipopolysaccharide trigger distinct phosphoinositide 3-kinase-dependent pathways to NF-kappa B activation in primary B cells. Int Immunol (2001) 0.89
CD19-deficient mice exhibit poor responsiveness to oral immunization despite evidence of unaltered total IgA levels, germinal centers and IgA-isotype switching in Peyer's patches. Eur J Immunol (2000) 0.84
Structural organization of the mouse phosphatidylinositol 3-kinase p110d gene. Biochem Biophys Res Commun (2001) 0.80
Requirement of bic/microRNA-155 for normal immune function. Science (2007) 16.24
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol (2004) 9.71
microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity (2007) 6.72
Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J (2003) 3.58
PTEN function: how normal cells control it and tumour cells lose it. Biochem J (2004) 3.06
Practical application of pharmacotherapy with long-acting risperidone for patients with schizophrenia. Psychiatr Serv (2004) 2.94
Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature (2004) 2.73
Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol (2009) 2.51
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood (2005) 2.35
PTEN: The down side of PI 3-kinase signalling. Cell Signal (2002) 2.34
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat Cell Biol (2002) 2.31
Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1. Biochem J (2002) 2.16
Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors. Nat Immunol (2006) 2.13
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat Immunol (2002) 2.03
BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity. Immunity (2003) 2.02
T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis. Immunity (2011) 2.00
Evidence for a direct link between glutathione biosynthesis and stress defense gene expression in Arabidopsis. Plant Cell (2004) 1.97
Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochem J (2004) 1.88
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem J (2004) 1.87
Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation. BMC Neurosci (2004) 1.81
Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Nat Cell Biol (2006) 1.76
HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. Nat Immunol (2010) 1.70
Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue. Blood (2004) 1.66
Calcium signalling and cell-fate choice in B cells. Nat Rev Immunol (2007) 1.64
Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. J Immunol (2010) 1.63
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol (2007) 1.62
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling. Nat Immunol (2013) 1.60
Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids. Biochem J (2003) 1.59
Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake. J Biol Chem (2008) 1.55
Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase. J Immunol (2005) 1.51
Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell (2006) 1.50
Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Nat Immunol (2010) 1.49
Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res (2004) 1.49
MicroRNA 125b inhibition of B cell differentiation in germinal centers. Int Immunol (2010) 1.47
Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4. J Exp Med (2009) 1.46
The role of endothelial PI3Kgamma activity in neutrophil trafficking. Blood (2005) 1.46
Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation. Immunity (2008) 1.43
Efficient inhibition of miR-155 function in vivo by peptide nucleic acids. Nucleic Acids Res (2010) 1.41
Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. J Biol Chem (2004) 1.40
Activity of any class IA PI3K isoform can sustain cell proliferation and survival. Proc Natl Acad Sci U S A (2010) 1.40
Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression. J Cell Sci (2006) 1.36
A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells. EMBO J (2006) 1.34
Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein. Proc Natl Acad Sci U S A (2010) 1.34
MyosinV controls PTEN function and neuronal cell size. Nat Cell Biol (2009) 1.32
Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J Biol Chem (2003) 1.31
Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells. Blood (2005) 1.31
Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat Immunol (2002) 1.29
PTEN is destabilized by phosphorylation on Thr366. Biochem J (2007) 1.28
The PI3K p110delta is required for down-regulation of RAG expression in immature B cells. J Immunol (2007) 1.27
The prevalence of osteoporosis in patients with severe hip and knee osteoarthritis awaiting joint arthroplasty. Age Ageing (2009) 1.26
Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing. Proc Natl Acad Sci U S A (2011) 1.26
Regulation of B- and T-cell differentiation by a single microRNA. Biochem Soc Trans (2008) 1.25
IFN-gamma-inducible expression of thymus and activation-regulated chemokine/CCL17 and macrophage-derived chemokine/CCL22 in epidermal keratinocytes and their roles in atopic dermatitis. Int Immunol (2002) 1.23
Immunological function in mice lacking the Rac-related GTPase RhoG. Mol Cell Biol (2004) 1.19
The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response. Mol Cell Biol (2007) 1.18
The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion. Blood (2007) 1.18
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates. J Biol Chem (2009) 1.17
The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. Dev Dyn (2006) 1.17
Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation. Mol Endocrinol (2006) 1.16
Differential redox regulation within the PTP superfamily. Cell Signal (2007) 1.15
PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity. Sci Signal (2012) 1.15
Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C. Blood (2002) 1.15
Screening for borderline personality disorder in outpatient youth. J Pers Disord (2008) 1.14
Macrophage microRNA-155 promotes cardiac hypertrophy and failure. Circulation (2013) 1.14
Rac GTPases play critical roles in early T-cell development. Blood (2008) 1.13
Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. J Neurovirol (2006) 1.11
Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals. BMC Cell Biol (2006) 1.11
Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. Biochem J (2002) 1.08
Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation. J Biol Chem (2007) 1.08
Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress. J Biol Chem (2010) 1.05
CCR4-bearing T cells participate in autoimmune diabetes. J Clin Invest (2002) 1.05
Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA. FEBS Lett (2005) 1.05
The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells. J Immunol (2008) 1.04
Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor. Biochem J (2012) 1.03
Essential role for thymosin β4 in regulating vascular smooth muscle cell development and vessel wall stability. Circ Res (2012) 1.03
Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells. J Biol Chem (2012) 1.03
Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy. Biochem J (2004) 1.02
MicroRNA fate upon targeting with anti-miRNA oligonucleotides as revealed by an improved Northern-blot-based method for miRNA detection. RNA (2011) 1.02
Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis. J Allergy Clin Immunol (2002) 1.02
B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta. Eur J Immunol (2008) 1.01
Bone density of the femoral neck following Birmingham hip resurfacing. Acta Orthop (2009) 1.00
Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs. Nucleic Acids Res (2011) 1.00
Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes. Blood (2010) 1.00
Potent and highly selective benzimidazole inhibitors of PI3-kinase delta. J Med Chem (2012) 0.99
Tribbles-2 is a novel regulator of inflammatory activation of monocytes. Int Immunol (2008) 0.99
MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs. PLoS One (2012) 0.99
Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling. Mol Cell Biol (2013) 0.99