A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMID 1371279)

Published in J Biol Chem on February 25, 1992

Authors

M L Bajt1, M H Ginsberg, A L Frelinger, M C Berndt, J C Loftus

Author Affiliations

1: Committee on Vascular Biology, Scripps Research Institute, La Jolla, California 92037.

Articles citing this

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen. J Cell Biol (1993) 3.14

Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia. Proc Natl Acad Sci U S A (1992) 1.95

A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins. J Cell Biol (1995) 1.42

Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex. J Clin Invest (1997) 1.26

Molecular evolution of integrins: genes encoding integrin beta subunits from a coral and a sponge. Proc Natl Acad Sci U S A (1997) 1.23

Glanzmann thrombasthenia: state of the art and future directions. Semin Thromb Hemost (2013) 1.08

A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg----214Trp mutation. J Clin Invest (1992) 1.00

Glanzmann thrombasthenia. Cooperation between sequence variants in cis during splice site selection. J Clin Invest (1996) 0.98

Three novel beta-propeller mutations causing Glanzmann thrombasthenia result in production of normally stable pro-alphaIIb, but variably impaired progression of pro-alphaIIbbeta3 from endoplasmic reticulum to Golgi. J Thromb Haemost (2005) 0.91

Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. J Clin Invest (1994) 0.91

Inherited platelet disorders: thrombocytopenias and thrombocytopathies. Blood Transfus (2009) 0.89

Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins. Proteins (2009) 0.88

Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association. J Clin Invest (1995) 0.87

Dynamic regulation of fibrinogen: integrin αIIbβ3 binding. Biochemistry (2010) 0.86

Demystified...adhesion molecule deficiencies. Mol Pathol (2001) 0.85

Differential recognition of snake venom proteins expressing specific Arg-Gly-Asp (RGD) sequence motifs by wild-type and variant integrin alphaIIbbeta3: further evidence for distinct sites of RGD ligand recognition exhibiting negative allostery. Biochem J (2000) 0.84

A two-amino acid insertion in the Cys146- Cys167 loop of the alphaIIb subunit is associated with a variant of Glanzmann thrombasthenia. Critical role of Asp163 in ligand binding. J Clin Invest (1998) 0.79

Activation mechanisms of αVβ3 integrin by binding to fibronectin: A computational study. Protein Sci (2017) 0.79

Proteolytic degradation of the RGD-binding and non-RGD-binding conformers of human platelet integrin glycoprotein IIb/IIIa: clues for identification of regions involved in the receptor's activation. Biochem J (1994) 0.78

Do cell junction protein mutations cause an airway phenotype in mice or humans? Am J Respir Cell Mol Biol (2011) 0.77

Interactions of integrin GPIIb/IIIa-derived peptides with fibrinogen investigated by NMR spectroscopy. Biochem J (1996) 0.75

Articles by these authors

Integrins: emerging paradigms of signal transduction. Annu Rev Cell Dev Biol (1995) 8.88

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature (1997) 8.52

Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors. Science (1986) 5.58

PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science (1990) 5.28

The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J Biol Chem (1999) 4.92

Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J Biol Chem (1996) 4.45

Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol (1994) 4.07

Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity. J Cell Biol (1996) 3.18

Integrin cytoplasmic domain-binding proteins. J Cell Sci (2000) 3.17

Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci U S A (2001) 3.07

Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell (1997) 2.84

Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa). Cell (1991) 2.81

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. Dev Cell (2001) 2.73

The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets. Proc Natl Acad Sci U S A (1985) 2.64

Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif. Trends Biochem Sci (1991) 2.62

Complementation of dominant suppression implicates CD98 in integrin activation. Nature (1997) 2.62

Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. Nature (1999) 2.59

Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb. Science (1991) 2.57

beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure. Proc Natl Acad Sci U S A (1998) 2.54

Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. J Biol Chem (2000) 2.52

Regulation of cell migration by the calcium-dependent protease calpain. J Biol Chem (1997) 2.52

A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. Science (1990) 2.42

Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix. Cell (1995) 2.36

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function. J Biol Chem (1991) 2.34

Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med (2000) 2.31

Specific and saturable binding of plasma fibronectin to thrombin-stimulated human platelets. J Biol Chem (1981) 2.31

Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration. Nat Cell Biol (2001) 2.29

Bernard-Soulier syndrome. Blood (1998) 2.29

Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Cell Regul (1990) 2.29

Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins. J Biol Chem (1998) 2.19

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. J Biol Chem (1990) 2.16

A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein. J Clin Invest (1986) 2.13

Differences in platelet function in patients with acute myeloid leukemia and myelodysplasia compared to equally thrombocytopenic patients with immune thrombocytopenia. J Thromb Haemost (2011) 2.11

Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions. J Cell Biol (1993) 2.08

Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins. J Virol (1999) 2.03

Cytoadhesins, integrins, and platelets. Thromb Haemost (1988) 2.03

Integrin activation takes shape. J Cell Biol (2002) 2.02

Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. Science (1988) 1.98

Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor, and thrombospondin on thrombin-stimulated human platelets. Blood (1985) 1.95

Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3. J Biol Chem (1994) 1.93

Trans-dominant inhibition of integrin function. Mol Biol Cell (1996) 1.92

Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin. J Cell Biol (1993) 1.86

Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells. Cancer Res (2001) 1.85

Evidence that three adhesive proteins interact with a common recognition site on activated platelets. J Biol Chem (1984) 1.83

Immunochemical and amino-terminal sequence comparison of two cytoadhesins indicates they contain similar or identical beta subunits and distinct alpha subunits. J Biol Chem (1987) 1.82

Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain. J Biol Chem (2001) 1.80

The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity. J Biol Chem (1995) 1.80

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3. EMBO J (1997) 1.79

The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin. J Exp Med (1999) 1.76

NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution. Biochemistry (2001) 1.76

Circulating monocyte-platelet aggregates are an early marker of acute myocardial infarction. J Am Coll Cardiol (2001) 1.74

Long range propagation of conformational changes in integrin alpha IIb beta 3. J Biol Chem (1993) 1.73

A point mutation in the integrin beta 3 cytoplasmic domain (S752-->P) impairs bidirectional signaling through alpha IIb beta 3 (platelet glycoprotein IIb-IIIa). Blood (1994) 1.71

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex. J Biol Chem (1991) 1.67

The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit. J Biol Chem (1990) 1.66

Integrin-mediated cell adhesion: the extracellular face. J Biol Chem (1994) 1.66

GMP-140 binding to neutrophils is inhibited by sulfated glycans. J Biol Chem (1991) 1.62

Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins. J Biol Chem (1994) 1.60

Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains. Curr Biol (2001) 1.59

Calpain cleavage of the cytoplasmic domain of the integrin beta 3 subunit. J Biol Chem (1995) 1.59

Effects of OKM5, a monoclonal antibody to glycoprotein IV, on platelet aggregation and thrombospondin surface expression. Blood (1990) 1.58

Prevention of activated neutrophil adhesion to endothelium by soluble adhesion protein GMP140. Science (1990) 1.54

Cellular adhesion: GPIIb-IIIa as a prototypic adhesion receptor. Prog Hemost Thromb (1989) 1.53

Evidence that pre-existent variability in platelet response to ADP accounts for 'clopidogrel resistance'. J Thromb Haemost (2006) 1.53

Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors. J Biol Chem (1994) 1.53

Detection and partial characterization of an inhibitor of plasminogen activator in human platelets. J Clin Invest (1984) 1.50

Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK. J Cell Biol (1993) 1.50

A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin Mac-1 (CD11b/CD18). J Biol Chem (1990) 1.49

Immunologic relationship between platelet membrane glycoprotein GPIIb/IIIa and cell surface molecules expressed by a variety of cells. Proc Natl Acad Sci U S A (1986) 1.48

PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function. J Cell Sci (1999) 1.47

Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion. J Biol Chem (1988) 1.47

Molecular mechanisms of platelet adhesion and activation. Int J Biochem Cell Biol (1997) 1.46

Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit. J Cell Biol (1995) 1.46

The inner world of cell adhesion: integrin cytoplasmic domains. Trends Cell Biol (1994) 1.44

"Inside-out" signal transduction inhibited by isolated integrin cytoplasmic domains. J Biol Chem (1994) 1.43

Dual antiplatelet therapy unmasks distinct platelet reactivity in patients with coronary artery disease. J Thromb Haemost (2008) 1.42

Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets. J Biol Chem (1987) 1.41

Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases. J Thromb Haemost (2007) 1.41

Purification and preliminary characterization of the glycoprotein Ib complex in the human platelet membrane. Eur J Biochem (1985) 1.40

Adhesive signaling in platelets. Curr Opin Cell Biol (1994) 1.40

Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences. J Exp Med (1994) 1.39

Distinct domains of CD98hc regulate integrins and amino acid transport. J Biol Chem (2000) 1.39

The death effector domain of PEA-15 is involved in its regulation of integrin activation. J Biol Chem (1998) 1.39

Redistribution of the fibrinogen receptor of human platelets after surface activation. J Cell Biol (1984) 1.38

Glycoprotein Ib-IX-V. Int J Biochem Cell Biol (2003) 1.38

Identification and quantitation of platelet-associated fibronectin antigen. J Clin Invest (1979) 1.38

Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors. Stem Cells (1998) 1.37

Ligand binding to integrin alphaIIbbeta3 is dependent on a MIDAS-like domain in the beta3 subunit. J Biol Chem (1996) 1.37

Reduced surface expression and binding of fibronectin by thrombin-stimulated thrombasthenic platelets. J Clin Invest (1983) 1.36

Thrombin increases expression of fibronectin antigen on the platelet surface. Proc Natl Acad Sci U S A (1980) 1.36

Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J Cell Biol (1991) 1.36