Published in Science on March 25, 1977
Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition. J Exp Med (1981) 12.03
H-2 antigens of the thymus determine lymphocyte specificity. J Exp Med (1978) 3.91
Evidence for an immunoglobulin-dependent antigen-specific helper T cell. Proc Natl Acad Sci U S A (1977) 2.72
Antigen from Francisella tularensis: nonidentity between determinants participating in cell-mediated and humoral reactions. Infect Immun (1984) 2.37
Antigen presentation in the murine T-lymphocyte proliferative response. I. Requirement for genetic identity at the major histocompatibility complex. J Exp Med (1977) 2.30
The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens. J Exp Med (1978) 2.20
Interactive effect of Gm allotypes and HLA-B locus antigens on the human antibody response to a bacterial antigen. Clin Exp Immunol (1980) 2.12
The I-J subregion codes for determinats on suppressor factor(s) which limit the contact sensitivity response to picryl chloride. J Exp Med (1977) 2.07
The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression. J Exp Med (1978) 2.00
Acquisition of murine major histocompatibility complex gene products by schistosomula of Schistosoma mansoni. J Exp Med (1978) 1.98
Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites. Proc Natl Acad Sci U S A (1979) 1.94
Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum. Proc Natl Acad Sci U S A (1977) 1.93
Distribution of HLA class 1 antigens in normal human tissue and in mammary cancer. J Clin Pathol (1981) 1.87
Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets. Proc Natl Acad Sci U S A (1985) 1.78
Genetic control of immunoregulatory circuits. Genes linked to the Ig locus govern communication between regulatory T-cell sets. J Exp Med (1979) 1.77
Secretion of mediators following T lymphocyte-macrophage interaction is regulated by the major histocompatibility complex. Proc Natl Acad Sci U S A (1977) 1.68
In irradiation chimeras, K or D regions of the chimeric host, not of the donor lymphocytes, determine immune responsiveness of antiviral cytotoxic T cells. J Exp Med (1978) 1.57
Alteration in suppressor cell activity in chronic active hepatitis. Proc Natl Acad Sci U S A (1978) 1.57
Increased synthesis and expression of H-2 antigens on thymocytes as a result of radiation leukemia virus infection: a possible mechanism for H-2 linked control of virus-induced neoplasia. J Exp Med (1978) 1.53
The role of H-2-linked genes in helper T-cell function. I. In vitro expression in B cells of immune response genes controlling helper T-cell activity. J Exp Med (1977) 1.49
Interaction of HLA and Gm in autoimmune chronic active hepatitis. Clin Exp Immunol (1981) 1.43
Cellular, molecular, and genetic characteristics of T cell reactivity to collagen in man. Proc Natl Acad Sci U S A (1981) 1.41
Haplotyping the human T-cell receptor beta-chain gene complex by use of restriction fragment length polymorphisms. Proc Natl Acad Sci U S A (1990) 1.38
Further structural studies of the heavy chain of HLA antigens and its similarity to immunoglobulins. Proc Natl Acad Sci U S A (1977) 1.30
T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten. J Exp Med (1978) 1.27
Histocompatibility linked immune responsiveness and restrictions imposed on sensitized lymphocytes. J Exp Med (1977) 1.24
Cells expressing Ia antigens in the avian thymus. J Exp Med (1984) 1.20
Induction of specific transplantation immune reactions using anti-idiotypic antibodies. J Exp Med (1978) 1.18
Genetic control of the immune response to collagen. II. Antibody responses produced in fetal liver restored radiation chimeras and thymus reconstituted F1 hybrid nude mice. J Exp Med (1979) 1.15
Analysis of histocompatibility requirements for proliferative and helper T cell activity. T cell populations depleted of alloreactive cells by negative selection. J Exp Med (1980) 1.14
T-cell regulation of human peripheral blood B-cells responsiveness. J Exp Med (1977) 1.11
T cells respond preferentially to antigens that are similar to self H-2. Proc Natl Acad Sci U S A (1981) 1.05
Immunoglobulin G heavy chain (Gm) allotypes in multiple sclerosis. J Clin Invest (1981) 1.04
Activated human T lymphocytes display new surface glycoproteins. Proc Natl Acad Sci U S A (1978) 1.04
The xid gene controls Ia.W39-associated immune response gene function. J Exp Med (1981) 1.04
Photoaffinity labeling demonstrates binding between Ia molecules and nominal antigen on antigen-presenting cells. Proc Natl Acad Sci U S A (1986) 1.04
Antigen receptors on murine T lymphocytes in contact sensitivity. I. Functional inhibition of effector T cells by monovalent 2,4-dinitrophenol: implication for a two-receptor model. J Exp Med (1981) 1.02
Primary structure of murine major histocompatibility complex alloantigens: isolation, biochemical characterization, and preliminary alignment of CNBr fragments from the H-2Ib glycoprotein. Proc Natl Acad Sci U S A (1978) 1.01
Physiological regulation of antigen binding to T cells: role of a soluble macrophage factor and of interferon. Proc Natl Acad Sci U S A (1977) 1.00
Specificity of T cell clones for antigen and autologous major histocompatibility complex products determines specificity for foreign major histocompatibility complex products. J Exp Med (1983) 1.00
Primary structure of murine major histocompatibility complex alloantigens: amino acid sequence studies of the cyanogen bromide fragments of the H-2Kb glycoprotein. Proc Natl Acad Sci U S A (1978) 0.99
T-cell hybridoma specific for a cytochrome c peptide: specific antigen binding and interleukin 2 production. Proc Natl Acad Sci U S A (1983) 0.99
Regulatory mechanisms in cell-mediated immune responses. VI. Interaction of H-2 and non-H-2 genes in elaboration of mixed leukocyte reaction suppressor factor. J Exp Med (1977) 0.98
Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge. Antiviral Res (2009) 0.98
The presence of HLA-DR antigens on lactating human breast epithelium and milk fat globule membranes. Clin Exp Immunol (1980) 0.94
Suppression of the mixed lymphocyte reaction in man by a soluble T-cell factor. Specificity of the factor for both responder and stimulator. J Exp Med (1978) 0.91
T lymphocyte-mediated suppression of myeloma function in vitro. II. Evidence for regulation of hapten-binding myelomas by syngeneic hapten-specific cytolytic T lymphocytes. J Exp Med (1980) 0.89
Factors influencing the secondary antibody response to flagellin in man. Clin Exp Immunol (1978) 0.85
Genetic control of immune response to myoglobin. Ir gene function in genetic restriction between T and B lymphocytes. J Exp Med (1982) 0.83
Schistosomiasis: immunologic properties of developing schistosomula. Am J Pathol (1981) 0.82
Macrophage proteases and rheumatic diseases: regulation of plasminogen activator by thymus-derived lymphocytes. Agents Actions (1978) 0.82
The T cell antigen receptor. Biochem J (1985) 0.80
T Cell Adaptive Immunity Proceeds through Environment-Induced Adaptation from the Exposure of Cryptic Genetic Variation. Front Genet (2012) 0.76
Lymphocytes. 1. Function. Genetic restrictions in the immune response. J Clin Pathol Suppl (R Coll Pathol) (1979) 0.76
Role of macrophages in T lymphocyte response to Candida allergen in man with special reference to HLA-D and DR. Clin Exp Immunol (1981) 0.75
Antigen recognition by H-2-restricted cytolytic T lymphocytes is not mediated by two independent receptors. J Exp Med (1984) 0.75
Genetic control of allogeneic interactions in the guinea-pig. V. Evidence for a dissociation between genes coding for A GPLA-B region-controlled determinant and genes coding for MLC suppressor cells. Immunology (1983) 0.75
Histocompatibility-linked immune response genes. Science (1972) 16.79
Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science (1987) 13.03
Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature (1985) 11.55
Identification of a T cell-derived b cell growth factor distinct from interleukin 2. J Exp Med (1982) 9.49
The regulatory influence of activated T cells on B cell responses to antigen. Adv Immunol (1972) 9.43
Genetic control of specific immune responses. Adv Immunol (1969) 8.81
Properties of antibodies cytophilic for macrophages. J Exp Med (1966) 8.64
Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol (1994) 8.43
Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol (1990) 7.93
The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med (1992) 7.80
Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex. J Exp Med (1975) 7.64
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med (1990) 7.09
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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature (1996) 6.17
B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol (1986) 6.16
Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci U S A (1993) 6.12
Cell selection by antigen in the immune response. Adv Immunol (1969) 6.05
CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med (1994) 5.90
The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products. Transplant Rev (1975) 5.88
Carrier function in anti-hapten immune responses. I. Enhancement of primary and secondary anti-hapten antibody responses by carrier preimmunization. J Exp Med (1970) 5.71
Genetic control of immune responses in vitro. V. Stimulation of suppressor T cells in nonresponder mice by the terpolymer L-glutamic acid 60-L-alanine 30-L-tyrosine 10 (GAT). J Exp Med (1974) 5.55
Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature (1989) 5.10
Regulation of B-cell growth and differentiation by soluble factors. Annu Rev Immunol (1983) 5.09
A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes. J Immunol (1978) 5.07
Role of MHC gene products in immune regulation. Science (1981) 4.84
T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci U S A (2001) 4.76
NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol (2000) 4.75
Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1. Proc Natl Acad Sci U S A (1986) 4.69
Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science (1993) 4.63
The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs. J Exp Med (1966) 4.58
Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1. J Exp Med (1985) 4.47
Carrier function in anti-hapten antibody responses. 3. Stimulation of antibody synthesis and facilitation of hapten-specific secondary antibody responses by graft-versus-host reactions. J Exp Med (1971) 4.29
Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S). J Immunol (1989) 4.20
Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions. Proc Natl Acad Sci U S A (1973) 4.12
Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science (1993) 4.08
Cell interactions between histoincompatible T and B lymphocytes. IV. Involvement of the immune response (Ir) gene in the control of lymphocyte interactions in responses controlled by the gene. J Exp Med (1973) 4.05
B-cell stimulatory factor-1/interleukin 4. Annu Rev Immunol (1987) 4.04
IL-4 is required to generate and sustain in vivo IgE responses. J Immunol (1988) 4.04
Functional heterogeneity of murine lymphoid cells. I. Responsiveness to and surface binding of concanavalin A and phytohemagglutinin. J Immunol (1972) 3.96
A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression. Scand J Immunol (1981) 3.85
Histocompatibility-linked immune response gene function in guinea pigs. Specific inhibition of antigen-induced lymphocyte proliferation by alloantisera. J Exp Med (1972) 3.81
X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells. J Exp Med (1975) 3.70
Interaction between antigen-presenting cells and primed T lymphocytes: an assessment of Ir gene expression in the antigen-presenting cell. Immunol Rev (1978) 3.67
Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). J Immunol (1976) 3.64
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T-cell and mast cell lines respond to B-cell stimulatory factor 1. Proc Natl Acad Sci U S A (1986) 3.56
The effect of the amount of mycobacterial adjuvants on the immune response of strain 2, strain 13 and Hartley strain guinea pigs to DNP-PLL and DNP-GL. J Immunol (1969) 3.53
Activation events during thymic selection. J Exp Med (1992) 3.43
Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha. Proc Natl Acad Sci U S A (1984) 3.43
Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production. Science (1995) 3.37
Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J Exp Med (1984) 3.36
Frequency of B lymphocytes responsive to anti-immunoglobulin. J Exp Med (1982) 3.30
Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc Natl Acad Sci U S A (1993) 3.27
Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors. J Exp Med (1980) 3.21
B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J Immunol (1987) 3.18
Genetic control of specific immune suppression. II. H-2-linked dominant genetic control of immune suppression by the random copolymer L-glutamic acid50-L-tyrosine50 (GT). J Exp Med (1975) 3.17
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Regulation by the H-2 gene complex of macrophage-lymphoid cell interactions in secondary antibody responses in vitro. J Exp Med (1976) 3.10
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X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect. J Exp Med (1975) 3.03
Ia antigen-bearing B cell tumor lines can present protein antigen and alloantigen in a major histocompatibility complex-restricted fashion to antigen-reactive T cells. J Exp Med (1982) 3.01
Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc Natl Acad Sci U S A (1991) 3.01
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Antibody-dependent lymphoid cell-mediated cytotoxicity: no requirement for thymus-derived lymphocytes. Science (1972) 2.98
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Receptors on immunocompetent cells. II. Specificity and nature of receptors on dinitrophenylated guinea pig albumin- 125 I-binding lymphocytes of normal guinea pigs. J Exp Med (1971) 2.92
Linkage between the poly-L-lysine gene and the locus controlling the major histocompatibility antigens in strain 2 guinea pigs. Proc Natl Acad Sci U S A (1970) 2.89
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Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells. Proc Natl Acad Sci U S A (1992) 2.56
Carrier function in anti-hapten immune responses. II. Specific properties of carrier cells capable of enhancing anti-hapten antibody responses. J Exp Med (1970) 2.54
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