Published in Proc Natl Acad Sci U S A on October 24, 2000
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev (2003) 4.40
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J (2002) 3.45
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IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A (2004) 2.12
Hypoxia links ATR and p53 through replication arrest. Mol Cell Biol (2002) 2.03
Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol Cell Biol (2004) 1.85
Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. Mol Cell Biol (2002) 1.83
p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1. Mol Cell Biol (2003) 1.75
ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice. Cancer Cell (2012) 1.70
Mutation of mouse p53 Ser23 and the response to DNA damage. Mol Cell Biol (2002) 1.65
Selenomethionine regulation of p53 by a ref1-dependent redox mechanism. Proc Natl Acad Sci U S A (2002) 1.45
Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol (2006) 1.45
Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389. Mol Cell Biol (2004) 1.44
Sensing of intermediates in V(D)J recombination by ATM. Genes Dev (2002) 1.42
Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Mol Cell Biol (2005) 1.31
Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis. Mol Cell Biol (2010) 1.23
Cellular senescence in cancer treatment: friend or foe? J Clin Invest (2004) 1.23
Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts. PLoS Genet (2009) 1.17
Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Proc Natl Acad Sci U S A (2001) 1.08
Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex. Cereb Cortex (2008) 1.08
Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response. J Virol (2005) 1.04
Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements. Nucleic Acids Res (2010) 1.03
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. PLoS Biol (2014) 1.01
Low levels of glutathione peroxidase 1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in pro-oxidant-induced aponecrosis. Biochem J (2003) 1.00
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Suppression of Myc oncogenic activity by nucleostemin haploinsufficiency. Oncogene (2011) 0.93
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AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol Cell Biol (2013) 0.90
Altered mammary gland development in the p53+/m mouse, a model of accelerated aging. Dev Biol (2007) 0.89
p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system. PLoS One (2011) 0.88
Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis. Mol Cancer Res (2010) 0.86
p53 suppresses tetraploid development in mice. Sci Rep (2015) 0.85
Induction and bypass of p53 during productive infection by polyomavirus. J Virol (2002) 0.85
Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein. J Biol Chem (2012) 0.84
Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta. Proc Natl Acad Sci U S A (2008) 0.81
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Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response. Mol Pharmacol (2012) 0.79
p53: a molecular marker for the detection of cancer. Expert Opin Med Diagn (2008) 0.78
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Regulation of p53 expression, phosphorylation and subcellular localization by a G-protein-coupled receptor. Oncogene (2009) 0.77
Effect of age on the sensitivity of the rat thyroid gland to ionizing radiation. J Radiat Res (2015) 0.76
Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness. Int J Mol Sci (2016) 0.75
Deficiency of the tumor promoter gene wip1 induces insulin resistance. Mol Endocrinol (2015) 0.75
Is p53 Involved in Tissue-Specific Insulin Resistance Formation? Oxid Med Cell Longev (2017) 0.75
p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation. Stem Cell Reports (2016) 0.75
Investigating the Influence of Magnesium Ions on p53-DNA Binding Using Atomic Force Microscopy. Int J Mol Sci (2017) 0.75
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell (1992) 19.87
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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (1998) 11.90
Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell (1997) 10.52
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science (1998) 8.74
DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science (2000) 7.85
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A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev (1999) 6.34
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev (2000) 5.90
DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev (1997) 5.76
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev (2000) 5.72
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol (1999) 4.88
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Regulation of p53 function and stability by phosphorylation. Mol Cell Biol (1999) 3.24
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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J (1999) 3.00
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Analysis of the gene coding for the murine cellular tumour antigen p53. EMBO J (1984) 2.94
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.87
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J (1999) 2.64
DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization. EMBO J (1999) 2.50
p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J (2000) 2.38
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Mutations in serines 15 and 20 of human p53 impair its apoptotic activity. Oncogene (1999) 1.56
Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks. Mol Cell Biol (1999) 1.27
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Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation. Cancer Res (1995) 1.24
P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells. Oncogene (1999) 1.23
The ATM gene and protein: possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress. Cancer Surv (1997) 1.05
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Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
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