Published in Biochemistry on July 01, 1964
Bactericidal and bacteriolytic activity of serum against gram-negative bacteria. Microbiol Rev (1983) 5.73
Germinal-center organization and cellular dynamics. Immunity (2007) 5.62
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell (2010) 5.49
Cell separation on antigen-coated columns. Elimination of high rate antibody-forming cells and immunological memory cells. J Exp Med (1969) 5.38
Antibody heterogeneity and serological reactions. Bacteriol Rev (1967) 4.16
General methods for the study of cells and serum during the immune response: the response to dinitrophenyl in mice. Clin Exp Immunol (1969) 4.00
The mechanism of antigenic stimulation of primary and secondary clonal precursor cells. J Exp Med (1972) 3.41
The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response. EMBO J (1997) 3.09
T cell affinity maturation by selective expansion during infection. J Exp Med (1999) 3.08
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J Exp Med (1998) 3.04
Characteristics of streptococcal group-specific antibody isolated from hyperimmune rabbits. J Exp Med (1966) 3.03
Studies on the regulation of avidity at the level of the single antibody-forming cell. The effect of antigen dose and time after immunization. J Exp Med (1970) 2.74
Kinetic and affinity limits on antibodies produced during immune responses. Proc Natl Acad Sci U S A (1995) 2.41
Antihapten antibody specificity and L chain type. J Exp Med (1967) 2.33
Somatic evolution of variable region structures during an immune response. Proc Natl Acad Sci U S A (1986) 2.23
Studies on the control of antibody synthesis. Effect of antibody affinity upon its ability to suppress antibody formation. Immunology (1968) 2.20
Studies on the effect of the carrier molecule on antihapten antibody synthesis. I. Effect of carrier on the nature of the antibody synthesized. J Exp Med (1966) 2.16
Determination of avidity of anti-albumin antibodies in the mouse. Influence of the number of cells transferred on the quality of the secondary adoptive response. Immunology (1969) 2.16
Precision and accuracy of a procedure for detecting recent human immunodeficiency virus infections by calculating the antibody avidity index by an automated immunoassay-based method. J Clin Microbiol (2002) 2.11
Receptors on immunocompetent cells. 3. Specificity and nature of receptors on dinitrophenylated guinea pig albumin- 125 I-binding cells of immunized guinea pigs. J Exp Med (1971) 2.11
Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced. J Exp Med (2002) 2.07
Studies on the control of antibody synthesis. 3. Changes in heterogeneity of antibody affinity during the course of the immune response. Immunology (1973) 2.07
The heterogeneity of antibody affinity in inbred mice and its possible immunopathologic significance. Clin Exp Immunol (1972) 2.04
Receptors on immunocompetent cells. V. Cellular correlates of the "maturation" of the immune response. J Exp Med (1972) 2.03
Changes in antibody avidity after virus infections: detection by an immunosorbent assay in which a mild protein-denaturing agent is employed. J Clin Microbiol (1984) 2.03
Studies on the effect of the carrier molecule on antihapten antibody synthesis. II. Carrier specificity of anti-2,4-dinitrophenyl-poly-l-lysine antibodies. J Exp Med (1966) 1.94
Clearance of Rh-positive red cells by low concentrations of Rh antibody. Immunology (1967) 1.92
Ontogeny of B-lymphocyte function. I. Restricted heterogeneity of the antibody response of B lymphocytes from neonatal and fetal mice. J Exp Med (1974) 1.86
Sequential changes in the relative affinity of antibodies synthesized during the immune response. J Exp Med (1967) 1.80
Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity. Proc Natl Acad Sci U S A (1995) 1.79
bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells. J Exp Med (2000) 1.76
Specificity of the antibodies produced by single cells following immunization with antigens bearing two types of antigenic determinants. J Exp Med (1967) 1.75
Substance abuse vaccines. Ann N Y Acad Sci (2008) 1.74
Complement components required for virus neutralization by early immunoglobulin antibody. Proc Natl Acad Sci U S A (1969) 1.72
Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc Natl Acad Sci U S A (2012) 1.70
Isolation of antigen-binding cells from unprimed mice: demonstration of antibody-forming cell precursor activity and correlation between precursor and secreted antibody avidities. J Exp Med (1974) 1.65
Symposium on in vitro studies of the immune response. I. Variations in the immune response to a simple determinant. Bacteriol Rev (1966) 1.65
Antigen-specific B cell memory: expression and replenishment of a novel b220(-) memory b cell compartment. J Exp Med (2000) 1.58
Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA. DNA Repair (Amst) (2007) 1.57
Immunological memory in mice. I. Physical separation and partial characterization of memory cells for different immunoglobulin classes from each other and from antibody-producing cells. J Exp Med (1970) 1.57
Thermodynamics of the binding of biotin and some analogues by avidin. Biochem J (1966) 1.53
Binding of a monoclonal antibody and its Fab fragment to supported phospholipid monolayers measured by total internal reflection fluorescence microscopy. Biophys J (1990) 1.49
Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells. J Immunol (2009) 1.49
Gastric cancer associated structure in mucus glycoproteins shown as a clinically useful marker. Gut (1991) 1.48
The effect of the carrier protein on the immune response and on the induction of tolerance in mice to the 2,4-dinitrophenyl determinant. Immunology (1969) 1.48
A quantitative study of the stimulation of DNA synthesis in lymph node cell cultures by anti-lymphocyte serum, anti-gamma globulin serum, specific antigen, and phytohemagglutinin. J Exp Med (1969) 1.47
Antigen recognition: in vitro studies on the specificity of the cellular immune response. J Exp Med (1969) 1.46
Immune responses in vitro. II. Suppression of the immune response in vitro by specific antibody. J Exp Med (1969) 1.45
Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice. J Exp Med (1999) 1.44
Rubella-specific IgG subclass avidity ELISA and its role in the differentiation between primary rubella and rubella reinfection. Epidemiol Infect (1988) 1.43
Quantitative investigations of idiotypic antibodies. 3. Persistence and variations of idiotypic specificities during the course of immunization. J Exp Med (1970) 1.43
Streptococcal group-specific antibodies: occurrence of a restricted population following secondary immunization. Proc Natl Acad Sci U S A (1968) 1.42
Regulation of cellular antibody synthesis. Cellular 7S production and longevity of 7S antigen-sensitive cells in the absence of antibody feedback. J Exp Med (1968) 1.42
Immunological memory in mice. II. Cell interactions in the secondary immune response studies by means of immunoglobulin allotype markers. J Exp Med (1970) 1.42
Immune responses in vitro. V. Suppression of M, G, and A plaque-forming cell responses in cultures of primed mouse spleen cells by class-specific antibody to mouse immunoglobulins. J Exp Med (1972) 1.40
Quantitative studies of the immunoglobulin sequence in the response of the rabbit to a somatic antigen. J Exp Med (1966) 1.40
Receptors on immunocompetent cells. IV. Direct measurement of avidity of cell receptors and cooperative binding of multivalent ligands. J Exp Med (1972) 1.38
Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice. J Immunol (2007) 1.36
Polymorphism of myosin among skeletal muscle fiber types. J Cell Biol (1977) 1.36
Restricted reassociation of heavy and light chains from hapten-specific monoclonal antibodies. Proc Natl Acad Sci U S A (1981) 1.36
Protection against Salmonella typhi infection in mice after immunization with outer membrane proteins isolated from Salmonella typhi 9,12,d, Vi. Infect Immun (1988) 1.33
Contact regions for dinitrophenyl and menadione haptens in an immunoglobulin binding more than one antigen. Proc Natl Acad Sci U S A (1972) 1.32
B lymphocyte memory: role of stromal cell complement and FcgammaRIIB receptors. J Exp Med (2002) 1.32
Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies. Cell (2015) 1.27
Studies on antigenic competition. J Exp Med (1969) 1.26
Clonal dominance. I. Restricted nature of the IgM antibody response to group A streptococcal carbohydrate in mice. J Exp Med (1975) 1.24
The primary and secondary antibody response to Escherichia coli O6 lipopolysaccharide analysed at the humoral and cellular level. Amount and avidity of the antibodies in relation to protective capacity. Immunology (1973) 1.23
Vaccines for cocaine abuse. Hum Vaccin (2009) 1.23
The effect of dose in tolerance induction on the subsequent response to a cross-reactive antigen. Immunology (1969) 1.23
Cellular heterogeneity in the production of an anti-hapten antibody. J Exp Med (1967) 1.22
Studies on the control of antibody synthesis. VI. Effect of antigen dose and time after immunization on antibody affinity and heterogeneity in the mouse. Clin Exp Immunol (1974) 1.22
The relationship of antibody-forming cells to rosette-forming cells. Immunology (1971) 1.20
In vitro-initiated secondary anti-hapten response. II. Increasing cell avidity for antigen. J Exp Med (1970) 1.18
Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans. Immunity (2015) 1.18
Ultracentrifugal studies of the reactions of rheumatoid factor with native human gamma-G-globulin. Immunology (1966) 1.17
Induction and reversal of immune paralysis in vitro. J Exp Med (1970) 1.16
Discriminating neoantigenic differences between fibrinogen and fibrin derivatives. Proc Natl Acad Sci U S A (1973) 1.15
Structural and binding analysis of a two domain extracellular CD2 molecule. J Exp Med (1989) 1.14
The functional activities of IgG and IgM anti-A and anti-B. Immunology (1967) 1.14
The strange cross-reaction of menadione (vitamin K3) and 2,4-dinitrophenyl ligands with a myeloma protein and some conventional antibodies. J Exp Med (1974) 1.13
Gamma-irradiated scrub typhus immunogens: development and duration of immunity. Infect Immun (1978) 1.13
Detection of Australia antigen by radioimmunoassay. Proc Natl Acad Sci U S A (1971) 1.13
Molecular dynamics in the membranes of helper T cells. Proc Natl Acad Sci U S A (1988) 1.12
Breaking the affinity ceiling for antibodies and T cell receptors. Proc Natl Acad Sci U S A (2000) 1.12
Quantitation of reversible binding by particle counting: hapten-antibody interaction as a model system. Proc Natl Acad Sci U S A (1992) 1.12
Complete inhibition of the expression of an idiotype by a mechanism of B-cell dominance. J Exp Med (1977) 1.11
Studies on the control of antibody synthesis. XII. Genetic influences on antibody affinity. Immunology (1978) 1.10
Micro complement fixation assay for type-specific group A streptococcal antibody. Infect Immun (1971) 1.10
The immune response to influenza virus. II. Effect of the route and schedule of vaccination on the quantity and avidity of antibodies. Immunology (1968) 1.09
Evolving concepts of specificity in immune reactions. Proc Natl Acad Sci U S A (2010) 1.09
Heterogeneity of the cellular immune response. I. Kinetics of lymphocyte stimulation during sensitization and recovery from tolerance. J Exp Med (1971) 1.08
Maturation of the immkune response in vitro. Focal fluctuation and changes in affinity of anti-beta-D-galactosidase activating antibody. J Exp Med (1972) 1.07
Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics. Adv Drug Deliv Rev (2009) 1.07
Dual regulatory role of the thymus in the maturation of immune response in the rabbit. J Exp Med (1974) 1.07
Pathogen responses to host immunity: the impact of time delays and memory on the evolution of virulence. Proc Biol Sci (2006) 1.07
Quantitative variations in L chain types in guinea pig antihapten antibodies. J Exp Med (1966) 1.05
Human constant regions influence the antibody binding characteristics of mouse-human chimeric IgG subclasses. Immunology (1996) 1.05
Factors influencing the immune response. II. Effects of the physical state of the antigen and of lymphoreticular cell proliferation on the response to intraperitoneal injection of bovine serum albumin in rabbits. Clin Exp Immunol (1967) 1.05
Binding of nicotinamide-adenine dinucleotides to diphtheria toxin. Biochem J (1967) 1.05
Studies of hypersensitivity to low molecular weight substances. III. The 2,4-dinitrophenyl group as a determinant in the preciptin reaction. J Immunol (1954) 7.50
The preparation and some properties of purified antibody specific for the 2,4-dinitrophenyl group. J Exp Med (1960) 5.58
PREPARATION OF PURIFIED ANTI-2,4-DINITROPHENYL ANTIBODIES. Methods Med Res (1964) 5.10
The zone of localization of antibodies. V. An attempt to saturate antibody-binding sites in mouse kidney. J Immunol (1950) 4.73
Elicitation of delayed allergic skin reactions with haptens; the dependence of elicitation on hapten combination with protein. J Exp Med (1952) 4.58
The secretion of antibody by isolated lymph node cells. J Biol Chem (1961) 4.08
A study of the distribution of 2,4-dinitrobenzene sensitizers between isolated lymph node cells and extracellular medium in relation to induction of contact skin sensitivity. J Exp Med (1959) 4.07
Hypersensitivity to penicillenic acid derivatives in human beings with penicillin allergy. J Exp Med (1962) 3.26
A new mixed disulphide: penicillamine-cysteine. Nature (1954) 3.24
EQUILIBRIUM DIALYSIS FOR MEASUREMENT OF ANTIBODY-HAPTEN AFFINITIES. Methods Med Res (1964) 2.45
Some immunochemical properties of penicillenic acid. An antigenic determinant derived from penicillin. J Exp Med (1960) 2.40
A theory of delayed hypersensitivity. Science (1962) 2.17
Observations on the mechanism of secretion of gamma-globulins by isolated lymph node cells. J Biol Chem (1962) 2.16
Specific inhibition of wheal-and-erythema responses with univalent haptens and univalent antibody fragments. J Exp Med (1960) 2.13
The zone of localization of antibodies VIII. Some properties of the antigen responsible for the renal localization of anti-kidney serum. J Immunol (1950) 2.10
The effect of antigenic stimulation on incorporation of phosphate and methionine into proteins of isolated lymph node cells. J Exp Med (1959) 2.03
Polyfunctional dinitrophenyl haptens as reagents for elicitation of immediate type allergic skin responses. J Exp Med (1962) 1.91
IMMUNE TOLERANCE AND AN EXTRACELLULAR REGULATORY ROLE FOR BIVALENT ANTIBODY. Nature (1964) 1.89
The zone of localization of antibodies. VI. The rate of localization of anti-mouse-kidney serum. J Immunol (1950) 1.89
The preparation and some properties of penicillenic acid derivatives relevant to penicillin hypersensitivity. J Exp Med (1962) 1.75
Studies of hypersensitivity to low molecular weight substances. II. Reactions of some allergenic substituted dinitrobenzenes with cysteine or cystine of skin proteins. J Exp Med (1953) 1.56
INDUCTION OF UNRESPONSIVENESS AND IMMUNITY IN NEWBORN AND ADULT MICE WITH PNEUMOCOCCAL POLYSACCHARIDE. J Immunol (1963) 1.55
The zone of localization of antibodies. X. The use of radioactive sulfur 35 as a label for anti-kidney serum. J Immunol (1950) 1.52
DETERMINATION OF ANTIBODY AFFINITY FOR HAPTENS AND ANTIGENS BY MEANS OF FLUORESCENCE QUENCHING. Methods Med Res (1964) 1.45
The distribution and utilization of glucose in isolated lymph node cells. J Biol Chem (1959) 1.29
Specific localization of anti-rat-lung serum in the lung. Proc Soc Exp Biol Med (1950) 1.22
The immunologic reactivity of bovine serum albumin labeled with trace-amounts of radioactive iodine (I131). J Immunol (1949) 1.22
The interaction of purified antibody with homologous hapten; antibody valence and binding constant. J Am Chem Soc (1949) 1.21
The solubilization of microsomal antibody activity by the specific interaction between the crystallizable fraction of gamma-globulin and lymphnode microsomes. Proc Natl Acad Sci U S A (1961) 1.17
A BIOASSAY FOR ESTIMATION OF PNEUMOCOCCAL POLYSACCHARIDE IN UNRESPONSIVE (PARALYZED) MICE. J Immunol (1964) 1.10
The induction in mice of sensitization and immunological unresponsiveness by neonatal injection of bovine gamma-globulin. J Immunol (1961) 1.10
Studies on the runting syndrome in newborn mice. J Exp Med (1959) 1.03
QUANTITATIVE STUDIES ON THE PRECIPITATION OF ANTI-2,4DINITROPHENYL ANTIBODY IN ANTIGEN EXCESS. J Immunol (1964) 1.02
The zone of localization of antibodies. IX. The properties of anti-rat-lung serum. J Immunol (1950) 0.99
Delayed allergic skin responses of the contact dermatitis type. Bull N Y Acad Med (1956) 0.91
VARIATIONS IN THE IMMUNE RESPONSE TO A SIMPLE DETERMINANT. Trans Assoc Am Physicians (1964) 0.89
Antigenic determinants of conjugated proteins in relation to allergic responses. Fed Proc (1962) 0.86
Ultraviolet absorption spectroscopy of immune precipitates. J Immunol (1948) 0.85
Incorporation of amino acids into a gamma-globulin-like protein by cell-free extracts from lymph nodes. Trans Assoc Am Physicians (1961) 0.82
Primary systemic amyloidosis. Am J Med (1946) 0.76
PREPARATION OF PURIFIED ANTI-GAMMA-GLOBULIN ANTIBODIES. Methods Med Res (1964) 0.75
Protein metabolism. Med Clin North Am (1955) 0.75
Immune responses and regression of autochthonous tumors. Cancer Res (1961) 0.75
Adenomatoid transformation of the glomerular capsular epithelium. Am J Pathol (1946) 0.75
Measurement and study of immune precipitates by means of ultraviolet absorption spectroscopy. Fed Proc (1948) 0.75
Turnover of serum protein in adrenalectomized rats. Proc Soc Exp Biol Med (1947) 0.75
Failure of adrenal cortical activity to influence circulating antibodies and gamma globulin. Proc Soc Exp Biol Med (1947) 0.75
Immunochemical studies with proteins labelled with trace amounts of radioactive iodine. Fed Proc (1948) 0.75
Studies on the runting syndrome in newborn mice. Bull Soc Int Chir (1959) 0.75
SOME METHODS APPLICABLE TO STUDY OF EXPERIMENTAL HYPERSENSITIVITY. Methods Med Res (1964) 0.75
Suppression of circulating antibodies in pyridoxin deficiency. Proc Soc Exp Biol Med (1946) 0.75
Diamine oxidase (histaminase) activity of kidney and other organs in the hypersensitive state. Am J Physiol (1946) 0.75