Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies.

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Published in Cell on February 05, 2015

Authors

Shenshen Wang1, Jordi Mata-Fink2, Barry Kriegsman3, Melissa Hanson4, Darrell J Irvine5, Herman N Eisen6, Dennis R Burton7, K Dane Wittrup8, Mehran Kardar9, Arup K Chakraborty10

Author Affiliations

1: Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139.
2: Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
3: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
4: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
5: Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
6: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
7: Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037.
8: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
9: Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139.
10: Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139. Electronic address: arupc@mit.edu.

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