Published in Mol Cell Biol on December 01, 1992
UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. EMBO J (1993) 1.86
The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1. Proc Natl Acad Sci U S A (2003) 1.64
The X protein of hepatitis B virus coactivates potent activation domains. Mol Cell Biol (1995) 1.36
A switch region determines the cell type-specific positive or negative action of YY1 on the activity of the human papillomavirus type 18 promoter. J Virol (1995) 1.08
Goals for signal transduction pathways: linking up with transcriptional regulation. EMBO J (1994) 1.03
Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science (1989) 25.68
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell (1987) 20.61
How eukaryotic transcriptional activators work. Nature (1988) 19.34
GAL4-VP16 is an unusually potent transcriptional activator. Nature (1988) 16.53
Deletion analysis of GAL4 defines two transcriptional activating segments. Cell (1987) 14.13
Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell (1988) 12.68
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta (1991) 11.78
Gene regulation by proteins acting nearby and at a distance. Nature (1986) 9.71
Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. Cell (1988) 9.34
Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. Genes Dev (1988) 8.82
The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain. Cell (1989) 8.60
Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell (1990) 8.18
Phosphorylation of c-jun mediated by MAP kinases. Nature (1991) 8.07
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell (1988) 7.76
A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A (1988) 7.47
Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature (1988) 7.45
Negative effect of the transcriptional activator GAL4. Nature (1988) 7.15
Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID. Nature (1990) 7.11
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell (1991) 6.89
The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell (1989) 6.24
Mechanism of action of an acidic transcriptional activator in vitro. Cell (1991) 6.04
Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation. Cell (1991) 6.04
An estrogen-responsive element derived from the 5' flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells. Cell (1986) 5.22
Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains. Cell (1992) 5.14
12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region. Mol Cell Biol (1987) 4.86
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature (1991) 4.74
The yeast UASG is a transcriptional enhancer in human HeLa cells in the presence of the GAL4 trans-activator. Cell (1988) 4.22
Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell (1989) 4.17
Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature (1991) 4.17
The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1. Cell (1992) 4.11
GAL4 activates gene expression in mammalian cells. Cell (1988) 3.81
Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex. Genes Dev (1991) 3.77
Distinct classes of transcriptional activating domains function by different mechanisms. Cell (1990) 3.75
A novel mediator between activator proteins and the RNA polymerase II transcription apparatus. Cell (1990) 3.74
The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell (1988) 3.64
Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: evidence for transcriptional adaptors. Cell (1990) 3.31
Mechanism of action of a yeast activator: direct effect of GAL4 derivatives on mammalian TFIID-promoter interactions. Cell (1988) 3.17
The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast. Nature (1988) 2.77
Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element. Oncogene (1988) 2.43
jun: oncogene and transcription factor. Adv Cancer Res (1990) 2.32
Dissection of functional domains of the pituitary-specific transcription factor GHF-1. Nature (1990) 2.23
Jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner. New Biol (1989) 1.47
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell (1987) 20.61
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell (1991) 6.89
DNA binding of the glucocorticoid receptor is not essential for survival. Cell (1998) 6.40
12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region. Mol Cell Biol (1987) 4.86
Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J (1987) 4.56
Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature (1989) 4.42
ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J (1995) 4.28
Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell (1989) 4.17
Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev (1999) 3.51
Comparison of human stromelysin and collagenase by cloning and sequence analysis. Biochem J (1986) 3.31
Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J (1993) 3.28
Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein. EMBO J (1993) 2.83
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol (1990) 2.73
Posttranscriptional regulation of c-fos mRNA expression. Nucleic Acids Res (1987) 2.66
Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene (1995) 2.64
Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts. Mol Cell Biol (1986) 2.63
Structure and chromosomal localization of the functional intronless human JUN protooncogene. Proc Natl Acad Sci U S A (1988) 2.51
c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin. Cell (2000) 2.35
Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J (2001) 2.34
Different requirements for formation of Jun: Jun and Jun: Fos complexes. Genes Dev (1989) 2.22
The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. Nucleic Acids Res (1996) 2.09
Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. Science (1997) 1.93
UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. EMBO J (1993) 1.86
The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription. Oncogene (1989) 1.78
The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep (2001) 1.76
Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1. EMBO J (1992) 1.74
Fos is an essential component of the mammalian UV response. EMBO J (1995) 1.73
The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells. Mol Cell Biol (1991) 1.59
JunB is essential for mammalian placentation. EMBO J (1999) 1.57
AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element. J Biol Chem (2001) 1.51
Modulation of AP-1/ATF transcription factor activity by the adenovirus-E1A oncogene products. Bioessays (1995) 1.50
The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin. J Cell Biol (1999) 1.48
Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. Cell Growth Differ (1995) 1.46
Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation. Genes Dev (1998) 1.42
Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone. Oncogene (1999) 1.38
Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the response. Photochem Photobiol (1992) 1.37
The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. Mol Cell Biol (1997) 1.36
Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J (1997) 1.23
Structural organization and chromosomal localization of the mouse collagenase type I gene. Biochem J (1995) 1.22
Collagenase-3 (MMP-13) and integral membrane protein 2a (Itm2a) are marker genes of chondrogenic/osteoblastic cells in bone formation: sequential temporal, and spatial expression of Itm2a, alkaline phosphatase, MMP-13, and osteocalcin in the mouse. J Bone Miner Res (2000) 1.22
Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation. Carcinogenesis (1994) 1.19
Identification of novel tumour-associated genes differentially expressed in the process of squamous cell cancer development. Oncogene (2006) 1.19
Organotypic cocultures with genetically modified mouse fibroblasts as a tool to dissect molecular mechanisms regulating keratinocyte growth and differentiation. J Invest Dermatol (2001) 1.19
c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents. Mol Cell Biol (2000) 1.18
The mammalian genetic stress response. Adv Enzyme Regul (1986) 1.17
A switch region determines the cell type-specific positive or negative action of YY1 on the activity of the human papillomavirus type 18 promoter. J Virol (1995) 1.08
Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1 beta or phorbol ester. Biochem Biophys Res Commun (1987) 1.06
Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5' activator protein-1-binding site. Mol Endocrinol (1990) 1.05
The glucocorticoid receptor synergizes with Jun homodimers to activate AP-1-regulated promoters lacking GR binding sites. Chem Senses (1995) 1.01
Induction of the AP-1 members c-Jun and JunB by TGF-beta/Smad suppresses early Smad-driven gene activation. Oncogene (2001) 1.00
p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV. J Biol Chem (2000) 0.98
12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced gene sequences in human primary diploid fibroblasts and their expression in SV40-transformed fibroblasts. J Cell Biochem (1985) 0.97
JNK/SAPK activity contributes to TRAIL-induced apoptosis. Cell Death Differ (1999) 0.97
A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs. Mol Cell Biol (2000) 0.96
Is restricting tobacco sales the answer to adolescent smoking? Prev Med (2003) 0.90
Localisation of matrix metalloproteinases and TIMP-2 in resorbing mouse bone. Cell Tissue Res (2000) 0.89
FRMD3, a novel putative tumour suppressor in NSCLC. Oncogene (2007) 0.87
Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro. Nucleic Acids Res (1997) 0.87
Mutation of a phosphorylation site in the DNA-binding domain is required for redox-independent transactivation of AP1-dependent genes by v-Jun. Oncogene (1993) 0.86
Both ATF-2 and c-Jun are phosphorylated by stress-activated protein kinases in response to UV irradiation. Immunobiology (1995) 0.86
JNK/SAPK activity is not sufficient for anticancer therapy-induced apoptosis involving CD95-L, TRAIL and TNF-alpha. Int J Cancer (1999) 0.86
Keratinocyte-specific onset of serine protease BSSP expression in experimental carcinogenesis. J Invest Dermatol (2001) 0.86
Altered AP-1/ATF complexes in adenovirus-E1-transformed cells due to EIA-dependent induction of ATF3. Oncogene (1996) 0.86
NFkappaB activation is required for interferon regulatory factor-1-mediated interferon beta induction. Eur J Biochem (1999) 0.84
Targets for signal-transducing protein kinases. Cold Spring Harb Symp Quant Biol (1988) 0.83
Expression of the recessive glomerulosclerosis gene Mpv17 regulates MMP-2 expression in fibroblasts, the kidney, and the inner ear of mice. Mol Biol Cell (1998) 0.83
The catalytic domain of activated collagenase I (MMP-1) is absolutely required for interaction with its specific inhibitor, tissue inhibitor of metalloproteinases-1 (TIMP-1). Eur J Biochem (1997) 0.83
Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases. Cell Regul (1990) 0.81
Transcriptional control of human papillomavirus type 18 oncogene expression in different cell lines: role of transcription factor YY1. Virus Genes (1995) 0.80
Evaluation of dental restorations: a comparative study between clinical and digital photographic assessments. Oper Dent (2013) 0.79
DNA-binding activity of Jun is increased through its interaction with Fos. J Cell Biochem (1990) 0.79
Expression of collagenase-3 (MMP-13) in c-fos-induced osteosarcomas and chondrosarcomas is restricted to a subset of cells of the osteo-/chondrogenic lineage. Differentiation (2001) 0.79
TAp63alpha indirectly regulates a cutaneous HPV promoter through complex formation with Jun family members. Oncogene (2006) 0.78
Characterization of mammary epithelial cell line HC11 using the NIA 15k gene array reveals potential regulators of the undifferentiated and differentiated phenotypes. Differentiation (2009) 0.76
c-jun expression and growth stimulation in human ovarian carcinoma cell lines following exposure to cytokines. Int J Cancer (1995) 0.75
Expression of human collagenase I (MMP-1) and TIMP-1 in a baculovirus-based expression system. Methods Mol Biol (2001) 0.75
[The family of the addict: critical review of the literature]. Psychiatr Enfant (1983) 0.75
Ovarian adenocarcinomas express members of different cytokine pathways - analysis and quantification of transcripts from the tgf-alpha and m-csf fms pathways and the transcription factor cjun. Int J Oncol (1993) 0.75
Signal transduction into the nucleus: fifth colloquium on cellular signal transduction. Heidelberg, Germany, January 1996. J Cancer Res Clin Oncol (1996) 0.75
Amplification of the expression of major histocompatibility class-I antigens by inducers of differentiation and gamma interferon in murine and human solid tumor-cell lines. Int J Oncol (1993) 0.75
Drug addicts attending specialised institutions: towards a drug addiction data bank? Drug Alcohol Depend (1991) 0.75