Published in Proc Natl Acad Sci U S A on July 01, 1991
Protein stability promotes evolvability. Proc Natl Acad Sci U S A (2006) 5.73
Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids. PLoS Genet (2008) 2.90
Arabidopsis cytochrome P450 monooxygenase 71A13 catalyzes the conversion of indole-3-acetaldoxime in camalexin synthesis. Plant Cell (2007) 2.19
High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli. Proc Natl Acad Sci U S A (1995) 2.00
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Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest (2006) 1.59
CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata. Proc Natl Acad Sci U S A (2004) 1.53
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Abundant bacterial expression and reconstitution of an intrinsic membrane-transport protein from bovine mitochondria. Biochem J (1993) 1.40
Mycobacterium tuberculosis CYP130: crystal structure, biophysical characterization, and interactions with antifungal azole drugs. J Biol Chem (2007) 1.33
Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. PLoS Negl Trop Dis (2010) 1.30
Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. PLoS Negl Trop Dis (2009) 1.29
Evolution favors protein mutational robustness in sufficiently large populations. BMC Biol (2007) 1.29
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Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes. Proc Natl Acad Sci U S A (1993) 1.22
Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease. J Clin Invest (1993) 1.17
Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us? Philos Trans R Soc Lond B Biol Sci (2013) 1.16
Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. FEBS J (2008) 1.14
Evolution of diterpene metabolism: Sitka spruce CYP720B4 catalyzes multiple oxidations in resin acid biosynthesis of conifer defense against insects. Plant Physiol (2011) 1.14
Engineering microbial factories for synthesis of value-added products. J Ind Microbiol Biotechnol (2011) 1.13
The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother (2014) 1.13
CYP2C9 genotype-dependent effects on in vitro drug-drug interactions: switching of benzbromarone effect from inhibition to activation in the CYP2C9.3 variant. Mol Pharmacol (2005) 1.08
CYP2C9-CYP3A4 protein-protein interactions: role of the hydrophobic N terminus. Drug Metab Dispos (2010) 1.06
Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals. Appl Environ Microbiol (2010) 1.04
Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli. Mol Pharmacol (2009) 1.03
CYP2C8 exists as a dimer in natural membranes. Drug Metab Dispos (2010) 0.99
Cloning and expression of cytochrome P450 enzymes catalyzing the conversion of tyrosine to p-hydroxyphenylacetaldoxime in the biosynthesis of cyanogenic glucosides in Triglochin maritima. Plant Physiol (2000) 0.99
Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli. Appl Environ Microbiol (2007) 0.99
Purification, characterization, and cDNA cloning of an NADPH-cytochrome P450 reductase from mung bean. Proc Natl Acad Sci U S A (1993) 0.97
Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase. Proc Natl Acad Sci U S A (1993) 0.97
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Characterization of heme environment and mechanism of peroxide bond cleavage in human prostacyclin synthase. Biochim Biophys Acta (2005) 0.96
Organization of cytochrome P450 enzymes involved in sex steroid synthesis: PROTEIN-PROTEIN INTERACTIONS IN LIPID MEMBRANES. J Biol Chem (2009) 0.95
Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. Pharmacogenet Genomics (2008) 0.95
A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds. Chemistry (2009) 0.93
High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein. Proc Natl Acad Sci U S A (1992) 0.93
The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system. Pharmacogenet Genomics (2007) 0.93
Polymorphic variants of CYP2C9: mechanisms involved in reduced catalytic activity. Mol Pharmacol (2007) 0.92
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Heterologous expression of rat liver microsomal glutathione transferase in simian COS cells and Escherichia coli. Biochem J (1995) 0.91
Biosynthetic pathway for the cyanide-free production of phenylacetonitrile in Escherichia coli by utilizing plant cytochrome P450 79A2 and bacterial aldoxime dehydratase. Appl Environ Microbiol (2014) 0.90
Navigating the protein fitness landscape with Gaussian processes. Proc Natl Acad Sci U S A (2012) 0.90
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Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51). Appl Environ Microbiol (2014) 0.88
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Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase. Biochemistry (2008) 0.88
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Reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1. Bioorg Med Chem Lett (2010) 0.85
Human cytochrome P450 4F11: heterologous expression in bacteria, purification, and characterization of catalytic function. Arch Biochem Biophys (2009) 0.85
Enhanced heterologous expression of two Streptomyces griseolus cytochrome P450s and Streptomyces coelicolor ferredoxin reductase as potentially efficient hydroxylation catalysts. Appl Environ Microbiol (2003) 0.85
A highly conserved mycobacterial cholesterol catabolic pathway. Environ Microbiol (2013) 0.85
Functional analysis of phenylalanine residues in the active site of cytochrome P450 2C9. Biochemistry (2008) 0.84
Functional studies of N-terminally modified CYP2J2 epoxygenase in model lipid bilayers. Protein Sci (2013) 0.84
Genetic and biochemical investigations of the role of MamP in redox control of iron biomineralization in Magnetospirillum magneticum. Proc Natl Acad Sci U S A (2015) 0.83
Unveiling the crucial intermediates in androgen production. Proc Natl Acad Sci U S A (2015) 0.83
Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. J Lipid Res (2014) 0.82
In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus. Antimicrob Agents Chemother (2015) 0.80
Enhanced bacterial expression of several mammalian cytochrome P450s by codon optimization and chaperone coexpression. Biotechnol Lett (2009) 0.80
A key cytochrome P450 hydroxylase in pradimicin biosynthesis. Bioorg Med Chem Lett (2011) 0.80
The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. Antimicrob Agents Chemother (2016) 0.80
Heterologous expression of the isopimaric acid pathway in Nicotiana benthamiana and the effect of N-terminal modifications of the involved cytochrome P450 enzyme. J Biol Eng (2015) 0.79
A new CYP3A5 variant, CYP3A5*11, is shown to be defective in nifedipine metabolism in a recombinant cDNA expression system. Drug Metab Dispos (2006) 0.79
Design and improvement of artificial redox modules by molecular fusion of flavodoxin and flavodoxin reductase from Escherichia coli. Sci Rep (2015) 0.79
Characterization of Saccharomyces cerevisiae CYP51 and a CYP51 fusion protein with NADPH cytochrome P-450 oxidoreductase expressed in Escherichia coli. Antimicrob Agents Chemother (1997) 0.79
Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins. PLoS One (2015) 0.78
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Cytochrome P450 proteins and potential utilization in biodegradation. Environ Health Perspect (1995) 0.78
Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli. Proc Natl Acad Sci U S A (2016) 0.78
Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51). Antimicrob Agents Chemother (2015) 0.78
Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. Appl Environ Microbiol (2015) 0.77
Comparison of CYP3A4 and CYP3A5: the effects of cytochrome b5 and NADPH-cytochrome P450 reductase on testosterone hydroxylation activities. Drug Metab Pharmacokinet (2012) 0.77
Recent Structural Insights into Cytochrome P450 Function. Trends Pharmacol Sci (2016) 0.77
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Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicol Appl Pharmacol (2016) 0.76
Specificity of Protein Covalent Modification by the Electrophilic Proteasome Inhibitor Carfilzomib in Human Cells. Mol Cell Proteomics (2016) 0.76
Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coli. Chem Res Toxicol (2012) 0.76
Cytochrome P450 125A4, the Third Cholesterol C-26 Hydroxylase from Mycobacterium smegmatis. Biochemistry (2015) 0.75
Activity, inhibition, and induction of cytochrome P450 2J2 in adult human primary cardiomyocytes. Drug Metab Dispos (2013) 0.75
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Isotope-Labeling Studies Support the Electrophilic Compound I Iron Active Species, FeO(3+), for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side-Chain Cleavage Enzyme, Cytochrome P450 11A1. J Am Chem Soc (2016) 0.75
Modifications in the N-terminus of an insect cytochrome P450 enhance production of catalytically active protein in baculovirus-Sf9 cell expression systems. Insect Biochem Mol Biol (2007) 0.75
Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa. Sci Rep (2016) 0.75
Comparison of microbial hosts and expression systems for mammalian CYP1A1 catalysis. J Ind Microbiol Biotechnol (2011) 0.75
Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus. Biochim Biophys Acta (2017) 0.75
The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through its Inhibition of T. rubrum CYP51. Antimicrob Agents Chemother (2017) 0.75
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