Published in Physiol Rev on October 01, 2003
Structure of the connexin 26 gap junction channel at 3.5 A resolution. Nature (2009) 4.44
Life cycle of connexins in health and disease. Biochem J (2006) 3.44
Connexin43 phosphorylation: structural changes and biological effects. Biochem J (2009) 2.75
Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion. Mol Biol Cell (2005) 2.62
The gap junction cellular internet: connexin hemichannels enter the signalling limelight. Biochem J (2006) 2.24
Selectivity of connexin 43 channels is regulated through protein kinase C-dependent phosphorylation. Circ Res (2006) 2.02
Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. J Clin Invest (2009) 1.98
Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1. Mol Biol Cell (2011) 1.81
Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue. Mol Cancer Res (2012) 1.73
Phosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC. J Cell Biol (2007) 1.70
A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract. J Med Genet (2006) 1.68
Analysis of Connexin43 phosphorylated at S325, S328 and S330 in normoxic and ischemic heart. J Cell Sci (2006) 1.66
Gap junctions. Compr Physiol (2012) 1.59
Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue. Brain Res Brain Res Rev (2004) 1.54
ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. J Neurochem (2011) 1.52
Oxidative stress, lens gap junctions, and cataracts. Antioxid Redox Signal (2009) 1.49
Key connexin 43 phosphorylation events regulate the gap junction life cycle. J Membr Biol (2007) 1.48
Gap junctions in the control of vascular function. Antioxid Redox Signal (2009) 1.47
Biological role of connexin intercellular channels and hemichannels. Arch Biochem Biophys (2012) 1.45
Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism. J Neurosci (2011) 1.43
Gap-junction channels dysfunction in deafness and hearing loss. Antioxid Redox Signal (2009) 1.39
Tumor-associated macrophages (TAMs) form an interconnected cellular supportive network in anaplastic thyroid carcinoma. PLoS One (2011) 1.39
Endothelial Ca2+ wavelets and the induction of myoendothelial feedback. Am J Physiol Cell Physiol (2012) 1.35
A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts. J Med Genet (2007) 1.35
Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration. Antioxid Redox Signal (2009) 1.34
Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress. Front Biosci (2007) 1.34
Gap junctions mediate human immunodeficiency virus-bystander killing in astrocytes. J Neurosci (2007) 1.33
Intercellular Ca(2+) waves: mechanisms and function. Physiol Rev (2012) 1.32
Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues. Biochim Biophys Acta (2011) 1.32
Defining electrical communication in skeletal muscle resistance arteries: a computational approach. J Physiol (2005) 1.30
Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential. Proc Natl Acad Sci U S A (2007) 1.30
Gap junction- and hemichannel-independent actions of connexins. Biochim Biophys Acta (2004) 1.30
Paracrine signaling through plasma membrane hemichannels. Biochim Biophys Acta (2012) 1.28
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate. J Cell Biol (2007) 1.25
Regulation of cerebral blood flow. Int J Vasc Med (2011) 1.25
Expression of genes encoding innate host defense molecules in normal human monocytes in response to Candida albicans. Infect Immun (2005) 1.24
Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes. Mol Biol Cell (2007) 1.23
An aberrant sequence in a connexin46 mutant underlies congenital cataracts. J Biol Chem (2005) 1.22
Connexins in vascular physiology and pathology. Antioxid Redox Signal (2009) 1.22
Transcriptional modulation of genes encoding structural characteristics of differentiating enterocytes during development of a polarized epithelium in vitro. Mol Biol Cell (2007) 1.22
Diverse deafness mechanisms of connexin mutations revealed by studies using in vitro approaches and mouse models. Brain Res (2009) 1.20
Specific Cx43 phosphorylation events regulate gap junction turnover in vivo. FEBS Lett (2014) 1.19
Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368. J Cell Biol (2004) 1.18
Glial connexins and gap junctions in CNS inflammation and disease. J Neurochem (2008) 1.17
Connexins and the kidney. Am J Physiol Regul Integr Comp Physiol (2010) 1.15
eNOS activation and NO function: pregnancy adaptive programming of capacitative entry responses alters nitric oxide (NO) output in vascular endothelium--new insights into eNOS regulation through adaptive cell signaling. J Endocrinol (2011) 1.15
Connexins and gap junctions in mammary gland development and breast cancer progression. J Membr Biol (2007) 1.15
Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses. Mol Biol Cell (2008) 1.15
Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels. J Gen Physiol (2004) 1.13
The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. J Neuroimmune Pharmacol (2012) 1.13
Living-cell microarrays. Annu Rev Biomed Eng (2009) 1.12
Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression. Hum Mol Genet (2008) 1.12
Connexin mutants and cataracts. Front Pharmacol (2013) 1.11
Cytokines and junction restructuring events during spermatogenesis in the testis: an emerging concept of regulation. Cytokine Growth Factor Rev (2009) 1.11
ZO-1 is required for protein kinase C gamma-driven disassembly of connexin 43. Cell Signal (2006) 1.10
Connexin 43 regulates epicardial cell polarity and migration in coronary vascular development. Development (2009) 1.10
ERp29 restricts Connexin43 oligomerization in the endoplasmic reticulum. Mol Biol Cell (2009) 1.10
Gating, permselectivity and pH-dependent modulation of channels formed by connexin57, a major connexin of horizontal cells in the mouse retina. J Physiol (2009) 1.08
Golgi bypass: skirting around the heart of classical secretion. Cold Spring Harb Perspect Biol (2011) 1.07
Insights on the mechanisms of Ca(2+) regulation of connexin26 hemichannels revealed by human pathogenic mutations (D50N/Y). J Gen Physiol (2013) 1.06
Both sides now: multiple interactions of ATP with pannexin-1 hemichannels. Focus on "A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP". Am J Physiol Cell Physiol (2009) 1.06
Connexin 43 in LA-25 cells with active v-src is phosphorylated on Y247, Y265, S262, S279/282, and S368 via multiple signaling pathways. Cell Commun Adhes (2008) 1.06
Differential expression of connexins in trigeminal ganglion neurons and satellite glial cells in response to chronic or acute joint inflammation. Neuron Glia Biol (2009) 1.05
Preferential induction of apoptotic cell death in melanoma cells as compared with normal keratinocytes using a non-thermal plasma torch. Cancer Biol Ther (2012) 1.05
Dynamic model for ventricular junctional conductance during the cardiac action potential. Am J Physiol Heart Circ Physiol (2004) 1.05
Connexin 43 confers resistance to hydrogen peroxide-mediated apoptosis. Biochem Biophys Res Commun (2007) 1.05
Localized expression of an Ins(1,4,5)P3 receptor at the myoendothelial junction selectively regulates heterocellular Ca2+ communication. J Cell Sci (2008) 1.04
Tonabersat inhibits trigeminal ganglion neuronal-satellite glial cell signaling. Headache (2009) 1.04
Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension. Kidney Int (2010) 1.03
A novel GJA8 mutation (p.I31T) causing autosomal dominant congenital cataract in a Chinese family. Mol Vis (2009) 1.03
Endocytic processing of connexin43 gap junctions: a morphological study. Biochem J (2006) 1.03
Junctional and nonjunctional effects of heptanol and glycyrrhetinic acid derivates in rat mesenteric small arteries. Br J Pharmacol (2004) 1.02
Hereditary non-syndromic sensorineural hearing loss: transforming silence to sound. J Mol Diagn (2004) 1.02
Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells. Am J Physiol Cell Physiol (2009) 1.02
The temperature and type of intracellular ice formation in preimplantation mouse embryos as a function of the developmental stage. Biol Reprod (2010) 1.01
N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26. J Cell Sci (2006) 1.01
Methodologies for characterizing phosphoproteins by mass spectrometry. Cell Commun Adhes (2006) 1.01
Dissection of two Cx37-independent conducted vasodilator mechanisms by deletion of Cx40: electrotonic versus regenerative conduction. Am J Physiol Heart Circ Physiol (2008) 1.01
Trafficking and recycling of the connexin43 gap junction protein during mitosis. Traffic (2010) 1.01
Dexamethasone disrupts intercellular junction formation and cytoskeleton organization in human trabecular meshwork cells. Mol Vis (2010) 1.00
Posttranslational modifications in connexins and pannexins. J Membr Biol (2012) 1.00
Sphingosine 1-phosphate induces myoblast differentiation through Cx43 protein expression: a role for a gap junction-dependent and -independent function. Mol Biol Cell (2006) 1.00
The perinexus: a new feature of Cx43 gap junction organization. Heart Rhythm (2011) 1.00
Connexin43-dependent mechanism modulates renin secretion and hypertension. J Clin Invest (2006) 1.00
Restoration of functional gap junctions through internal ribosome entry site-dependent synthesis of endogenous connexins in density-inhibited cancer cells. Mol Cell Biol (2005) 1.00
Staphylococcus aureus-derived peptidoglycan induces Cx43 expression and functional gap junction intercellular communication in microglia. J Neurochem (2005) 1.00
Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells. Br J Pharmacol (2005) 1.00
Connexin 43 as a signaling platform for increasing the volume and spatial distribution of regenerated tissue. Proc Natl Acad Sci U S A (2009) 0.99
Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress. J Biol Chem (2013) 0.99
Interaction of connexin43 and protein kinase C-delta during FGF2 signaling. BMC Biochem (2010) 0.98
Biological and biophysical properties of vascular connexin channels. Int Rev Cell Mol Biol (2009) 0.98
Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection. Pharmacol Ther (2015) 0.97
Identification of novel genes and pathways regulating SREBP transcriptional activity. PLoS One (2009) 0.97
Characterization of gap junction remodeling in epicardial border zone of healing canine infarcts and electrophysiological effects of partial reversal by rotigaptide. Circ Arrhythm Electrophysiol (2011) 0.97
Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 0.97
Low oxygen tension and synthetic nanogratings improve the uniformity and stemness of human mesenchymal stem cell layer. Mol Ther (2010) 0.97
Connexin 43 in ischemic pre- and postconditioning. Heart Fail Rev (2007) 0.97
Tunneling nanotubes (TNT): A potential mechanism for intercellular HIV trafficking. Commun Integr Biol (2009) 0.96
The antiarrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43. Br J Pharmacol (2006) 0.96
Cardiac gap junction channels show quantitative differences in selectivity. Circ Res (2002) 2.28
Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation. Circ Res (2002) 1.54
Oxidative stress, lens gap junctions, and cataracts. Antioxid Redox Signal (2009) 1.49
Loss of function and impaired degradation of a cataract-associated mutant connexin50. Eur J Cell Biol (2003) 1.48
A mutant connexin50 with enhanced hemichannel function leads to cell death. Invest Ophthalmol Vis Sci (2009) 1.43
Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells. J Cell Sci (2004) 1.40
Pathways for degradation of connexins and gap junctions. Cardiovasc Res (2004) 1.38
Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctions. J Physiol (2004) 1.37
An aberrant sequence in a connexin46 mutant underlies congenital cataracts. J Biol Chem (2005) 1.22
Autophagy: a pathway that contributes to connexin degradation. J Cell Sci (2011) 1.17
Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels. J Gen Physiol (2004) 1.13
Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5. Cardiovasc Res (2004) 1.11
Connexin mutants and cataracts. Front Pharmacol (2013) 1.11
Biophysical evidence that connexin-36 forms functional gap junction channels between pancreatic mouse beta-cells. Am J Physiol Endocrinol Metab (2004) 1.09
Dynamic model for ventricular junctional conductance during the cardiac action potential. Am J Physiol Heart Circ Physiol (2004) 1.05
Connexin40 and connexin43 determine gating properties of atrial gap junction channels. J Mol Cell Cardiol (2009) 1.05
Redistribution of connexin45 in gap junctions of connexin43-deficient hearts. Cardiovasc Res (2002) 1.03
Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50. Am J Physiol Cell Physiol (2011) 1.02
N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26. J Cell Sci (2006) 1.01
Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50. Invest Ophthalmol Vis Sci (2008) 1.01
An intact connexin N-terminus is required for function but not gap junction formation. J Cell Sci (2008) 0.95
Desipramine prevents stress-induced changes in depressive-like behavior and hippocampal markers of neuroprotection. Behav Pharmacol (2009) 0.95
Atomic force microscopy of Connexin40 gap junction hemichannels reveals calcium-dependent three-dimensional molecular topography and open-closed conformations of both the extracellular and cytoplasmic faces. J Biol Chem (2011) 0.94
An MIP/AQP0 mutation with impaired trafficking and function underlies an autosomal dominant congenital lamellar cataract. Exp Eye Res (2012) 0.93
Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function. Mol Biol Cell (2012) 0.92
Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis. J Cell Sci (2007) 0.92
Cx30.2 can form heteromeric gap junction channels with other cardiac connexins. Biochem Biophys Res Commun (2008) 0.92
A connexin50 mutant, CX50fs, that causes cataracts is unstable, but is rescued by a proteasomal inhibitor. J Biol Chem (2013) 0.92
Transgenic overexpression of connexin50 induces cataracts. Exp Eye Res (2007) 0.90
Different domains are critical for oligomerization compatibility of different connexins. Biochem J (2011) 0.89
Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization. J Membr Biol (2012) 0.89
Connexin50D47A decreases levels of fiber cell connexins and impairs lens fiber cell differentiation. Invest Ophthalmol Vis Sci (2013) 0.89
Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins. Biochem Biophys Res Commun (2005) 0.88
Identification of CaMKII phosphorylation sites in Connexin43 by high-resolution mass spectrometry. J Proteome Res (2011) 0.88
The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation. Mol Vis (2009) 0.87
The N terminus of connexin37 contains an alpha-helix that is required for channel function. J Biol Chem (2009) 0.87
Gap junction synthesis and degradation as therapeutic targets. Curr Drug Targets (2002) 0.87
The first transmembrane domain (TM1) of β2-subunit binds to the transmembrane domain S1 of α-subunit in BK potassium channels. FEBS Lett (2012) 0.87
The cytoplasmic accumulations of the cataract-associated mutant, Connexin50P88S, are long-lived and form in the endoplasmic reticulum. Exp Eye Res (2008) 0.85
Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases. Curr Vasc Pharmacol (2009) 0.85
Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis. Biochem Biophys Res Commun (2004) 0.84
Highly restricted pattern of connexin36 expression in chick somite development. Anat Embryol (Berl) (2004) 0.82
A carboxyl terminal domain of connexin43 is critical for gap junction plaque formation but not for homo- or hetero-oligomerization. Cell Commun Adhes (2003) 0.82
Octodon degus (Molina 1782): a model in comparative biology and biomedicine. Cold Spring Harb Protoc (2013) 0.80
c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias. Cardiovasc Res (2012) 0.80
Structural organization of intercellular channels II. Amino terminal domain of the connexins: sequence, functional roles, and structure. Biochim Biophys Acta (2011) 0.79
Modulation of gap junction channels and hemichannels by growth factors. Mol Biosyst (2012) 0.79
Residual Cx45 and its relationship to Cx43 in murine ventricular myocardium. Channels (Austin) (2011) 0.79
Inducible coexpression of connexin37 or connexin40 with connexin43 selectively affects intercellular molecular transfer. J Membr Biol (2012) 0.78
The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating. J Membr Biol (2014) 0.76