Published in Mol Biol Cell on July 11, 2012
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Diseases associated with leaky hemichannels. Front Cell Neurosci (2015) 0.84
Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca(2+) signaling in HeLa cells. Front Cell Neurosci (2014) 0.81
Characterization of a novel water pocket inside the human Cx26 hemichannel structure. Biophys J (2014) 0.80
Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels. J Gen Physiol (2016) 0.78
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Connexinopathies: a structural and functional glimpse. BMC Cell Biol (2016) 0.75
Altered cellular localization and hemichannel activities of KID syndrome associated connexin26 I30N and D50Y mutations. BMC Cell Biol (2016) 0.75
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Comparative protein structure modeling using Modeller. Curr Protoc Bioinformatics (2006) 8.72
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Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc Natl Acad Sci U S A (2001) 3.17
Gating and regulation of connexin 43 (Cx43) hemichannels. Proc Natl Acad Sci U S A (2003) 2.79
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Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA. J Cell Biol (1989) 2.74
The single transmembrane domains of ErbB receptors self-associate in cell membranes. J Biol Chem (2001) 2.25
Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels. J Gen Physiol (2003) 1.87
Casein kinase 1 regulates connexin-43 gap junction assembly. J Biol Chem (2002) 1.83
Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes. J Biol Chem (2004) 1.65
Loss-of-function and residual channel activity of connexin26 mutations associated with non-syndromic deafness. FEBS Lett (2003) 1.56
Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation. Circ Res (2002) 1.54
Essential role of a GXXXG motif for membrane channel formation by Helicobacter pylori vacuolating toxin. J Biol Chem (2003) 1.50
Molecular basis of childhood deafness resulting from mutations in the GJB2 (connexin 26) gene. Hum Genet (2000) 1.48
Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells. J Cell Sci (2004) 1.40
Gap-junction channels dysfunction in deafness and hearing loss. Antioxid Redox Signal (2009) 1.39
Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions. Proc Natl Acad Sci U S A (2005) 1.39
Changes in apparent free energy of helix-helix dimerization in a biological membrane due to point mutations. J Mol Biol (2007) 1.36
Specific amino-acid residues in the N-terminus and TM3 implicated in channel function and oligomerization compatibility of connexin43. J Cell Sci (2003) 1.27
An aberrant sequence in a connexin46 mutant underlies congenital cataracts. J Biol Chem (2005) 1.22
Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation. Curr Opin Neurobiol (2011) 1.20
Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics. J Gen Physiol (2011) 1.19
Conformational changes in a pore-forming region underlie voltage-dependent "loop gating" of an unapposed connexin hemichannel. J Gen Physiol (2009) 1.18
Subunit oligomerization, and topology of the inositol 1,4, 5-trisphosphate receptor. J Biol Chem (1999) 1.18
Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2. J Biol Chem (2008) 1.11
Assembly of nicotinic and other Cys-loop receptors. J Neurochem (2011) 1.07
Assembly of gap junction channels: mechanism, effects of calmodulin antagonists and identification of connexin oligomerization determinants. Eur J Biochem (2001) 1.06
Heteromeric connexons formed by the lens connexins, connexin43 and connexin56. Eur J Cell Biol (2001) 1.06
Homo- and hetero-oligomerization of G protein-coupled receptors. Life Sci (2003) 1.05
Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum. J Biol Chem (2005) 1.04
The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors. Mol Neurobiol (2010) 1.03
Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2. Biochemistry (2010) 0.96
Homozygosity for the V37I Connexin 26 mutation in three unrelated children with sensorineural hearing loss. Clin Genet (2002) 0.93
Domain assembly of NAADP-gated two-pore channels. Biochem J (2012) 0.92
Different domains are critical for oligomerization compatibility of different connexins. Biochem J (2011) 0.89
Distinct structural elements in the first membrane-spanning segment of the epithelial sodium channel. J Biol Chem (2006) 0.88
Dimerization and ligand binding affect the structure network of A(2A) adenosine receptor. Biochim Biophys Acta (2010) 0.88
A modified, dual reporter TOXCAT system for monitoring homodimerization of transmembrane segments of proteins. Biochem Biophys Res Commun (2005) 0.83
Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev (2003) 4.87
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Gating and regulation of connexin 43 (Cx43) hemichannels. Proc Natl Acad Sci U S A (2003) 2.79
Cardiac gap junction channels show quantitative differences in selectivity. Circ Res (2002) 2.28
New roles for astrocytes: gap junction hemichannels have something to communicate. Trends Neurosci (2003) 2.25
Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia. J Neurosci (2007) 2.06
S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. Proc Natl Acad Sci U S A (2006) 1.74
Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue. Brain Res Brain Res Rev (2004) 1.54
Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation. Circ Res (2002) 1.54
ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. J Neurochem (2011) 1.52
Oxidative stress, lens gap junctions, and cataracts. Antioxid Redox Signal (2009) 1.49
Loss of function and impaired degradation of a cataract-associated mutant connexin50. Eur J Cell Biol (2003) 1.48
TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses. J Immunol (2003) 1.46
A mutant connexin50 with enhanced hemichannel function leads to cell death. Invest Ophthalmol Vis Sci (2009) 1.43
Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells. J Cell Sci (2004) 1.40
Gap-junction channels dysfunction in deafness and hearing loss. Antioxid Redox Signal (2009) 1.39
Pathways for degradation of connexins and gap junctions. Cardiovasc Res (2004) 1.38
Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctions. J Physiol (2004) 1.37
Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration. Antioxid Redox Signal (2009) 1.34
Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential. Proc Natl Acad Sci U S A (2007) 1.30
FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels. Proc Natl Acad Sci U S A (2010) 1.30
Amyloid β-induced death in neurons involves glial and neuronal hemichannels. J Neurosci (2011) 1.28
An aberrant sequence in a connexin46 mutant underlies congenital cataracts. J Biol Chem (2005) 1.22
Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43. J Cell Sci (2004) 1.19
Autophagy: a pathway that contributes to connexin degradation. J Cell Sci (2011) 1.17
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J (2012) 1.17
Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses. Mol Biol Cell (2008) 1.15
Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels. J Gen Physiol (2004) 1.13
The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. J Neuroimmune Pharmacol (2012) 1.13
Currently used methods for identification and characterization of hemichannels. Cell Commun Adhes (2008) 1.13
Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective. Mol Cell Neurosci (2010) 1.12
Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5. Cardiovasc Res (2004) 1.11
Connexin mutants and cataracts. Front Pharmacol (2013) 1.11
Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels. Glia (2011) 1.11
Connexin and pannexin hemichannels in inflammatory responses of glia and neurons. Brain Res (2012) 1.10
Biophysical evidence that connexin-36 forms functional gap junction channels between pancreatic mouse beta-cells. Am J Physiol Endocrinol Metab (2004) 1.09
Dynamic model for ventricular junctional conductance during the cardiac action potential. Am J Physiol Heart Circ Physiol (2004) 1.05
Connexin40 and connexin43 determine gating properties of atrial gap junction channels. J Mol Cell Cardiol (2009) 1.05
Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization. Am J Physiol Cell Physiol (2010) 1.05
Redistribution of connexin45 in gap junctions of connexin43-deficient hearts. Cardiovasc Res (2002) 1.03
Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50. Am J Physiol Cell Physiol (2011) 1.02
Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Front Pharmacol (2013) 1.02
Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells. Am J Physiol Cell Physiol (2009) 1.02
ACh-induced endothelial NO synthase translocation, NO release and vasodilatation in the hamster microcirculation in vivo. J Physiol (2002) 1.01
Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells. J Immunol (2007) 1.01
Identification of second messengers that induce expression of functional gap junctions in microglia cultured from newborn rats. Brain Res (2002) 1.01
N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26. J Cell Sci (2006) 1.01
Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50. Invest Ophthalmol Vis Sci (2008) 1.01
Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress. J Biol Chem (2013) 0.99
Permeation of calcium through purified connexin 26 hemichannels. J Biol Chem (2012) 0.98
Functional role of gap junctions in cytokine-induced leukocyte adhesion to endothelium in vivo. Am J Physiol Heart Circ Physiol (2008) 0.97
An intact connexin N-terminus is required for function but not gap junction formation. J Cell Sci (2008) 0.95
Desipramine prevents stress-induced changes in depressive-like behavior and hippocampal markers of neuroprotection. Behav Pharmacol (2009) 0.95
Atomic force microscopy of Connexin40 gap junction hemichannels reveals calcium-dependent three-dimensional molecular topography and open-closed conformations of both the extracellular and cytoplasmic faces. J Biol Chem (2011) 0.94
An MIP/AQP0 mutation with impaired trafficking and function underlies an autosomal dominant congenital lamellar cataract. Exp Eye Res (2012) 0.93
De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy. Proc Natl Acad Sci U S A (2013) 0.92
The association of dynamin with synaptophysin regulates quantal size and duration of exocytotic events in chromaffin cells. J Neurosci (2010) 0.92
Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis. J Cell Sci (2007) 0.92
Cx30.2 can form heteromeric gap junction channels with other cardiac connexins. Biochem Biophys Res Commun (2008) 0.92
A connexin50 mutant, CX50fs, that causes cataracts is unstable, but is rescued by a proteasomal inhibitor. J Biol Chem (2013) 0.92
Glial hemichannels and their involvement in aging and neurodegenerative diseases. Rev Neurosci (2012) 0.91
Dynamin-2 regulates fusion pore expansion and quantal release through a mechanism that involves actin dynamics in neuroendocrine chromaffin cells. PLoS One (2013) 0.91
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion. J Membr Biol (2007) 0.90
Transgenic overexpression of connexin50 induces cataracts. Exp Eye Res (2007) 0.90
Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments. J Neurochem (2009) 0.90
Different domains are critical for oligomerization compatibility of different connexins. Biochem J (2011) 0.89
Regulation of hepatic connexins in cholestasis: possible involvement of Kupffer cells and inflammatory mediators. Am J Physiol Gastrointest Liver Physiol (2002) 0.89
The formation of skeletal muscle myotubes requires functional membrane receptors activated by extracellular ATP. Brain Res Brain Res Rev (2004) 0.89
Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization. J Membr Biol (2012) 0.89
Connexin50D47A decreases levels of fiber cell connexins and impairs lens fiber cell differentiation. Invest Ophthalmol Vis Sci (2013) 0.89
Gap junctions at the dendritic cell-T cell interface are key elements for antigen-dependent T cell activation. J Immunol (2009) 0.89
Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins. Biochem Biophys Res Commun (2005) 0.88
Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels. Adv Exp Med Biol (2012) 0.88
Identification of CaMKII phosphorylation sites in Connexin43 by high-resolution mass spectrometry. J Proteome Res (2011) 0.88
ATP is required and advances cytokine-induced gap junction formation in microglia in vitro. Mediators Inflamm (2013) 0.88
FasL-triggered death of Jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between Fas and the purinergic receptor P2X(7). J Cell Physiol (2013) 0.88
Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro. Cell Immunol (2007) 0.87