Published in J Biol Chem on September 25, 2003
Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase. BMC Struct Biol (2010) 1.07
A link between hinge-bending domain motions and the temperature dependence of catalysis in 3-isopropylmalate dehydrogenase. Biophys J (2009) 0.80
Kinetic Landscape of a Peptide Bond-Forming Prolyl Oligopeptidase. Biochemistry (2017) 0.75
Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins? Front Aging Neurosci (2017) 0.75
Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP). Sci Rep (2017) 0.75
A multifunctional serine protease primes the malaria parasite for red blood cell invasion. EMBO J (2009) 1.67
Arabidopsis thaliana circadian clock is regulated by the small GTPase LIP1. Curr Biol (2007) 1.62
Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development. J Biol Chem (2003) 1.35
The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage. Diagn Microbiol Infect Dis (2013) 1.30
Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major. Autophagy (2009) 1.26
Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J Biol Chem (2008) 1.20
Measuring elastase, proteinase 3 and cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates. Nat Protoc (2008) 1.18
Membrane fusion induced by vesicular stomatitis virus depends on histidine protonation. J Biol Chem (2003) 1.17
Metacaspase 2 of Trypanosoma brucei is a calcium-dependent cysteine peptidase active without processing. FEBS Lett (2007) 1.16
ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety. J Biol Chem (2004) 1.15
Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein. Biochem J (2003) 1.12
Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates. J Biol Chem (2002) 1.12
Controlling {beta}-amyloid oligomerization by the use of naphthalene sulfonates: trapping low molecular weight oligomeric species. J Biol Chem (2005) 1.05
A glimpse on biological activities of tellurium compounds. An Acad Bras Cienc (2009) 1.03
Detection of SPM-1-producing Pseudomonas aeruginosa and class D β-lactamase-producing Acinetobacter baumannii isolates by use of liquid chromatography-mass spectrometry and matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol (2012) 1.03
Structural characterization of mouse neutrophil serine proteases and identification of their substrate specificities: relevance to mouse models of human inflammatory diseases. J Biol Chem (2009) 1.01
Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects. J Biol Chem (2005) 1.01
Metagenomic analysis of a tropical composting operation at the são paulo zoo park reveals diversity of biomass degradation functions and organisms. PLoS One (2013) 0.99
A continuous fluorescence resonance energy transfer angiotensin I-converting enzyme assay. Nat Protoc (2006) 0.99
Cathepsin X binds to cell surface heparan sulfate proteoglycans. Arch Biochem Biophys (2005) 0.99
Design and use of highly specific substrates of neutrophil elastase and proteinase 3. Am J Respir Cell Mol Biol (2003) 0.99
Trypanosoma brucei metacaspase 4 is a pseudopeptidase and a virulence factor. J Biol Chem (2011) 0.99
T-cell molecular mimicry in Chagas disease: identification and partial structural analysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chain. J Autoimmun (2005) 0.99
Cysteine-protease activity elicited by Ca2+ stimulus in Plasmodium. Mol Biochem Parasitol (2005) 0.98
Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions. J Biol Chem (2005) 0.97
Heparan sulfate modulates kinin release by Trypanosoma cruzi through the activity of cruzipain. J Biol Chem (2001) 0.96
Amylolytic microorganism from são paulo zoo composting: isolation, identification, and amylase production. Enzyme Res (2011) 0.94
Influence of charge distribution at the active site surface on the substrate specificity of human neutrophil protease 3 and elastase. A kinetic and molecular modeling analysis. J Biol Chem (2006) 0.94
Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B. Anal Biochem (2004) 0.93
A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions. Arch Biochem Biophys (2009) 0.93
Role of the bradykinin B2 receptor for the local and systemic inflammatory response that follows severe reperfusion injury. Br J Pharmacol (2003) 0.92
Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates. Eur J Biochem (2002) 0.92
Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding. J Mol Biol (2004) 0.92
Probing the interaction between vesicular stomatitis virus and phosphatidylserine. Eur Biophys J (2005) 0.91
Identification of the allosteric regulatory site of insulysin. PLoS One (2011) 0.90
Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth. Mol Cancer (2007) 0.89
In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes. Peptides (2007) 0.88
Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates. J Biol Chem (2002) 0.88
Identification of bradykinins in solitary wasp venoms. Toxicon (2002) 0.88
Hydrolytic properties and substrate specificity of the foot-and-mouth disease leader protease. Biochemistry (2009) 0.88
Immune evasion by pathogenic Leptospira strains: the secretion of proteases that directly cleave complement proteins. J Infect Dis (2013) 0.88
Inhibition of neutrophil elastase by alpha1-protease inhibitor at the surface of human polymorphonuclear neutrophils. J Immunol (2005) 0.88
Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L. Arch Biochem Biophys (2004) 0.87
Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L. Biol Chem (2005) 0.87
Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally quenched fluorescent substrates. Biochem J (2005) 0.87
S3 to S3' subsite specificity of recombinant human cathepsin K and development of selective internally quenched fluorescent substrates. Biochem J (2003) 0.87
Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice. J Neuroinflammation (2008) 0.87
Mammalian pitrilysin: substrate specificity and mitochondrial targeting. Biochemistry (2009) 0.87
Selective inhibition of carotenoid cleavage dioxygenases: phenotypic effects on shoot branching. J Biol Chem (2008) 0.87
Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate. Arterioscler Thromb Vasc Biol (2013) 0.87
Investigating the substrate specificity and oligomerisation of the leader protease of foot and mouth disease virus using NMR. J Mol Biol (2007) 0.87
Nardilysin cleaves peptides at monobasic sites. Biochemistry (2003) 0.87
Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw. Eur J Pharmacol (2007) 0.86
Measurement of free and membrane-bound cathepsin G in human neutrophils using new sensitive fluorogenic substrates. Biochem J (2002) 0.86
Interaction between dengue virus fusion peptide and lipid bilayers depends on peptide clustering. Mol Membr Biol (2008) 0.86
Biochemical and functional characterization of a metalloprotease from the thermophilic fungus Thermoascus aurantiacus. J Agric Food Chem (2009) 0.86
Cathepsin B carboxydipeptidase specificity analysis using internally quenched fluorescent peptides. Biochem J (2002) 0.85
Fluorescence resonance energy transfer (FRET) peptides and cycloretro-inverso peptides derived from bradykinin as substrates and inhibitors of prolyl oligopeptidase. Peptides (2007) 0.85
Peptide blockers of the inhibition of neuronal nicotinic acetylcholine receptors by amyloid beta. J Biol Chem (2005) 0.85
Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides for defining substrate specificity of the angiotensin I-converting enzyme and development of selective C-domain substrates. Biochemistry (2004) 0.85
A structure-based site-directed mutagenesis study on the neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) catalysis. FEBS Lett (2003) 0.85
Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay. PLoS Negl Trop Dis (2013) 0.85
T-cell recognition of Paracoccidioides brasiliensis gp43-derived peptides in patients with paracoccidioidomycosis and healthy individuals. Clin Vaccine Immunol (2007) 0.84
Purification, characterization, and specificity determination of a new serine protease secreted by Penicillium waksmanii. Appl Biochem Biotechnol (2012) 0.84
The role of kinin B1 and B2 receptors in the scratching behaviour induced by proteinase-activated receptor-2 agonists in mice. Br J Pharmacol (2010) 0.83
Kininogenase activity of Thalassophryne nattereri fish venom. Biochem Pharmacol (2004) 0.83
Modeling the Trypanosoma cruzi Tc85-11 protein and mapping the laminin-binding site. Biochem Biophys Res Commun (2004) 0.83
Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin-1. J Cell Physiol (2008) 0.83
Involvement of proteinase-activated receptors 1 and 2 in spreading and phagocytosis by murine adherent peritoneal cells: modulation by the C-terminal of S100A9 protein. Eur J Pharmacol (2009) 0.82
Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus. Neurobiol Dis (2008) 0.82
Internally quenched fluorescent peptide libraries with randomized sequences designed to detect endopeptidases. Anal Biochem (2011) 0.82
The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi. FEMS Microbiol Lett (2006) 0.82
The use of Fluorescence Resonance Energy Transfer (FRET) peptides for measurement of clinically important proteolytic enzymes. An Acad Bras Cienc (2009) 0.82
Lytic activity and structural differences of amphipathic peptides derived from trialysin. Biochemistry (2006) 0.82
Cathepsin D-mediated yolk protein degradation is blocked by acid phosphatase inhibitors. Arch Biochem Biophys (2005) 0.82
Angiotensin I-converting enzyme inhibitor peptides derived from the endostatin-containing NC1 fragment of human collagen XVIII. Biol Chem (2006) 0.82
Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites. Malar J (2012) 0.81
Temperature and salts effects on the peptidase activities of the recombinant metallooligopeptidases neurolysin and thimet oligopeptidase. Eur J Biochem (2002) 0.81
T cell epitope characterization in tandemly repetitive Trypanosoma cruzi B13 protein. Microbes Infect (2005) 0.81
Calcium modulates endopeptidase 24.15 (EC 3.4.24.15) membrane association, secondary structure and substrate specificity. FEBS J (2005) 0.81
The identification and biochemical properties of the catalytic specificity of a serine peptidase secreted by Aspergillus fumigatus Fresenius. Protein Pept Lett (2014) 0.81
Solvent effects in optical spectra of ortho-aminobenzoic acid derivatives. J Fluoresc (2009) 0.80
Determination of Specificity and Biochemical Characteristics of Neutral Protease Isolated from Myceliophthora thermophila. Protein Pept Lett (2015) 0.80
Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom. Neurosci Lett (2002) 0.80
Yellow fever virus NS2B/NS3 protease: hydrolytic properties and substrate specificity. Biochem Biophys Res Commun (2011) 0.80
Structure-activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S. Bioorg Med Chem (2011) 0.80
Schistosoma mansoni histone acetyltransferase GCN5: linking histone acetylation to gene activation. Mol Biochem Parasitol (2004) 0.80
The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin. Peptides (2004) 0.80
Serpin mechanism of hepatitis C virus nonstructural 3 (NS3) protease inhibition: induced fit as a mechanism for narrow specificity. J Biol Chem (2003) 0.80
Correlation between catalysis and tertiary structure arrangement in an archaeal halophilic subtilase. Biochimie (2011) 0.80
Controlled peptide solvation in portion-mixing libraries of FRET peptides: improved specificity determination for Dengue 2 virus NS2B-NS3 protease and human cathepsin S. J Comb Chem (2007) 0.80
Spectroscopic characterization of 2-amino-N-hexadecyl-benzamide (AHBA), a new fluorescence probe for membranes. Biophys Chem (2006) 0.80
Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi. J Enzyme Inhib Med Chem (2010) 0.80
Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site. J Biol Chem (2002) 0.80
Neprilysin carboxydipeptidase specificity studies and improvement in its detection with fluorescence energy transfer peptides. Biol Chem (2007) 0.79
Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B. J Med Chem (2002) 0.79