Published in Mol Biol Cell on August 07, 2003
Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins. J Cell Sci (2009) 2.39
Glucose-sensing mechanisms in pancreatic beta-cells. Philos Trans R Soc Lond B Biol Sci (2005) 1.83
Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells. Mol Biol Cell (2005) 1.69
Small G proteins in islet beta-cell function. Endocr Rev (2009) 1.68
Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes. J Cell Sci (2004) 1.53
TLR4-mediated expulsion of bacteria from infected bladder epithelial cells. Proc Natl Acad Sci U S A (2009) 1.38
Actomyosin II contractility expels von Willebrand factor from Weibel-Palade bodies during exocytosis. J Cell Biol (2011) 1.35
Filamentous actin regulates insulin exocytosis through direct interaction with Syntaxin 4. J Biol Chem (2008) 1.30
The Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex. Mol Biol Cell (2006) 1.22
Motion matters: secretory granule motion adjacent to the plasma membrane and exocytosis. Mol Biol Cell (2006) 1.17
ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis. EMBO J (2006) 1.16
The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells. Sci Rep (2015) 1.14
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. Blood (2009) 1.11
How peptide hormone vesicles are transported to the secretion site for exocytosis. Mol Endocrinol (2008) 1.04
Regulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512. J Biol Chem (2008) 1.04
Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic beta-cells. J Physiol (2008) 1.04
The class V myosin motor, myosin 5c, localizes to mature secretory vesicles and facilitates exocytosis in lacrimal acini. Am J Physiol Cell Physiol (2008) 1.01
Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells. Exp Mol Med (2013) 0.99
MyRIP anchors protein kinase A to the exocyst complex. J Biol Chem (2007) 0.98
Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis. Proc Natl Acad Sci U S A (2012) 0.94
Distinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin. Traffic (2014) 0.93
β2-Syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granules. PLoS One (2010) 0.93
A role for glutamate transporters in the regulation of insulin secretion. PLoS One (2011) 0.92
RNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cells. Biochem J (2004) 0.91
In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets. J Endocrinol (2010) 0.91
PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport. Mol Endocrinol (2012) 0.90
Regulation of cellular communication by signaling microdomains in the blood vessel wall. Pharmacol Rev (2014) 0.90
Rab11-FIP2 interaction with MYO5B regulates movement of Rab11a-containing recycling vesicles. Traffic (2014) 0.88
Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis. Mol Biol Cell (2011) 0.86
The GTPase Rab37 Participates in the Control of Insulin Exocytosis. PLoS One (2013) 0.85
The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane. Mol Biol Cell (2012) 0.84
Myosin5a tail associates directly with Rab3A-containing compartments in neurons. J Biol Chem (2011) 0.84
Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells. Islets (2012) 0.84
MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway. Mol Biol Cell (2012) 0.83
Roles of myosin Va and Rab3D in membrane remodeling of immature secretory granules. Cell Mol Neurobiol (2010) 0.80
Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic β-cells. PLoS One (2012) 0.79
Activated Cdc42-bound IQGAP1 determines the cellular endocytic site. Mol Cell Biol (2013) 0.79
Identifying Tmem59 related gene regulatory network of mouse neural stem cell from a compendium of expression profiles. BMC Syst Biol (2011) 0.79
Phosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice. Diabetes (2011) 0.79
Role of Rab27 in synaptic transmission at the squid giant synapse. Proc Natl Acad Sci U S A (2008) 0.78
Interplay between Rab27a effectors in pancreatic β-cells. World J Diabetes (2015) 0.78
Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress. Mol Cell Proteomics (2012) 0.77
Interaction between MyRIP and the actin cytoskeleton regulates Weibel-Palade body trafficking and exocytosis. J Cell Sci (2015) 0.76
Key proteins involved in insulin vesicle exocytosis and secretion. Biomed Rep (2017) 0.75
The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells. Nat Commun (2016) 0.75
Granuphilin exclusively mediates functional granule docking to the plasma membrane. Sci Rep (2016) 0.75
Molecular mechanism of docking of dense-core vesicles to the plasma membrane in neuroendocrine cells. Med Mol Morphol (2008) 0.75
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
Rab proteins as membrane organizers. Nat Rev Mol Cell Biol (2001) 19.95
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev (2002) 10.71
Post-transcriptional gene silencing by double-stranded RNA. Nat Rev Genet (2001) 5.84
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology (1992) 5.45
Identification of an organelle receptor for myosin-Va. Nat Cell Biol (2002) 4.06
cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol (2000) 2.83
Rab27a regulates the peripheral distribution of melanosomes in melanocytes. J Cell Biol (2001) 2.76
Rab27a is required for regulated secretion in cytotoxic T lymphocytes. J Cell Biol (2001) 2.74
RNA interference and small interfering RNAs. Chembiochem (2001) 2.40
Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. J Biol Chem (2002) 2.40
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Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice. J Cell Biol (2001) 1.95
The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol Cell Biol (2002) 1.87
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. J Biol Chem (2001) 1.86
Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur J Biochem (1999) 1.82
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest (2002) 1.81
Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex. Mol Endocrinol (2003) 1.65
Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain. J Biol Chem (1995) 1.63
Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. Biochem Mol Med (1997) 1.63
MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. EMBO Rep (2002) 1.46
Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells. J Biol Chem (1999) 1.45
Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. J Biol Chem (2002) 1.44
Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis. Mol Biol Cell (2002) 1.38
Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells. J Cell Sci (1996) 1.33
The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes. Mol Cell Biol (2003) 1.32
Involvement of Rab27b in the regulated secretion of pituitary hormones. Endocrinology (2002) 1.30
Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells. Mol Endocrinol (1999) 1.27
Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a. Mol Cell Biol (2002) 1.22
Beta-granule transport and exocytosis. Semin Cell Dev Biol (2000) 1.22
Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domain. Biochem Biophys Res Commun (2001) 1.11
Disruption of Rab3-calmodulin interaction, but not other effector interactions, prevents Rab3 inhibition of exocytosis. EMBO J (1999) 1.11
Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells. J Biol Chem (1997) 1.09
Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. Biochem Biophys Res Commun (2001) 1.07
Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Biochem Biophys Res Commun (2002) 1.03
The Rab3-interacting molecule RIM is expressed in pancreatic beta-cells and is implicated in insulin exocytosis. FEBS Lett (2000) 1.00
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell (2008) 6.66
Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol (2009) 5.44
Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome. Nat Genet (2003) 4.44
Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet (2007) 3.79
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell (2006) 3.71
Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle. EMBO J (2002) 3.53
Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2. PLoS Genet (2006) 3.16
Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31. Nat Genet (2003) 2.98
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J (2005) 2.76
Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death. Curr Biol (2002) 2.72
Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. Cell Metab (2007) 2.71
SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci U S A (2004) 2.41
Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells. Hum Mol Genet (2005) 2.38
Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin. Hum Mol Genet (2003) 2.37
MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. J Biol Chem (2006) 2.29
Connexin30 (Gjb6)-deficiency causes severe hearing impairment and lack of endocochlear potential. Hum Mol Genet (2003) 2.17
Interactions in the network of Usher syndrome type 1 proteins. Hum Mol Genet (2004) 2.16
A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth. Development (2008) 2.09
Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol Biol Cell (2008) 2.08
Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. J Neurosci (2007) 2.05
Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly. Hum Mol Genet (2004) 2.04
Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis. Neuron (2002) 2.01
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. J Biol Chem (2001) 1.86
Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes (2008) 1.85
Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs. Biol Chem (2008) 1.85
Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells. Dev Biol (2005) 1.84
Usher I syndrome: unravelling the mechanisms that underlie the cohesion of the growing hair bundle in inner ear sensory cells. J Cell Sci (2005) 1.84
Diabetes mellitus, a microRNA-related disease? Transl Res (2011) 1.82
Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells. Diabetes (2010) 1.80
Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Hum Mol Genet (2003) 1.80
Prevalence and evolutionary origins of the del(GJB6-D13S1830) mutation in the DFNB1 locus in hearing-impaired subjects: a multicenter study. Am J Hum Genet (2003) 1.79
How the genetics of deafness illuminates auditory physiology. Annu Rev Physiol (2011) 1.78
Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Genes Cells (2006) 1.76
Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells. J Neurosci (2010) 1.72
SLC26A4 gene is frequently involved in nonsyndromic hearing impairment with enlarged vestibular aqueduct in Caucasian populations. Eur J Hum Genet (2006) 1.69
Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique. Neuropsychopharmacology (2006) 1.69
Circulating microRNAs as novel biomarkers for diabetes mellitus. Nat Rev Endocrinol (2013) 1.69
Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. Proc Natl Acad Sci U S A (2002) 1.65
Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells. J Cell Sci (2006) 1.62
OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. J Cell Biol (2011) 1.61
Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans. Mol Biol Cell (2006) 1.61
Complete exon sequencing of all known Usher syndrome genes greatly improves molecular diagnosis. Orphanet J Rare Dis (2011) 1.57
Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. J Biol Chem (2007) 1.56
Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation. J Biol Chem (2008) 1.54
Rab10 in insulin-stimulated GLUT4 translocation. Biochem J (2008) 1.53
Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome. Am J Hum Genet (2007) 1.52
Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy. Nat Genet (2006) 1.51
MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. EMBO Rep (2002) 1.46
Synaptotagmin IV regulates glial glutamate release. Proc Natl Acad Sci U S A (2004) 1.46
Calcium- and otoferlin-dependent exocytosis by immature outer hair cells. J Neurosci (2008) 1.46
Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Dev Cell (2009) 1.45
Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets. J Biol Chem (2003) 1.45
Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes. Nat Cell Biol (2004) 1.45
Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J Cell Biol (2013) 1.44
Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nat Cell Biol (2012) 1.42
An ARF6/Rab35 GTPase cascade for endocytic recycling and successful cytokinesis. Curr Biol (2012) 1.41
Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis. Proc Natl Acad Sci U S A (2007) 1.41
Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes. Mol Biol Cell (2009) 1.40
Rab27A and its effector MyRIP link secretory granules to F-actin and control their motion towards release sites. J Cell Biol (2003) 1.40
Rab35 regulates Arf6 activity through centaurin-β2 (ACAP2) during neurite outgrowth. J Cell Sci (2012) 1.39
Stereocilin-deficient mice reveal the origin of cochlear waveform distortions. Nature (2008) 1.39
Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. Traffic (2008) 1.38
Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases. Structure (2008) 1.38
Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis. Mol Biol Cell (2002) 1.38
Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapses. J Neurosci (2009) 1.37
Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. EMBO J (2010) 1.34
Usher syndrome (sensorineural deafness and retinitis pigmentosa): pathogenesis, molecular diagnosis and therapeutic approaches. Curr Opin Neurol (2012) 1.33
Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice. Diabetes (2012) 1.32
The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes. Mol Cell Biol (2003) 1.32
Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nat Genet (2008) 1.31
Proteomics analysis of insulin secretory granules. Mol Cell Proteomics (2007) 1.31
Comprehensive screening for novel rab-binding proteins by GST pull-down assay using 60 different mammalian Rabs. Traffic (2010) 1.30
The small GTPase Rab27B regulates amylase release from rat parotid acinar cells. J Cell Sci (2004) 1.30
Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells. Pflugers Arch (2009) 1.30
Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia. Proc Natl Acad Sci U S A (2011) 1.30
Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate. J Biol Chem (2004) 1.30
Mouse models for human hereditary deafness. Curr Top Dev Biol (2008) 1.28
Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway. Diabetes (2008) 1.27
Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev Cell (2010) 1.25
Methicillin-resistant Staphylococcus aureus in Saarland, Germany: a statewide admission prevalence screening study. PLoS One (2013) 1.25
Identification of EPI64 as a GTPase-activating protein specific for Rab27A. J Biol Chem (2006) 1.25
BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. PLoS Pathog (2009) 1.24
The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway. Mol Biol Cell (2008) 1.23
The Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex. Mol Biol Cell (2006) 1.22
Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane. J Comp Neurol (2011) 1.22
Defect in the gene encoding the EAR/EPTP domain-containing protein TSPEAR causes DFNB98 profound deafness. Hum Mol Genet (2012) 1.21
Mutations in the alternatively spliced exons of USH1C cause non-syndromic recessive deafness. Hum Genet (2002) 1.21
GJB2 and GJB6 mutations: genotypic and phenotypic correlations in a large cohort of hearing-impaired patients. Arch Otolaryngol Head Neck Surg (2005) 1.19
Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4. EMBO Rep (2013) 1.19
MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity. J Clin Invest (2012) 1.17