PubRank

Huaxi Xu

Author PubWeight™ 146.23‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol 2013 4.16
2 Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol 2002 3.23
3 Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. J Biol Chem 2004 2.85
4 Gleevec inhibits beta-amyloid production but not Notch cleavage. Proc Natl Acad Sci U S A 2003 2.44
5 Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci U S A 2003 2.32
6 APP processing in Alzheimer's disease. Mol Brain 2011 2.02
7 Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. J Biol Chem 2007 1.91
8 PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J Biol Chem 2003 1.77
9 Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription. Proc Natl Acad Sci U S A 2009 1.76
10 Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis. Clin Dev Immunol 2012 1.70
11 Does insulin dysfunction play a role in Alzheimer's disease? Trends Pharmacol Sci 2002 1.62
12 Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. J Biol Chem 2002 1.61
13 Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci U S A 2007 1.61
14 Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med 2013 1.61
15 Epidemiology of hand, foot, and mouth disease and genotype characterization of Enterovirus 71 in Jiangsu, China. J Clin Virol 2010 1.58
16 Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells. J Immunol 2010 1.57
17 Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. Proc Natl Acad Sci U S A 2002 1.51
18 Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease. J Clin Endocrinol Metab 2011 1.50
19 Proteolytic processing of Alzheimer's β-amyloid precursor protein. J Neurochem 2011 1.50
20 Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. J Neurochem 2003 1.47
21 Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends Neurosci 2003 1.43
22 Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proc Natl Acad Sci U S A 2007 1.41
23 Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. Proc Natl Acad Sci U S A 2006 1.41
24 Pathological and physiological functions of presenilins. Mol Neurodegener 2006 1.38
25 The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis. Rheumatol Int 2011 1.37
26 Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. J Biol Chem 2005 1.37
27 Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. J Biol Chem 2002 1.34
28 Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease. Mol Neurodegener 2014 1.24
29 NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. Mol Neurodegener 2010 1.23
30 Transforming growth factor beta activates Smad2 in the absence of receptor endocytosis. J Biol Chem 2002 1.22
31 Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. J Neurosci 2005 1.21
32 Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production. Neurobiol Dis 2007 1.20
33 Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms. J Biol Chem 2012 1.15
34 Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A 2006 1.14
35 Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components. J Biol Chem 2004 1.11
36 Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolism. Curr Mol Med 2007 1.11
37 Trafficking regulation of proteins in Alzheimer's disease. Mol Neurodegener 2014 1.08
38 Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia. FASEB J 2006 1.07
39 Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. J Biol Chem 2002 1.07
40 Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta degrading protease. J Alzheimers Dis 2010 1.07
41 Differential regulation of BACE1 expression by oxidative and nitrosative signals. Mol Neurodegener 2011 1.06
42 A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol Dis 2002 1.04
43 Identification and characterization of class 1 integrons among Pseudomonas aeruginosa isolates from patients in Zhenjiang, China. Int J Infect Dis 2009 1.02
44 Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB. Mol Cell Biol 2006 1.02
45 Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid. J Neurosci 2012 1.02
46 Herbaspirillum species: a potential pathogenic bacteria isolated from acute lymphoblastic leukemia patient. Curr Microbiol 2010 1.02
47 Application of quantitative real-time PCR for rapid identification of Bacteroides fragilis group and related organisms in human wound samples. Anaerobe 2011 1.01
48 Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways. Cardiovasc Res 2012 1.01
49 Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules. FASEB J 2006 0.99
50 Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration. J Neurosci 2012 0.99
51 IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKCβ/Erk1/2/NF-κB-dependent signaling pathway. Int Immunol 2012 0.98
52 Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures. J Neurochem 2004 0.98
53 Improved prediction of coreceptor usage and phenotype of HIV-1 based on combined features of V3 loop sequence using random forest. J Microbiol 2007 0.97
54 Leptin signaling protects NK cells from apoptosis during development in mouse bone marrow. Cell Mol Immunol 2009 0.97
55 DNMT3B promoter polymorphism and risk of gastric cancer. Dig Dis Sci 2009 0.97
56 Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. J Neurochem 2007 0.97
57 HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion. Eur J Immunol 2011 0.96
58 Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc. J Biol Chem 2010 0.96
59 Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling. J Neurosci 2009 0.96
60 Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration. J Neurosci 2012 0.96
61 β-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells. Eur J Immunol 2013 0.95
62 Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment. J Neurosci 2014 0.95
63 Increased IL-17-producing CD4(+) T cells in patients with esophageal cancer. Cell Immunol 2011 0.94
64 Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis. Clin Dev Immunol 2011 0.94
65 Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1. J Biol Chem 2009 0.94
66 Over-expression of calpastatin aggravates cardiotoxicity induced by doxorubicin. Cardiovasc Res 2013 0.93
67 Glucocorticoid-induced tumor necrosis factor receptor family-related protein exacerbates collagen-induced arthritis by enhancing the expansion of Th17 cells. Am J Pathol 2011 0.93
68 Corynebacterium pyruviciproducens sp. nov., a pyruvic acid producer. Int J Syst Evol Microbiol 2009 0.93
69 A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation. Neuron 2009 0.91
70 RpoE may promote flagellar gene expression in Salmonella enterica serovar typhi under hyperosmotic stress. Curr Microbiol 2010 0.91
71 Insulin signaling in sporadic Alzheimer's disease. Sci Signal 2009 0.90
72 MiR-346 regulates CD4⁺CXCR5⁺ T cells in the pathogenesis of Graves' disease. Endocrine 2015 0.90
73 Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation. Mol Neurodegener 2008 0.89
74 Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production. Arthritis Rheum 2008 0.89
75 Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis. J Neurochem 2007 0.89
76 Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway. Neurobiol Aging 2011 0.89
77 Investigation of the expression patterns and correlation of DNA methyltransferases and class I histone deacetylases in ovarian cancer tissues. Oncol Lett 2012 0.88
78 Downregulation of Hlx closely related to the decreased expressions of T-bet and Runx3 in patients with gastric cancer may be associated with a pathological event leading to the imbalance of Th1/Th2. Clin Dev Immunol 2012 0.87
79 Increased CD4CD25+FOXP3+ regulatory T Cells in cancer patients from conversion of CD4+CD25- T cells through tumor-derived factors. Onkologie 2008 0.87
80 Molecular characterization of a functional type VI secretion system in Salmonella enterica serovar Typhi. Curr Microbiol 2011 0.86
81 Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice. Int J Mol Med 2006 0.86
82 Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell culture. J Neurochem 2006 0.86
83 Chemokine/chemokine receptor interactions contribute to the accumulation of Th17 cells in patients with esophageal squamous cell carcinoma. Hum Immunol 2012 0.85
84 Increased frequency of Th17 cells in the peripheral blood of children infected with enterovirus 71. J Med Virol 2012 0.85
85 Transcriptional expression of fljB:z66, a flagellin gene located on a novel linear plasmid of Salmonella enterica serovar Typhi under environmental stresses. New Microbiol 2008 0.84
86 Global transcriptional response of Salmonella enterica serovar Typhi to anti-z66 antiserum. FEMS Microbiol Lett 2009 0.83
87 Th17 cell expansion in gastric cancer may contribute to cancer development and metastasis. Immunol Res 2014 0.83
88 Crystal structure of the glutamate receptor GluA1 N-terminal domain. Biochem J 2011 0.83
89 The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation. Hum Mol Genet 2010 0.83
90 Mesenchymal stem cells isolated from human uterine cervix cancer tissues. Cell Biol Int 2011 0.82
91 Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau. Mol Neurodegener 2006 0.82
92 Identification of a fljA gene on a linear plasmid as the repressor gene of fliC in Salmonella enterica serovar Typhi. Microbiol Immunol 2009 0.82
93 p53-dependent control of transactivation of the Pen2 promoter by presenilins. J Cell Sci 2009 0.82
94 Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice. Mol Neurodegener 2015 0.82
95 M1 muscarinic acetylcholine receptor in Alzheimer's disease. Neurosci Bull 2014 0.82
96 Decreased expression of microRNA-125a-3p upregulates interleukin-23 receptor in patients with Hashimoto's thyroiditis. Immunol Res 2015 0.81
97 Mutations in Helicobacter pylori porD and oorD genes may contribute to furazolidone resistance. Croat Med J 2006 0.81
98 A monoclonal antibody against human UL16-binding protein 3. Hybridoma (Larchmt) 2012 0.81
99 Tat-mediated intracellular delivery of T-bet protein into THP-1 cells can induce Th1-type response. Immunol Invest 2008 0.81
100 Notch signaling mediates TNF-α-induced IL-6 production in cultured fibroblast-like synoviocytes from rheumatoid arthritis. Clin Dev Immunol 2011 0.81
101 Immunologic mapping of glycomes: implications for cancer diagnosis and therapy. Front Biosci (Schol Ed) 2011 0.81
102 Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17. J Pineal Res 2014 0.80
103 Expression of FLJB:Z66 on a Linear Plasmid of Salmonella Enterica Serovar Typhi is Dependent on FLIA and FLHDC and Regulated By OMPR. Braz J Microbiol 2010 0.80
104 Enhancing specific-antibody production to the ragB vaccine with GITRL that expand Tfh, IFN-γ(+) T cells and attenuates Porphyromonas gingivalis infection in mice. PLoS One 2013 0.80
105 Correlation between the frequency of Th17 cell and the expression of microRNA-206 in patients with dermatomyositis. Clin Dev Immunol 2013 0.80
106 Increased expression of mGITRL on D2SC/1 cells by particulate β-glucan impairs the suppressive effect of CD4+CD25+ regulatory T cells and enhances the effector T cell proliferation. Cell Immunol 2011 0.80
107 Presenilins regulate the cellular level of the tumor suppressor PTEN. Neurobiol Aging 2007 0.80
108 An isoleucine-zipper motif enhances costimulation of human soluble trimeric GITR ligand. Cell Mol Immunol 2010 0.80
109 Up-regulated HMGB1 in EAM directly led to collagen deposition by a PKCβ/Erk1/2-dependent pathway: cardiac fibroblast/myofibroblast might be another source of HMGB1. J Cell Mol Med 2014 0.80
110 Ubiquitin-proteasome pathway mediates degradation of APH-1. J Neurochem 2006 0.80
111 Fis is essential for the stability of linear plasmid pBSSB1 and affects the motility of Salmonella enterica serovar Typhi. PLoS One 2012 0.80
112 MUC1 glycopeptide epitopes predicted by computational glycomics. Int J Oncol 2012 0.79
113 Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. J Neurosci 2013 0.79
114 Transcriptional regulation and its misregulation in Alzheimer's disease. Mol Brain 2013 0.79
115 PTD-hFOXP3 protein acts as an immune regulator to convert human CD4(+)CD25(-) T cells to regulatory T-like cells. J Cell Biochem 2012 0.79
116 Complex class 1 integron containing bla ( CTX-M-1 ) genes isolated from Escherichia coli: a potentially novel resistant gene-capturing tool kit. Curr Microbiol 2011 0.79
117 Ferritin light chain interacts with PEN-2 and affects γ-secretase activity. Neurosci Lett 2013 0.79
118 Up-regulation of GITRL on dendritic cells by WGP improves anti-tumor immunity in murine Lewis lung carcinoma. PLoS One 2012 0.78
119 APP regulates NGF receptor trafficking and NGF-mediated neuronal differentiation and survival. PLoS One 2013 0.78
120 Dendritic cells engineered to express GITRL enhance therapeutic immunity in murine Lewis lung carcinoma. Cancer Lett 2010 0.78
121 Genotyping of Salmonella enterica serovar Typhi strains isolated from 1959 to 2006 in China and analysis of genetic diversity by genomic microarray. Croat Med J 2011 0.78
122 Corynebacterium pyruviciproducens promotes the production of ovalbumin specific antibody via stimulating dendritic cell differentiation and up-regulating Th2 biased immune response. Vaccine 2011 0.78
123 OmpR may regulate the putative YehU/YehT two-component system in Salmonella enterica serovar Typhi under hypotonic growth condition. Curr Microbiol 2011 0.78
124 Chronic intake of high fish oil diet induces myeloid-derived suppressor cells to promote tumor growth. Cancer Immunol Immunother 2014 0.78
125 Identification and characterization of a cis-encoded antisense RNA associated with the replication process of Salmonella enterica serovar Typhi. PLoS One 2013 0.78
126 Dietary fish oil exacerbates concanavalin A induced hepatitis through promoting hepatocyte apoptosis and altering immune cell populations. J Toxicol Sci 2014 0.77
127 Mig-14 plays an important role in influencing gene expression of Salmonella enterica serovar Typhi, which contributes to cell invasion under hyperosmotic conditions. Res Microbiol 2013 0.77
128 Functional characterization of myeloid-derived suppressor cell subpopulations during the development of experimental arthritis. Eur J Immunol 2014 0.77
129 Corynebacterium pyruviciproducens, as an immune modulator, can promote the activity of macrophages and up-regulate antibody response to particulate antigen. Exp Biol Med (Maywood) 2012 0.77
130 Substrate check of gamma-secretase. Nat Struct Mol Biol 2010 0.77
131 Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid. J Neurochem 2009 0.77
132 A method of experimental rheumatoid arthritis induction using collagen type II isolated from chicken sternal cartilage. Mol Med Rep 2013 0.76
133 Alteration of beta-secretase traffic by the receptor tyrosine kinase signaling pathway - a new mechanism for regulating Alzheimer's beta-amyloid production. Cell Res 2007 0.75
134 Clinical and prognostic significance of Arl4c expression in colorectal cancer. Cancer Biomark 2016 0.75
135 Downregulation of Runx3 is closely related to the decreased Th1-associated factors in patients with gastric carcinoma. Tumour Biol 2014 0.75
136 The bla(CTX-M-1) gene located in a novel complex class I integron bearing an ISCR1 element in Escherichia coli isolates from Zhenjiang, China. J Antimicrob Chemother 2008 0.75
137 Role of positive selection in functional divergence of mammalian neuronal apoptosis inhibitor proteins during evolution. J Biomed Biotechnol 2011 0.75
138 Avian influenza: should China be alarmed? Yonsei Med J 2007 0.75
139 Structural bioinformatics-based identification of EGFR inhibitor gefitinib as a putative lead compound for BACE. Chem Biol Drug Des 2014 0.75
140 Comparison of prognostic value of two kinds of severity scoring systems for hospital mortality prediction of elderly patients with acute kidney injury. Aging Clin Exp Res 2011 0.75
141 [Expressions and implications of Th1/Th2 cytokines in injured rat brain and spinal cord]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2013 0.75
142 IL-4 can inhibit IL-17 production in collagen induced arthritis. Iran J Immunol 2011 0.75
143 GITRL as a genetic adjuvant enhances enterovirus 71 VP1 DNA vaccine immunogenicity. Immunol Res 2015 0.75
144 Over-expression of Hlx homeobox gene in DC2.4 dendritic cell enhances its maturation and antigen presentation. Cell Immunol 2012 0.75
145 [Adeno-associated virus mediated T-bet gene transfer into SGC-7901 cell to regulate IFN-gamma production]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2009 0.75
146 Virulence-defective strains of Salmonella enterica serovar Typhi as candidates for education at level 2 facilities. Microbiol Immunol 2006 0.75