Chaperones increase association of tau protein with microtubules.

Heat shock protein 70 (hsp70) as an emerging drug target. J Med Chem (2010) 2.21

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set. Physiol Genomics (2008) 2.11

Chemical manipulation of hsp70 ATPase activity regulates tau stability. J Neurosci (2009) 2.05

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A (2007) 1.77

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases. Nat Rev Drug Discov (2011) 1.71

Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets. Cold Spring Harb Perspect Med (2011) 1.68

Modulation of the maladaptive stress response to manage diseases of protein folding. PLoS Biol (2014) 1.54

Allostery in the Hsp70 chaperone proteins. Top Curr Chem (2013) 1.52

Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. J Mol Biol (2011) 1.49

Hsp70 and its molecular role in nervous system diseases. Biochem Res Int (2011) 1.44

Histone deacetylase 6 interacts with the microtubule-associated protein tau. J Neurochem (2008) 1.38

Heat shock protein 90 in neurodegenerative diseases. Mol Neurodegener (2010) 1.38

Heat shock proteins: cellular and molecular mechanisms in the central nervous system. Prog Neurobiol (2010) 1.37

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol (2012) 1.37

To fold or not to fold: modulation and consequences of Hsp90 inhibition. Future Med Chem (2009) 1.29

Recent advances in our understanding of neurodegeneration. J Neural Transm (Vienna) (2009) 1.27

Very brief focal ischemia simulating transient ischemic attacks (TIAs) can injure brain and induce Hsp70 protein. Brain Res (2008) 1.25

Targeting Abeta and tau in Alzheimer's disease, an early interim report. Exp Neurol (2009) 1.18

Tau oligomers and tau toxicity in neurodegenerative disease. Biochem Soc Trans (2012) 1.18

Neuronal expression of constitutive heat shock proteins: implications for neurodegenerative diseases. Cell Stress Chaperones (2007) 1.16

A novel calcium-binding protein is associated with tau proteins in tauopathy. J Neurochem (2008) 1.16

Intrinsically disordered proteins display no preference for chaperone binding in vivo. PLoS Comput Biol (2008) 1.13

Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Mol Neurobiol (2010) 1.13

Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat. Neurobiol Dis (2005) 1.13

Nitric oxide in health and disease of the nervous system. Antioxid Redox Signal (2009) 1.13

High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase. Bioorg Med Chem (2007) 1.11

Purine-scaffold Hsp90 inhibitors. Curr Top Med Chem (2009) 1.11

Hsp90-Tau complex reveals molecular basis for specificity in chaperone action. Cell (2014) 1.11

Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone. J Neurosci Res (2008) 1.10

Protein homeostasis as a therapeutic target for diseases of protein conformation. Curr Top Med Chem (2012) 1.10

Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev (2014) 1.10

Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases. Annu Rev Pharmacol Toxicol (2014) 1.09

Imbalance of Hsp70 family variants fosters tau accumulation. FASEB J (2012) 1.07

Hsc70 rapidly engages tau after microtubule destabilization. J Biol Chem (2010) 1.06

Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Biochemistry (2011) 1.05

Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line. Bioorg Med Chem (2008) 1.05

Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology. Am J Pathol (2004) 1.03

NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy. Hum Mol Genet (2011) 1.02

Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases. Exp Neurol (2012) 1.02

Epithelial-mesenchymal transition stimulates human cancer cells to extend microtubule-based invasive protrusions and suppresses cell growth in collagen gel. PLoS One (2012) 1.01

Chaperone signalling complexes in Alzheimer's disease. J Cell Mol Med (2009) 0.99

Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice. J Biol Chem (2012) 0.99

The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis. J Mol Biol (2015) 0.98

Natural product inhibitors of Hsp90: potential leads for drug discovery. Mini Rev Med Chem (2009) 0.98

Detection and quantification of tau aggregation using a membrane filter assay. Anal Biochem (2007) 0.97

Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold. Bioorg Med Chem (2008) 0.96

Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila. PLoS One (2014) 0.96

Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: implications for progression of AD. J Proteome Res (2009) 0.96

Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta. Mol Cell Biol (2010) 0.95

Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. ACS Chem Biol (2012) 0.94

Heat shock proteins in neurodegenerative disorders and aging. J Cell Commun Signal (2014) 0.93

Protein homeostasis, aging and Alzheimer's disease. Mol Neurobiol (2012) 0.93

Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease. Mol Neurobiol (2007) 0.92

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies. Future Med Chem (2011) 0.92

The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins. J Biol Chem (2012) 0.91

Molecular chaperones and neuronal proteostasis. Semin Cell Dev Biol (2015) 0.91

Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases. Mol Cell Pharmacol (2010) 0.91

Proteomic analysis of microtubule-associated proteins during macrophage activation. Mol Cell Proteomics (2009) 0.91

Barcoding heat shock proteins to human diseases: looking beyond the heat shock response. Dis Model Mech (2014) 0.90

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron (2015) 0.89

Tau protein modifications and interactions: their role in function and dysfunction. Int J Mol Sci (2014) 0.89

NeuroD6 genomic signature bridging neuronal differentiation to survival via the molecular chaperone network. J Neurosci Res (2010) 0.88

Tau alternative splicing and frontotemporal dementia. Alzheimer Dis Assoc Disord (2005) 0.88

Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nat Chem Biol (2015) 0.87

Brain pathology in myotonic dystrophy: when tauopathy meets spliceopathy and RNAopathy. Front Mol Neurosci (2014) 0.87

Hsp70 alters tau function and aggregation in an isoform specific manner. Biochemistry (2012) 0.87

Heat shock protein 70: roles in multiple sclerosis. Mol Med (2012) 0.87

Heat shock proteins in long-lived worms and mice with insulin/insulin-like signaling mutations. Aging (Albany NY) (2009) 0.87

The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics. J Biol Chem (2011) 0.87

Molecular chaperone dysfunction in neurodegenerative diseases and effects of curcumin. Biomed Res Int (2014) 0.87

Protein S-nitrosylation: role for nitric oxide signaling in neuronal death. Biochim Biophys Acta (2011) 0.86

Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid. J Biol Chem (2012) 0.86

Dealing with misfolded proteins: examining the neuroprotective role of molecular chaperones in neurodegeneration. Molecules (2010) 0.86

Possible Cis-acting signal that could be involved in the localization of different mRNAs in neuronal axons. Theor Biol Med Model (2005) 0.86

CHIP-ping away at tau. J Clin Invest (2007) 0.85

Heterozygous yeast deletion collection screens reveal essential targets of Hsp90. PLoS One (2011) 0.85

Association of HSP70 and its co-chaperones with Alzheimer's disease. J Alzheimers Dis (2011) 0.83

On the design of broad based screening assays to identify potential pharmacological chaperones of protein misfolding diseases. Curr Top Med Chem (2012) 0.83

Current advances in the treatment of Alzheimer's disease: focused on considerations targeting Aβ and tau. Transl Neurodegener (2012) 0.83

The last tangle of tau. J Alzheimers Dis (2008) 0.82

Heat shock protein 70 in Alzheimer's disease. Biomed Res Int (2014) 0.82

Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau. Mol Neurodegener (2006) 0.82

Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology. PLoS Comput Biol (2010) 0.82

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement. J Biol Chem (2015) 0.82

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins. EMBO J (2016) 0.81

Management of cytoskeleton architecture by molecular chaperones and immunophilins. Cell Signal (2011) 0.81

Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun. ASN Neuro (2012) 0.81

Propofol-induced protection of SH-SY5Y cells against hydrogen peroxide is associated with the HO-1 via the ERK pathway. Int J Med Sci (2013) 0.81

Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention. J Alzheimers Dis Parkinsonism (2013) 0.81

Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics. Curr Neuropharmacol (2011) 0.81

Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies. Mol Neurobiol (2011) 0.80

Potential synergy between tau aggregation inhibitors and tau chaperone modulators. Alzheimers Res Ther (2013) 0.80

The role of heat shock protein 70 in the protective effect of YC-1 on β-amyloid-induced toxicity in differentiated PC12 cells. PLoS One (2013) 0.80

Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins. PLoS One (2014) 0.80

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Hum Mol Genet (2015) 0.80

Roles of tau protein in health and disease. Acta Neuropathol (2017) 0.80

Reconstructing the Hsp90/Tau Machine. Curr Enzym Inhib (2013) 0.79

Cellular factors modulating the mechanism of tau protein aggregation. Cell Mol Life Sci (2015) 0.79

Present and prospective clinical therapeutic regimens for Alzheimer's disease. Neuropsychiatr Dis Treat (2008) 0.79

Opportunities and challenges for molecular chaperone modulation to treat protein-conformational brain diseases. Neurotherapeutics (2013) 0.79

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23

Molecular chaperones in cellular protein folding. Nature (1996) 14.00

Neurodegenerative tauopathies. Annu Rev Neurosci (2001) 9.53

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science (2001) 6.15

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet (2000) 6.12

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell (1998) 5.52

Translating cell biology into therapeutic advances in Alzheimer's disease. Nature (1999) 5.42

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat Genet (1999) 4.93

Intraneuronal Abeta42 accumulation in human brain. Am J Pathol (2000) 3.83

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease. J Cell Biol (1998) 3.53

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron (1993) 3.45

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils. Proc Natl Acad Sci U S A (2000) 3.43

Calcium and GTP: essential components in vesicular trafficking between the endoplasmic reticulum and Golgi apparatus. J Cell Biol (1989) 3.26

The crystal structure of the peptide-binding fragment from the yeast Hsp40 protein Sis1. Structure (2000) 2.80

Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates. Methods Enzymol (1999) 2.65

From the cradle to the grave: molecular chaperones that may choose between folding and degradation. EMBO Rep (2001) 2.55

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure. J Biol Chem (2001) 2.32

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. Hum Mol Genet (2001) 2.29

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain. J Cell Biol (1995) 2.29

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. J Neurosci (1999) 2.25

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med (1998) 2.20

Molecular chaperones and the cytoskeleton. J Cell Sci (1997) 2.14

Transport of vesicular stomatitis virus G protein to the cell surface is signal mediated in polarized and nonpolarized cells. J Cell Biol (1996) 2.06

A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J Cell Sci (2001) 1.86

Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins. J Cell Biol (1999) 1.72

Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cells. J Cell Biol (1993) 1.52

Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci (2002) 1.42

Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells. Mol Biol Cell (2000) 1.39

Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease. Proc Natl Acad Sci U S A (2000) 1.28

The 'jaws' model of tau-microtubule interaction examined in CHO cells. J Cell Sci (1997) 1.16

Unfolding the role of chaperones and chaperonins in human disease. Trends Genet (2001) 1.14

Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. J Biol Chem (2002) 1.07

Beta-internexin is a microtubule-associated protein identical to the 70-kDa heat-shock cognate protein and the clathrin uncoating ATPase. J Biol Chem (1989) 1.02

Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Am J Pathol (1999) 0.99

Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments. J Neurosci (2001) 0.97

Chloroquine myopathy suggests that tau is degraded in lysosomes: implication for the formation of paired helical filaments in Alzheimer's disease. Neurosci Res (1998) 0.93

Directionality of polypeptide transfer in the mitochondrial pathway of chaperone-mediated protein folding. Biol Chem (1998) 0.89

Identification of a protein altered in mutants resistant to microtubule inhibitors as a member of the major heat shock protein (hsp70) family. Mol Cell Biol (1990) 0.88

Heat shock proteins protect against stress-related phosphorylation of tau in neuronal PC12 cells that have acquired thermotolerance. J Neurosci (1994) 0.88

Alzheimer-specific epitope of AT100 in transfected cell lines with tau: toward an efficient cell model of tau abnormal phosphorylation. Neurosci Lett (1998) 0.82

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med (2003) 12.94

Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci (2005) 9.17

A translational profiling approach for the molecular characterization of CNS cell types. Cell (2008) 8.69

A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell (2010) 7.94

Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell (2008) 7.74

Pathways of chaperone-mediated protein folding in the cytosol. Nat Rev Mol Cell Biol (2004) 6.45

The c-Myc target gene network. Semin Cancer Biol (2006) 5.98

Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell (2009) 5.49

Dichotomous dopaminergic control of striatal synaptic plasticity. Science (2008) 5.47

HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell (2007) 4.81

Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli. Cell (2005) 4.78

GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol (2003) 4.60

A stress sensor for the bacterial periplasm. Cell (2003) 4.52

Cerebellar neurodegeneration in the absence of microRNAs. J Exp Med (2007) 4.48

MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell (2009) 4.47

Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell (2003) 4.46

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol (2013) 4.16

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell (2011) 3.98

Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science (2010) 3.97

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell (2003) 3.96

Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proc Natl Acad Sci U S A (2004) 3.87

Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc Natl Acad Sci U S A (2004) 3.85

DARPP-32: an integrator of neurotransmission. Annu Rev Pharmacol Toxicol (2004) 3.84

Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics (2008) 3.78

Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens. Proc Natl Acad Sci U S A (2006) 3.68

Molecular chaperone functions in protein folding and proteostasis. Annu Rev Biochem (2013) 3.56

Alterations in 5-HT1B receptor function by p11 in depression-like states. Science (2006) 3.55

Structural features of the GroEL-GroES nano-cage required for rapid folding of encapsulated protein. Cell (2006) 3.45

Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron (2013) 3.27

Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia. Nat Neurosci (2003) 3.25

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol (2002) 3.23

Pharmacological inhibitors of glycogen synthase kinase 3. Trends Pharmacol Sci (2004) 3.05

Advanced materials for energy storage. Adv Mater (2010) 3.04

Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron (2008) 3.01

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95

Genetic evidence supports demic diffusion of Han culture. Nature (2004) 2.92

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. J Biol Chem (2004) 2.85

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J (2009) 2.83

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab (2012) 2.80

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Nature (2010) 2.80

Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding. Cell (2008) 2.80

Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature (2006) 2.77

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses. Neurobiol Dis (2005) 2.70

Fatty liver and the metabolic syndrome among Shanghai adults. J Gastroenterol Hepatol (2005) 2.67

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain. J Neurosci (2004) 2.64

Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s. EMBO J (2006) 2.58

Diverse psychotomimetics act through a common signaling pathway. Science (2003) 2.52

Mechanism of induction and suppression of antiviral immunity directed by virus-derived small RNAs in Drosophila. Cell Host Microbe (2008) 2.48

Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol (2002) 2.45

Gleevec inhibits beta-amyloid production but not Notch cleavage. Proc Natl Acad Sci U S A (2003) 2.44

Suppression of antiviral silencing by cucumber mosaic virus 2b protein in Arabidopsis is associated with drastically reduced accumulation of three classes of viral small interfering RNAs. Plant Cell (2007) 2.43

Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proc Natl Acad Sci U S A (2011) 2.37

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors. Proc Natl Acad Sci U S A (2010) 2.36

Protein synthesis upon acute nutrient restriction relies on proteasome function. Science (2005) 2.32

Global surveillance of emerging Influenza virus genotypes by mass spectrometry. PLoS One (2007) 2.29

Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron (2009) 2.26

Real-time observation of trigger factor function on translating ribosomes. Nature (2006) 2.23

A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP. Neuron (2006) 2.23

Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin. Science (2002) 2.22

Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanotechnology. Nano Lett (2005) 2.22

Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. J Hepatol (2005) 2.21

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation. Mol Cell (2004) 2.19

Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers. Mol Cell (2006) 2.16

IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity. J Neurosci (2011) 2.15

Roles of molecular chaperones in protein misfolding diseases. Semin Cell Dev Biol (2004) 2.14

Global regulation of nucleotide biosynthetic genes by c-Myc. PLoS One (2008) 2.12

Structure and function of RbcX, an assembly chaperone for hexadecameric Rubisco. Cell (2007) 2.11

Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia. J Neurosci (2007) 2.11

Aluminum induces tau aggregation in vitro but not in vivo. J Alzheimers Dis (2007) 2.10

A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature (2008) 2.10

Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. Sci Transl Med (2010) 2.09

Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes. J Biol Chem (2002) 2.04

Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies. Neuron (2003) 2.04

APP processing in Alzheimer's disease. Mol Brain (2011) 2.02

GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J Biol Chem (2004) 1.99

Type 1 phosphatase, a negative regulator of cardiac function. Mol Cell Biol (2002) 1.97

MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science (2013) 1.95

Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange. Mol Cell (2005) 1.94

Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit. Proc Natl Acad Sci U S A (2007) 1.93

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. J Neurochem (2004) 1.92

Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature (2002) 1.91

Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. J Biol Chem (2007) 1.91

The neurobiology of dopamine signaling. Arch Neurol (2004) 1.89

The native 3D organization of bacterial polysomes. Cell (2009) 1.88

Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. J Neurosci (2006) 1.88

Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Proc Natl Acad Sci U S A (2004) 1.86

Function of trigger factor and DnaK in multidomain protein folding: increase in yield at the expense of folding speed. Cell (2004) 1.85

Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia. Sci Signal (2009) 1.84

Isolation of a novel swine influenza virus from Oklahoma in 2011 which is distantly related to human influenza C viruses. PLoS Pathog (2013) 1.83

Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci (2002) 1.82

Three-dimensional architecture of presynaptic terminal cytomatrix. J Neurosci (2007) 1.82

High-energy MnO2 nanowire/graphene and graphene asymmetric electrochemical capacitors. ACS Nano (2010) 1.81

Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol (2011) 1.81