Published in Metab Eng on February 23, 2010
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Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue. Biochem J (2004) 1.63
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Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue. Gastroenterology (2007) 1.58
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Rational design of combination enzyme therapy for celiac sprue. Chem Biol (2006) 1.28
Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. Proc Natl Acad Sci U S A (2010) 1.27
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Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity. Proc Natl Acad Sci U S A (2005) 1.27
Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules. J Am Chem Soc (2003) 1.24
Kinetic and structural analysis of a new group of Acyl-CoA carboxylases found in Streptomyces coelicolor A3(2). J Biol Chem (2002) 1.24
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Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion. J Immunol (2004) 1.23
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Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure (2002) 1.21
Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas. Mol Cancer Ther (2005) 1.20
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Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation. Proc Natl Acad Sci U S A (2012) 1.19
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Structure and mechanism of the trans-acting acyltransferase from the disorazole synthase. Biochemistry (2011) 1.18
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Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. J Biol Chem (2003) 1.17
A non-human primate model for gluten sensitivity. PLoS One (2008) 1.17
Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease. Chem Biol (2006) 1.17
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Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization. J Pharmacol Exp Ther (2004) 1.15
Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry. Biochemistry (2005) 1.14
Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from Myxococcus xanthus: implications for Celiac Sprue therapy. Biotechnol Bioeng (2005) 1.13
Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2. Biochemistry (2005) 1.11
Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Appl Environ Microbiol (2003) 1.10
A food-grade enzyme preparation with modest gluten detoxification properties. PLoS One (2009) 1.10
Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase. J Am Chem Soc (2010) 1.09
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Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement. Gastroenterology (2007) 1.07
Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles. J Med Chem (2006) 1.07
Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase. J Am Chem Soc (2003) 1.06
Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. PLoS Biol (2004) 1.06
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In vitro reconstitution and analysis of the 6-deoxyerythronolide B synthase. J Am Chem Soc (2013) 1.06
Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket. J Am Chem Soc (2012) 1.06
Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. Biochemistry (2002) 1.05
Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase. Biochemistry (2004) 1.04
Activation of extracellular transglutaminase 2 by thioredoxin. J Biol Chem (2011) 1.03
The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units. Biochemistry (2004) 1.03
Protein engineering of improved prolyl endopeptidases for celiac sprue therapy. Protein Eng Des Sel (2008) 1.03
Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. J Mol Biol (2003) 1.03
Oral enzyme therapy for celiac sprue. Methods Enzymol (2012) 1.03
Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Biochemistry (2002) 1.02
Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase. Bioorg Med Chem Lett (2008) 1.02
Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds. Angew Chem Int Ed Engl (2013) 1.02
Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase. J Am Chem Soc (2003) 1.01
Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2). Biochemistry (2006) 1.01
Genetic engineering of Escherichia coli for biofuel production. Annu Rev Genet (2010) 1.00
Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. Biochemistry (2003) 0.99
Visualization of transepithelial passage of the immunogenic 33-residue peptide from alpha-2 gliadin in gluten-sensitive macaques. PLoS One (2010) 0.99
Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. J R Soc Interface (2013) 0.99
Building-block selectivity of polyketide synthases. Curr Opin Chem Biol (2003) 0.99
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Manipulation and analysis of polyketide synthases. Methods Enzymol (2004) 0.97
A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases. Microbiology (2003) 0.97