Published in Appl Environ Microbiol on April 01, 2006
Evolution of polyketide synthases in bacteria. Proc Natl Acad Sci U S A (2008) 1.78
Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. ACS Synth Biol (2013) 1.40
Genetics of Streptomyces rimosus, the oxytetracycline producer. Microbiol Mol Biol Rev (2006) 1.15
The bacterial translation stress response. FEMS Microbiol Rev (2014) 1.14
Cyclization of aromatic polyketides from bacteria and fungi. Nat Prod Rep (2010) 1.05
Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters. Chembiochem (2010) 1.03
Avoidance of suicide in antibiotic-producing microbes. J Ind Microbiol Biotechnol (2010) 1.01
StreptomeDB: a resource for natural compounds isolated from Streptomyces species. Nucleic Acids Res (2012) 0.99
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575. J Am Chem Soc (2009) 0.98
Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides. J Ind Microbiol Biotechnol (2013) 0.96
Draft Genome Sequence of the Oxytetracycline-Producing Bacterium Streptomyces rimosus ATCC 10970. Genome Announc (2013) 0.90
Emerging strategies and integrated systems microbiology technologies for biodiscovery of marine bioactive compounds. Mar Drugs (2014) 0.87
Decoding and engineering tetracycline biosynthesis. Metab Eng (2008) 0.87
Oxytetracycline biosynthesis. J Biol Chem (2010) 0.86
Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus. Appl Environ Microbiol (2010) 0.84
Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944. J Biol Chem (2010) 0.83
Heterologous expression and manipulation of three tetracycline biosynthetic pathways. Angew Chem Int Ed Engl (2012) 0.80
The Biosynthesis of Capuramycin-type Antibiotics: IDENTIFICATION OF THE A-102395 BIOSYNTHETIC GENE CLUSTER, MECHANISM OF SELF-RESISTANCE, AND FORMATION OF URIDINE-5'-CARBOXAMIDE. J Biol Chem (2015) 0.79
Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus. Microb Cell Fact (2015) 0.78
Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli. PLoS One (2013) 0.78
Synthetic biology of antimicrobial discovery. ACS Synth Biol (2012) 0.76
Biosynthesis of Oxytetracycline by Streptomyces rimosus: Past, Present and Future Directions in the Development of Tetracycline Antibiotics. Food Technol Biotechnol (2017) 0.75
Heterogeneity of tetracycline resistance determinants. Plasmid (1980) 6.42
Genome sequence of the plant pathogen Ralstonia solanacearum. Nature (2002) 6.23
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc Natl Acad Sci U S A (2001) 4.56
Engineered biosynthesis of novel polyketides. Science (1993) 3.16
A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics. Science (2005) 3.03
Tetracyclines, molecular and clinical aspects. J Antimicrob Chemother (1992) 2.86
Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits. Nature (1995) 2.56
The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability. Proc Natl Acad Sci U S A (2003) 2.37
The amidotransferases. Adv Enzymol Relat Areas Mol Biol (1993) 2.07
Biosynthesis and attachment of novel bacterial polyketide synthase starter units. Nat Prod Rep (2002) 2.05
An antibiotic factory caught in action. Nat Struct Mol Biol (2004) 1.81
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide. Chem Biol (2005) 1.58
Characterization of an oxytetracycline-resistance gene, otrA, of Streptomyces rimosus. Mol Microbiol (1991) 1.58
Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product. Biochemistry (1999) 1.56
Organisation and functions of the actVA region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor. Mol Gen Genet (1991) 1.47
Polyketide chain length control by chain length factor. J Am Chem Soc (2003) 1.35
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin. Gene (1996) 1.34
Cloning and nucleotide sequence of the gene responsible for chlorination of tetracycline. Biosci Biotechnol Biochem (1995) 1.33
Escherichia coli aromatic amino acid aminotransferase: characterization and comparison with aspartate aminotransferase. Biochemistry (1993) 1.33
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin. Gene (1994) 1.31
Enzymatic synthesis of a bacterial polyketide from acetyl and malonyl coenzyme A. Science (1993) 1.29
Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase. Proc Natl Acad Sci U S A (1996) 1.28
Purification and in vitro reconstitution of the essential protein components of an aromatic polyketide synthase. Biochemistry (1998) 1.28
Glycylcyclines: third-generation tetracycline antibiotics. Curr Opin Pharmacol (2001) 1.28
Molecular cloning of resistance genes and architecture of a linked gene cluster involved in biosynthesis of oxytetracycline by Streptomyces rimosus. Mol Gen Genet (1989) 1.27
Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins. J Bacteriol (1993) 1.27
Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism. J Biol Chem (2000) 1.22
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040. Arch Microbiol (2002) 1.19
Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity. Biochemistry (2004) 1.18
Biosynthesis of polyketides (other than actinomycete macrolides). Nat Prod Rep (1999) 1.18
The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis. J Bacteriol (1998) 1.13
Cloning and heterologous expression in Streptomyces lividans of Streptomyces rimosus genes involved in oxytetracycline biosynthesis. J Bacteriol (1989) 1.12
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway. Mol Gen Genet (1996) 1.10
Glutamine-dependent nitrogen transfer in Escherichia coli asparagine synthetase B. Searching for the catalytic triad. J Biol Chem (1994) 1.08
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus. J Bacteriol (2002) 1.08
Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. PLoS Biol (2004) 1.06
Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase. Chem Biol (1999) 1.05
The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units. Biochemistry (2004) 1.03
In vitro reconstitution and analysis of the chain initiating enzymes of the R1128 polyketide synthase. Biochemistry (2001) 1.00
Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus. Gene (1994) 0.99
Mechanisms of drug/H+ antiport: complete cysteine-scanning mutagenesis and the protein engineering approach. Curr Opin Chem Biol (2003) 0.95
Interaction of the membrane-bound succinate dehydrogenase with substrate and competitive inhibitors. Biochim Biophys Acta (1984) 0.93
Cloning, sequencing, and heterologous expression of the elmGHIJ genes involved in the biosynthesis of the polyketide antibiotic elloramycin from Streptomyces olivaceus Tü2353. J Nat Prod (2001) 0.93
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus. Mol Gen Genet (1999) 0.91
Revised sequence of OtrB (tet347) tetracycline efflux protein from Streptomyces rimosus. Antimicrob Agents Chemother (1998) 0.90
Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length. J Biol Chem (2005) 0.89
Kinetic mechanism of Escherichia coli asparagine synthetase B. Biochemistry (1998) 0.89
Identification and cloning of the gene involved in the final step of chlortetracycline biosynthesis in Streptomyces aureofaciens. Biosci Biotechnol Biochem (2004) 0.88
Mutagenesis and chemical rescue indicate residues involved in beta-aspartyl-AMP formation by Escherichia coli asparagine synthetase B. J Biol Chem (1997) 0.87
Disruption of an aromatase/cyclase from the oxytetracycline gene cluster of Streptomyces rimosus results in production of novel polyketides with shorter chain lengths. J Biol Chem (1999) 0.84
Chemistry. A new route to designer antibiotics. Science (2005) 0.81
Glutamic acid gamma-monohydroxamate and hydroxylamine are alternate substrates for Escherichia coli asparagine synthetase B. Biochemistry (1996) 0.77
Mechanism of the incidental production of a melanin-like pigment during 6-demethylchlortetracycline production in Streptomyces aureofaciens. Appl Environ Microbiol (2000) 0.77
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol (2005) 3.40
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci (2009) 3.24
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem (2002) 2.45
Tembusu virus in ducks, china. Emerg Infect Dis (2011) 2.30
The type I fatty acid and polyketide synthases: a tale of two megasynthases. Nat Prod Rep (2007) 2.28
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature (2009) 1.94
A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol (2009) 1.94
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87
Tgf-Beta signaling in development. Sci STKE (2007) 1.70
Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. J Am Chem Soc (2007) 1.55
Functional CT for quantifying tumor perfusion in antiangiogenic therapy in a rat model. Radiology (2005) 1.55
A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proc Natl Acad Sci U S A (2008) 1.54
Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum. Chem Biol (2010) 1.51
Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system. Hypertension (2004) 1.50
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol (2005) 1.48
Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers. Chem Biol (2013) 1.47
Tailoring nanocarriers for intracellular protein delivery. Chem Soc Rev (2011) 1.42
Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2006) 1.42
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. J Am Chem Soc (2011) 1.41
Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. J Am Chem Soc (2010) 1.41
Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem (2006) 1.41
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nat Med (2012) 1.40
Magnetic sensors for protease assays. Angew Chem Int Ed Engl (2003) 1.39
Navigating the fungal polyketide chemical space: from genes to molecules. J Org Chem (2012) 1.36
Polyketide chain length control by chain length factor. J Am Chem Soc (2003) 1.35
The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene (2005) 1.35
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proc Natl Acad Sci U S A (2008) 1.34
Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33
Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol Ther (2006) 1.32
Redirecting the cyclization steps of fungal polyketide synthase. J Am Chem Soc (2007) 1.32
Biochemical and structural characterization of an essential acyl coenzyme A carboxylase from Mycobacterium tuberculosis. J Bacteriol (2006) 1.29
Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem (2010) 1.28
Role of Nedd4 and ubiquitination of Rous sarcoma virus Gag in budding of virus-like particles from cells. J Virol (2004) 1.27
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3. EMBO J (2011) 1.27
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proc Natl Acad Sci U S A (2010) 1.25
A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J Biol Chem (2010) 1.23
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. J Am Chem Soc (2011) 1.22
Metabolic engineering for the production of natural products. Annu Rev Chem Biomol Eng (2011) 1.22
A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells. J Biol Chem (2006) 1.22
Geographical, seasonal and gender differences in folate status among Chinese adults. J Nutr (2003) 1.19
Regeneration of the cavernous nerve by Sonic hedgehog using aligned peptide amphiphile nanofibers. Biomaterials (2010) 1.18
Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity. Biochemistry (2004) 1.18
Acyltransferase mediated polyketide release from a fungal megasynthase. J Am Chem Soc (2009) 1.18
Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate specificity. Biochemistry (2004) 1.17
Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. J Biol Chem (2010) 1.17
A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nat Chem Biol (2012) 1.17
Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo. Oncogene (2003) 1.17
Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehog. Biol Reprod (2006) 1.17
The functionally exchangeable L domains in RSV and HIV-1 Gag direct particle release through pathways linked by Tsg101. Traffic (2005) 1.16
Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22. Cancer Lett (2013) 1.16
Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer. Clin Cancer Res (2009) 1.16
Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry (2011) 1.15
Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. Chem Biol (2006) 1.14
Novel factor XIII probes for blood coagulation imaging. Chembiochem (2003) 1.13
Fatty acid biosynthesis in actinomycetes. FEMS Microbiol Rev (2011) 1.13
Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1. Metab Eng (2011) 1.13
ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria. Microbiology (2009) 1.13
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli. Proc Natl Acad Sci U S A (2008) 1.12
Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1. J Biol Chem (2004) 1.11
A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe. Neoplasia (2004) 1.11
Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase. J Am Chem Soc (2012) 1.10
Activation of RXR and RAR signaling promotes myogenic differentiation of myoblastic C2C12 cells. Differentiation (2009) 1.09
Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugate. Bioconjug Chem (2003) 1.09
Geochemistry of soil gas in the seismic fault zone produced by the Wenchuan Ms 8.0 earthquake, southwestern China. Geochem Trans (2010) 1.08
Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis. Hepatology (2008) 1.08
Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks. ACS Chem Biol (2013) 1.08
Recovery from AKI following multiple wasp stings: a case series. Clin J Am Soc Nephrol (2013) 1.07
Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae. J Am Chem Soc (2010) 1.07
Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway. J Biol Chem (2007) 1.07
Tsg101 can replace Nedd4 function in ASV Gag release but not membrane targeting. Virology (2008) 1.06
Biochemical characterization of the minimal polyketide synthase domains in the lovastatin nonaketide synthase LovB. FEBS J (2007) 1.06
Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. Biochemistry (2002) 1.05
Hierarchical MoS₂/polyaniline nanowires with excellent electrochemical performance for lithium-ion batteries. Adv Mater (2012) 1.05
Cyclization of aromatic polyketides from bacteria and fungi. Nat Prod Rep (2010) 1.05
Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A (2011) 1.04
Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. Nat Chem Biol (2012) 1.04
Pan and sentinel lymph node visualization using a near-infrared fluorescent probe. Mol Imaging (2003) 1.03
The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene. J Am Chem Soc (2013) 1.02
Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2). Biochemistry (2006) 1.01
Engineering natural products using combinatorial biosynthesis and biocatalysis. Curr Opin Biotechnol (2008) 1.01
Vigilant vector: heart-specific promoter in an adeno-associated virus vector for cardioprotection. Hypertension (2002) 1.01
Longitudinal lesion of the spinal cord in a patient with Vogt-Koyanagi-Harada disease. J Neurol Neurosurg Psychiatry (2010) 1.01
Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440. J Am Chem Soc (2012) 1.00
Influence relevance voting: an accurate and interpretable virtual high throughput screening method. J Chem Inf Model (2009) 1.00
General synthesis of mesoporous spheres of metal oxides and phosphates. J Am Chem Soc (2003) 1.00
Synthetic biological approaches to natural product biosynthesis. Curr Opin Biotechnol (2012) 1.00
Improving simvastatin bioconversion in Escherichia coli by deletion of bioH. Metab Eng (2007) 0.99
2.6 A X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase . Biochemistry (2009) 0.99
Early diagnosis of osteoarthritis using cathepsin B sensitive near-infrared fluorescent probes. Osteoarthritis Cartilage (2004) 0.99