Published in Aging Cell on October 01, 2003
Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol (2008) 2.86
The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev (2011) 2.38
When cells get stressed: an integrative view of cellular senescence. J Clin Invest (2004) 2.37
Associations between diet, lifestyle factors, and telomere length in women. Am J Clin Nutr (2010) 2.23
Does a sentinel or a subset of short telomeres determine replicative senescence? Mol Biol Cell (2004) 1.92
Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genet (2008) 1.80
Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing. ACS Chem Biol (2011) 1.77
Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia. Mol Cell Biol (2007) 1.71
Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT). Mol Cell Biol (2004) 1.65
Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol Cell Biol (2007) 1.62
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res (2007) 1.60
SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts. PLoS One (2008) 1.58
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence. Epigenetics Chromatin (2008) 1.50
Telomere length in peripheral leukocyte DNA and gastric cancer risk. Cancer Epidemiol Biomarkers Prev (2009) 1.48
5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation. EMBO J (2004) 1.42
Senescent cells harbour features of the cancer epigenome. Nat Cell Biol (2013) 1.34
Phenotypic and functional characterization of human mammary stem/progenitor cells in long term culture. PLoS One (2009) 1.33
Cellular senescence and chromatin structure. Chromosoma (2007) 1.26
Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling. Mol Cell Biol (2004) 1.25
Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population. Skelet Muscle (2011) 1.05
Regulation of senescence in cancer and aging. J Aging Res (2011) 0.98
Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts. Proc Natl Acad Sci U S A (2008) 0.95
Thrombin and TNF-alpha/IL-1beta synergistically induce fibroblast-mediated collagen gel degradation. Am J Respir Cell Mol Biol (2006) 0.94
Cellular senescence: unravelling complexity. Age (Dordr) (2009) 0.93
Spontaneous immortalization of clinically normal colon-derived fibroblasts from a familial adenomatous polyposis patient. Neoplasia (2004) 0.93
Endogenous oxidative stress prevents telomerase-dependent immortalization of human endothelial cells. Mech Ageing Dev (2010) 0.88
Stable cellular senescence is associated with persistent DDR activation. PLoS One (2014) 0.87
Stable knockdown of PASG enhances DNA demethylation but does not accelerate cellular senescence in TIG-7 human fibroblasts. Epigenetics (2008) 0.85
A connection between magnesium deficiency and aging: new insights from cellular studies. Magnes Res (2008) 0.85
A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations. PLoS One (2012) 0.84
Up-regulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16(INK4a) protein and confers resistance to oxidative stress. J Biol Chem (2013) 0.78
Long-term quiescent fibroblast cells transit into senescence. PLoS One (2014) 0.77
Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells. J Biol Chem (2011) 0.77
Characterization of cholesterol homeostasis in telomerase-immortalized Tangier disease fibroblasts reveals marked phenotype variability. J Biol Chem (2013) 0.77
Ring-like distribution of constitutive heterochromatin in bovine senescent cells. PLoS One (2011) 0.76
Combined activation of the energy and cellular-defense pathways may explain the potent anti-senescence activity of methylene blue. Redox Biol (2015) 0.75
BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature (2005) 16.87
Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A (2007) 5.95
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res (2004) 5.57
Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells. Nat Cell Biol (2007) 5.50
Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst (2003) 5.09
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res (2006) 3.45
Human telomerase and its regulation. Microbiol Mol Biol Rev (2002) 3.11
Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis (2004) 3.07
Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer Res (2007) 2.81
Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell (2009) 2.76
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J (2005) 2.69
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res (2010) 2.54
Telomere-end processing the terminal nucleotides of human chromosomes. Mol Cell (2005) 2.39
Historical claims and current interpretations of replicative aging. Nat Biotechnol (2002) 2.38
Human diseases of telomerase dysfunction: insights into tissue aging. Nucleic Acids Res (2007) 2.34
Role of telomeres and telomerase in cancer. Semin Cancer Biol (2011) 2.20
A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med (2006) 2.16
Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell (2011) 2.07
A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism. Science (2009) 2.02
Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line. Invest Ophthalmol Vis Sci (2005) 2.02
Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res (2004) 2.01
Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again. Differentiation (2002) 1.99
Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies. Aging Cell (2007) 1.98
The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth. Clin Cancer Res (2010) 1.96
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A (2009) 1.96
High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Res (2005) 1.94
Does a sentinel or a subset of short telomeres determine replicative senescence? Mol Biol Cell (2004) 1.92
Telomerase therapeutics for cancer: challenges and new directions. Nat Rev Drug Discov (2006) 1.91
Actions of human telomerase beyond telomeres. Cell Res (2008) 1.79
hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene (2003) 1.78
Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Cancer Res (2004) 1.74
Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology (2009) 1.72
BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. EMBO J (2003) 1.71
Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol. Nat Protoc (2006) 1.70
Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition. Cancer Res (2004) 1.66
Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT). Mol Cell Biol (2004) 1.65
A three-dimensional model of differentiation of immortalized human bronchial epithelial cells. Differentiation (2006) 1.64
Telomerase: a target for cancer therapeutics. Cancer Cell (2002) 1.64
Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene (2005) 1.64
Human telomeres have different overhang sizes at leading versus lagging strands. Mol Cell (2006) 1.62
Modification of subtelomeric DNA. Mol Cell Biol (2004) 1.60
In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res (2005) 1.59
Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol Cancer Res (2013) 1.57
Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation. Cancer Res (2006) 1.55
Quantitative telomeric overhang determination using a double-strand specific nuclease. Nucleic Acids Res (2007) 1.53
Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers. PLoS Med (2007) 1.52
Human CST promotes telomere duplex replication and general replication restart after fork stalling. EMBO J (2012) 1.47
Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Rev (2010) 1.46
Telomere dynamics in macaques and humans. J Gerontol A Biol Sci Med Sci (2007) 1.46
Is there an antiaging medicine? J Gerontol A Biol Sci Med Sci (2002) 1.46
Telomeres and telomerase in normal and cancer stem cells. FEBS Lett (2010) 1.46
Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts. Invest Ophthalmol Vis Sci (2003) 1.39
The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. EMBO Rep (2006) 1.36
Telomerase in cancer and aging. Crit Rev Oncol Hematol (2002) 1.36
Analysis of telomeres and telomerase. Curr Protoc Cell Biol (2003) 1.35
A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation. Oncogene (2002) 1.34
Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a. Cancer Res (2010) 1.34
Telomere biology in Metazoa. FEBS Lett (2010) 1.32
Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells. Mol Cell Biol (2005) 1.31
Human CST has independent functions during telomere duplex replication and C-strand fill-in. Cell Rep (2012) 1.29
Human Ku70/80 associates physically with telomerase through interaction with hTERT. J Biol Chem (2002) 1.29
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. J Clin Invest (2011) 1.27
Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions. Mol Cell (2011) 1.26
Telomerase regulation: not just flipping the switch. Curr Opin Genet Dev (2002) 1.24
The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines. Cancer Res (2010) 1.23
p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells. Oncogene (2002) 1.21