Published in EMBO Rep on February 01, 2006
DNA end resection: many nucleases make light work. DNA Repair (Amst) (2009) 3.28
Transcriptomic biomarkers for individual risk assessment in new-onset heart failure. Circulation (2008) 2.15
Telomere length homeostasis. Chromosoma (2006) 2.12
DNA damage response at functional and dysfunctional telomeres. Genes Dev (2008) 1.75
Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2. Mol Cell Biol (2009) 1.60
Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres. EMBO J (2009) 1.54
Quantitative telomeric overhang determination using a double-strand specific nuclease. Nucleic Acids Res (2007) 1.53
The MRN complex in double-strand break repair and telomere maintenance. FEBS Lett (2010) 1.53
Nijmegen breakage syndrome (NBS). Orphanet J Rare Dis (2012) 1.27
Tetrahymena POT1a regulates telomere length and prevents activation of a cell cycle checkpoint. Mol Cell Biol (2006) 1.24
Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection. Mol Cell Biol (2006) 1.23
The mre11 complex and the response to dysfunctional telomeres. Mol Cell Biol (2009) 1.22
Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening. Genes Dev (2012) 1.12
Taming the tiger by the tail: modulation of DNA damage responses by telomeres. EMBO J (2009) 1.12
Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protection. EMBO J (2010) 1.11
Protection and replication of telomeres in fission yeast. Biochem Cell Biol (2009) 1.10
L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1. EMBO J (2011) 1.10
Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy. J Clin Invest (2009) 1.07
Shelterin complex and associated factors at human telomeres. Nucleus (2011) 1.04
Replication of telomeres and the regulation of telomerase. Cold Spring Harb Perspect Biol (2013) 1.03
BRCA1 localization to the telomere and its loss from the telomere in response to DNA damage. J Biol Chem (2009) 1.02
Chromosome end protection by blunt-ended telomeres. Genes Dev (2012) 0.97
Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis. Proc Natl Acad Sci U S A (2009) 0.91
Mechanisms of telomere loss and their consequences for chromosome instability. Front Oncol (2012) 0.87
Defending the end zone: studying the players involved in protecting chromosome ends. FEBS Lett (2010) 0.86
Deficient repair of particulate hexavalent chromium-induced DNA double strand breaks leads to neoplastic transformation. Mutat Res (2007) 0.86
Evolution of species-specific promoter-associated mechanisms for protecting chromosome ends by Drosophila Het-A telomeric transposons. Proc Natl Acad Sci U S A (2010) 0.83
Cardiovascular genetic medicine: genomic assessment of prognosis and diagnosis in patients with cardiomyopathy and heart failure. J Cardiovasc Transl Res (2008) 0.82
Telomeres do the (un)twist: helicase actions at chromosome termini. Biochim Biophys Acta (2009) 0.82
To trim or not to trim: progression and control of DSB end resection. Cell Cycle (2013) 0.82
The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line. PLoS Genet (2013) 0.81
Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks. Nucleic Acids Res (2015) 0.80
To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres? Front Biosci (Landmark Ed) (2010) 0.78
CDK1 differentially regulates G-overhang generation at leading- and lagging-strand telomeres in telomerase-negative cells in G2 phase. Cell Cycle (2012) 0.77
If the cap fits, wear it: an overview of telomeric structures over evolution. Cell Mol Life Sci (2013) 0.76
Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy. BMC Cancer (2016) 0.75
Differential Expression of Non-Shelterin Genes Associated with High Telomerase Levels and Telomere Shortening in Plasma Cell Disorders. PLoS One (2015) 0.75
Telomeres in aging and disease: lessons from zebrafish. Dis Model Mech (2016) 0.75
Regulation of telomere metabolism by the RNA processing protein Xrn1. Nucleic Acids Res (2017) 0.75
Effects of initial telomere length distribution on senescence onset and heterogeneity. J Theor Biol (2016) 0.75
Meiotic localization of Mre11 and Rad50 in wild type, spo11-1, and MRN complex mutants of Coprinus cinereus. Chromosoma (2009) 0.75
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem (2004) 14.93
A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol (1973) 7.28
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol Cell (1998) 6.50
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J (1998) 5.79
Regulation of telomerase by telomeric proteins. Annu Rev Biochem (2004) 5.69
Sensing and repairing DNA double-strand breaks. Carcinogenesis (2002) 5.52
Protection of mammalian telomeres. Oncogene (2002) 5.38
Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell (1997) 4.86
Regulation and mechanisms of mammalian double-strand break repair. Oncogene (2003) 4.43
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet (2000) 4.30
Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr Biol (1998) 3.63
Evidence for a new step in telomere maintenance. Cell (1996) 3.03
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol Cell (2003) 3.01
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J (2005) 2.69
Telomerase and DNA end replication: no longer a lagging strand problem? Science (1995) 2.67
Strand-specific postreplicative processing of mammalian telomeres. Science (2001) 2.64
The terminal DNA structure of mammalian chromosomes. EMBO J (1997) 2.63
Telomere-end processing the terminal nucleotides of human chromosomes. Mol Cell (2005) 2.39
Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres. Mol Cell Biol (2003) 2.33
Functional links between telomeres and proteins of the DNA-damage response. Genes Dev (2004) 2.29
The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex. Genes Dev (2004) 2.10
The 3' 5' exonucleases. Nat Rev Mol Cell Biol (2002) 2.07
Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere. Curr Biol (2001) 2.05
Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae. Genes Cells (1997) 2.04
The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics (2000) 1.89
Indecent exposure: when telomeres become uncapped. Mol Cell (2004) 1.82
Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet (2003) 1.78
Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance. Curr Biol (2004) 1.41
The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. Curr Biol (2004) 1.38
The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks. DNA Repair (Amst) (2004) 1.38
RAD50 function is essential for telomere maintenance in Arabidopsis. Proc Natl Acad Sci U S A (2001) 1.32
Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae. Mol Cell (2005) 1.27
Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres. Cancer Res (2000) 1.20
Human telomeres maintain their overhang length at senescence. Mol Cell Biol (2005) 1.16
Telomeres and the DNA damage response: why the fox is guarding the henhouse. DNA Repair (Amst) (2004) 1.10
Effects of double-strand break repair proteins on vertebrate telomere structure. Nucleic Acids Res (2002) 1.04
Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Curr Biol (2001) 1.01
BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature (2005) 16.87
Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A (2007) 5.95
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res (2004) 5.57
Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells. Nat Cell Biol (2007) 5.50
Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst (2003) 5.09
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res (2006) 3.45
Human telomerase and its regulation. Microbiol Mol Biol Rev (2002) 3.11
Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis (2004) 3.07
Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer Res (2007) 2.81
Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell (2009) 2.76
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J (2005) 2.69
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res (2010) 2.54
Telomere-end processing the terminal nucleotides of human chromosomes. Mol Cell (2005) 2.39
Historical claims and current interpretations of replicative aging. Nat Biotechnol (2002) 2.38
Human diseases of telomerase dysfunction: insights into tissue aging. Nucleic Acids Res (2007) 2.34
Role of telomeres and telomerase in cancer. Semin Cancer Biol (2011) 2.20
A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med (2006) 2.16
Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell (2011) 2.07
Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line. Invest Ophthalmol Vis Sci (2005) 2.02
A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism. Science (2009) 2.02
Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res (2004) 2.01
Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again. Differentiation (2002) 1.99
Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies. Aging Cell (2007) 1.98
The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth. Clin Cancer Res (2010) 1.96
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A (2009) 1.96
High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Res (2005) 1.94
Does a sentinel or a subset of short telomeres determine replicative senescence? Mol Biol Cell (2004) 1.92
Telomerase therapeutics for cancer: challenges and new directions. Nat Rev Drug Discov (2006) 1.91
Actions of human telomerase beyond telomeres. Cell Res (2008) 1.79
hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene (2003) 1.78
Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Cancer Res (2004) 1.74
Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology (2009) 1.72
BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. EMBO J (2003) 1.71
Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol. Nat Protoc (2006) 1.70
Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition. Cancer Res (2004) 1.66
Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT). Mol Cell Biol (2004) 1.65
Telomerase: a target for cancer therapeutics. Cancer Cell (2002) 1.64
A three-dimensional model of differentiation of immortalized human bronchial epithelial cells. Differentiation (2006) 1.64
Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene (2005) 1.64
Human telomeres have different overhang sizes at leading versus lagging strands. Mol Cell (2006) 1.62
Modification of subtelomeric DNA. Mol Cell Biol (2004) 1.60
In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res (2005) 1.59
Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol Cancer Res (2013) 1.57
Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation. Cancer Res (2006) 1.55
Quantitative telomeric overhang determination using a double-strand specific nuclease. Nucleic Acids Res (2007) 1.53
Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers. PLoS Med (2007) 1.52
Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell (2003) 1.51
Human CST promotes telomere duplex replication and general replication restart after fork stalling. EMBO J (2012) 1.47
Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Rev (2010) 1.46
Telomere dynamics in macaques and humans. J Gerontol A Biol Sci Med Sci (2007) 1.46
Is there an antiaging medicine? J Gerontol A Biol Sci Med Sci (2002) 1.46
Telomeres and telomerase in normal and cancer stem cells. FEBS Lett (2010) 1.46
Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts. Invest Ophthalmol Vis Sci (2003) 1.39
Telomerase in cancer and aging. Crit Rev Oncol Hematol (2002) 1.36
Analysis of telomeres and telomerase. Curr Protoc Cell Biol (2003) 1.35
A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation. Oncogene (2002) 1.34
Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a. Cancer Res (2010) 1.34
Telomere biology in Metazoa. FEBS Lett (2010) 1.32
Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells. Mol Cell Biol (2005) 1.31
Human CST has independent functions during telomere duplex replication and C-strand fill-in. Cell Rep (2012) 1.29
Human Ku70/80 associates physically with telomerase through interaction with hTERT. J Biol Chem (2002) 1.29
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. J Clin Invest (2011) 1.27
Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions. Mol Cell (2011) 1.26
Telomerase regulation: not just flipping the switch. Curr Opin Genet Dev (2002) 1.24