Published in Mol Cell Biol on May 01, 2004
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
Associations between diet, lifestyle factors, and telomere length in women. Am J Clin Nutr (2010) 2.23
Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res (2011) 1.79
A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs. EMBO J (2009) 1.56
Telomeres, lifestyle, cancer, and aging. Curr Opin Clin Nutr Metab Care (2011) 1.35
Age-related changes in subtelomeric methylation in the normal Japanese population. J Gerontol A Biol Sci Med Sci (2009) 0.89
Accelerated aging during chronic oxidative stress: a role for PARP-1. Oxid Med Cell Longev (2013) 0.85
Human subtelomeric copy number variations. Cytogenet Genome Res (2009) 0.84
Biology of telomeres: importance in etiology of esophageal cancer and as therapeutic target. Transl Res (2013) 0.81
Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts. Nat Commun (2015) 0.80
DNA methylation Landscape of body size variation in sheep. Sci Rep (2015) 0.79
BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo. Oncotarget (2016) 0.77
The Telomeric Complex and Metabolic Disease. Genes (Basel) (2017) 0.76
Novel evolutionary models and periodic charts in p- and q-individual chromosomes of auxiliary lymph node and buccal cells. Dis Markers (2013) 0.75
Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97
Cytosine methylation and the ecology of intragenomic parasites. Trends Genet (1997) 13.66
Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription. Cell (1990) 12.50
Mammalian telomeres end in a large duplex loop. Cell (1999) 12.12
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A (1988) 11.81
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J (1992) 10.97
A survey of telomerase activity in human cancer. Eur J Cancer (1997) 10.84
Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci U S A (2000) 8.12
Structure and variability of human chromosome ends. Mol Cell Biol (1990) 6.18
Telomere end-replication problem and cell aging. J Mol Biol (1992) 5.37
Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell (1997) 4.86
Human telomeres contain at least three types of G-rich repeat distributed non-randomly. Nucleic Acids Res (1989) 4.72
Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev (1997) 3.42
Methylation of CpG sequences in eukaryotic DNA. FEBS Lett (1981) 3.39
Effect of site-specific methylation on restriction endonucleases and DNA modification methyltransferases. Nucleic Acids Res (1993) 3.09
Human telomeres are attached to the nuclear matrix. EMBO J (1992) 3.08
A position effect on the time of replication origin activation in yeast. Cell (1992) 2.94
Telomere analysis by fluorescence in situ hybridization and flow cytometry. Nucleic Acids Res (1998) 2.75
Telomere position effect in human cells. Science (2001) 2.61
The complex structure and dynamic evolution of human subtelomeres. Nat Rev Genet (2002) 2.57
Historical claims and current interpretations of replicative aging. Nat Biotechnol (2002) 2.38
Structure, function, and replication of Saccharomyces cerevisiae telomeres. Annu Rev Genet (1996) 2.32
Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J Biol Chem (2000) 2.14
beta-D-glucosyl-hydroxymethyluracil: a novel modified base present in the DNA of the parasitic protozoan T. brucei. Cell (1993) 2.00
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit. Hum Mol Genet (1997) 1.97
Stable length polymorphism of up to 260 kb at the tip of the short arm of human chromosome 16. Cell (1991) 1.87
Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity. EMBO Rep (2002) 1.79
beta-D-glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres. Proc Natl Acad Sci U S A (1998) 1.60
The telomeric GGGTTA repeats of Trypanosoma brucei contain the hypermodified base J in both strands. Nucleic Acids Res (1996) 1.39
A novel DNA nucleotide in Trypanosoma brucei only present in the mammalian phase of the life-cycle. Nucleic Acids Res (1991) 1.29
REBASE--restriction enzymes and methylases. Nucleic Acids Res (1993) 1.24
High levels of sequence polymorphism and linkage disequilibrium at the telomere of 12q: implications for telomere biology and human evolution. Am J Hum Genet (2000) 1.08
Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment. Mol Cell Biol (1999) 1.02
The plasticity of human telomeres demonstrated by a hypervariable telomere repeat array that is located on some copies of 16p and 16q. Hum Mol Genet (1999) 0.98
BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature (2005) 16.87
Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A (2007) 5.95
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res (2004) 5.57
Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells. Nat Cell Biol (2007) 5.50
Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst (2003) 5.09
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res (2006) 3.45
Human telomerase and its regulation. Microbiol Mol Biol Rev (2002) 3.11
Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis (2004) 3.07
Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer Res (2007) 2.81
Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell (2009) 2.76
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J (2005) 2.69
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res (2010) 2.54
Telomere-end processing the terminal nucleotides of human chromosomes. Mol Cell (2005) 2.39
Historical claims and current interpretations of replicative aging. Nat Biotechnol (2002) 2.38
Human diseases of telomerase dysfunction: insights into tissue aging. Nucleic Acids Res (2007) 2.34
Role of telomeres and telomerase in cancer. Semin Cancer Biol (2011) 2.20
A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med (2006) 2.16
Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell (2011) 2.07
A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism. Science (2009) 2.02
Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line. Invest Ophthalmol Vis Sci (2005) 2.02
Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res (2004) 2.01
Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again. Differentiation (2002) 1.99
Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies. Aging Cell (2007) 1.98
The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth. Clin Cancer Res (2010) 1.96
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A (2009) 1.96
High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Res (2005) 1.94
Does a sentinel or a subset of short telomeres determine replicative senescence? Mol Biol Cell (2004) 1.92
Telomerase therapeutics for cancer: challenges and new directions. Nat Rev Drug Discov (2006) 1.91
Actions of human telomerase beyond telomeres. Cell Res (2008) 1.79
hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene (2003) 1.78
Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Cancer Res (2004) 1.74
Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology (2009) 1.72
BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. EMBO J (2003) 1.71
Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol. Nat Protoc (2006) 1.70
Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition. Cancer Res (2004) 1.66
Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT). Mol Cell Biol (2004) 1.65
A three-dimensional model of differentiation of immortalized human bronchial epithelial cells. Differentiation (2006) 1.64
Telomerase: a target for cancer therapeutics. Cancer Cell (2002) 1.64
Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene (2005) 1.64
Human telomeres have different overhang sizes at leading versus lagging strands. Mol Cell (2006) 1.62
In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res (2005) 1.59
Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol Cancer Res (2013) 1.57
Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation. Cancer Res (2006) 1.55
Quantitative telomeric overhang determination using a double-strand specific nuclease. Nucleic Acids Res (2007) 1.53
Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers. PLoS Med (2007) 1.52
Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell (2003) 1.51
Human CST promotes telomere duplex replication and general replication restart after fork stalling. EMBO J (2012) 1.47
Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Rev (2010) 1.46
Telomere dynamics in macaques and humans. J Gerontol A Biol Sci Med Sci (2007) 1.46
Is there an antiaging medicine? J Gerontol A Biol Sci Med Sci (2002) 1.46
Telomeres and telomerase in normal and cancer stem cells. FEBS Lett (2010) 1.46
Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts. Invest Ophthalmol Vis Sci (2003) 1.39
Telomerase in cancer and aging. Crit Rev Oncol Hematol (2002) 1.36
The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. EMBO Rep (2006) 1.36
Analysis of telomeres and telomerase. Curr Protoc Cell Biol (2003) 1.35
A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation. Oncogene (2002) 1.34
Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a. Cancer Res (2010) 1.34
Telomere biology in Metazoa. FEBS Lett (2010) 1.32
Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells. Mol Cell Biol (2005) 1.31
Human Ku70/80 associates physically with telomerase through interaction with hTERT. J Biol Chem (2002) 1.29
Human CST has independent functions during telomere duplex replication and C-strand fill-in. Cell Rep (2012) 1.29
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. J Clin Invest (2011) 1.27
Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions. Mol Cell (2011) 1.26
Telomerase regulation: not just flipping the switch. Curr Opin Genet Dev (2002) 1.24
The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines. Cancer Res (2010) 1.23
p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells. Oncogene (2002) 1.21