Published in J Natl Cancer Inst on August 20, 2003
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet (2009) 6.91
Epidemiology and risk factors for kidney cancer. Nat Rev Urol (2010) 5.25
Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study. Lancet Oncol (2008) 3.60
The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev (2011) 3.29
Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J Natl Cancer Inst (2010) 3.18
Telomeres, stem cells, senescence, and cancer. J Clin Invest (2004) 2.87
A prospective study of telomere length and the risk of skin cancer. J Invest Dermatol (2008) 2.75
Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One (2011) 2.61
A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma. Clin Cancer Res (2009) 2.48
Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A (2009) 2.44
Contemporary epidemiology of renal cell cancer. Cancer J (2008) 2.40
Telomere length in prospective and retrospective cancer case-control studies. Cancer Res (2010) 2.30
Associations between diet, lifestyle factors, and telomere length in women. Am J Clin Nutr (2010) 2.23
A prospective study of relative telomere length and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev (2009) 2.23
The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer. Aging Cell (2009) 2.22
The individual blood cell telomere attrition rate is telomere length dependent. PLoS Genet (2009) 2.17
Obesity and weight gain in adulthood and telomere length. Cancer Epidemiol Biomarkers Prev (2009) 1.91
A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. Cancer Prev Res (Phila) (2011) 1.86
The genetics and clinical manifestations of telomere biology disorders. Genet Med (2010) 1.83
Telomeres and early-life stress: an overview. Biol Psychiatry (2012) 1.75
Telomere length, oxidative damage, antioxidants and breast cancer risk. Int J Cancer (2009) 1.70
Telomere length and genetic analyses in population-based studies of endometrial cancer risk. Cancer (2010) 1.61
The role of telomere biology in bone marrow failure and other disorders. Mech Ageing Dev (2007) 1.56
Multivitamin use and telomere length in women. Am J Clin Nutr (2009) 1.54
Retracted Role of senescence and mitotic catastrophe in cancer therapy. Cell Div (2010) 1.51
Genetic anticipation is associated with telomere shortening in hereditary breast cancer. PLoS Genet (2011) 1.51
Shorter telomeres associate with a reduced risk of melanoma development. Cancer Res (2011) 1.49
Telomere length in peripheral leukocyte DNA and gastric cancer risk. Cancer Epidemiol Biomarkers Prev (2009) 1.48
A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer. Lung Cancer (2011) 1.47
Physical activity, sedentary behavior, and leukocyte telomere length in women. Am J Epidemiol (2012) 1.43
Blood cell telomere length is a dynamic feature. PLoS One (2011) 1.41
Telomere biology in healthy aging and disease. Pflugers Arch (2009) 1.41
Inverse association between adiposity and telomere length: The Fels Longitudinal Study. Am J Hum Biol (2010) 1.37
Epidemiologic evidence for a role of telomere dysfunction in cancer etiology. Mutat Res (2011) 1.37
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Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity? Br J Cancer (2007) 1.32
Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot study. Cancer Causes Control (2009) 1.32
Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility. Lung Cancer (2009) 1.31
Bladder cancer in the elderly. Urol Oncol (2009) 1.26
Constitutive short telomere length of chromosome 17p and 12q but not 11q and 2p is associated with an increased risk for esophageal cancer. Cancer Prev Res (Phila) (2009) 1.22
Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study. Hum Mol Genet (2015) 1.20
Shortened telomeres in individuals with abuse in alcohol consumption. Int J Cancer (2011) 1.19
Telomere length in blood cells and breast cancer risk: investigations in two case-control studies. Breast Cancer Res Treat (2009) 1.18
Psychological intervention and health outcomes among women treated for breast cancer: a review of stress pathways and biological mediators. Brain Behav Immun (2008) 1.17
Genome-wide association study of relative telomere length. PLoS One (2011) 1.16
Association of leukocyte telomere length with colorectal cancer risk: nested case-control findings from the Shanghai Women's Health Study. Cancer Epidemiol Biomarkers Prev (2012) 1.14
Beyond average: potential for measurement of short telomeres. Aging (Albany NY) (2012) 1.12
Familial and genetic risk of transitional cell carcinoma of the urinary tract. Urol Oncol (2008) 1.11
Air pollution exposure and telomere length in highly exposed subjects in Beijing, China: a repeated-measure study. Environ Int (2012) 1.08
Tumor suppressor mechanisms in immune aging. Curr Opin Immunol (2009) 1.08
RecQ helicases in DNA double strand break repair and telomere maintenance. Mutat Res (2011) 1.08
Associations between rotating night shifts, sleep duration, and telomere length in women. PLoS One (2011) 1.07
Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers. Environ Health (2009) 1.07
High phobic anxiety is related to lower leukocyte telomere length in women. PLoS One (2012) 1.06
The long and short of telomeres and cancer association studies. J Natl Cancer Inst (2013) 1.04
Telomere length in peripheral blood leukocytes and lung cancer risk: a large case-control study in Caucasians. Cancer Res (2014) 1.04
Relative telomere length and cognitive decline in the Nurses' Health Study. Neurosci Lett (2011) 1.04
The new biology: beyond the Modern Synthesis. Biol Direct (2007) 1.03
Long telomeres in peripheral blood leukocytes are associated with an increased risk of soft tissue sarcoma. Cancer (2013) 1.03
Risk of renal cell carcinoma in relation to blood telomere length in a population-based case-control study. Br J Cancer (2011) 1.02
Shorter telomere length in peripheral blood lymphocytes of workers exposed to polycyclic aromatic hydrocarbons. Carcinogenesis (2009) 1.01
Telomere attrition in isolated high-grade prostatic intraepithelial neoplasia and surrounding stroma is predictive of prostate cancer. Neoplasia (2007) 1.00
Telomere length and pancreatic cancer: a case-control study. Cancer Epidemiol Biomarkers Prev (2012) 0.98
Telomeres and thyroid cancer. Curr Genomics (2009) 0.96
TERT-CLPTM1L polymorphism rs401681 contributes to cancers risk: evidence from a meta-analysis based on 29 publications. PLoS One (2012) 0.94
The association of telomere length with colorectal cancer differs by the age of cancer onset. Clin Transl Gastroenterol (2014) 0.93
Diet-related telomere shortening and chromosome stability. Mutagenesis (2011) 0.92
Association between leukocyte telomere length and glioma risk: a case-control study. Neuro Oncol (2013) 0.92
The evolving discipline of molecular epidemiology of cancer. Carcinogenesis (2009) 0.92
Telomere biology: integrating chromosomal end protection with DNA damage response. Chromosoma (2005) 0.92
Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer. Br J Cancer (2008) 0.90
Telomerase deficiency affects the formation of chromosomal translocations by homologous recombination in Saccharomyces cerevisiae. PLoS One (2008) 0.90
Genetic susceptibility to bladder cancer risk and outcome. Per Med (2011) 0.90
Telomeres, early-life stress and mental illness. Adv Psychosom Med (2015) 0.90
Prevention effects ameliorate the prospective association between nonsupportive parenting and diminished telomere length. Prev Sci (2015) 0.89
Telomere length and anaemia in old age: results from the Newcastle 85-plus Study and the Leiden 85-plus Study. Age Ageing (2011) 0.89
Genetic variants in telomere-maintenance genes and bladder cancer risk. PLoS One (2012) 0.88
Telomere length and common disease: study design and analytical challenges. Hum Genet (2015) 0.87
Telomere length and TERT functional polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck. Cancer Epidemiol Biomarkers Prev (2011) 0.87
Telomerase-dependent and independent telomere maintenance and its clinical implications in medullary thyroid carcinoma. J Clin Endocrinol Metab (2014) 0.86
Arsenic exposure through drinking water is associated with longer telomeres in peripheral blood. Chem Res Toxicol (2012) 0.86
Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma. PLoS One (2014) 0.86
The relationship between COPD and lung cancer. Lung Cancer (2015) 0.85
The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress. PLoS One (2010) 0.85
Genetic predisposition to higher body mass index or type 2 diabetes and leukocyte telomere length in the Nurses' Health Study. PLoS One (2013) 0.85
Impact of chemotherapy on telomere length in sporadic and familial breast cancer patients. Breast Cancer Res Treat (2014) 0.84
Nonsupportive parenting affects telomere length in young adulthood among African Americans: mediation through substance use. J Fam Psychol (2014) 0.84
A genome-wide association study identifies a locus on TERT for mean telomere length in Han Chinese. PLoS One (2014) 0.84
Association between socioeconomic factors and cancer risk: a population cohort study in Scotland (1991-2006). PLoS One (2014) 0.84
Change in peripheral blood leukocyte telomere length and mortality in breast cancer survivors. J Natl Cancer Inst (2014) 0.83
Immunosenescence and rheumatoid arthritis: does telomere shortening predict impending disease? Autoimmun Rev (2011) 0.83
Reliability and short-term intra-individual variability of telomere length measurement using monochrome multiplexing quantitative PCR. PLoS One (2011) 0.83
Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat). Toxicol Lett (2011) 0.83
Shorter peripheral blood telomeres are a potential biomarker for patients with advanced colorectal adenomas. Int J Biol Markers (2012) 0.83
Telomere length variation: A potential new telomere biomarker for lung cancer risk. Lung Cancer (2015) 0.82
A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer. Clin Cancer Res (2010) 0.82
Short telomere lengths in peripheral blood leukocytes are associated with an increased risk of oral premalignant lesion and oral squamous cell carcinoma. Cancer (2013) 0.82
Telomere length in peripheral blood lymphocytes contributes to the development of HPV-associated oropharyngeal carcinoma. Cancer Res (2013) 0.82
Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02
BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature (2005) 16.87
Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet (2004) 13.71
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med (2007) 12.24
Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell (2009) 11.65
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med (2007) 9.80
Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. Am J Hum Genet (2008) 7.36
Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet (2008) 7.07
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The Department of Veterans Affairs Laryngeal Cancer Study Group. N Engl J Med (1991) 6.39
Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A (2007) 5.95
Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat Genet (2004) 5.83
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet (2009) 5.62
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res (2004) 5.57
Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat Genet (2008) 5.43
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum (2005) 5.18
A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res (2008) 5.05
In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc (2015) 4.70
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet (2012) 4.46
A risk model for prediction of lung cancer. J Natl Cancer Inst (2007) 4.25
The PhenX Toolkit: get the most from your measures. Am J Epidemiol (2011) 4.19
PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. Am J Hum Genet (2005) 3.95
Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet (2010) 3.91
Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis. Am J Hum Genet (2004) 3.83
Characterization of BRCA1 and BRCA2 mutations in a large United States sample. J Clin Oncol (2006) 3.73
Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families. Arthritis Rheum (2003) 3.73
Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med (2009) 3.70
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. J Natl Cancer Inst (2008) 3.67
DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways. Nucleic Acids Res (2008) 3.66
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet (2009) 3.52
Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol (2010) 3.49
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res (2006) 3.45
Fingerprinting the circulating repertoire of antibodies from cancer patients. Nat Biotechnol (2002) 3.32
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. Nat Genet (2010) 3.24
Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J Natl Cancer Inst (2010) 3.18
Podoplanin: a novel marker for oral cancer risk in patients with oral premalignancy. J Clin Oncol (2008) 3.16
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nat Genet (2010) 3.15
Human telomerase and its regulation. Microbiol Mol Biol Rev (2002) 3.11
Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer. J Clin Oncol (2008) 3.09
Gene and pathway-based second-wave analysis of genome-wide association studies. Eur J Hum Genet (2010) 3.03
A 3'-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis. Lancet Oncol (2011) 2.95
Effects of nativity, age at migration, and acculturation on smoking among adult Houston residents of Mexican descent. Am J Public Health (2005) 2.94
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature (2010) 2.85
Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer Res (2007) 2.81
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet (2009) 2.76
Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell (2009) 2.76
Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development. Clin Cancer Res (2002) 2.71
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J (2005) 2.69
Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p. Cell Host Microbe (2008) 2.68
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Cancer Res (2009) 2.63
Randomized phase III trial of low-dose isotretinoin for prevention of second primary tumors in stage I and II head and neck cancer patients. J Natl Cancer Inst (2006) 2.61
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat Genet (2010) 2.61
Transforming epidemiology for 21st century medicine and public health. Cancer Epidemiol Biomarkers Prev (2013) 2.56
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res (2010) 2.54
Germline p53 mutations in a cohort with childhood sarcoma: sex differences in cancer risk. Am J Hum Genet (2003) 2.52
microRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysis. Cancer Res (2009) 2.51
Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis. Am J Hum Genet (2002) 2.47
Telomere-end processing the terminal nucleotides of human chromosomes. Mol Cell (2005) 2.39
Historical claims and current interpretations of replicative aging. Nat Biotechnol (2002) 2.38
Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. Cancer Res (2008) 2.37
DNA repair capacity in peripheral lymphocytes predicts survival of patients with non-small-cell lung cancer treated with first-line platinum-based chemotherapy. J Clin Oncol (2011) 2.34
Human diseases of telomerase dysfunction: insights into tissue aging. Nucleic Acids Res (2007) 2.34
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst (2003) 2.31
Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib. Cancer Res (2006) 2.31
A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis. Carcinogenesis (2008) 2.31
Genome-wide association study identifies three new melanoma susceptibility loci. Nat Genet (2011) 2.29
Birthplace, years of residence in the United States, and obesity among Mexican-American adults. Obesity (Silver Spring) (2007) 2.28
Bias in estimates of quantitative-trait-locus effect in genome scans: demonstration of the phenomenon and a method-of-moments procedure for reducing bias. Am J Hum Genet (2002) 2.25
Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: results of a phase I trial. J Clin Oncol (2002) 2.25
Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward. Clin Cancer Res (2006) 2.24
Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes. Am J Hum Genet (2006) 2.22
Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res (2007) 2.22
Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck. J Clin Oncol (2005) 2.18
EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients. Cancer Res (2005) 2.17
Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis. Arthritis Rheum (2013) 2.17
Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst (2008) 2.17
Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction. Am J Epidemiol (2012) 2.16
A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med (2006) 2.16
Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. J Natl Cancer Inst (2008) 2.15
Extension of variance components approach to incorporate temporal trends and longitudinal pedigree data analysis. Genet Epidemiol (2002) 2.14
Body mass index and risk of lung cancer among never, former, and current smokers. J Natl Cancer Inst (2012) 2.13
Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Clin Cancer Res (2008) 2.11
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis. J Natl Cancer Inst (2005) 2.09