Published in Proc Natl Acad Sci U S A on November 15, 1993
Chromosome methylation patterns during mammalian preimplantation development. Genes Dev (1998) 2.75
Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells. EMBO J (1997) 2.34
Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern. Proc Natl Acad Sci U S A (1997) 2.04
An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA. EMBO J (1998) 1.74
Regulation of X-chromosome inactivation in development in mice and humans. Microbiol Mol Biol Rev (1998) 1.72
DNA methylation is a reversible biological signal. Proc Natl Acad Sci U S A (1999) 1.69
Evidence that protein binding specifies sites of DNA demethylation. Mol Cell Biol (1999) 1.67
DNA demethylation. Proc Natl Acad Sci U S A (1999) 1.43
Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Res (2008) 1.22
5-Methylcytosine DNA glycosylase participates in the genome-wide loss of DNA methylation occurring during mouse myoblast differentiation. Nucleic Acids Res (2001) 1.14
Comparison of DNA methylation patterns among mouse cell lines by restriction landmark genomic scanning. Mol Cell Biol (1994) 1.09
DNA methylation program during development. Front Biol (Beijing) (2012) 1.07
Evidence for conserved DNA and histone H3 methylation reprogramming in mouse, bovine and rabbit zygotes. Epigenetics Chromatin (2008) 0.87
The battle of the sexes after fertilization: behaviour of paternal and maternal chromosomes in the early mammalian embryo. Chromosome Res (2001) 0.83
TRIM28 Controls Genomic Imprinting through Distinct Mechanisms during and after Early Genome-wide Reprogramming. Cell Rep (2015) 0.81
Localization of DNA methyltransferase-1 during oocyte differentiation, in vitro maturation and early embryonic development in cow. Eur J Histochem (2009) 0.77
Parental imprinting of the mouse insulin-like growth factor II gene. Cell (1991) 7.11
Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development (1987) 6.16
Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell (1993) 5.22
Parental imprinting of the mouse H19 gene. Nature (1991) 5.13
Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line. Genes Dev (1992) 4.02
The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Nature (1991) 3.48
Methylation levels of maternal and paternal genomes during preimplantation development. Development (1991) 2.46
The ontogeny of allele-specific methylation associated with imprinted genes in the mouse. EMBO J (1993) 2.32
Properties and localization of DNA methyltransferase in preimplantation mouse embryos: implications for genomic imprinting. Genes Dev (1992) 2.32
Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene. Genes Dev (1992) 2.19
Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine. Proc Natl Acad Sci U S A (1993) 1.69
Methylation changes in the apolipoprotein AI gene during embryonic development of the mouse. Proc Natl Acad Sci U S A (1991) 1.68
Tissue-specific methylation patterns and expression of the human apolipoprotein AI gene. J Biol Chem (1990) 1.10
Decrease in DNA methylase activity during preimplantation development in the mouse. Development (1991) 1.05
DNA methylation and gene function. Science (1980) 14.01
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A (1998) 9.32
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet (2000) 8.58
Sequence specificity of methylation in higher plant DNA. Nature (1981) 7.58
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science (1997) 7.57
Identification and characterization of an IkappaB kinase. Cell (1997) 6.71
Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat Biotechnol (2001) 6.30
Sp1 elements protect a CpG island from de novo methylation. Nature (1994) 5.60
IRAK: a kinase associated with the interleukin-1 receptor. Science (1996) 5.32
Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell (1993) 5.22
Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet (1999) 4.55
Effect of local medical opinion leaders on quality of care for acute myocardial infarction: a randomized controlled trial. JAMA (1998) 4.36
Efficient correction of a mutation by use of chemically synthesized DNA. Proc Natl Acad Sci U S A (1978) 4.13
Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line. Genes Dev (1992) 4.02
Direct detection of methylated cytosine in DNA by use of the restriction enzyme MspI. Nucleic Acids Res (1979) 3.99
Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nat Med (1995) 3.61
HLA and AIDS: a cautionary tale. Trends Mol Med (2001) 3.51
Substrate and sequence specificity of a eukaryotic DNA methylase. Nature (1982) 3.42
Methylation of CpG sequences in eukaryotic DNA. FEBS Lett (1981) 3.39
Structure of the DNA of bacteriophage phiX174. VII. Methylation. J Mol Biol (1970) 3.23
Pattern of methylation of two genes coding for housekeeping functions. Proc Natl Acad Sci U S A (1983) 3.03
Methylation of foreign DNA sequences in eukaryotic cells. Proc Natl Acad Sci U S A (1980) 3.01
In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells. Proc Natl Acad Sci U S A (1982) 2.92
Restriction enzyme digestion of hemimethylated DNA. Nucleic Acids Res (1981) 2.87
Cloning, characterization, and expression in Escherichia coli of the gene coding for the CpG DNA methylase from Spiroplasma sp. strain MQ1(M.SssI). Nucleic Acids Res (1990) 2.86
The process of infection with Bacteriophage phi-X174. XXIX. In vivo studies on the synthesis of the single-stranded DNA of progeny phi-X174 bacteriophage. J Mol Biol (1969) 2.59
Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins (2005) 2.59
The absence of detectable methylated bases in Drosophila melanogaster DNA. FEBS Lett (1982) 2.57
DNA methylation and its possible biological roles. Prog Nucleic Acid Res Mol Biol (1981) 2.55
Clonal inheritance of the pattern of DNA methylation in mouse cells. Proc Natl Acad Sci U S A (1982) 2.52
Long-term effectiveness of diet-plus-exercise interventions vs. diet-only interventions for weight loss: a meta-analysis. Obes Rev (2009) 2.49
IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem (1999) 2.43
Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development (2001) 2.37
DNA methylation patterns. Formation and function. Biochim Biophys Acta (1984) 2.36
Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci U S A (1993) 2.35
Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Invest (2000) 2.32
The ontogeny of allele-specific methylation associated with imprinted genes in the mouse. EMBO J (1993) 2.32
Delayed hospital presentation in patients who have had acute myocardial infarction. Ann Intern Med (1997) 2.30
PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats. J Control Release (2001) 2.15
DNA demethylation in vitro: involvement of RNA. Cell (1996) 2.07
Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease. J Intern Med (2014) 2.06
Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern. Proc Natl Acad Sci U S A (1997) 2.04
Studies on the biological role of dna methylation; IV. Mode of methylation of DNA in E. coli cells. Nucleic Acids Res (1980) 2.04
Hydroporation as the mechanism of hydrodynamic delivery. Gene Ther (2004) 1.97
Demethylation of CpG islands in embryonic cells. Nature (1991) 1.92
Distribution of 5-methylcytosine in chromatin. Proc Natl Acad Sci U S A (1977) 1.90
Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiation. Proc Natl Acad Sci U S A (1986) 1.79
Methylation of thymine residues during oligonucleotide synthesis. Nucleic Acids Res (1985) 1.74
Methylation changes in the apolipoprotein AI gene during embryonic development of the mouse. Proc Natl Acad Sci U S A (1991) 1.68
Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc Natl Acad Sci U S A (1997) 1.67
Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3). Diabetologia (2008) 1.66
Procaryotic and eucaryotic traits of DNA methylation in spiroplasmas (mycoplasmas). J Bacteriol (1985) 1.62
Limb remote-preconditioning protects against focal ischemia in rats and contradicts the dogma of therapeutic time windows for preconditioning. Neuroscience (2007) 1.61
Variations in DNA methylation during mouse cell differentiation in vivo and in vitro. Proc Natl Acad Sci U S A (1984) 1.59
DNA methylation and development. Biochim Biophys Acta (1990) 1.58
Sequential changes in DNA methylation patterns of the rat phosphoenolpyruvate carboxykinase gene during development. Proc Natl Acad Sci U S A (1985) 1.55
Methylated bases in mycoplasmal DNA. Nucleic Acids Res (1980) 1.51
Recurrent germline mutation in MSH2 arises frequently de novo. J Med Genet (2000) 1.49
Inhibition of promoter activity by methylation: possible involvement of protein mediators. Proc Natl Acad Sci U S A (1991) 1.47
The effect of comorbidity on use of thrombolysis or aspirin in patients with acute myocardial infarction eligible for treatment. J Gen Intern Med (1997) 1.46
Effects of alcohol ingestion on estrogens in postmenopausal women. JAMA (1996) 1.44
Computer algorithms for the automated measurement of retinal arteriolar diameters. Br J Ophthalmol (2001) 1.42
Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel. Am J Physiol Heart Circ Physiol (2001) 1.42
Structural impact of hydrodynamic injection on mouse liver. Gene Ther (2006) 1.41
DNA methylation in eukaryotic cells. Int Rev Cytol (1984) 1.40
The imprinting box of the Prader-Willi/Angelman syndrome domain. Nat Genet (2000) 1.37
Immunotherapy of malignancy by in vivo gene transfer into tumors. Proc Natl Acad Sci U S A (1993) 1.36
The imprinting box of the mouse Igf2r gene. Nature (1999) 1.36
Dynamic methylation adjustment and counting as part of imprinting mechanisms. Proc Natl Acad Sci U S A (1996) 1.35
Clinic-based evaluation of Clearview Chlamydia MF for detection of Chlamydia trachomatis in vaginal and cervical specimens from women at high risk in China. Sex Transm Infect (2006) 1.34
Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice. Physiol Genomics (2000) 1.34
Studies on the biological role of DNA methylation. II. Role of phiX174 DNA methylation in the process of viral progeny DNA synthesis. Nucleic Acids Res (1976) 1.33
Three-layer core/shell structure in Au-Pd bimetallic nanoparticles. Nano Lett (2007) 1.32
Studies on the biological role of DNA methylation: V. The pattern of E.coli DNA methylation. Nucleic Acids Res (1982) 1.29
Effect of in vitro DNA methylation on beta-globin gene expression. Proc Natl Acad Sci U S A (1988) 1.29
Immobilized Pseudomonas cepacia lipase for biodiesel fuel production from soybean oil. Bioresour Technol (2005) 1.29
Gene transfer in vivo with DNA-liposome complexes: safety and acute toxicity in mice. Hum Gene Ther (1992) 1.28
Sequence and substrate specificity of isolated DNA methylases from Escherichia coli C. J Bacteriol (1983) 1.28
NMR structural studies of intramolecular (Y+)n.(R+)n(Y-)nDNA triplexes in solution: imino and amino proton and nitrogen markers of G.TA base triple formation. Biochemistry (1991) 1.26
Histone H1-mediated inhibition of transcription initiation of methylated templates in vitro. J Biol Chem (1993) 1.25
Digital light-directed synthesis. A microarray platform that permits rapid reaction optimization on a combinatorial basis. J Comb Chem (2000) 1.25
Identification of two cis-acting elements that independently regulate the length of poly(A) on Xenopus albumin pre-mRNA. RNA (1998) 1.23
Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycle. Proc Natl Acad Sci U S A (1985) 1.23
Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling. J Biol Chem (2001) 1.23
Analysis of the complete genome of Tembusu virus, a flavivirus isolated from ducks in China. Transbound Emerg Dis (2011) 1.23
Regulation of the synthesis of 5-phosphoribosyl-I-pyrophosphate in intact red blood cells and in cell-free preparations. Biochim Biophys Acta (1969) 1.22
DNA CTG triplet repeats involved in dynamic mutations of neurologically related gene sequences form stable duplexes. Nucleic Acids Res (1995) 1.20
Studies on the biological role of DNA methylation: inhibition of methylation and maturation of the bacteriophage phichi174 by nicotinamide. Nucleic Acids Res (1975) 1.20
Nitrogen export from an agriculture watershed in the Taihu Lake area, China. Environ Geochem Health (2004) 1.19
RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation. J Biol Chem (2001) 1.18
Gene methylation patterns and expression. EXS (1993) 1.18
Consultation between cardiologists and generalists in the management of acute myocardial infarction: implications for quality of care. Arch Intern Med (1998) 1.17
Cell cycle-dependent regulation of eukaryotic DNA methylase level. J Biol Chem (1985) 1.17
Methylation of replicating and post-replicated mouse L-cell DNA. Proc Natl Acad Sci U S A (1983) 1.17
Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding. An NMR and UV spectroscopic study. J Mol Biol (1996) 1.17
Potassium-induced loop conformational transition of a potent anti-HIV oligonucleotide. J Biomol Struct Dyn (1997) 1.16
Pharmacodynamics of immediate and delayed effects of paclitaxel: role of slow apoptosis and intracellular drug retention. Cancer Res (1998) 1.15
Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization. Hum Gene Ther (1992) 1.15
Electro-acupuncture relieves chronic visceral hyperalgesia in rats. Neurosci Lett (2004) 1.15
RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans. J Biol Chem (1999) 1.14