Published in Cell Signal on December 01, 2003
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nat Struct Mol Biol (2004) 2.52
Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05
Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa. J Biol Chem (2010) 1.94
Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J (2005) 1.53
CRISPR interference: a structural perspective. Biochem J (2013) 1.48
The signaling helix: a common functional theme in diverse signaling proteins. Biol Direct (2006) 1.46
Crystal structure of the guanylyl cyclase Cya2. Proc Natl Acad Sci U S A (2008) 1.44
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. J Biol Chem (2005) 1.28
Adenylate cyclase regulates elongation of mammalian primary cilia. Exp Cell Res (2009) 1.27
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. BMC Struct Biol (2008) 1.26
Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c. EMBO J (2005) 1.23
Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin. EMBO J (2005) 1.22
cAMP-regulated protein lysine acetylases in mycobacteria. J Biol Chem (2010) 1.18
The Pseudomonas aeruginosa Chp chemosensory system regulates intracellular cAMP levels by modulating adenylate cyclase activity. Mol Microbiol (2010) 1.18
In vitro and in vivo characterization of the Pseudomonas aeruginosa cyclic AMP (cAMP) phosphodiesterase CpdA, required for cAMP homeostasis and virulence factor regulation. J Bacteriol (2010) 1.17
Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase. FEBS J (2011) 1.08
Involvement of a membrane-bound class III adenylate cyclase in regulation of anaerobic respiration in Shewanella oneidensis MR-1. J Bacteriol (2009) 1.08
The Pseudomonas aeruginosa Vfr regulator controls global virulence factor expression through cyclic AMP-dependent and -independent mechanisms. J Bacteriol (2010) 1.01
Cyclic AMP in mycobacteria: characterization and functional role of the Rv1647 ortholog in Mycobacterium smegmatis. J Bacteriol (2008) 0.99
Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem (2008) 0.97
Retracted Escherichia coli exports cyclic AMP via TolC. J Bacteriol (2010) 0.95
Characterization of phylogenetically distant members of the adenylate cyclase family from mycobacteria: Rv1647 from Mycobacterium tuberculosis and its orthologue ML1399 from M. leprae. Biochem J (2005) 0.94
The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions. J Mol Evol (2009) 0.94
Multiple lineage specific expansions within the guanylyl cyclase gene family. BMC Evol Biol (2006) 0.94
The role of cyclic nucleotides in axon guidance. Adv Exp Med Biol (2007) 0.93
From drought sensing to developmental control: evolution of cyclic AMP signaling in social amoebas. Mol Biol Evol (2008) 0.90
The linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase C. J Biol Chem (2009) 0.90
Transmembrane signaling in chimeras of the Escherichia coli aspartate and serine chemotaxis receptors and bacterial class III adenylyl cyclases. J Biol Chem (2009) 0.89
Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide. J Biol Chem (2008) 0.88
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa. J Mol Biol (2011) 0.88
Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling. Sensors (Basel) (2011) 0.87
Adenylyl cyclase activity of Cya1 from the cyanobacterium Synechocystis sp. strain PCC 6803 is inhibited by bicarbonate. J Bacteriol (2005) 0.86
The S-helix determines the signal in a Tsr receptor/adenylyl cyclase reporter. J Biol Chem (2012) 0.85
A walk into the LuxR regulators of Actinobacteria: phylogenomic distribution and functional diversity. PLoS One (2012) 0.84
Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp. Nat Commun (2015) 0.83
International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacol Rev (2017) 0.83
Functional dissection of adenylate cyclase R, an inducer of spore encapsulation. J Biol Chem (2010) 0.83
Crystallization of the class IV adenylyl cyclase from Yersinia pestis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.83
Identification of a haem domain in human soluble adenylate cyclase. Biosci Rep (2012) 0.83
A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice. Am J Respir Cell Mol Biol (2014) 0.81
Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites. PLoS One (2012) 0.80
Lineage-specific domain fusion in the evolution of purine nucleotide cyclases in cyanobacteria. J Mol Evol (2008) 0.79
Guanylyl cyclase sees the light. J Biol (2008) 0.79
Catalytic Mechanism of Mammalian Adenylyl Cyclase: A Computational Investigation. Biochemistry (2015) 0.76
Regulation by the quorum sensor from Vibrio indicates a receptor function for the membrane anchors of adenylate cyclases. Elife (2016) 0.75
The YHS-Domain of an Adenylyl Cyclase from Mycobacterium phlei Is a Probable Copper-Sensor Module. PLoS One (2015) 0.75
New structural forms of a mycobacterial adenylyl cyclase Rv1625c. IUCrJ (2014) 0.75
Receptor Guanylyl Cyclases in Sensory Processing. Front Endocrinol (Lausanne) (2017) 0.75
An adenylyl cyclase with a phosphodiesterase domain in basal plants with a motile sperm system. Sci Rep (2016) 0.75
The HAMP domain structure implies helix rotation in transmembrane signaling. Cell (2006) 4.34
Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons. Proc Natl Acad Sci U S A (2006) 2.02
A single, bi-functional aquaglyceroporin in blood-stage Plasmodium falciparum malaria parasites. J Biol Chem (2001) 1.83
The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme. Science (2005) 1.52
Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization. Proc Natl Acad Sci U S A (2005) 1.40
Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis. Proc Natl Acad Sci U S A (2004) 1.34
The mechanisms of HAMP-mediated signaling in transmembrane receptors. Structure (2011) 1.30
A GAF-domain-regulated adenylyl cyclase from Anabaena is a self-activating cAMP switch. EMBO J (2002) 1.28
The cytosolic domains of Ca2+-sensitive adenylyl cyclases dictate their targeting to plasma membrane lipid rafts. J Biol Chem (2004) 1.25
Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c. EMBO J (2005) 1.23
Ammonia permeability of the aquaglyceroporins from Plasmodium falciparum, Toxoplasma gondii and Trypansoma brucei. Mol Microbiol (2006) 1.13
Mechanism of regulation of receptor histidine kinases. Structure (2012) 1.13
Adenylyl cyclase Rv1264 from Mycobacterium tuberculosis has an autoinhibitory N-terminal domain. J Biol Chem (2002) 1.05
Aquaporin-mediated fluid regulation in the inner ear. Cell Mol Neurobiol (2003) 1.04
cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11. J Biol Chem (2005) 1.04
The effect of HAMP domains on class IIIb adenylyl cyclases from Mycobacterium tuberculosis. Eur J Biochem (2004) 0.99
A single aquaporin gene encodes a water/glycerol/urea facilitator in Toxoplasma gondii with similarity to plant tonoplast intrinsic proteins. FEBS Lett (2003) 0.98
Adenylyl cyclases from Plasmodium, Paramecium and Tetrahymena are novel ion channel/enzyme fusion proteins. Cell Signal (2004) 0.97
Retracted Escherichia coli exports cyclic AMP via TolC. J Bacteriol (2010) 0.95
Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv. FEBS J (2006) 0.94
HAMP domain-mediated signal transduction probed with a mycobacterial adenylyl cyclase as a reporter. J Biol Chem (2011) 0.92
Versatility of signal transduction encoded in dimeric adenylyl cyclases. Curr Opin Struct Biol (2008) 0.90
The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites. Proc Natl Acad Sci U S A (2005) 0.90
Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264. Int J Med Microbiol (2006) 0.89
Transmembrane signaling in chimeras of the Escherichia coli aspartate and serine chemotaxis receptors and bacterial class III adenylyl cyclases. J Biol Chem (2009) 0.89
Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection. FEBS J (2005) 0.87
Dihydroxyacetone and methylglyoxal as permeants of the Plasmodium aquaglyceroporin inhibit parasite proliferation. Biochim Biophys Acta (2006) 0.87
Characterization of the tandem GAF domain of human phosphodiesterase 5 using a cyanobacterial adenylyl cyclase as a reporter enzyme. J Biol Chem (2006) 0.85
The S-helix determines the signal in a Tsr receptor/adenylyl cyclase reporter. J Biol Chem (2012) 0.85
Transmembrane receptor chimeras to probe HAMP domain function. Methods Enzymol (2010) 0.84
Guanylyl cyclases in unicellular organisms. Mol Cell Biochem (2002) 0.83
The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid. J Mol Biol (2007) 0.81
The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain. FEBS J (2008) 0.80
Changes in purine specificity in tandem GAF chimeras from cyanobacterial cyaB1 adenylate cyclase and rat phosphodiesterase 2. FEBS J (2007) 0.79
Polyphosphates from Mycobacterium bovis--potent inhibitors of class III adenylate cyclases. FEBS J (2009) 0.78
Interaction of Rv1625c, a mycobacterial class IIIa adenylyl cyclase, with a mammalian congener. Mol Microbiol (2005) 0.77
Functional chimeras of the phosphodiesterase 5 and 10 tandem GAF domains. J Biol Chem (2008) 0.77
Functional chimeras between the catalytic domains of the mycobacterial adenylyl cyclase Rv1625c and a Paramecium guanylyl cyclase. FEBS Lett (2004) 0.77
The regulatory tandem domains of human phosphodiesterases 1 and 4 regulate a cyanobacterial adenylyl cyclase. Cell Signal (2012) 0.77
Intramolecular signaling in tandem-GAF domains from PDE5 and PDE10 studied with a cyanobacterial adenylyl cyclase reporter. Cell Signal (2011) 0.76
Biochemical characterization of the tandem HAMP domain from Natronomonas pharaonis as an intraprotein signal transducer. FEBS J (2014) 0.75