Published in EMBO J on July 15, 2002
Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre. Mol Microbiol (2013) 1.67
PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. EMBO J (2003) 1.56
Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization. Proc Natl Acad Sci U S A (2005) 1.40
Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling. J Cell Biol (2003) 1.34
Free methionine-(R)-sulfoxide reductase from Escherichia coli reveals a new GAF domain function. Proc Natl Acad Sci U S A (2007) 1.31
The NifL-NifA System: a multidomain transcriptional regulatory complex that integrates environmental signals. J Bacteriol (2004) 1.31
A two-component regulator of universal stress protein expression and adaptation to oxygen starvation in Mycobacterium smegmatis. J Bacteriol (2003) 1.24
The Pseudomonas aeruginosa Chp chemosensory system regulates intracellular cAMP levels by modulating adenylate cyclase activity. Mol Microbiol (2010) 1.18
Regulation of prokaryotic adenylyl cyclases by CO2. Biochem J (2006) 1.16
Cyclic nucleotide binding proteins in the Arabidopsis thaliana and Oryza sativa genomes. BMC Bioinformatics (2005) 1.10
Genomic structure of an economically important cyanobacterium, Arthrospira (Spirulina) platensis NIES-39. DNA Res (2010) 1.08
Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase. Proc Natl Acad Sci U S A (2014) 1.03
The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions. J Mol Evol (2009) 0.94
Engineering adenylate cyclases regulated by near-infrared window light. Proc Natl Acad Sci U S A (2014) 0.92
The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites. Proc Natl Acad Sci U S A (2005) 0.90
Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi. Biochem J (2004) 0.90
Bicarbonate disruption of the pulmonary endothelial barrier via activation of endogenous soluble adenylyl cyclase, isoform 10. Am J Physiol Lung Cell Mol Physiol (2013) 0.78
Identification of bacterial guanylate cyclases. Proteins (2015) 0.78
Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi. Biochem J (2006) 0.77
Cyclic nucleotide binding and structural changes in the isolated GAF domain of Anabaena adenylyl cyclase, CyaB2. PeerJ (2015) 0.76
The YHS-Domain of an Adenylyl Cyclase from Mycobacterium phlei Is a Probable Copper-Sensor Module. PLoS One (2015) 0.75
SMART, a simple modular architecture research tool: identification of signaling domains. Proc Natl Acad Sci U S A (1998) 36.83
A highly sensitive adenylate cyclase assay. Anal Biochem (1974) 20.13
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science (1997) 4.52
The GAF domain: an evolutionary link between diverse phototransducing proteins. Trends Biochem Sci (1997) 4.10
Structure of the adenylyl cyclase catalytic core. Nature (1997) 2.81
Complexity and diversity of mammalian adenylyl cyclases. Annu Rev Pharmacol Toxicol (1996) 2.70
Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. J Mol Biol (2001) 2.68
Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor. EMBO J (2000) 2.64
Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Curr Opin Cell Biol (2000) 2.62
Two-metal-Ion catalysis in adenylyl cyclase. Science (1999) 2.31
Functional classification of cNMP-binding proteins and nucleotide cyclases with implications for novel regulatory pathways in Mycobacterium tuberculosis. Genome Res (2000) 1.79
Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases. J Biol Chem (1998) 1.66
Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin. Science (1995) 1.60
Truncation and alanine-scanning mutants of type I adenylyl cyclase. Biochemistry (1995) 1.48
Structure, mechanism, and regulation of mammalian adenylyl cyclase. J Biol Chem (1999) 1.36
The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone. J Biol Chem (1993) 1.35
Isolation and characterization of multiple adenylate cyclase genes from the cyanobacterium Anabaena sp. strain PCC 7120. J Bacteriol (1997) 1.32
Catalytic mechanism and regulation of mammalian adenylyl cyclases. Mol Pharmacol (1998) 1.30
Identification of key amino acids in a conserved cGMP-binding site of cGMP-binding phosphodiesterases. A putative NKXnD motif for cGMP binding. J Biol Chem (1996) 1.26
Adenylyl cyclases: structure, regulation and function in an enzyme superfamily. Mol Cell Endocrinol (1997) 1.21
Probing domain functions of chimeric PDE6alpha'/PDE5 cGMP-phosphodiesterase. J Biol Chem (1998) 1.20
Adenylyl cyclase Rv1625c of Mycobacterium tuberculosis: a progenitor of mammalian adenylyl cyclases. EMBO J (2001) 1.19
Two cytoplasmic domains of mammalian adenylyl cyclase form a Gs alpha- and forskolin-activated enzyme in vitro. J Biol Chem (1996) 1.13
Effector-mediated stimulation of ATPase activity by the sigma 54-dependent transcriptional activator FHLA from Escherichia coli. J Bacteriol (1995) 1.11
The conserved asparagine and arginine are essential for catalysis of mammalian adenylyl cyclase. J Biol Chem (1997) 1.11
An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase. J Biol Chem (1995) 1.08
The Spirulina platensis adenylate cyclase gene, cyaC, encodes a novel signal transduction protein. Plant Cell Physiol (1997) 1.04
Bacterial adenylyl cyclases. Prog Nucleic Acid Res Mol Biol (1993) 1.03
Bifunctional structure of two adenylyl cyclases from the myxobacterium Stigmatella aurantiaca. Biochimie (1997) 1.00
Adenylyl cyclases: a heterogeneous class of ATP-utilizing enzymes. Prog Nucleic Acid Res Mol Biol (1994) 1.00
A dual mechanism for regulating cAMP levels in Escherichia coli. J Biol Chem (1995) 0.99
Molecular cloning of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase cDNA. Identification and distribution of isozyme variants. J Biol Chem (1991) 0.97
Mammalian adenylyl cyclases. Adv Second Messenger Phosphoprotein Res (1998) 0.92
CyaG, a novel cyanobacterial adenylyl cyclase and a possible ancestor of mammalian guanylyl cyclases. J Biol Chem (2000) 0.91
Activation of a cyanobacterial adenylate cyclase, CyaC, by autophosphorylation and a subsequent phosphotransfer reaction. J Biol Chem (1999) 0.89
Studies of the molecular mechanism of discrimination between cGMP and cAMP in the allosteric sites of the cGMP-binding cGMP-specific phosphodiesterase (PDE5). J Biol Chem (1999) 0.85
A guanylyl cyclase from Paramecium with 22 transmembrane spans. Expression of the catalytic domains and formation of chimeras with the catalytic domains of mammalian adenylyl cyclases. J Biol Chem (2000) 0.84
The HAMP domain structure implies helix rotation in transmembrane signaling. Cell (2006) 4.34
Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons. Proc Natl Acad Sci U S A (2006) 2.02
A single, bi-functional aquaglyceroporin in blood-stage Plasmodium falciparum malaria parasites. J Biol Chem (2001) 1.83
The class III adenylyl cyclases: multi-purpose signalling modules. Cell Signal (2003) 1.75
The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme. Science (2005) 1.52
Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization. Proc Natl Acad Sci U S A (2005) 1.40
Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis. Proc Natl Acad Sci U S A (2004) 1.34
The mechanisms of HAMP-mediated signaling in transmembrane receptors. Structure (2011) 1.30
The cytosolic domains of Ca2+-sensitive adenylyl cyclases dictate their targeting to plasma membrane lipid rafts. J Biol Chem (2004) 1.25
Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c. EMBO J (2005) 1.23
Ammonia permeability of the aquaglyceroporins from Plasmodium falciparum, Toxoplasma gondii and Trypansoma brucei. Mol Microbiol (2006) 1.13
Mechanism of regulation of receptor histidine kinases. Structure (2012) 1.13
Adenylyl cyclase Rv1264 from Mycobacterium tuberculosis has an autoinhibitory N-terminal domain. J Biol Chem (2002) 1.05
Aquaporin-mediated fluid regulation in the inner ear. Cell Mol Neurobiol (2003) 1.04
cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11. J Biol Chem (2005) 1.04
The effect of HAMP domains on class IIIb adenylyl cyclases from Mycobacterium tuberculosis. Eur J Biochem (2004) 0.99
A single aquaporin gene encodes a water/glycerol/urea facilitator in Toxoplasma gondii with similarity to plant tonoplast intrinsic proteins. FEBS Lett (2003) 0.98
Adenylyl cyclases from Plasmodium, Paramecium and Tetrahymena are novel ion channel/enzyme fusion proteins. Cell Signal (2004) 0.97
Retracted Escherichia coli exports cyclic AMP via TolC. J Bacteriol (2010) 0.95
Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv. FEBS J (2006) 0.94
HAMP domain-mediated signal transduction probed with a mycobacterial adenylyl cyclase as a reporter. J Biol Chem (2011) 0.92
Versatility of signal transduction encoded in dimeric adenylyl cyclases. Curr Opin Struct Biol (2008) 0.90
The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites. Proc Natl Acad Sci U S A (2005) 0.90
Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264. Int J Med Microbiol (2006) 0.89
Transmembrane signaling in chimeras of the Escherichia coli aspartate and serine chemotaxis receptors and bacterial class III adenylyl cyclases. J Biol Chem (2009) 0.89
Dihydroxyacetone and methylglyoxal as permeants of the Plasmodium aquaglyceroporin inhibit parasite proliferation. Biochim Biophys Acta (2006) 0.87
Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection. FEBS J (2005) 0.87
Characterization of the tandem GAF domain of human phosphodiesterase 5 using a cyanobacterial adenylyl cyclase as a reporter enzyme. J Biol Chem (2006) 0.85
The S-helix determines the signal in a Tsr receptor/adenylyl cyclase reporter. J Biol Chem (2012) 0.85
Transmembrane receptor chimeras to probe HAMP domain function. Methods Enzymol (2010) 0.84
Guanylyl cyclases in unicellular organisms. Mol Cell Biochem (2002) 0.83
The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid. J Mol Biol (2007) 0.81
The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain. FEBS J (2008) 0.80
Changes in purine specificity in tandem GAF chimeras from cyanobacterial cyaB1 adenylate cyclase and rat phosphodiesterase 2. FEBS J (2007) 0.79
Polyphosphates from Mycobacterium bovis--potent inhibitors of class III adenylate cyclases. FEBS J (2009) 0.78
Functional chimeras between the catalytic domains of the mycobacterial adenylyl cyclase Rv1625c and a Paramecium guanylyl cyclase. FEBS Lett (2004) 0.77
Functional chimeras of the phosphodiesterase 5 and 10 tandem GAF domains. J Biol Chem (2008) 0.77
Interaction of Rv1625c, a mycobacterial class IIIa adenylyl cyclase, with a mammalian congener. Mol Microbiol (2005) 0.77
The regulatory tandem domains of human phosphodiesterases 1 and 4 regulate a cyanobacterial adenylyl cyclase. Cell Signal (2012) 0.77
Intramolecular signaling in tandem-GAF domains from PDE5 and PDE10 studied with a cyanobacterial adenylyl cyclase reporter. Cell Signal (2011) 0.76
Biochemical characterization of the tandem HAMP domain from Natronomonas pharaonis as an intraprotein signal transducer. FEBS J (2014) 0.75