Published in Diabetes on November 01, 2003
Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence? Diabetologia (2010) 2.21
Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States. Ann N Y Acad Sci (2013) 2.15
β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition. Am J Pathol (2011) 1.59
Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons. Proc Natl Acad Sci U S A (2009) 1.45
Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets. Diabetologia (2008) 1.22
Attenuation of endocrine-exocrine pancreatic communication in type 2 diabetes: pancreatic extracellular matrix ultrastructural abnormalities. J Cardiometab Syndr (2008) 1.06
Diabetes and its comorbidities--where East meets West. Nat Rev Endocrinol (2013) 0.99
Clustering and internalization of toxic amylin oligomers in pancreatic cells require plasma membrane cholesterol. J Biol Chem (2011) 0.97
Pericytopathy: oxidative stress and impaired cellular longevity in the pancreas and skeletal muscle in metabolic syndrome and type 2 diabetes. Oxid Med Cell Longev (2010) 0.97
Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in the HIP rat model of diabetes. Exp Biol Med (Maywood) (2008) 0.96
MCP-1 upregulates amylin expression in murine pancreatic β cells through ERK/JNK-AP1 and NF-κB related signaling pathways independent of CCR2. PLoS One (2011) 0.96
Possible Mechanisms of Local Tissue Renin-Angiotensin System Activation in the Cardiorenal Metabolic Syndrome and Type 2 Diabetes Mellitus. Cardiorenal Med (2011) 0.87
Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice. Diabetes (2009) 0.87
Treating hypertension while protecting the vulnerable islet in the cardiometabolic syndrome. J Am Soc Hypertens (2008) 0.85
Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance. Diabetes (2008) 0.83
Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients. Amyloid (2014) 0.82
Degradation of islet amyloid polypeptide by neprilysin. Diabetologia (2012) 0.81
Distinct internalization pathways of human amylin monomers and its cytotoxic oligomers in pancreatic cells. PLoS One (2013) 0.79
Insulin concerns and promises. Diabetes Care (2011) 0.78
Heterogeneity in distribution of amyloid-positive islets in type-2 diabetic patients. Virchows Arch (2005) 0.77
Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations. PLoS One (2013) 0.76
Neuroendocrine hormone amylin in diabetes. World J Diabetes (2016) 0.75
Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implications. J Diabetes Investig (2015) 0.75
Islet inflammation in type 2 diabetes and physiology. J Clin Invest (2017) 0.75
Selenium-enriched Spirulina protects INS-1E pancreatic beta cells from human islet amyloid polypeptide-induced apoptosis through suppression of ROS-mediated mitochondrial dysfunction and PI3/AKT pathway. Eur J Nutr (2014) 0.75
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet (2008) 9.39
Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature (2007) 8.03
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet (2011) 4.50
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. Nat Genet (2009) 4.11
Associations of hyperglycemia and insulin usage with the risk of cancer in type 2 diabetes: the Hong Kong diabetes registry. Diabetes (2010) 3.77
Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes (2008) 3.45
Effectiveness of telephone counselling by a pharmacist in reducing mortality in patients receiving polypharmacy: randomised controlled trial. BMJ (2006) 3.02
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet (2010) 2.81
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. Nat Genet (2010) 2.75
Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis. Clin Rheumatol (2007) 2.18
Abnormal liver function test predicts type 2 diabetes: a community-based prospective study. Diabetes Care (2007) 2.18
Fat redistribution and adipocyte transformation in uninephrectomized rats. Kidney Int (2008) 2.18
Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States. Ann N Y Acad Sci (2013) 2.15
Phenotypic heterogeneity and associations of two aldose reductase gene polymorphisms with nephropathy and retinopathy in type 2 diabetes. Diabetes Care (2003) 1.78
Development and validation of an all-cause mortality risk score in type 2 diabetes. Arch Intern Med (2008) 1.69
Glomerular filtration rate, cardiorenal end points, and all-cause mortality in type 2 diabetic patients. Diabetes Care (2006) 1.68
Sulodexide fails to demonstrate renoprotection in overt type 2 diabetic nephropathy. J Am Soc Nephrol (2011) 1.66
Cigarette smoking is an independent risk factor for type 2 diabetes: a four-year community-based prospective study. Clin Endocrinol (Oxf) (2009) 1.61
Patients with systemic lupus erythematosus show increased platelet activation and endothelial dysfunction induced by acute hyperhomocysteinemia. J Rheumatol (2003) 1.58
Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Br J Nutr (2004) 1.58
Personalized management of hyperglycemia in type 2 diabetes: reflections from a Diabetes Care Editors' Expert Forum. Diabetes Care (2013) 1.56
OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine. Pharmacogenet Genomics (2008) 1.50
Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese. J Clin Endocrinol Metab (2007) 1.47
Renin angiotensin aldosterone system blockade and renal disease in patients with type 2 diabetes: a subanalysis of Japanese patients from the RENAAL study. Clin Exp Nephrol (2006) 1.46
Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. PLoS One (2011) 1.46
Independent associations between low-density lipoprotein cholesterol and cancer among patients with type 2 diabetes mellitus. CMAJ (2008) 1.45
The beneficial effects of Tai Chi Chuan on blood pressure and lipid profile and anxiety status in a randomized controlled trial. J Altern Complement Med (2003) 1.43
Surgeon training and use of radioactive iodine in stage I thyroid cancer patients. Ann Surg Oncol (2012) 1.43
Effects of dual blockade of the renin-angiotensin system on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy and hypertension in the ORIENT: a post-hoc analysis (ORIENT-Hypertension). Hypertens Res (2013) 1.42
Drug-induced endocrine and metabolic disorders. Drug Saf (2007) 1.42
Cardiac troponin T mutations in Chinese patients with hypertrophic cardiomyopathy. Chin Med J (Engl) (2004) 1.39
Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. J Hum Genet (2009) 1.38
Association of the D8S282 marker near the lipoprotein lipase gene locus with systolic blood pressure in healthy Chinese subjects. J Hypertens (2002) 1.38
Topography of the northern hemisphere of Mercury from MESSENGER laser altimetry. Science (2012) 1.38
Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. Clin Cancer Res (2002) 1.36
Development and validation of stroke risk equation for Hong Kong Chinese patients with type 2 diabetes: the Hong Kong Diabetes Registry. Diabetes Care (2007) 1.34
Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab (2010) 1.34
Development and validation of a total coronary heart disease risk score in type 2 diabetes mellitus. Am J Cardiol (2007) 1.32
Metabolic syndrome predicts new onset of chronic kidney disease in 5,829 patients with type 2 diabetes: a 5-year prospective analysis of the Hong Kong Diabetes Registry. Diabetes Care (2008) 1.32
European bone mineral density loci are also associated with BMD in East-Asian populations. PLoS One (2010) 1.29
Genome-wide association study identifies three novel loci for type 2 diabetes. Hum Mol Genet (2013) 1.28
Frequent hypermethylation of promoter region of RASSF1A in tumor tissues and voided urine of urinary bladder cancer patients. Int J Cancer (2003) 1.24
Low HDL cholesterol, metformin use, and cancer risk in type 2 diabetes: the Hong Kong Diabetes Registry. Diabetes Care (2010) 1.23
Hepatic angiomyolipoma-misdiagnosis as hepatocellular carcinoma: A report of 14 cases. World J Gastroenterol (2000) 1.21
Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression. Diabetes (2012) 1.20
Risk factors in V-shaped risk associations with all-cause mortality in type 2 diabetes-The Hong Kong Diabetes Registry. Diabetes Metab Res Rev (2008) 1.20
Effects of structured care by a pharmacist-diabetes specialist team in patients with type 2 diabetic nephropathy. Am J Med (2005) 1.20
Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. Diabetes (2004) 1.19
Total antioxidant and ascorbic acid content of fresh fruits and vegetables: implications for dietary planning and food preservation. Br J Nutr (2002) 1.19
The role of clinicians in determining radioactive iodine use for low-risk thyroid cancer. Cancer (2012) 1.17
The effects of nasal continuous positive airway pressure on platelet activation in obstructive sleep apnea syndrome. Chest (2004) 1.17
Effects of protocol-driven care versus usual outpatient clinic care on survival rates in patients with type 2 diabetes. Am J Manag Care (2003) 1.16
Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents. Diabetes (2008) 1.16
100 or 30 years after Janeway or Bartter, Healthwatch helps avoid 'flying blind'. Biomed Pharmacother (2004) 1.15
Variation in the management of thyroid cancer. J Clin Endocrinol Metab (2013) 1.15
Low LDL cholesterol, albuminuria, and statins for the risk of cancer in type 2 diabetes: the Hong Kong diabetes registry. Diabetes Care (2009) 1.13
Risk association of HbA1c variability with chronic kidney disease and cardiovascular disease in type 2 diabetes: prospective analysis of the Hong Kong Diabetes Registry. Diabetes Metab Res Rev (2013) 1.13
Protective effects of trilinolein extracted from panax notoginseng against cardiovascular disease. Acta Pharmacol Sin (2002) 1.13
Leuprolide acetate 1-month depot for central precocious puberty: hormonal suppression and recovery. Int J Pediatr Endocrinol (2011) 1.13
Spectrums of opportunistic infections and malignancies in HIV-infected patients in tertiary care hospital, China. PLoS One (2013) 1.12
Measuring depressive symptoms using the Patient Health Questionnaire-9 in Hong Kong Chinese subjects with type 2 diabetes. J Affect Disord (2013) 1.11
Association between adherence to statin therapy and lipid control in Hong Kong Chinese patients at high risk of coronary heart disease. Br J Clin Pharmacol (2004) 1.10
Protein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cells. Mol Biol Cell (2006) 1.10
Predicting values of lipids and white blood cell count for all-site cancer in type 2 diabetes. Endocr Relat Cancer (2008) 1.10
The effect of orlistat-induced weight loss, without concomitant hypocaloric diet, on cardiovascular risk factors and insulin sensitivity in young obese Chinese subjects with or without type 2 diabetes. Arch Intern Med (2002) 1.10
Subclinical carotid atherosclerosis in patients with psoriatic arthritis. Arthritis Rheum (2008) 1.09
Innate and adaptive cellular immunity in flavivirus-naïve human recipients of a live-attenuated dengue serotype 3 vaccine produced in Vero cells (VDV3). Vaccine (2006) 1.08
Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetes. Diabetes (2007) 1.08
Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues. J Clin Endocrinol Metab (2004) 1.07
Lipid control and use of lipid-regulating drugs for prevention of cardiovascular events in Chinese type 2 diabetic patients: a prospective cohort study. Cardiovasc Diabetol (2010) 1.07
Co-occurrence of diabetes and depression: conceptual considerations for an emerging global health challenge. J Affect Disord (2012) 1.07
Genome-wide scan for type 2 diabetes loci in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. Diabetes (2004) 1.07
BMI and waist circumference in predicting cardiovascular risk factor clustering in Chinese adolescents. Obesity (Silver Spring) (2007) 1.06