Published in Nat Genet on April 26, 2007
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
A HapMap harvest of insights into the genetics of common disease. J Clin Invest (2008) 18.31
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genetic mapping in human disease. Science (2008) 15.12
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet (2008) 12.43
Human genetic variation and its contribution to complex traits. Nat Rev Genet (2009) 12.11
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes (2009) 8.70
Genome-wide association studies: potential next steps on a genetic journey. Hum Mol Genet (2008) 7.54
Heterogeneity in meta-analyses of genome-wide association investigations. PLoS One (2007) 5.77
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet (2009) 5.43
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest (2007) 5.02
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet (2007) 5.02
Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev (2007) 4.91
Recent and ongoing selection in the human genome. Nat Rev Genet (2007) 4.62
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes (2008) 4.57
Association between a literature-based genetic risk score and cardiovascular events in women. JAMA (2010) 4.46
Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study. J Am Med Inform Assoc (2011) 4.20
New common variants affecting susceptibility to basal cell carcinoma. Nat Genet (2009) 4.15
Genomewide association for schizophrenia in the CATIE study: results of stage 1. Mol Psychiatry (2008) 4.14
Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. Ann Intern Med (2009) 3.68
Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet (2010) 3.63
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51
Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia (2010) 3.48
A genomic background based method for association analysis in related individuals. PLoS One (2007) 3.46
Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes (2008) 3.45
Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes (2009) 3.45
Power to detect risk alleles using genome-wide tag SNP panels. PLoS Genet (2007) 3.29
Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups. PLoS Genet (2010) 3.27
A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet (2010) 3.25
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet (2010) 3.24
The genetics of type 2 diabetes: what have we learned from GWAS? Ann N Y Acad Sci (2010) 3.09
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes (2009) 2.92
Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes (2009) 2.85
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet (2010) 2.81
The emerging genetic architecture of type 2 diabetes. Cell Metab (2008) 2.77
Human genetics illuminates the paths to metabolic disease. Nature (2009) 2.74
Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet (2012) 2.70
Genome-wide association studies in type 2 diabetes. Curr Diab Rep (2009) 2.60
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes (2009) 2.54
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes (2008) 2.46
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44
Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study. Diabetologia (2011) 2.43
Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes (2008) 2.41
What can genome-wide association studies tell us about the genetics of common disease? PLoS Genet (2008) 2.35
Copy number variants and common disorders: filling the gaps and exploring complexity in genome-wide association studies. PLoS Genet (2007) 2.32
Methodological challenges of genome-wide association analysis in Africa. Nat Rev Genet (2010) 2.27
Psoriasis and metabolic disease: epidemiology and pathophysiology. Curr Opin Rheumatol (2008) 2.25
Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations. Diabetologia (2007) 2.23
Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. Diabetes (2010) 2.16
Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS One (2007) 2.16
Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. Mol Psychiatry (2009) 2.09
Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene. Am J Hum Genet (2008) 2.09
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2009) 2.03
Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Diabetes (2008) 2.01
Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. PLoS One (2008) 1.94
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proc Natl Acad Sci U S A (2009) 1.93
No association of multiple type 2 diabetes loci with type 1 diabetes. Diabetologia (2009) 1.92
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nat Genet (2012) 1.90
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet (2012) 1.90
Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes. Hum Mol Genet (2010) 1.89
Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Diabetes (2009) 1.87
Isolated populations and complex disease gene identification. Genome Biol (2008) 1.83
Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region. Hum Genet (2008) 1.81
Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest (2011) 1.80
Singapore Genome Variation Project: a haplotype map of three Southeast Asian populations. Genome Res (2009) 1.73
Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion. Mol Endocrinol (2009) 1.72
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program. Diabetes (2008) 1.71
The complex genetics of multiple sclerosis: pitfalls and prospects. Brain (2008) 1.68
The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies. BMC Med Genet (2008) 1.68
Considerations for designing a prototype genetic test for use in translational research. Public Health Genomics (2009) 1.67
Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants. Hum Mol Genet (2008) 1.65
Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle. J Clin Invest (2007) 1.65
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes (2008) 1.64
Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008. J Clin Endocrinol Metab (2008) 1.61
Type 2 diabetes risk alleles are associated with reduced size at birth. Diabetes (2009) 1.58
Genetic testing and common disorders in a public health framework: how to assess relevance and possibilities. Background Document to the ESHG recommendations on genetic testing and common disorders. Eur J Hum Genet (2011) 1.57
Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases. PLoS Genet (2010) 1.57
Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. BMC Med Genet (2010) 1.54
Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants. Genet Epidemiol (2013) 1.52
Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study. PLoS One (2008) 1.51
Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes (2008) 1.48
Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. J Biol Chem (2010) 1.47
Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. PLoS One (2010) 1.46
The epidemiology of diabetes in Korea: from the economics to genetics. Korean Diabetes J (2010) 1.45
Genome-wide association studies: progress and potential for drug discovery and development. Nat Rev Drug Discov (2008) 1.45
Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics. Mol Psychiatry (2009) 1.44
Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies. PLoS One (2010) 1.43
Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men. Am J Clin Nutr (2009) 1.43
A genome-wide association study of the metabolic syndrome in Indian Asian men. PLoS One (2010) 1.42
A genome-wide association study of gestational diabetes mellitus in Korean women. Diabetes (2012) 1.41
Technical reproducibility of genotyping SNP arrays used in genome-wide association studies. PLoS One (2012) 1.36
Inferring genetic ancestry: opportunities, challenges, and implications. Am J Hum Genet (2010) 1.36
Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain. Neurobiol Dis (2012) 1.35
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China. Diabetologia (2009) 1.34
Finding the missing heritability of complex diseases. Nature (2009) 67.95
The structure of haplotype blocks in the human genome. Science (2002) 50.88
A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
A high-resolution recombination map of the human genome. Nat Genet (2002) 28.66
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Enterotypes of the human gut microbiome. Nature (2011) 24.36
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Genetics of gene expression and its effect on disease. Nature (2008) 21.35
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med (2003) 20.06
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71
Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med (2004) 19.42
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet (2007) 19.18
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med (2008) 18.27
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96