Published in J Biol Chem on October 28, 2003
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The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages. PLoS One (2010) 3.30
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J Biol Chem (2004) 2.91
A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med (2014) 2.51
Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses. J Immunol (2002) 2.24
Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span. J Immunol (2003) 2.18
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TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation. J Leukoc Biol (2011) 1.98
Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection. J Immunol (2003) 1.88
The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms. Oncogene (2002) 1.67
Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: a potential mechanism of persistent infection. J Immunol (2002) 1.64
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Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest (2011) 1.44
Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. J Clin Invest (2005) 1.42
WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung. Respir Res (2006) 1.39
Acceleration of human neutrophil apoptosis by TRAIL. J Immunol (2003) 1.38
Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia. Am J Respir Crit Care Med (2008) 1.33
Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection. FASEB J (2004) 1.33
The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis. Clin Infect Dis (2005) 1.30
Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses. FASEB J (2006) 1.30
Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia. J Immunol (2006) 1.27
The expression and roles of Toll-like receptors in the biology of the human neutrophil. J Leukoc Biol (2005) 1.26
Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury. J Immunol (2002) 1.25
Interleukin 18 receptor 1 gene polymorphisms are associated with asthma. Eur J Hum Genet (2008) 1.23
Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor. Thromb Haemost (2005) 1.23
Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo. J Immunol (2005) 1.20
SPLUNC1 (PLUNC) is expressed in glandular tissues of the respiratory tract and in lung tumours with a glandular phenotype. J Pathol (2005) 1.18
Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways. J Biol Chem (2007) 1.17
Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes. Am J Respir Crit Care Med (2005) 1.16
Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line. Mol Cancer (2010) 1.15
Differential epithelial expression of the putative innate immune molecule SPLUNC1 in cystic fibrosis. Respir Res (2007) 1.13
Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells. J Immunol (2004) 1.12
Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor. J Immunol (2007) 1.12
Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages. Infect Immun (2011) 1.11
Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains. Infect Immun (2003) 1.09
Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation. PLoS One (2011) 1.08
Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation. J Immunol (2004) 1.08
Identifying and hurdling obstacles to translational research. Nat Rev Immunol (2007) 1.07
Hunting for genes by functional screens. Cytokine Growth Factor Rev (2004) 1.06
Interleukin-1 receptor antagonist alters the response to vessel wall injury in a porcine coronary artery model. Cardiovasc Res (2005) 1.05
Granulocyte apoptosis in the pathogenesis and resolution of lung disease. Clin Sci (Lond) (2006) 1.03
Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa. Am J Respir Crit Care Med (2007) 1.03
A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci. PLoS Pathog (2011) 1.02
Modeling inflammation in the zebrafish: how a fish can help us understand lung disease. Exp Lung Res (2007) 1.02
Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin. J Immunol (2008) 1.01
Functional mapping and identification of novel regulators for the Toll/Interleukin-1 signalling network by transcription expression cloning. Cell Signal (2005) 1.01
Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease. J Immunol (2010) 1.01
Zebrafish as a model for the study of neutrophil biology. J Leukoc Biol (2013) 1.01
Distribution of human PLUNC/BPI fold-containing (BPIF) proteins. Biochem Soc Trans (2011) 1.00
The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival. Am J Pathol (2004) 0.99
Tribbles-2 is a novel regulator of inflammatory activation of monocytes. Int Immunol (2008) 0.99
Pneumococcal pneumonia: mechanisms of infection and resolution. Chest (2012) 0.97
Anti-inflammatory effect of pre-elafin in lipopolysaccharide-induced acute lung inflammation. Biol Chem (2002) 0.96
Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts. Histochem Cell Biol (2010) 0.94
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis. J Immunol (2012) 0.94
Toll-like receptors and chronic lung disease. Clin Sci (Lond) (2005) 0.93
Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model. Adv Hematol (2012) 0.93
LPLUNC1 modulates innate immune responses to Vibrio cholerae. J Infect Dis (2011) 0.92
Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4. Immunology (2005) 0.92
Endotoxin tolerance induces selective alterations in neutrophil function. J Leukoc Biol (2005) 0.92
Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines. J Leukoc Biol (2012) 0.91
The HIF/VHL pathway: from oxygen sensing to innate immunity. Am J Respir Cell Mol Biol (2007) 0.91
Regulation of neutrophil senescence by microRNAs. PLoS One (2011) 0.91
Regulation of nuclear translocation of nuclear factor-kappaB relA: evidence for complex dynamics at the single-cell level. Biochem J (2003) 0.90
Penicillin enhances the toll-like receptor 2-mediated proinflammatory activity of Streptococcus pneumoniae. J Infect Dis (2003) 0.90
Staphylococcus aureus induces eosinophil cell death mediated by α-hemolysin. PLoS One (2012) 0.90
Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 0.89
Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function. Arthritis Res Ther (2009) 0.89
A central role for monocytes in Toll-like receptor-mediated activation of the vasculature. Immunology (2009) 0.89
Pulmonary Genomics, Proteomics, and PLUNCs. Am J Respir Cell Mol Biol (2007) 0.89
Action of intracellular IL-1Ra (Type 1) is independent of the IL-1 intracellular signalling pathway. Cytokine (2006) 0.88
Reducing the toll of inflammatory lung disease. Chest (2007) 0.88
Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract. FEBS Lett (2005) 0.88