Published in FASEB J on August 25, 2006
Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium. PLoS Pathog (2010) 1.82
Upregulation of the TLR3 pathway by Kaposi's sarcoma-associated herpesvirus during primary infection. J Virol (2008) 1.57
Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity. Clin Exp Immunol (2007) 1.30
CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy. Eur J Immunol (2008) 1.22
Poly(I:C) drives type I IFN- and TGFβ-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Invest Dermatol (2010) 1.17
Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages. Infect Immun (2011) 1.11
Emodin suppresses lipopolysaccharide-induced pro-inflammatory responses and NF-κB activation by disrupting lipid rafts in CD14-negative endothelial cells. Br J Pharmacol (2010) 1.08
Novel roles of peroxiredoxins in inflammation, cancer and innate immunity. J Clin Biochem Nutr (2012) 1.04
Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection. J Virol (2011) 0.97
Translational mini-review series on immunology of vascular disease: inflammation, infections and Toll-like receptors in cardiovascular disease. Clin Exp Immunol (2009) 0.96
Periodontal therapy alters gene expression of peripheral blood monocytes. J Clin Periodontol (2007) 0.93
Ambient ozone and pulmonary innate immunity. Immunol Res (2011) 0.93
Toll-like receptor 7 rapidly relaxes human airways. Am J Respir Crit Care Med (2013) 0.92
Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines. J Leukoc Biol (2012) 0.91
Influenza-induced production of interferon-alpha is defective in geriatric individuals. J Clin Immunol (2010) 0.91
Transcriptional regulation of cytokine function in airway smooth muscle cells. Pulm Pharmacol Ther (2009) 0.90
A central role for monocytes in Toll-like receptor-mediated activation of the vasculature. Immunology (2009) 0.89
Volatile emanations from in vitro airway cells infected with human rhinovirus. J Breath Res (2014) 0.89
A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains. J Immunol (2008) 0.88
Diesel exhaust particles override natural injury-limiting pathways in the lung. Am J Physiol Lung Cell Mol Physiol (2010) 0.88
Pellino-1 selectively regulates epithelial cell responses to rhinovirus. J Virol (2012) 0.87
Innate immune receptors in human airway smooth muscle cells: activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 agonists. PLoS One (2013) 0.86
It's all in the family: multiple Toll-like receptors offer promise as novel therapeutic targets for stroke neuroprotection. Future Neurol (2009) 0.86
Pathological networking: a new approach to understanding COPD. Thorax (2007) 0.85
Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells. Respir Res (2008) 0.85
Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1. Immunology (2008) 0.83
CCL2 release by airway smooth muscle is increased in asthma and promotes fibrocyte migration. Allergy (2014) 0.83
Opposing roles of RNA receptors TLR3 and RIG-I in the inflammatory response to double-stranded RNA in a Kaposi's sarcoma cell line. Cell Immunol (2007) 0.82
High mobility group box 1 and adenosine are both released by endothelial cells during hypothermic preservation. Clin Exp Immunol (2008) 0.80
Diesel exhaust particle exposure in vitro alters monocyte differentiation and function. PLoS One (2012) 0.78
Characterization of TLR-induced inflammatory responses in COPD and control lung tissue explants. Int J Chron Obstruct Pulmon Dis (2016) 0.75
Toll-Like Receptor 7-Targeted Therapy in Respiratory Disease. Transfus Med Hemother (2016) 0.75
Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy. PLoS One (2014) 0.75
Targeting Neutrophilic Inflammation Using Polymersome-Mediated Cellular Delivery. J Immunol (2017) 0.75
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet (2002) 8.57
Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med (2009) 8.36
Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med (2002) 6.52
Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma. Am J Respir Crit Care Med (2013) 4.95
Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med (2006) 4.83
A transgenic zebrafish model of neutrophilic inflammation. Blood (2006) 3.93
Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. Chest (2006) 3.59
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med (2011) 3.58
The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages. PLoS One (2010) 3.30
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J Biol Chem (2004) 2.91
Age-dependent incidence, time course, and consequences of thymic renewal in adults. J Clin Invest (2005) 2.84
A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med (2014) 2.51
Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax (2007) 2.37
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol (2012) 2.24
Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses. J Immunol (2002) 2.24
Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span. J Immunol (2003) 2.18
Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2003) 2.13
Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish. J Leukoc Biol (2010) 2.08
TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation. J Leukoc Biol (2011) 1.98
Induced sputum inflammatory mediator concentrations in chronic cough. Am J Respir Crit Care Med (2003) 1.98
The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med (2005) 1.95
TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol (2002) 1.92
Increased sputum and bronchial biopsy IL-13 expression in severe asthma. J Allergy Clin Immunol (2008) 1.92
IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma. Am J Respir Crit Care Med (2010) 1.91
Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection. J Immunol (2003) 1.88
Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol (2005) 1.87
Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. J Endotoxin Res (2006) 1.86
Severe asthma in adults: what are the important questions? J Allergy Clin Immunol (2007) 1.85
Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med (2012) 1.85
A pilot study of MUC-1/CEA/TRICOM poxviral-based vaccine in patients with metastatic breast and ovarian cancer. Clin Cancer Res (2011) 1.82
Airway hyperresponsiveness is dissociated from airway wall structural remodeling. J Allergy Clin Immunol (2008) 1.76
High prevalence of osteonecrosis of the femoral head in HIV-infected adults. Ann Intern Med (2002) 1.74
Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. Chest (2010) 1.73
Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: a potential mechanism of persistent infection. J Immunol (2002) 1.64
Eosinophilic airway inflammation in COPD. Int J Chron Obstruct Pulmon Dis (2006) 1.61
Toll-like receptors in health and disease: complex questions remain. J Immunol (2003) 1.57
Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma. Am J Respir Crit Care Med (2006) 1.53
Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis. J Allergy Clin Immunol (2004) 1.52
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood (2013) 1.48
Association between neutrophilic airway inflammation and airflow limitation in adults with asthma. Chest (2007) 1.46
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest (2011) 1.44
Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. J Clin Invest (2005) 1.42
C3a, mast cells, and asthma. FASEB J (2005) 1.42
Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma. J Allergy Clin Immunol (2011) 1.38
The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy. Am J Respir Med (2002) 1.38
Acceleration of human neutrophil apoptosis by TRAIL. J Immunol (2003) 1.38
A comparison of the validity of different diagnostic tests in adults with asthma. Chest (2002) 1.36
The low-toxicity versions of LPS, MPL adjuvant and RC529, are efficient adjuvants for CD4+ T cells. J Leukoc Biol (2005) 1.34
Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-beta 1. J Immunol (2008) 1.34
Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia. Am J Respir Crit Care Med (2008) 1.33
An empiric integrative approach to the management of cough: ACCP evidence-based clinical practice guidelines. Chest (2006) 1.33
Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection. FASEB J (2004) 1.33
The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis. Clin Infect Dis (2005) 1.30
Functional transient receptor potential melastatin 7 channels are critical for human mast cell survival. J Immunol (2007) 1.30
Clinical, radiologic, and induced sputum features of chronic obstructive pulmonary disease in nonsmokers: a descriptive study. Am J Respir Crit Care Med (2002) 1.27
Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia. J Immunol (2006) 1.27
The expression and roles of Toll-like receptors in the biology of the human neutrophil. J Leukoc Biol (2005) 1.26
Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury. J Immunol (2002) 1.25
Interleukin 18 receptor 1 gene polymorphisms are associated with asthma. Eur J Hum Genet (2008) 1.23
Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol (2008) 1.23
Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor. Thromb Haemost (2005) 1.23
Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma. J Allergy Clin Immunol (2010) 1.21
KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation. Am J Respir Cell Mol Biol (2007) 1.20
Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo. J Immunol (2005) 1.20
Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes. Thorax (2010) 1.19
Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways. J Biol Chem (2007) 1.17
Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis. J Allergy Clin Immunol (2007) 1.17
Pulmonary hypertension in COPD: results from the ASPIRE registry. Eur Respir J (2012) 1.16
Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes. Am J Respir Crit Care Med (2005) 1.16
The role of TLRs in neutrophil activation. Curr Opin Pharmacol (2011) 1.15