Published in Nucleic Acids Res on September 21, 2007
Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet (2010) 10.71
The Molecular Biology Database Collection: 2008 update. Nucleic Acids Res (2007) 2.46
HHMD: the human histone modification database. Nucleic Acids Res (2009) 1.27
DiseaseMeth: a human disease methylation database. Nucleic Acids Res (2011) 1.22
NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva. Cancer Prev Res (Phila) (2011) 1.21
MethHC: a database of DNA methylation and gene expression in human cancer. Nucleic Acids Res (2014) 1.17
HLungDB: an integrated database of human lung cancer research. Nucleic Acids Res (2009) 1.13
Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes. Nucleic Acids Res (2009) 1.09
MethylomeDB: a database of DNA methylation profiles of the brain. Nucleic Acids Res (2011) 1.06
GeneSetDB: A comprehensive meta-database, statistical and visualisation framework for gene set analysis. FEBS Open Bio (2012) 1.01
Synthetic biology: an emerging research field in China. Biotechnol Adv (2011) 1.00
Genomic impact of cigarette smoke, with application to three smoking-related diseases. Crit Rev Toxicol (2012) 1.00
DAnCER: disease-annotated chromatin epigenetics resource. Nucleic Acids Res (2010) 0.98
Biological databases for human research. Genomics Proteomics Bioinformatics (2015) 0.96
Lnc2Cancer: a manually curated database of experimentally supported lncRNAs associated with various human cancers. Nucleic Acids Res (2015) 0.96
CpG_MPs: identification of CpG methylation patterns of genomic regions from high-throughput bisulfite sequencing data. Nucleic Acids Res (2012) 0.96
Epstein-Barr virus-induced epigenetic alterations following transient infection. Int J Cancer (2012) 0.92
PCMdb: pancreatic cancer methylation database. Sci Rep (2014) 0.90
NGSmethDB: an updated genome resource for high quality, single-cytosine resolution methylomes. Nucleic Acids Res (2013) 0.86
MethBank: a database integrating next-generation sequencing single-base-resolution DNA methylation programming data. Nucleic Acids Res (2014) 0.85
Databases and web tools for cancer genomics study. Genomics Proteomics Bioinformatics (2015) 0.85
EpiFactors: a comprehensive database of human epigenetic factors and complexes. Database (Oxford) (2015) 0.85
MyBASE: a database for genome polymorphism and gene function studies of Mycobacterium. BMC Microbiol (2009) 0.83
A seven-gene CpG-island methylation panel predicts breast cancer progression. BMC Cancer (2015) 0.82
MethCancerDB--aberrant DNA methylation in human cancer. Br J Cancer (2008) 0.81
The tendency to recreate ancestral CG dinucleotides in the human genome. BMC Evol Biol (2011) 0.80
Combining position weight matrices and document-term matrix for efficient extraction of associations of methylated genes and diseases from free text. PLoS One (2013) 0.79
HEMD: an integrated tool of human epigenetic enzymes and chemical modulators for therapeutics. PLoS One (2012) 0.79
Methylation of a panel of genes in peripheral blood leukocytes is associated with colorectal cancer. Sci Rep (2016) 0.78
Genome-wide DNA methylome variation in two genetically distinct chicken lines using MethylC-seq. BMC Genomics (2015) 0.77
Genome-wide and gene-specific epigenomic platforms for hepatocellular carcinoma biomarker development trials. Gastroenterol Res Pract (2014) 0.77
DDMGD: the database of text-mined associations between genes methylated in diseases from different species. Nucleic Acids Res (2014) 0.77
Databases and bioinformatics tools for the study of DNA repair. Mol Biol Int (2011) 0.76
EPITRANS: a database that integrates epigenome and transcriptome data. Mol Cells (2013) 0.76
DevMouse, the mouse developmental methylome database and analysis tools. Database (Oxford) (2014) 0.75
NGSmethDB 2017: enhanced methylomes and differential methylation. Nucleic Acids Res (2016) 0.75
The most redundant sequences in human CpG island library are derived from mitochondrial genome. Genomics Proteomics Bioinformatics (2010) 0.75
Human cancer databases (review). Oncol Rep (2014) 0.75
DREMECELS: A Curated Database for Base Excision and Mismatch Repair Mechanisms Associated Human Malignancies. PLoS One (2016) 0.75
The landscape for epigenetic/epigenomic biomedical resources. Epigenetics (2012) 0.75
CASP-8 -652 6N ins/del polymorphism and cancer risk: A literature-based systematic HuGE review and meta-analysis. Exp Ther Med (2012) 0.75
DiseaseMeth version 2.0: a major expansion and update of the human disease methylation database. Nucleic Acids Res (2016) 0.75
MethSMRT: an integrative database for DNA N6-methyladenine and N4-methylcytosine generated by single-molecular real-time sequencing. Nucleic Acids Res (2016) 0.75
Genome-Wide Prediction of DNA Methylation Using DNA Composition and Sequence Complexity in Human. Int J Mol Sci (2017) 0.75
Integrating Epigenomics into the Understanding of Biomedical Insight. Bioinform Biol Insights (2016) 0.75
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
A census of human cancer genes. Nat Rev Cancer (2004) 36.20
The epigenomics of cancer. Cell (2007) 30.91
Ensembl 2007. Nucleic Acids Res (2006) 20.10
Database resources of the National Center for Biotechnology. Nucleic Acids Res (2003) 18.26
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
The history of cancer epigenetics. Nat Rev Cancer (2004) 14.38
The UCSC genome browser database: update 2007. Nucleic Acids Res (2006) 13.04
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer (2004) 12.35
Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A (2002) 12.33
Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet (2007) 9.88
Mapping the cancer genome. Pinpointing the genes involved in cancer will help chart a new course across the complex landscape of human malignancies. Sci Am (2007) 4.66
Purification of CpG islands using a methylated DNA binding column. Nat Genet (1994) 4.31
Large-scale structure of genomic methylation patterns. Genome Res (2005) 4.11
The CpG island searcher: a new WWW resource. In Silico Biol (2003) 3.42
Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum Genet (1989) 2.80
BGI-RIS: an integrated information resource and comparative analysis workbench for rice genomics. Nucleic Acids Res (2004) 2.69
The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation. Proc Natl Acad Sci U S A (1996) 2.63
SilkDB: a knowledgebase for silkworm biology and genomics. Nucleic Acids Res (2005) 2.50
EPD in its twentieth year: towards complete promoter coverage of selected model organisms. Nucleic Acids Res (2006) 2.49
Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. Am J Hum Genet (1991) 2.45
DNA methylation and gene silencing in cancer: which is the guilty party? Oncogene (2002) 2.23
Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research. Nucleic Acids Res (2006) 2.14
From genome to epigenome. Hum Mol Genet (2005) 2.03
CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome. Nucleic Acids Res (2005) 1.89
An improved version of the DNA Methylation database (MethDB). Nucleic Acids Res (2003) 1.61
ChickVD: a sequence variation database for the chicken genome. Nucleic Acids Res (2005) 1.45
Atlas of Genetics and Cytogenetics in Oncology and Haematology, year 2003. Nucleic Acids Res (2003) 1.29
Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma. Biochem Biophys Res Commun (2003) 1.19
Both hypomethylation and hypermethylation in a 0.2-kb region of a DNA repeat in cancer. Mol Cancer Res (2005) 1.02
Hypomethylation of DNA in human cancer cells: a site-specific change in the c-myc oncogene. J Natl Cancer Inst (1984) 0.98
Human epigenome project--up and running. PLoS Biol (2003) 0.98
How epigenetics integrates nuclear functions. Workshop on epigenetics and chromatin: transcriptional regulation and beyond. EMBO Rep (2005) 0.91
DNA hypomethylation of CAGE promotors in squamous cell carcinoma of uterine cervix. Ann N Y Acad Sci (2006) 0.87
The Cancer Genome Anatomy Project: power tools for cancer biologists. Cancer Invest (2003) 0.80
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
De novo assembly of human genomes with massively parallel short read sequencing. Genome Res (2009) 45.91
A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler. Gigascience (2012) 20.89
International network of cancer genome projects. Nature (2010) 20.35
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
SNP detection for massively parallel whole-genome resequencing. Genome Res (2009) 15.96
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
WEGO: a web tool for plotting GO annotations. Nucleic Acids Res (2006) 13.06
Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Nat Genet (2007) 12.62
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature (2006) 11.90
A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature (2012) 11.68
Sequencing of 50 human exomes reveals adaptation to high altitude. Science (2010) 11.27
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (2011) 11.12
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol (2008) 10.42
MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell (2007) 9.33
Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. Lancet (2008) 9.17
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
Changes in diabetes-related complications in the United States, 1990-2010. N Engl J Med (2014) 8.73
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4. N Engl J Med (2011) 7.11
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet (2011) 5.73
Human Y chromosome base-substitution mutation rate measured by direct sequencing in a deep-rooting pedigree. Curr Biol (2009) 5.70
Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell (2012) 5.62
Building the sequence map of the human pan-genome. Nat Biotechnol (2009) 5.53
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet (2010) 5.44
The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell (2012) 5.16
Self-monitoring in weight loss: a systematic review of the literature. J Am Diet Assoc (2011) 5.12
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology (2007) 4.83
AlleleSeq: analysis of allele-specific expression and binding in a network framework. Mol Syst Biol (2011) 4.71
The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science (2009) 4.63
RePS: a sequence assembler that masks exact repeats identified from the shotgun data. Genome Res (2002) 4.35
The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol (2010) 4.25
Genome-wide patterns of genetic variation among elite maize inbred lines. Nat Genet (2010) 4.06
Priming of naive T cells inside tumors leads to eradication of established tumors. Nat Immunol (2004) 3.95
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat Genet (2013) 3.87
The genetic legacy of the Mongols. Am J Hum Genet (2003) 3.84
Glycolytic enzymes can modulate cellular life span. Cancer Res (2005) 3.78
Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell (2003) 3.75
NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest (2003) 3.69
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66
Large-gap quantum spin Hall insulators in tin films. Phys Rev Lett (2013) 3.60
Regulation of OsSPL14 by OsmiR156 defines ideal plant architecture in rice. Nat Genet (2010) 3.56
Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery. Nucleic Acids Res (2005) 3.56
Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop of resource-poor farmers. Nat Biotechnol (2011) 3.51
An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin Cancer Res (2012) 3.48
A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology (2004) 3.42
Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation. Nature (2013) 3.40
Deep RNA sequencing at single base-pair resolution reveals high complexity of the rice transcriptome. Genome Res (2010) 3.34
The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg (2013) 3.25
Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection. N Engl J Med (2015) 3.13
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature (2010) 3.09
HIV/STD risk behaviors and perceptions among rural-to-urban migrants in China. AIDS Educ Prev (2004) 3.04
Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans. DNA Res (2004) 2.95
Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol (2007) 2.94
Whole-genome sequence of Schistosoma haematobium. Nat Genet (2012) 2.91
Enhancing patient safety and quality of care by improving the usability of electronic health record systems: recommendations from AMIA. J Am Med Inform Assoc (2013) 2.90
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest (2008) 2.89
Draft genome of the wheat A-genome progenitor Triticum urartu. Nature (2013) 2.86
The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Cell Metab (2008) 2.84
Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes (2007) 2.83
Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome. J Natl Cancer Inst (2012) 2.79
N-substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion. Antimicrob Agents Chemother (2004) 2.76
Rapid cardiotonic effects of lipid emulsion infusion*. Crit Care Med (2013) 2.76
BGI-RIS: an integrated information resource and comparative analysis workbench for rice genomics. Nucleic Acids Res (2004) 2.69
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science (2009) 2.68
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Cancer Discov (2012) 2.68
Trends in physical activity, sedentary behavior, diet, and BMI among US adolescents, 2001-2009. Pediatrics (2013) 2.66
Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock. Science (2006) 2.62
Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression. Cell Stem Cell (2012) 2.61
A complete sequence of the T. tengcongensis genome. Genome Res (2002) 2.60
A developmental approach to complex PTSD: childhood and adult cumulative trauma as predictors of symptom complexity. J Trauma Stress (2009) 2.59
Lessons from "Unexpected increased mortality after implementation of a commercially sold computerized physician order entry system". Pediatrics (2006) 2.55
PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature (2011) 2.53
The effect of passengers and risk-taking friends on risky driving and crashes/near crashes among novice teenagers. J Adolesc Health (2011) 2.53
Exome sequencing identifies ZNF644 mutations in high myopia. PLoS Genet (2011) 2.52
Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron (2003) 2.51
SilkDB: a knowledgebase for silkworm biology and genomics. Nucleic Acids Res (2005) 2.50
Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov (2013) 2.49
Physics. Learning and scientific reasoning. Science (2009) 2.49
PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. Cell (2008) 2.49
Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing. Am J Hum Genet (2013) 2.47
A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates. PLoS One (2007) 2.47
Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly. Nat Biotechnol (2011) 2.45
A user-centered framework for redesigning health care interfaces. J Biomed Inform (2005) 2.43