The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging.

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Published in Prog Neurobiol on December 06, 2006

Authors

Sriram Venneti1, Brian J Lopresti, Clayton A Wiley

Author Affiliations

1: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science (2005) 14.43

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Microglia: a sensor for pathological events in the CNS. Trends Neurosci (1996) 12.00

ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55

Inflammatory blockade restores adult hippocampal neurogenesis. Science (2003) 10.14

Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci U S A (1986) 8.45

Simplified reference tissue model for PET receptor studies. Neuroimage (1996) 8.28

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med (2003) 7.83

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology (1988) 6.79

Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci U S A (2003) 5.09

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci (2000) 4.14

Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci (1999) 3.90

In-vivo measurement of activated microglia in dementia. Lancet (2001) 3.51

A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol (1984) 3.11

Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci U S A (2001) 2.95

Microglia: intrinsic immuneffector cell of the brain. Brain Res Brain Res Rev (1995) 2.92

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol (1992) 2.92

MRI as a biomarker of disease progression in a therapeutic trial of milameline for AD. Neurology (2003) 2.88

Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science (1990) 2.87

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Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology (2005) 2.79

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Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci U S A (1992) 2.72

Interleukin 1 of the central nervous system is produced by ameboid microglia. J Exp Med (1986) 2.62

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis (2005) 2.59

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proc Natl Acad Sci U S A (2003) 2.58

Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J Leukoc Biol (2003) 2.50

Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study. Neurobiol Dis (2004) 2.29

Visualising microglial activation in vivo. Glia (2002) 2.27

High densities of benzodiazepine receptors in human cortical areas. Nature (1977) 1.97

Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev (1999) 1.92

Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog Neurobiol (1998) 1.91

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Microglial activation correlates with severity in Huntington disease: a clinical and PET study. Neurology (2006) 1.88

Peripheral benzodiazepine receptors and mitochondrial function. Neurochem Int (2002) 1.82

Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis. J Neurosci Res (1994) 1.70

Monokine production by microglial cell clones. Eur J Immunol (1989) 1.64

PET visualization of microglia in multiple sclerosis patients using [11C]PK11195. Eur J Neurol (2003) 1.59

Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging. Eur J Neurosci (2002) 1.57

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Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders. Neuroscience (2005) 1.47

Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195. Neurology (2000) 1.47

PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci Res (1997) 1.43

Synthesis of the enantiomers of [N-methyl-11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats. Nucl Med Biol (1994) 1.43

Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat. J Neurosci (1995) 1.42

Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line. J Biol Chem (1997) 1.40

Identification of genes involved in the host response to neurovirulent alphavirus infection. J Virol (2001) 1.39

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[11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis. Neurology (1999) 1.36

Traumatic brain injury leads to increased expression of peripheral-type benzodiazepine receptors, neuronal death, and activation of astrocytes and microglia in rat thalamus. Exp Neurol (2000) 1.32

Human microglia convert l-tryptophan into the neurotoxin quinolinic acid. Biochem J (1996) 1.32

Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide. I. In vitro studies. Life Sci (1983) 1.31

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Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage. Blood (1996) 1.21

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In vivo imaging of activated microglia using [11C]PK11195 and positron emission tomography in patients after ischemic stroke. Neuroreport (2000) 1.18

Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control. Mol Pharmacol (1989) 1.17

PET study of carbon-11-PK 11195 binding to peripheral type benzodiazepine sites in glioblastoma: a case report. J Nucl Med (1991) 1.17

Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study. Mult Scler (2005) 1.17

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Neuroscience. Brain under surveillance: the microglia patrol. Science (2005) 1.16

Macrophages and the nervous system. Int Rev Cytol (1991) 1.16

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PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS. J Clin Invest (2004) 1.15

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Cytokine induction of MIP-1 alpha and MIP-1 beta in human fetal microglia. J Immunol (1998) 1.14

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CD40-CD40L interactions induce chemokine expression by human microglia: implications for human immunodeficiency virus encephalitis and multiple sclerosis. Am J Pathol (2002) 1.11

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Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain. J Med Chem (2004) 1.10

Imaging of a glioma using peripheral benzodiazepine receptor ligands. Proc Natl Acad Sci U S A (1987) 1.09

Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment. J Neurovirol (2006) 1.07

Binding characteristics of [3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors. Eur J Pharmacol (1999) 1.04

Labelling of "peripheral-type" benzodiazepine binding sites in the rat brain by using [3H]PK 11195, an isoquinoline carboxamide derivative: kinetic studies and autoradiographic localization. J Neurochem (1983) 1.03

Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q. J Immunol (2001) 1.03

Imaging the peripheral benzodiazepine receptor response in central nervous system demyelination and remyelination. Toxicol Sci (2006) 1.01

In vivo imaging of cerebral "peripheral benzodiazepine binding sites" in patients with hepatic encephalopathy. Gut (2005) 1.01

Phagocytosis of apoptotic inflammatory cells by microglia and its therapeutic implications: termination of CNS autoimmune inflammation and modulation by interferon-beta. Glia (2003) 1.01

Viruses and apoptosis: meddling with mitochondria. Virology (2001) 1.00

Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3 isoquinolinecarboxamide. II. In vivo studies. Life Sci (1983) 1.00

The GABAA receptors. Biochem J (1995) 1.00

Modulation of human microglial cell superoxide production by cytokines. J Leukoc Biol (1995) 0.99

Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106. Life Sci (1999) 0.99

In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon. Stroke (1993) 0.96

In search of the function of the peripheral-type benzodiazepine receptor. Endocr Res (2004) 0.96

Region-selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain. J Neurochem (2002) 0.96

Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells. J Neurochem (2002) 0.95

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in corticobasal degeneration. Mov Disord (2004) 0.95

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An agent-based model of inflammation and fibrosis following particulate exposure in the lung. Math Biosci (2011) 0.98

Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [(11)C]-N-propyl-norapomorphine: preliminary evaluation and reproducibility studies. Synapse (2009) 0.97

YKL-40 expression in traumatic brain injury: an initial analysis. J Neurotrauma (2010) 0.93

In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusers. Am J Psychiatry (2011) 0.93

The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: implications for PET imaging of neuroinflammation in lentiviral encephalitis. Neurobiol Dis (2007) 0.92

Longitudinal analysis of activation markers on monocyte subsets during the development of simian immunodeficiency virus encephalitis. J Neuroimmunol (2006) 0.92

YKL-40 is directly produced by tumor cells and is inversely linked to EGFR in glioblastomas. Int J Clin Exp Pathol (2010) 0.91

Microglia: key innate immune cells of the brain. Toxicol Pathol (2010) 0.91

Antibody breadth and protective efficacy are increased by vaccination with computationally optimized hemagglutinin but not with polyvalent hemagglutinin-based H5N1 virus-like particle vaccines. Clin Vaccine Immunol (2011) 0.90

Webcasting pathology department conferences in a geographically distributed medical center. Hum Pathol (2004) 0.89

Recovery of replication-competent HIV type 1-infected circulating monocytes from individuals receiving antiretroviral therapy. AIDS Res Hum Retroviruses (2002) 0.86

Imaging of dopamine D2/3 agonist binding in cocaine dependence: a [11C]NPA positron emission tomography study. Synapse (2011) 0.86

Immune response to the West Nile virus in aged non-human primates. PLoS One (2010) 0.86

Exacerbation of experimental autoimmune encephalomyelitis in the absence of breast regression protein 39/chitinase 3-like 1. J Neuropathol Exp Neurol (2012) 0.85

Destruction of extracellular matrix proteoglycans is pervasive in simian retroviral neuroinfection. Neurobiol Dis (2004) 0.84

Elicitation of anti-1918 influenza virus immunity early in life prevents morbidity and lower levels of lung infection by 2009 pandemic H1N1 influenza virus in aged mice. J Virol (2011) 0.84

Neuronal intranuclear inclusion disease without polyglutamine inclusions in a child. J Neuropathol Exp Neurol (2005) 0.84

A reliable primary human CNS culture protocol for morphological studies of dendritic and synaptic elements. J Neurosci Methods (2002) 0.83

Systemic and brain macrophage infections in relation to the development of simian immunodeficiency virus encephalitis. J Virol (2008) 0.82

Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PET. J Nucl Med (2009) 0.82

Utility of 3'-[(18)F]fluoro-3'-deoxythymidine as a PET tracer to monitor response to gene therapy in a xenograft model of head and neck carcinoma. Am J Nucl Med Mol Imaging (2013) 0.82

Acute murine H5N1 influenza A encephalitis. Brain Pathol (2011) 0.81

Detection of HIV-1 DNA in microglia/macrophages, astrocytes and neurons isolated from brain tissue with HIV-1 encephalitis by laser capture microdissection. Brain Pathol (2003) 0.81

Human Parechovirus 3 Meningitis and Fatal Leukoencephalopathy. J Neuropathol Exp Neurol (2015) 0.80

Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner. Neurosci Lett (2007) 0.79

Pocket proteins p107 and p130 exhibit increased expression in macrophages during SIV encephalitis. Neuropathology (2005) 0.78

Altered cerebellar and prefrontal cortex function in rhesus monkeys that previously self-administered cocaine. Psychopharmacology (Berl) (2014) 0.78

H1N1, but not H3N2, influenza A virus infection protects ferrets from H5N1 encephalitis. J Virol (2013) 0.78

HIV-1/AIDS neuropathology in a Canadian teaching centre. Can J Neurol Sci (2004) 0.77

Human biodistribution and dosimetry of the PET radioligand [¹¹C]flumazenil (FMZ). Mol Imaging Biol (2012) 0.77

Preventive immunization of aged and juvenile non-human primates to β-amyloid. J Neuroinflammation (2012) 0.77

In vivo imaging in an ABSL-3 regional biocontainment laboratory. Pathog Dis (2014) 0.77

February 2003: a 53-year-old male with new onset seizures. Brain Pathol (2003) 0.77

Absence of fetal transmission of H1N1 despite severe maternal infection. Influenza Other Respir Viruses (2011) 0.75

The cost of silencing HIV in the brain. Neurology (2013) 0.75

Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues. PLoS Pathog (2017) 0.75

October 2003: a 59-year-old woman with sudden onset of diplopia. Listerial rhombencephalitis. Brain Pathol (2004) 0.75