Published in Biochemistry on November 25, 2003
Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol (2005) 2.08
K+ channel modulators for the treatment of neurological disorders and autoimmune diseases. Chem Rev (2008) 1.52
How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits. J Gen Physiol (2008) 1.08
Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells. Mol Pharmacol (2012) 0.96
Electrophysiological characterization of Ts6 and Ts7, K⁺ channel toxins isolated through an improved Tityus serrulatus venom purification procedure. Toxins (Basel) (2014) 0.84
Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium. J Gen Physiol (2010) 0.81
Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK. Mar Drugs (2015) 0.77
Immunosuppressive evidence of Tityus serrulatus toxins Ts6 and Ts15: insights of a novel K(+) channel pattern in T cells. Immunology (2016) 0.75
Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant. Proc Natl Acad Sci U S A (2016) 0.75
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Nat Genet (2008) 6.69
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet (2010) 3.93
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet (2009) 2.76
Phylogenetic and case-control study on hepatitis E virus infection in Germany. J Infect Dis (2008) 2.50
Therapeutic potential of venom peptides. Nat Rev Drug Discov (2003) 2.39
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05
Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior. Proc Natl Acad Sci U S A (2005) 1.84
Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature (2003) 1.84
ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors. Mol Pharmacol (2008) 1.72
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene. Hum Mol Genet (2011) 1.58
Reactive oxygen species impair Slo1 BK channel function by altering cysteine-mediated calcium sensing. Nat Struct Mol Biol (2004) 1.57
Ion channels as drug targets: the next GPCRs. J Gen Physiol (2008) 1.51
Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry (2002) 1.48
Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various Swiss rivers with inputs from wastewater treatment plants. Environ Sci Technol (2006) 1.47
Hexabromocyclododecane challenges scientists and regulators. Environ Sci Technol (2005) 1.42
Hexabromocyclododecanes (HBCDs) in the environment and humans: a review. Environ Sci Technol (2006) 1.36
Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes (2006) 1.35
Extracellular loop C of NPC1L1 is important for binding to ezetimibe. Proc Natl Acad Sci U S A (2008) 1.35
Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel. J Gen Physiol (2006) 1.33
Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain. Biochemistry (2004) 1.30
Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720. Bioorg Med Chem Lett (2004) 1.24
Cholinergic augmentation of insulin release requires ankyrin-B. Sci Signal (2010) 1.21
Profiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-à-go-go related gene potassium channels. Assay Drug Dev Technol (2010) 1.20
Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes (2004) 1.16
Sodium channel blockade may contribute to the analgesic efficacy of antidepressants. J Pain (2006) 1.13
Anaerobic degradation of decabromodiphenyl ether. Environ Sci Technol (2005) 1.12
Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells. J Immunol (2003) 1.09
Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol (2011) 1.06
Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels. Proteins (2003) 1.05
Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel. Proc Natl Acad Sci U S A (2012) 1.03
Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes. Assay Drug Dev Technol (2004) 1.03
Protein surface recognition by rational design: nanomolar ligands for potassium channels. J Am Chem Soc (2003) 1.02
A high-throughput assay for evaluating state dependence and subtype selectivity of Cav2 calcium channel inhibitors. Assay Drug Dev Technol (2008) 1.02
Opsins in onychophora (velvet worms) suggest a single origin and subsequent diversification of visual pigments in arthropods. Mol Biol Evol (2012) 1.02
Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7. Biochemistry (2007) 1.01
Ischemic preconditioning improves maximal performance in humans. Eur J Appl Physiol (2009) 0.99
Pharmacologic inhibition of the renal outer medullary potassium channel causes diuresis and natriuresis in the absence of kaliuresis. J Pharmacol Exp Ther (2013) 0.99
Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener. ACS Chem Neurosci (2011) 0.99
Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits. Biochemistry (2002) 0.99
Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake. Mol Pharmacol (2008) 0.96
Anaerobic degradation of brominated flame retardants in sewage sludge. Chemosphere (2006) 0.96
Blocking sodium channels to treat neuropathic pain. Expert Opin Ther Targets (2007) 0.96
Role of hERG potassium channel assays in drug development. Channels (Austin) (2008) 0.96
Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. Proc Natl Acad Sci U S A (2013) 0.96
Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties. Biochemistry (2002) 0.95
Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker. J Pharmacol Exp Ther (2010) 0.94
A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel. Assay Drug Dev Technol (2010) 0.93
Positive allosteric interaction of structurally diverse T-type calcium channel antagonists. Cell Biochem Biophys (2009) 0.93
Isolation and structure of antagonists of chemokine receptor (CCR5). J Nat Prod (2004) 0.93
Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic beta-cells. J Physiol (2005) 0.93
Engineering-specific pharmacological binding sites for peptidyl inhibitors of potassium channels into KcsA. Biochemistry (2002) 0.92
Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats. Mol Pharmacol (2005) 0.92
Opsin evolution and expression in arthropod compound eyes and ocelli: insights from the cricket Gryllus bimaculatus. BMC Evol Biol (2012) 0.92
A high-capacity membrane potential FRET-based assay for NaV1.8 channels. Assay Drug Dev Technol (2006) 0.92
Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis. Mol Endocrinol (2003) 0.92
Effects of rare earth compounds on growth and apoptosis of leukemic cell lines. In Vitro Cell Dev Biol Anim (2003) 0.91
Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett (2012) 0.91
Miniaturization and HTS of a FRET-based membrane potential assay for K(ir) channel inhibitors. Assay Drug Dev Technol (2008) 0.91
Self-inactivating retroviral vector-mediated gene transfer induces oncogene activation and immortalization of primary murine bone marrow cells. Mol Ther (2009) 0.91
Potassium channels as targets for therapeutic intervention. Sci STKE (2005) 0.91
The inwardly rectifying potassium channel Kir1.1: development of functional assays to identify and characterize channel inhibitors. Assay Drug Dev Technol (2012) 0.90