Published in Mol Pharmacol on May 23, 2012
Scorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineering. Toxins (Basel) (2012) 0.91
Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism. PLoS One (2013) 0.87
Variability of Potassium Channel Blockers in Mesobuthus eupeus Scorpion Venom with Focus on Kv1.1: AN INTEGRATED TRANSCRIPTOMIC AND PROTEOMIC STUDY. J Biol Chem (2015) 0.84
Ion channels and anti-cancer immunity. Philos Trans R Soc Lond B Biol Sci (2014) 0.82
Transcriptome analysis of scorpion species belonging to the Vaejovis genus. PLoS One (2015) 0.82
Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity. Biomaterials (2013) 0.81
Role of the K(Ca)3.1 K+ channel in auricular lymph node CD4+ T-lymphocyte function of the delayed-type hypersensitivity model. Br J Pharmacol (2013) 0.81
Immunosuppressive peptides and their therapeutic applications. Drug Discov Today (2013) 0.80
Scorpions from Mexico: From Species Diversity to Venom Complexity. Toxins (Basel) (2015) 0.79
Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel. Sci Rep (2015) 0.79
Toxins Targeting the Kv1.3 Channel: Potential Immunomodulators for Autoimmune Diseases. Toxins (Basel) (2015) 0.78
N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3. FEBS J (2015) 0.78
Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant. Proc Natl Acad Sci U S A (2016) 0.75
The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS One (2016) 0.75
The antifungal plant defensin AtPDF2.3 from Arabidopsis thaliana blocks potassium channels. Sci Rep (2016) 0.75
Recombinant expression of Intrepicalcin from the scorpion Vaejovis intrepidus and its effect on skeletal ryanodine receptors. Biochim Biophys Acta (2017) 0.75
7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome. Pflugers Arch (2016) 0.75
Efficient functional neutralization of lethal peptide toxins in vivo by oligonucleotides. Sci Rep (2017) 0.75
Calcium signaling mechanisms in T lymphocytes. Annu Rev Immunol (2001) 7.06
Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol (1994) 4.24
The functional network of ion channels in T lymphocytes. Immunol Rev (2009) 3.21
Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A (2006) 3.13
The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. J Clin Invest (2003) 3.02
K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion. Nature (1984) 2.89
Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. J Biol Chem (2000) 2.85
Induction and monitoring of adoptive delayed-type hypersensitivity in rats. J Vis Exp (2007) 2.61
Mechanism of charybdotoxin block of a voltage-gated K+ channel. Biophys J (1993) 1.99
Induction and monitoring of active delayed type hypersensitivity (DTH) in rats. J Vis Exp (2007) 1.94
Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels. J Biol Chem (1993) 1.94
Calcium-activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacology. J Gen Physiol (1993) 1.93
Interaction of charybdotoxin with permeant ions inside the pore of a K+ channel. Neuron (1992) 1.87
ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. J Biol Chem (1998) 1.87
CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. Blood (2002) 1.81
Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation. J Exp Med (1993) 1.67
Selective blockers of voltage-gated K+ channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxin. Proc Natl Acad Sci U S A (1992) 1.65
Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin. Biochemistry (1992) 1.61
On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures. J Biol Chem (1997) 1.57
Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem (2001) 1.50
Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease. J Biol Chem (2008) 1.46
Complex subunit assembly of neuronal voltage-gated K+ channels. Basis for high-affinity toxin interactions and pharmacology. J Biol Chem (1997) 1.35
Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes. Mol Pharmacol (2009) 1.29
Ion channels and lymphocyte activation. Immunol Lett (2004) 1.27
Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes. J Immunol (2007) 1.27
TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 critically influence T lymphocyte effector functions. J Biol Chem (2008) 1.23
Stimulatory action of internal protons on Slo1 BK channels. Biophys J (2003) 1.19
Synthetic charybdotoxin-iberiotoxin chimeric peptides define toxin binding sites on calcium-activated and voltage-dependent potassium channels. Biochemistry (1993) 1.17
Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom. J Biol Chem (1998) 1.15
K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J (2005) 1.11
A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom. Biochem J (1997) 1.05
K+ channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression. Curr Pharm Des (2006) 1.03
Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species. Comp Biochem Physiol C Toxicol Pharmacol (2006) 0.95
Electrostatic mutations in iberiotoxin as a unique tool for probing the electrostatic structure of the maxi-K channel outer vestibule. Biochemistry (1999) 0.93
Effects of toxins Pi2 and Pi3 on human T lymphocyte Kv1.3 channels: the role of Glu7 and Lys24. J Membr Biol (2001) 0.90
Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile. Biochemistry (2003) 0.90
Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes. Biochemistry (2012) 0.88
TCR-dependent cell response is modulated by the timing of CD43 engagement. J Immunol (2006) 0.88
High-throughput profiling of ion channel activity in primary human lymphocytes. Anal Chem (2008) 0.88
Measurement of proliferative responses of cultured lymphocytes. Curr Protoc Immunol (2008) 0.87
Molecular basis of alpha-KTx specificity. Toxicon (2004) 0.85
A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus. Biochem Pharmacol (2008) 0.84
Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes. Mol Pharmacol (2004) 0.84
K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci (2004) 3.12
The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. J Clin Invest (2003) 3.02
Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science (2008) 2.67
Current views on scorpion toxins specific for K+-channels. Toxicon (2004) 2.60
Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity (2008) 2.23
Insight into organometallic intermediate and its evolution to covalent bonding in surface-confined ullmann polymerization. ACS Nano (2013) 2.11
Biomechanics of tendon injury and repair. J Biomech (2004) 1.93
Novel interactions between K+ channels and scorpion toxins. Trends Pharmacol Sci (2003) 1.91
The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc Natl Acad Sci U S A (2005) 1.69
Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution. Toxicon (2005) 1.67
Tendon healing in interleukin-4 and interleukin-6 knockout mice. J Biomech (2005) 1.65
Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. Toxicon (2011) 1.59
Potassium channels as therapeutic targets for autoimmune disorders. Curr Opin Drug Discov Devel (2003) 1.52
Effect of a chitosan-based hemostatic dressing on blood loss and survival in a model of severe venous hemorrhage and hepatic injury in swine. J Trauma (2003) 1.47
Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol (2004) 1.31
JNK and p38 MAP kinases in CD4+ and CD8+ T cells. Immunol Rev (2003) 1.24
CD8 cells of patients with diffuse cutaneous leishmaniasis display functional exhaustion: the latter is reversed, in vitro, by TLR2 agonists. PLoS Negl Trop Dis (2010) 1.20
Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nat Commun (2011) 1.19
Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease. J Pharmacol Exp Ther (2012) 1.19
Oestradiol potentiates the suppressive function of human CD4 CD25 regulatory T cells by promoting their proliferation. Immunology (2006) 1.14
Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibule. J Biol Chem (2002) 1.13
Detection of functional matrix metalloproteinases by zymography. J Vis Exp (2010) 1.13
Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones). BMC Genomics (2007) 1.12
Mining on scorpion venom biodiversity. Toxicon (2009) 1.11
Multifunctional host defense peptides: antimicrobial peptides, the small yet big players in innate and adaptive immunity. FEBS J (2009) 1.08
p38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD8+ T cells. Mol Cell Biol (2006) 1.06
Role of microRNAs in central nervous system development and pathology. J Neurosci Res (2011) 1.04
Fungal evolutionary genomics provides insight into the mechanisms of adaptive divergence in eukaryotes. Mol Ecol (2014) 1.02
Expression of CD64 as a potential marker of neonatal sepsis. Pediatr Allergy Immunol (2002) 1.02
Venom proteomic and venomous glands transcriptomic analysis of the Egyptian scorpion Scorpio maurus palmatus (Arachnida: Scorpionidae). Toxicon (2013) 1.00
Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins. J Biol Chem (2002) 0.99
An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways. Pain (2013) 0.98
The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function. Toxicon (2004) 0.97
Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum. Toxicon (2009) 0.97
Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins. J Biol Chem (2004) 0.97
Characterization of venom components from the scorpion Androctonus crassicauda of Turkey: peptides and genes. Toxicon (2006) 0.96
A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation. PLoS One (2013) 0.96
Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors. Br J Pharmacol (2009) 0.96
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. Toxicon (2012) 0.96
Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels. J Biol Chem (2009) 0.96
Role of GM-CSF in tolerance induction by mobilized hematopoietic progenitors. Blood (2008) 0.95
Four disulfide-bridged scorpion beta neurotoxin CssII: heterologous expression and proper folding in vitro. Biochim Biophys Acta (2007) 0.95
Resurgent current and voltage sensor trapping enhanced activation by a beta-scorpion toxin solely in Nav1.6 channel. Significance in mice Purkinje neurons. J Biol Chem (2006) 0.94
Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma. J Biol Chem (2014) 0.94
Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria. Toxicon (2012) 0.94
Mapping the receptor site for ergtoxin, a specific blocker of ERG channels. FEBS Lett (2002) 0.93
Sex in cheese: evidence for sexuality in the fungus Penicillium roqueforti. PLoS One (2012) 0.93
Ion channels in T lymphocytes: an update on facts, mechanisms and therapeutic targeting in autoimmune diseases. Immunol Lett (2009) 0.93
Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells. Eur J Immunol (2009) 0.92
Activation of skeletal ryanodine receptors by two novel scorpion toxins from Buthotus judaicus. J Biol Chem (2004) 0.92
KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis. J Biol Chem (2011) 0.91
Novel paradigms on scorpion toxins that affects the activating mechanism of sodium channels. Toxicon (2006) 0.91
Tendon properties in interleukin-4 and interleukin-6 knockout mice. J Biomech (2005) 0.91
New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing. J Biol Chem (2012) 0.91
Developmental switch of the expression of ion channels in human dendritic cells. J Immunol (2009) 0.91
Toxin gamma from Tityus serrulatus scorpion venom plays an essential role in immunomodulation of macrophages. Toxicon (2007) 0.91
CD3zeta expression and T cell proliferation are inhibited by TGF-beta1 and IL-10 in cervical cancer patients. J Clin Immunol (2009) 0.91
A large number of novel Ergtoxin-like genes and ERG K+-channels blocking peptides from scorpions of the genus Centruroides. FEBS Lett (2002) 0.90
Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum. Toxicon (2008) 0.90
Species diversity and peptide toxins blocking selectivity of ether-a-go-go-related gene subfamily K+ channels in the central nervous system. Mol Pharmacol (2006) 0.90
General biochemical and immunological characterization of the venom from the scorpion Tityus trivittatus of Argentina. Toxicon (2009) 0.90
A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3. FEBS Lett (2012) 0.90
Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities. Biochim Biophys Acta (2002) 0.90
Conjugated bilirubin affects cytokine profiles in hepatitis A virus infection by modulating function of signal transducer and activator of transcription factors. Immunology (2014) 0.90
Wide phylogenetic distribution of Scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of "orphan" components. Peptides (2006) 0.90
Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes. PLoS One (2013) 0.89
The change of the scFv into the Fab format improves the stability and in vivo toxin neutralization capacity of recombinant antibodies. Mol Immunol (2006) 0.89
Global transcriptome analysis of the scorpion Centruroides noxius: new toxin families and evolutionary insights from an ancestral scorpion species. PLoS One (2012) 0.89
Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J (2007) 0.89
An insecticidal peptide from the theraposid Brachypelma smithi spider venom reveals common molecular features among spider species from different genera. Peptides (2008) 0.89
Shaping synaptic plasticity: the role of activity-mediated epigenetic regulation on gene transcription. Int J Dev Neurosci (2013) 0.89
Venom from the centipede Scolopendra viridis Say: purification, gene cloning and phylogenetic analysis of a phospholipase A2. Toxicon (2009) 0.88
TCR-dependent cell response is modulated by the timing of CD43 engagement. J Immunol (2006) 0.88
Myelin basic protein-reactive T cells induce conduction failure in vivo but not in vitro. Neuroreport (2003) 0.88
Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes. Biochemistry (2012) 0.88
Polyethylenimine improves the transfection efficiency of primary cultures of post-mitotic rat fetal hypothalamic neurons. J Neurosci Methods (2003) 0.88
Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors. Pharmaceuticals (Basel) (2010) 0.88
On the evolution of invertebrate defensins. Trends Genet (2005) 0.88
Calcium gradients in conifer pollen tubes; dynamic properties differ from those seen in angiosperms. J Exp Bot (2005) 0.88
The CD43 coreceptor molecule recruits the zeta-chain as part of its signaling pathway. J Immunol (2003) 0.87
Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release. J Neurosci (2002) 0.87
The Cuban scorpion Rhopalurus junceus (Scorpiones, Buthidae): component variations in venom samples collected in different geographical areas. J Venom Anim Toxins Incl Trop Dis (2013) 0.87
Long-term follow-up after cyclophosphamide and cyclosporine-A therapy in steroid-dependent and -resistant nephrotic syndrome. Pediatr Nephrol (2008) 0.87
Potassium channel expression in human CD4+ regulatory and naïve T cells from healthy subjects and multiple sclerosis patients. Immunol Lett (2009) 0.86
Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins. Proteomics (2006) 0.86
Two new scorpion toxins that target voltage-gated Ca2+ and Na+ channels. Biochem Biophys Res Commun (2002) 0.86
Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins. J Chromatogr B Analyt Technol Biomed Life Sci (2004) 0.86