Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

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Published in Cell on November 14, 2003

Authors

Jérôme Feldmann1, Isabelle Callebaut, Graça Raposo, Stéphanie Certain, Delphine Bacq, Cécile Dumont, Nathalie Lambert, Marie Ouachée-Chardin, Gaëlle Chedeville, Hannah Tamary, Véronique Minard-Colin, Etienne Vilmer, Stéphane Blanche, Françoise Le Deist, Alain Fischer, Geneviève de Saint Basile

Author Affiliations

1: INSERM U429, Hôpital Necker-Enfants Malades, 75743 Paris, France.

Associated clinical trials:

Pilot Study of Etoposide-based Therapy and Hematopoietic Cell Transplantation for Hemophagocytic Lymphohistiocytosis (HELA2012) | NCT01547143

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