Published in Cell on November 14, 2003
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A new DAF-16 isoform regulates longevity. Nature (2010) 1.49
Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. PLoS Biol (2008) 1.47
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Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans. Neurobiol Aging (2008) 1.44
Spontaneous age-related neurite branching in Caenorhabditis elegans. J Neurosci (2011) 1.44
PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity. Cell (2013) 1.38
Transcriptional responses to pathogens in Caenorhabditis elegans. Curr Opin Microbiol (2008) 1.38
The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans. Aging Cell (2008) 1.37
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Quantitative in vivo redox sensors uncover oxidative stress as an early event in life. Mol Cell (2012) 1.34
DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics (2008) 1.34
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DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol (2013) 1.30
Profiling synaptic proteins identifies regulators of insulin secretion and lifespan. PLoS Genet (2008) 1.30
The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO. Cell Metab (2012) 1.29
The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. PLoS Biol (2010) 1.29
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C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline. PLoS One (2012) 1.26
Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity. Cell Host Microbe (2009) 1.25
Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz. PLoS Genet (2009) 1.25
Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans. BMC Microbiol (2012) 1.24
New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals. Aging Cell (2011) 1.24
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The insulin signaling cascade from nematodes to mammals: insights into innate immunity of Anopheles mosquitoes to malaria parasite infection. Dev Comp Immunol (2006) 1.21
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Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs. Dev Biol (2006) 1.11
Insulin regulates aging and oxidative stress in Anopheles stephensi. J Exp Biol (2008) 1.11
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PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism. PLoS Genet (2011) 1.10
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell (2015) 1.10
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EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity. Cell Metab (2010) 1.10
Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis. Antioxid Redox Signal (2013) 1.09
Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity. Genetics (2008) 1.09
Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature (2014) 1.06
Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep (2013) 1.06
A decline in p38 MAPK signaling underlies immunosenescence in Caenorhabditis elegans. PLoS Genet (2011) 1.06
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Promoting longevity by maintaining metabolic and proliferative homeostasis. J Exp Biol (2014) 1.05
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature (2003) 14.49
Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science (2003) 8.43
Rates of behavior and aging specified by mitochondrial function during development. Science (2002) 6.28
Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics (2002) 5.52
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet (2008) 4.93
Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet (2004) 4.77
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet (2005) 4.18
Timing requirements for insulin/IGF-1 signaling in C. elegans. Science (2002) 4.06
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science (2002) 3.85
Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron (2004) 3.56
Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS Biol (2010) 3.36
Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling. Cell (2006) 2.63
Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol (2010) 2.55
Mutations that increase the life span of C. elegans inhibit tumor growth. Science (2006) 2.48
Healthy animals with extreme longevity. Science (2003) 2.34
Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans. Curr Biol (2009) 2.22
Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab (2009) 2.20
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat Genet (2007) 2.17
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.79
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A (2010) 1.78
Waning immunity to pertussis following 5 doses of DTaP. Pediatrics (2013) 1.58
A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans. PLoS Genet (2009) 1.52
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Proc Natl Acad Sci U S A (2007) 1.46
Spontaneous age-related neurite branching in Caenorhabditis elegans. J Neurosci (2011) 1.44
The zinc finger protein REF-2 functions with the Hox genes to inhibit cell fusion in the ventral epidermis of C. elegans. Development (2002) 1.42
Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell Metab (2013) 1.37
Multiplexed target detection using DNA-binding dye chemistry in droplet digital PCR. Anal Chem (2013) 1.35
Caenorhabditis elegans integrates food and reproductive signals in lifespan determination. Aging Cell (2007) 1.31
The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. PLoS Biol (2010) 1.29
A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. Proc Natl Acad Sci U S A (2011) 1.28
A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet (2009) 1.27
New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals. Aging Cell (2011) 1.24
A steroid hormone that extends the lifespan of Caenorhabditis elegans. Aging Cell (2007) 1.17
Identification of genes that regulate a left-right asymmetric neuronal migration in Caenorhabditis elegans. Genetics (2003) 1.11
Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity. Genetics (2008) 1.09
The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development. Development (2005) 1.06
Sexual dysfunction in the older woman: an overview of the current understanding and management. Drugs Aging (2004) 1.06
Enrichment of regulatory motifs upstream of predicted DAF-16 targets. Nat Genet (2006) 0.97
Stimulation of movement in a quiescent, hibernation-like form of Caenorhabditis elegans by dopamine signaling. J Neurosci (2009) 0.95
The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts. Dev Biol (2011) 0.91
Notes from the Field: Measles Transmission in an International Airport at a Domestic Terminal Gate--April-May 2014. MMWR Morb Mortal Wkly Rep (2015) 0.91
A shift to organismal stress resistance in programmed cell death mutants. PLoS Genet (2013) 0.89
Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89
The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans. J Cell Sci (2013) 0.88
Rubella contact tracing associated with air travel. Travel Med Infect Dis (2011) 0.86
Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans. PLoS Genet (2012) 0.86
The role of androgens in hormone replacement therapy. Expert Opin Pharmacother (2005) 0.80
Atypical Presentations of Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6--Minnesota, 2014. MMWR Morb Mortal Wkly Rep (2015) 0.78
Sexual side effects of SSRI medications: potential treatment strategies for SSRI-induced female sexual dysfunction. Curr Womens Health Rep (2002) 0.77
QnAs with Cynthia Kenyon. Proc Natl Acad Sci U S A (2011) 0.76
Impact of pelvic floor disorders and prolapse on female sexual function and response. Urol Clin North Am (2002) 0.75
Safety and efficacy of topical nitroglycerin for treatment of vulvar pain in women with vulvodynia: a pilot study. J Gend Specif Med (2002) 0.75
Predictors of Pertussis Polymerase Chain Reaction Positive Results in Minnesota, 2005-2009. Pediatr Infect Dis J (2015) 0.75
Measles Outbreak - Minnesota April-May 2017. MMWR Morb Mortal Wkly Rep (2017) 0.75
Risk Factors Associated with Bordetella pertussis among Infants Aged ≤4 Months in the pre-Tdap Era - United States, 2002-2005. Pediatr Infect Dis J (2016) 0.75