Published in Science on May 16, 2003
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Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab (2010) 1.46
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PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity. Cell (2013) 1.38
Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system. J Neurosci (2012) 1.36
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Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans. PLoS Pathog (2009) 1.35
DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics (2008) 1.34
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HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity. Cell (2012) 1.32
Caenorhabditis elegans genomic response to soil bacteria predicts environment-specific genetic effects on life history traits. PLoS Genet (2009) 1.31
Ageing in a eusocial insect: molecular and physiological characteristics of life span plasticity in the honey bee. Funct Ecol (2008) 1.31
Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans. PLoS Biol (2012) 1.29
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Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet (2012) 1.28
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A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet (2009) 1.27
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Comparison of the small heat shock proteins alphaB-crystallin, MKBP, HSP25, HSP20, and cvHSP in heart and skeletal muscle. Histochem Cell Biol (2004) 1.26
Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity. Cell Host Microbe (2009) 1.25
Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest (2012) 1.25
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature (2003) 14.49
Rates of behavior and aging specified by mitochondrial function during development. Science (2002) 6.28
Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics (2002) 5.52
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell (2003) 5.39
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet (2008) 4.93
Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet (2004) 4.77
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet (2005) 4.18
Timing requirements for insulin/IGF-1 signaling in C. elegans. Science (2002) 4.06
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science (2002) 3.85
Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron (2004) 3.56
Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS Biol (2010) 3.36
Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling. Cell (2006) 2.63
Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol (2010) 2.55
Mutations that increase the life span of C. elegans inhibit tumor growth. Science (2006) 2.48
Healthy animals with extreme longevity. Science (2003) 2.34
Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell (2009) 2.32
Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans. Curr Biol (2009) 2.22
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Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. PLoS Biol (2010) 2.18
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat Genet (2007) 2.17
Mating induces shrinking and death in Caenorhabditis mothers. Science (2013) 1.93
The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol (2007) 1.89
TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance. Cell (2010) 1.86
The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genet (2011) 1.82
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.79
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A (2010) 1.78
Waning immunity to pertussis following 5 doses of DTaP. Pediatrics (2013) 1.58
TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. PLoS Genet (2009) 1.54
A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans. PLoS Genet (2009) 1.52
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Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Proc Natl Acad Sci U S A (2007) 1.46
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The zinc finger protein REF-2 functions with the Hox genes to inhibit cell fusion in the ventral epidermis of C. elegans. Development (2002) 1.42
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Caenorhabditis elegans integrates food and reproductive signals in lifespan determination. Aging Cell (2007) 1.31
The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. PLoS Biol (2010) 1.29
A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. Proc Natl Acad Sci U S A (2011) 1.28
A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet (2009) 1.27
New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals. Aging Cell (2011) 1.24
A steroid hormone that extends the lifespan of Caenorhabditis elegans. Aging Cell (2007) 1.17
EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan. EMBO J (2011) 1.13
Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. Dev Dyn (2010) 1.12
Identification of genes that regulate a left-right asymmetric neuronal migration in Caenorhabditis elegans. Genetics (2003) 1.11
Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity. Genetics (2008) 1.09
The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development. Development (2005) 1.06
The role of insulin/IGF-like signaling in C. elegans longevity and aging. Dis Model Mech (2010) 1.02
Enrichment of regulatory motifs upstream of predicted DAF-16 targets. Nat Genet (2006) 0.97
Stimulation of movement in a quiescent, hibernation-like form of Caenorhabditis elegans by dopamine signaling. J Neurosci (2009) 0.95
The Intersection of Aging, Longevity Pathways, and Learning and Memory in C. elegans. Front Genet (2012) 0.91
Notes from the Field: Measles Transmission in an International Airport at a Domestic Terminal Gate--April-May 2014. MMWR Morb Mortal Wkly Rep (2015) 0.91
The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts. Dev Biol (2011) 0.91
A shift to organismal stress resistance in programmed cell death mutants. PLoS Genet (2013) 0.89
Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89
The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans. J Cell Sci (2013) 0.88
Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans. PLoS Genet (2012) 0.86
Rubella contact tracing associated with air travel. Travel Med Infect Dis (2011) 0.86
Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms. Genesis (2011) 0.85
A new system for comparative functional genomics of Saccharomyces yeasts. Genetics (2013) 0.81
Atypical Presentations of Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6--Minnesota, 2014. MMWR Morb Mortal Wkly Rep (2015) 0.78
A microfluidic device and automatic counting system for the study of C. elegans reproductive aging. Lab Chip (2015) 0.78
QnAs with Cynthia Kenyon. Proc Natl Acad Sci U S A (2011) 0.76
DAF-16 and PQM-1: partners in longevity. Aging (Albany NY) (2014) 0.75
Risk Factors Associated with Bordetella pertussis among Infants Aged ≤4 Months in the pre-Tdap Era - United States, 2002-2005. Pediatr Infect Dis J (2016) 0.75
Measles Outbreak - Minnesota April-May 2017. MMWR Morb Mortal Wkly Rep (2017) 0.75
Predictors of Pertussis Polymerase Chain Reaction Positive Results in Minnesota, 2005-2009. Pediatr Infect Dis J (2015) 0.75