Published in Nature on November 20, 2003
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature (2009) 3.36
Genetic regulation of pituitary gland development in human and mouse. Endocr Rev (2009) 2.02
Regulation of the innate immune response by threonine-phosphatase of Eyes absent. Nature (2009) 1.69
Epigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations. Ann Surg Oncol (2011) 1.50
Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. J Biol Chem (2009) 1.38
Drosophila follicle cells: morphogenesis in an eggshell. Semin Cell Dev Biol (2008) 1.36
Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless. Genome Res (2006) 1.32
A Porphyromonas gingivalis haloacid dehalogenase family phosphatase interacts with human phosphoproteins and is important for invasion. Proc Natl Acad Sci U S A (2006) 1.31
Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2. Dev Cell (2012) 1.30
The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells. Oncogene (2010) 1.28
The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression. Pharmacol Ther (2006) 1.27
Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent. Dev Biol (2007) 1.23
A novel plant cysteine protease has a dual function as a regulator of 1-aminocyclopropane-1-carboxylic Acid synthase gene expression. Plant Cell (2005) 1.21
Eye evolution: common use and independent recruitment of genetic components. Philos Trans R Soc Lond B Biol Sci (2009) 1.20
Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol (2005) 1.17
Eya4-deficient mice are a model for heritable otitis media. J Clin Invest (2008) 1.16
The Eyes Absent proteins in development and disease. Cell Mol Life Sci (2012) 1.16
Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm. Dev Cell (2009) 1.10
The molecular circuitry governing retinal determination. Biochim Biophys Acta (2008) 1.10
Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. Oncogene (2009) 1.10
Targeting protein tyrosine phosphatases for anticancer drug discovery. Curr Pharm Des (2010) 1.10
Retinal differentiation in Drosophila. Wiley Interdiscip Rev Dev Biol (2012) 1.08
Sine oculis, a member of the SIX family of transcription factors, directs eye formation. Dev Biol (2006) 1.05
Dual transcriptional activities of SIX proteins define their roles in normal and ectopic eye development. Development (2012) 1.05
Modular evolution of phosphorylation-based signalling systems. Philos Trans R Soc Lond B Biol Sci (2012) 1.02
The EYA-SO/SIX complex in development and disease. Pediatr Nephrol (2012) 0.96
Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome. Nat Struct Mol Biol (2013) 0.96
Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development. Mol Cell Biol (2010) 0.95
The SIX1-EYA transcriptional complex as a therapeutic target in cancer. Expert Opin Ther Targets (2015) 0.94
My what big eyes you have: how the Drosophila retina grows. Dev Neurobiol (2011) 0.94
Novel method for high throughput DNA methylation marker evaluation using PNA-probe library hybridization and MALDI-TOF detection. Nucleic Acids Res (2006) 0.94
Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations. J Biol Chem (2009) 0.93
distal antenna and distal antenna-related function in the retinal determination network during eye development in Drosophila. Dev Biol (2007) 0.92
Drosophila nemo promotes eye specification directed by the retinal determination gene network. Genetics (2008) 0.92
WSTF does it all: a multifunctional protein in transcription, repair, and replication. Biochem Cell Biol (2011) 0.92
Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor. FASEB J (2009) 0.88
Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif. PLoS One (2012) 0.88
The retinal determination gene eyes absent is regulated by the EGF receptor pathway throughout development in Drosophila. Genetics (2009) 0.87
Pleiotropic effects in Eya3 knockout mice. BMC Dev Biol (2008) 0.86
A phosphotyrosine switch determines the antitumor activity of ERβ. J Clin Invest (2014) 0.86
Atypical protein phosphatases: emerging players in cellular signaling. Int J Mol Sci (2013) 0.86
Arabidopsis carboxyl-terminal domain phosphatase-like isoforms share common catalytic and interaction domains but have distinct in planta functions. Plant Physiol (2006) 0.85
The EYA tyrosine phosphatase activity is pro-angiogenic and is inhibited by benzbromarone. PLoS One (2012) 0.84
The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition. Mol Cell Biol (2012) 0.84
EYA1 mutations associated with the branchio-oto-renal syndrome result in defective otic development in Xenopus laevis. Biol Cell (2010) 0.84
Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration. J Biol Chem (2014) 0.84
Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity. J Biomol Screen (2012) 0.83
MAPK target sites of eyes absent are not required for eye development or survival in Drosophila. PLoS One (2012) 0.83
Transcriptional regulation of cranial sensory placode development. Curr Top Dev Biol (2015) 0.82
Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities. J Biol Chem (2013) 0.82
Structure and catalytic mechanism of human protein tyrosine phosphatome. BMB Rep (2012) 0.82
Eyes absent tyrosine phosphatase activity is not required for Drosophila development or survival. PLoS One (2013) 0.82
Distribution and function of splash, an achaete-scute homolog in the adult olfactory organ of the Caribbean spiny lobster Panulirus argus. Dev Neurobiol (2011) 0.81
Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination. Dev Biol (2012) 0.81
Distinct Biochemical Activities of Eyes absent During Drosophila Eye Development. Sci Rep (2016) 0.80
Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS. J Biol Chem (2015) 0.80
The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis. Dev Cell (2015) 0.80
Structure-activity relationships of benzbromarone metabolites and derivatives as EYA inhibitory anti-angiogenic agents. PLoS One (2013) 0.79
Biochemical and molecular analysis of LePS2;1: a phosphate starvation induced protein phosphatase gene from tomato. Planta (2008) 0.79
Multiple Functions of the Eya Phosphotyrosine Phosphatase. Mol Cell Biol (2015) 0.78
EYA1's conformation-specificity in dephosphorylating phosphothreonine in Myc and its activity on Myc stabilization in breast cancer. Mol Cell Biol (2016) 0.78
The PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway. Oncogene (2014) 0.77
The Eye Specification Network in Drosophila. Proc Indian Natl Sci Acad B Biol Sci (2004) 0.77
The canonical wnt signal restricts the glycogen synthase kinase 3/fbw7-dependent ubiquitination and degradation of eya1 phosphatase. Mol Cell Biol (2014) 0.77
Time course and side-by-side analysis of mesodermal, pre-myogenic, myogenic and differentiated cell markers in the chicken model for skeletal muscle formation. J Anat (2015) 0.77
Bacterial Virulence Factors: Secreted for Survival. Indian J Microbiol (2016) 0.77
Signal transduction: an eye on organ development. Nature (2003) 0.76
A potent and selective inhibitor for the UBLCP1 proteasome phosphatase. Bioorg Med Chem (2015) 0.76
BOR-syndrome-associated Eya1 mutations lead to enhanced proteasomal degradation of Eya1 protein. PLoS One (2014) 0.75
Retinal Expression of the Drosophila eyes absent Gene Is Controlled by Several Cooperatively Acting Cis-regulatory Elements. PLoS Genet (2016) 0.75
Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila. Genetics (2016) 0.75
Gene Expression Data from the Moon Jelly, Aurelia, Provide Insights into the Evolution of the Combinatorial Code Controlling Animal Sense Organ Development. PLoS One (2015) 0.75
Epigenetic Silencing of Eyes Absent 4 Gene by Acute Myeloid Leukemia 1-Eight-twenty-one Oncoprotein Contributes to Leukemogenesis in t(8;21) Acute Myeloid Leukemia. Chin Med J (Engl) (2016) 0.75
The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review). Int J Mol Med (2017) 0.75
InterPro: the integrative protein signature database. Nucleic Acids Res (2008) 25.07
The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res (2003) 24.72
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell (2002) 18.22
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol (2004) 16.83
The TIGRFAMs database of protein families. Nucleic Acids Res (2003) 13.59
InterPro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res (2011) 13.45
New developments in the InterPro database. Nucleic Acids Res (2007) 12.49
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature (2009) 11.46
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature (2002) 8.92
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell (2009) 6.55
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature (2008) 6.24
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet (2010) 6.10
Genome Properties: a system for the investigation of prokaryotic genetic content for microbiology, genome annotation and comparative genomics. Bioinformatics (2004) 5.91
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell (2003) 5.71
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell (2003) 5.21
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proc Natl Acad Sci U S A (2009) 5.15
A public genome-scale lentiviral expression library of human ORFs. Nat Methods (2011) 4.98
A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection. Cell (2009) 4.98
The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. J Clin Invest (2011) 4.41
Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet (2006) 4.23
TIGRFAMs and Genome Properties in 2013. Nucleic Acids Res (2012) 3.45
Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays. Nat Methods (2006) 3.29
Genomic insights to SAR86, an abundant and uncultivated marine bacterial lineage. ISME J (2011) 2.97
Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils. Appl Environ Microbiol (2009) 2.75
The SANT domain: a unique histone-tail-binding module? Nat Rev Mol Cell Biol (2004) 2.63
Proteomic and genetic approaches identify Syk as an AML target. Cancer Cell (2009) 2.39
Biological functions of the ISWI chromatin remodeling complex NURF. Genes Dev (2002) 2.37
Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic. BMC Biol (2006) 2.35
Signaling circuitries in development: insights from the retinal determination gene network. Development (2005) 1.94
Signal integration during development: insights from the Drosophila eye. Dev Dyn (2004) 1.90
Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk. Crit Rev Biochem Mol Biol (2006) 1.82
Post-translational modifications influence transcription factor activity: a view from the ETS superfamily. Bioessays (2005) 1.67
The Drosophila nucleosome remodeling factor NURF is required for Ecdysteroid signaling and metamorphosis. Genes Dev (2005) 1.60
Derepression by depolymerization; structural insights into the regulation of Yan by Mae. Cell (2004) 1.59
Glutamine deamidation destabilizes human gammaD-crystallin and lowers the kinetic barrier to unfolding. J Biol Chem (2006) 1.52
The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila. Curr Biol (2004) 1.51
The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription. Annu Rev Biochem (2007) 1.40
CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE. Development (2003) 1.27
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. Cell (2012) 1.26
Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus. Nat Biotechnol (2007) 1.25
Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentus. J Bacteriol (2006) 1.23
Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent. Dev Biol (2007) 1.23
CK1epsilon is required for breast cancers dependent on beta-catenin activity. PLoS One (2010) 1.22
New vision from Eyes absent: transcription factors as enzymes. Trends Genet (2005) 1.21
Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network. Mol Cell Biol (2003) 1.16
Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm. Dev Cell (2009) 1.10
Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification. J Bacteriol (2011) 1.09
Function of the ETS transcription factor Yan in border cell migration. Development (2005) 1.08
MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN. Mech Dev (2004) 1.04
Intersection of signal transduction pathways and development. Annu Rev Genet (2006) 1.03
Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives. Development (2010) 1.02
Whole genome analysis of Leptospira licerasiae provides insight into leptospiral evolution and pathogenicity. PLoS Negl Trop Dis (2012) 1.02
ProPhylo: partial phylogenetic profiling to guide protein family construction and assignment of biological process. BMC Bioinformatics (2011) 1.00
Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor Yan. Mol Cell Biol (2010) 1.00
X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily. Biochemistry (2004) 0.97
The relationship between long-range chromatin occupancy and polymerization of the Drosophila ETS family transcriptional repressor Yan. Genetics (2012) 0.94
Splits ends is a tissue/promoter specific regulator of Wingless signaling. Development (2003) 0.93
The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells. Development (2014) 0.92
Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development. Mech Dev (2007) 0.92
Characterization of the split ends-like gene spenito reveals functional antagonism between SPOC family members during Drosophila eye development. Genetics (2006) 0.86
3D chromatin interactions organize Yan chromatin occupancy and repression at the even-skipped locus. Genes Dev (2013) 0.86
Targeting Drosophila eye development. Genome Biol (2006) 0.83
The novel plant homeodomain protein rhinoceros antagonizes Ras signaling in the Drosophila eye. Genetics (2003) 0.83
Molecular genetics of spinocerebellar ataxia type 8 (SCA8). RNA Biol (2005) 0.82
Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination. Dev Biol (2012) 0.81
The Abelson tyrosine kinase regulates Notch endocytosis and signaling to maintain neuronal cell fate in Drosophila photoreceptors. Development (2012) 0.81
Maternal dietary intake during pregnancy has longstanding consequences for the health of her offspring. Can J Physiol Pharmacol (2013) 0.80
The SAM domain of human TEL2 can abrogate transcriptional output from TEL1 (ETV-6) and ETS1/ETS2. PLoS One (2012) 0.78
Abelson tyrosine kinase is required for Drosophila photoreceptor morphogenesis and retinal epithelial patterning. Dev Dyn (2011) 0.78
Preparation of soluble GST fusion proteins. Cold Spring Harb Protoc (2009) 0.77
New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function. Genesis (2004) 0.76
Chromatin occupancy patterns of the ETS repressor Yan: a mechanism for buffering gene expression against noise? Fly (Austin) (2013) 0.75
Antibody staining of Drosophila tissues--helpful hints. CSH Protoc (2008) 0.75
Dot blot assay for determining fusion protein antiserum quality. Cold Spring Harb Protoc (2011) 0.75
Determining fusion protein antiserum quality by staining of transfected Drosophila S2 cultured cells. Cold Spring Harb Protoc (2011) 0.75
Preparation of insoluble GST fusion proteins. Cold Spring Harb Protoc (2009) 0.75
Streamlined protocol for antibody staining of large numbers of samples in Drosophila. CSH Protoc (2008) 0.75