Published in Nat Immunol on November 30, 2003
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol (2010) 3.51
Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. J Exp Med (2006) 3.16
Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J Exp Med (2004) 2.76
Control systems and decision making for antibody production. Nat Immunol (2010) 2.60
Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization. J Exp Med (2005) 2.51
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol (2009) 2.29
High affinity germinal center B cells are actively selected into the plasma cell compartment. J Exp Med (2006) 2.19
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Plasma cell-specific transcription factor XBP-1s binds to and transactivates the Epstein-Barr virus BZLF1 promoter. J Virol (2007) 1.31
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B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion. J Exp Med (2006) 1.21
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The kinetics and phenotype of the human B-cell response following immunization with a heptavalent pneumococcal-CRM conjugate vaccine. Immunology (2006) 1.14
Differential requirement for OBF-1 during antibody-secreting cell differentiation. J Exp Med (2005) 1.10
Vitamin A and immune function: retinoic acid modulates population dynamics in antigen receptor and CD38-stimulated splenic B cells. Proc Natl Acad Sci U S A (2005) 1.09
Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor alpha chain expression on activated B cells. J Exp Med (2008) 1.06
Interleukin-5 regulates genes involved in B-cell terminal maturation. Immunology (2006) 1.03
Differential binding of Escherichia coli enterotoxins LT-IIa and LT-IIb and of cholera toxin elicits differences in apoptosis, proliferation, and activation of lymphoid cells. Infect Immun (2005) 1.02
CD98hc facilitates B cell proliferation and adaptive humoral immunity. Nat Immunol (2009) 1.00
The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation. J Exp Med (2014) 1.00
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Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity. Nat Commun (2013) 0.95
Intraclonal competition inhibits the formation of high-affinity antibody-secreting cells. J Immunol (2008) 0.95
B cell-specific deficiencies in mTOR limit humoral immune responses. J Immunol (2013) 0.92
Retinoic acid promotes mouse splenic B cell surface IgG expression and maturation stimulated by CD40 and IL-4. Cell Immunol (2007) 0.92
Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response. Nat Immunol (2016) 0.91
The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation. J Exp Med (2014) 0.91
A quantitative assessment of primary and secondary immune responses in cattle using a B cell ELISPOT assay. Vet Res (2008) 0.90
In vitro induction of immunoglobulin A (IgA)- and IgM-secreting plasma blasts by cholera toxin depends on T-cell help and is mediated by CD154 up-regulation and inhibition of gamma interferon synthesis. Infect Immun (2007) 0.90
Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation. Nat Immunol (2016) 0.88
Quantal and graded stimulation of B lymphocytes as alternative strategies for regulating adaptive immune responses. Nat Commun (2013) 0.87
Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G. Mol Cell Biol (2006) 0.85
Predicting CD62L expression during the CD8+ T-cell response in vivo. Immunol Cell Biol (2009) 0.84
Targeting plasma cells in autoimmune diseases. J Exp Med (2004) 0.84
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Matrix M(TM) adjuvanted virosomal H5N1 vaccine induces balanced Th1/Th2 CD4(+) T cell responses in man. Hum Vaccin Immunother (2014) 0.82
Inhibition of cyclooxygenase-2 impairs the expression of essential plasma cell transcription factors and human B-lymphocyte differentiation. Immunology (2010) 0.81
Oct2 and Obf1 as Facilitators of B:T Cell Collaboration during a Humoral Immune Response. Front Immunol (2014) 0.81
RNA-binding protein hnRNPLL regulates mRNA splicing and stability during B-cell to plasma-cell differentiation. Proc Natl Acad Sci U S A (2015) 0.80
A pilot study of the immune response to whole inactivated avian influenza H7N1 virus vaccine in mice. Influenza Other Respir Viruses (2009) 0.80
The Crebbp Acetyltransferase is a Haploinsufficient Tumor Suppressor in B Cell Lymphoma. Cancer Discov (2017) 0.80
Dynamic versus static biomarkers in cancer immune checkpoint blockade: unravelling complexity. Nat Rev Drug Discov (2017) 0.80
Regulatory constraints in the generation and differentiation of IgE-expressing B cells. Curr Opin Immunol (2014) 0.79
Phorbol myristate acetate, but not CD40L, induces the differentiation of CLL B cells into Ab-secreting cells. Immunol Cell Biol (2014) 0.78
Mechanisms of cell division as regulators of acute immune response. Syst Synth Biol (2014) 0.78
Transcription factors regulating B cell fate in the germinal centre. Clin Exp Immunol (2015) 0.77
Search for quantitative trait loci of atopy-associated immune responses using allergen-specific IgG1 as an "endophenotype". Hum Immunol (2007) 0.77
Modeling the dynamics of neonatal CD8(+) T-cell responses. Immunol Cell Biol (2016) 0.76
The flavors of plasma cells. Oncotarget (2015) 0.76
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Cellular and chromatin dynamics of antibody-secreting plasma cells. Wiley Interdiscip Rev Dev Biol (2015) 0.75
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Correlation between cell aggregation and antibody production in IgE-producing plasma cells. Biochem Biophys Rep (2017) 0.75
Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation. Nat Commun (2017) 0.75
T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol (2008) 5.78
T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol (2004) 5.53
Follicular B helper T cells in antibody responses and autoimmunity. Nat Rev Immunol (2005) 4.99
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med (2008) 4.76
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med (2010) 4.04
Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum (2010) 3.76
Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med (2005) 3.62
Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. Immunol Cell Biol (2009) 3.51
Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J Immunol (2007) 3.47
Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat Immunol (2006) 3.09
FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immunol (2007) 3.04
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells. J Clin Invest (2003) 2.87
Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity (2010) 2.79
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. J Exp Med (2003) 2.77
Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J Exp Med (2004) 2.76
Normalization of boutique two-color microarrays with a high proportion of differentially expressed probes. Genome Biol (2007) 2.68
Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1. Immunity (2007) 2.61
The origins, function, and regulation of T follicular helper cells. J Exp Med (2012) 2.59
B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol (2004) 2.54
Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules. Annu Rev Immunol (2007) 2.54
CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. J Immunol (2011) 2.54
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature (2009) 2.54
SLAM family receptors and SAP adaptors in immunity. Annu Rev Immunol (2011) 2.52
Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization. J Exp Med (2005) 2.51
Mcl-1 is essential for germinal center formation and B cell memory. Science (2010) 2.42
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med (2010) 2.42
Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity (2013) 2.37
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol (2009) 2.29
Persistence of naive CD45RA+ regulatory T cells in adult life. Blood (2005) 2.27
NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation. J Immunol (2007) 2.26
Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses. J Immunol (2003) 2.17
The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol (2012) 2.14
Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J Immunol (2006) 2.13
Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells. J Immunol (2009) 2.09
Measuring lymphocyte proliferation, survival and differentiation using CFSE time-series data. Nat Protoc (2007) 2.04
Lyn tyrosine kinase: accentuating the positive and the negative. Immunity (2005) 2.01
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol (2007) 1.97
Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity. J Immunol (2006) 1.96
Germinal center B and follicular helper T cells: siblings, cousins or just good friends? Nat Immunol (2011) 1.95
Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses. Nat Immunol (2011) 1.94
Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells. J Clin Invest (2005) 1.92
B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells. J Exp Med (2003) 1.89
Activation-induced B cell fates are selected by intracellular stochastic competition. Science (2012) 1.84
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med (2011) 1.79
B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells. J Exp Med (2011) 1.78
Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets. Blood (2010) 1.75
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The genetic network controlling plasma cell differentiation. Semin Immunol (2011) 1.66
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1. J Exp Med (2012) 1.65
Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow. Blood (2010) 1.63
Functional STAT3 deficiency compromises the generation of human T follicular helper cells. Blood (2012) 1.62
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A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells. J Immunol (2003) 1.53
Estimating lymphocyte division and death rates from CFSE data. Bull Math Biol (2006) 1.53
Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage. J Immunol (2005) 1.52
Division-linked differentiation can account for CD8+ T-cell phenotype in vivo. Eur J Immunol (2009) 1.51
The role of the BAFF/APRIL system in B cell homeostasis and lymphoid cancers. Curr Opin Pharmacol (2004) 1.47
Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells. J Immunol (2008) 1.45
Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease. J Clin Invest (2006) 1.44
SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells. Blood (2005) 1.44
CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers. Nat Immunol (2005) 1.43
IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J Exp Med (2010) 1.41
Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses. Proc Natl Acad Sci U S A (2007) 1.38
Isotype switching by human B cells is division-associated and regulated by cytokines. J Immunol (2002) 1.36
A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells. J Exp Med (2005) 1.35
Stochastic model of T cell proliferation: a calculus revealing IL-2 regulation of precursor frequencies, cell cycle time, and survival. J Immunol (2003) 1.35
The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes. J Immunol (2002) 1.35
A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor". J Immunol (2007) 1.34
Divide and conquer: the importance of cell division in regulating B-cell responses. Immunology (2004) 1.31
Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity. J Exp Med (2002) 1.29
Identification of Pax5 target genes in early B cell differentiation. J Immunol (2008) 1.28
Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Blood (2004) 1.28
IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo. Blood (2011) 1.28
Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP. PLoS Biol (2011) 1.27
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BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs. Proc Natl Acad Sci U S A (2010) 1.22
Activation rules: the two-signal theories of immune activation. Nat Rev Immunol (2002) 1.22
Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells. Blood (2007) 1.21