Published in J Exp Med on August 04, 2008
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell (2008) 4.13
Multiple layers of B cell memory with different effector functions. Nat Immunol (2009) 3.33
Regulation of microRNA expression and abundance during lymphopoiesis. Immunity (2010) 3.29
Origin of chromosomal translocations in lymphoid cancer. Cell (2010) 2.94
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol (2010) 2.80
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75
The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell (2009) 2.42
Estrogen directly activates AID transcription and function. J Exp Med (2009) 2.37
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation. Cell (2013) 2.06
Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med (2008) 1.78
Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense. Nat Immunol (2011) 1.74
New insights into pre-BCR and BCR signalling with relevance to B cell malignancies. Nat Rev Immunol (2013) 1.66
Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair. Proc Natl Acad Sci U S A (2010) 1.62
B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity. Cell (2014) 1.58
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A (2009) 1.50
B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers. Nat Immunol (2009) 1.41
HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Nat Immunol (2009) 1.41
Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells. Mol Cell (2011) 1.39
The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence. Proc Natl Acad Sci U S A (2009) 1.34
Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90. J Exp Med (2010) 1.33
AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity. Nat Struct Mol Biol (2009) 1.31
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes. Proc Natl Acad Sci U S A (2012) 1.26
Close proximity to Igh is a contributing factor to AID-mediated translocations. Mol Cell (2012) 1.23
Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. J Immunol (2009) 1.22
Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo. PLoS One (2008) 1.15
Regulation of Aicda expression and AID activity. Autoimmunity (2013) 1.11
Agricultural pesticide exposure and the molecular connection to lymphomagenesis. J Exp Med (2009) 1.10
Ikaros controls isotype selection during immunoglobulin class switch recombination. J Exp Med (2009) 1.10
IL-6 and MYC collaborate in plasma cell tumor formation in mice. Blood (2009) 1.07
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AID targeting is dependent on RNA polymerase II pausing. Semin Immunol (2012) 1.01
B cell TLRs and induction of immunoglobulin class-switch DNA recombination. Front Biosci (Landmark Ed) (2012) 0.99
Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes. Immunology (2009) 0.98
Regulation of B-cell development and function by microRNAs. Immunol Rev (2013) 0.95
Controlling somatic hypermutation in immunoglobulin variable and switch regions. Immunol Res (2010) 0.94
AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4. Autoimmunity (2011) 0.94
B cell-specific deficiencies in mTOR limit humoral immune responses. J Immunol (2013) 0.92
Activation-induced cytidine deaminase in antibody diversification and chromosome translocation. Adv Cancer Res (2012) 0.92
AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. PLoS One (2012) 0.89
Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age. PLoS One (2011) 0.89
Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma. Blood (2012) 0.89
p53 represses class switch recombination to IgG2a through its antioxidant function. J Immunol (2010) 0.88
Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation. Proc Natl Acad Sci U S A (2012) 0.88
Immunoglobulin class-switch recombination deficiencies. Arthritis Res Ther (2012) 0.88
Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance. Immunity (2015) 0.86
YY1 controls immunoglobulin class switch recombination and nuclear activation-induced deaminase levels. Mol Cell Biol (2012) 0.86
Mechanisms of Yin Yang 1 in oncogenesis: the importance of indirect effects. Crit Rev Oncog (2011) 0.86
Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1. EMBO J (2011) 0.85
Efficient AID targeting of switch regions is not sufficient for optimal class switch recombination. Nat Commun (2015) 0.84
The mechanisms regulating the subcellular localization of AID. Nucleus (2010) 0.84
Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity. Nat Rev Immunol (2016) 0.82
The APOBEC Protein Family: United by Structure, Divergent in Function. Trends Biochem Sci (2016) 0.82
In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression. PLoS One (2013) 0.82
Two forms of activation-induced cytidine deaminase differing in their ability to bind agarose. PLoS One (2010) 0.81
Msh6 protects mature B cells from lymphoma by preserving genomic stability. Am J Pathol (2010) 0.80
Waldenström macroglobulinemia: clinical and immunological aspects, natural history, cell of origin, and emerging mouse models. ISRN Hematol (2013) 0.79
Promising personalized therapeutic options for diffuse large B-cell Lymphoma Subtypes with oncogene addictions. Clin Cancer Res (2012) 0.79
Epigenetic function of activation-induced cytidine deaminase and its link to lymphomagenesis. Front Immunol (2014) 0.79
Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation. Biochem Soc Trans (2009) 0.79
Human lymphoid translocation fragile zones are hypomethylated and have accessible chromatin. Mol Cell Biol (2015) 0.79
Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice. J Pathol (2010) 0.79
Activation-induced cytidine deaminase and aberrant germinal center selection in the development of humoral autoimmunities. Am J Pathol (2011) 0.79
The origin of recurrent translocations in recombining lymphocytes: a balance between break frequency and nuclear proximity. Curr Opin Cell Biol (2013) 0.78
ATAD5 deficiency decreases B cell division and Igh recombination. J Immunol (2014) 0.78
Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint. J Clin Invest (2016) 0.78
Translocation of an antibody transgene requires AID and occurs by interchromosomal switching to all switch regions except the mu switch region. Eur J Immunol (2011) 0.77
Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination. Proc Natl Acad Sci U S A (2013) 0.76
AID-expressing epithelium is protected from oncogenic transformation by an NKG2D surveillance pathway. EMBO Mol Med (2015) 0.76
AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine. Oncotarget (2014) 0.76
Transgenic mouse model of IgM(+) lymphoproliferative disease mimicking Waldenström macroglobulinemia. Blood Cancer J (2016) 0.75
Anaplastic plasmacytoma of mouse--establishing parallels between subtypes of mouse and human plasma cell neoplasia. J Pathol (2010) 0.75
An efficient method to enrich for knock-out and knock-in cellular clones using the CRISPR/Cas9 system. Cell Mol Life Sci (2017) 0.75
BCL6 Overexpression Alters Gene Expression Profile in a Myeloma Cell Line and Is Associated with Decreased DNA Damage Response. Cancer Sci (2017) 0.75
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell (2000) 20.83
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell (2000) 9.99
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
Mechanism and regulation of class switch recombination. Annu Rev Immunol (2008) 5.98
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature (2001) 5.47
Two levels of protection for the B cell genome during somatic hypermutation. Nature (2008) 5.32
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity (2008) 5.03
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature (2002) 4.89
Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer (2005) 4.66
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity (2008) 4.59
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90
AID is required for c-myc/IgH chromosome translocations in vivo. Cell (2004) 3.89
In vivo imaging of germinal centres reveals a dynamic open structure. Nature (2007) 3.83
Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol Cell (2004) 3.81
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J Exp Med (2003) 3.55
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
Constitutive expression of AID leads to tumorigenesis. J Exp Med (2003) 3.16
AID is required for germinal center-derived lymphomagenesis. Nat Genet (2007) 2.79
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell (2007) 2.78
Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. J Exp Med (2004) 2.55
Regulation of AID expression in the immune response. J Exp Med (2007) 2.35
Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation. J Exp Med (2002) 2.18
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice. Nat Immunol (2004) 2.16
Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation. Nat Immunol (2003) 2.11
S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity (2007) 2.11
Neoplastic development in plasma cells. Immunol Rev (2003) 1.80
Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks. J Biol Chem (2004) 1.74
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. J Exp Med (2007) 1.70
AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization. Proc Natl Acad Sci U S A (2002) 1.47
Internal IgH class switch region deletions are position-independent and enhanced by AID expression. Proc Natl Acad Sci U S A (2002) 1.44
MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification. Mol Cell (2005) 1.43
Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. Proc Natl Acad Sci U S A (2005) 1.40
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements. J Exp Med (2007) 1.37
DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination. J Exp Med (2007) 1.30
BCL2 accelerates inflammation-induced BALB/c plasmacytomas and promotes novel tumors with coexisting T(12;15) and T(6;15) translocations. Cancer Res (2003) 0.99
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells. J Exp Med (2003) 11.08
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell (2010) 8.70
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol (2003) 8.55
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30
Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood (2008) 6.81
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
H2AX: the histone guardian of the genome. DNA Repair (Amst) (2004) 6.65
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell (2012) 6.49
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
DNA repair, genome stability, and aging. Cell (2005) 5.52
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell (2003) 5.26
Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity (2008) 4.59
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol (2006) 4.32
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29
Silencing of unsynapsed meiotic chromosomes in the mouse. Nat Genet (2004) 4.25
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol (2004) 4.14
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell (2008) 4.13
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat Immunol (2005) 4.11
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity (2007) 4.07
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol (2004) 4.04
Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell (2012) 4.02
Identification of early replicating fragile sites that contribute to genome instability. Cell (2013) 3.99
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature (2004) 3.94
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90
AID is required for c-myc/IgH chromosome translocations in vivo. Cell (2004) 3.89
The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell (2010) 3.88
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell (2011) 3.81
The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat Immunol (2005) 3.74
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell (2011) 3.65
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J Cell Biol (2006) 3.63
Interferon-γ links ultraviolet radiation to melanomagenesis in mice. Nature (2011) 3.56
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature (2008) 3.47
Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat Cell Biol (2005) 3.44
H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell (2003) 3.42
SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
Regulation of microRNA expression and abundance during lymphopoiesis. Immunity (2010) 3.29
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol (2011) 3.21
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab (2005) 3.15
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12
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Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J (2002) 2.96
Mechanism and control of class-switch recombination. Trends Immunol (2002) 2.95
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Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell (2010) 2.92
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature (2003) 2.92
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med (2002) 2.86
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol (2008) 2.85
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol (2007) 2.80
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol (2010) 2.80
Chromatin dynamics and the preservation of genetic information. Nature (2007) 2.80
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell (2007) 2.78
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74
Calorie restriction alters mitochondrial protein acetylation. Aging Cell (2009) 2.73
The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) (2004) 2.72
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CTCF-binding elements mediate control of V(D)J recombination. Nature (2011) 2.62
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Nature (2006) 2.60