Published in J Immunol on July 01, 2004
Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80
The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity (2008) 10.55
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity (2008) 9.61
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (2009) 9.22
Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity (2011) 5.98
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol (2008) 5.92
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity (2011) 5.59
Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol (2009) 5.59
New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol (2009) 5.57
SAP-controlled T-B cell interactions underlie germinal centre formation. Nature (2008) 5.14
Foxp3+ follicular regulatory T cells control the germinal center response. Nat Med (2011) 4.83
Follicular helper T cells: lineage and location. Immunity (2009) 4.75
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med (2010) 4.65
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med (2010) 4.04
Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med (2007) 3.91
Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity (2013) 3.72
Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis. Am J Respir Crit Care Med (2005) 3.72
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol (2010) 3.51
Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat Immunol (2010) 3.48
The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nat Immunol (2009) 3.44
T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med (2009) 3.40
ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J Exp Med (2008) 3.39
Characteristics of the earliest cross-neutralizing antibody response to HIV-1. PLoS Pathog (2011) 3.29
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity (2010) 3.00
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS One (2011) 2.92
Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol (2010) 2.85
Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity (2010) 2.79
B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers. Nat Med (2015) 2.69
Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination. Sci Transl Med (2013) 2.64
In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol (2010) 2.63
Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev (2010) 2.61
The origins, function, and regulation of T follicular helper cells. J Exp Med (2012) 2.59
CD4 T follicular helper cell dynamics during SIV infection. J Clin Invest (2012) 2.55
Expansion of HIV-specific T follicular helper cells in chronic HIV infection. J Clin Invest (2012) 2.55
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production. J Exp Med (2012) 2.46
Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma. Blood (2009) 2.43
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med (2009) 2.38
Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J Immunol (2012) 2.34
The good, the bad and the ugly - TFH cells in human health and disease. Nat Rev Immunol (2013) 2.33
Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. Semin Immunol (2008) 2.20
SLAM receptors and SAP influence lymphocyte interactions, development and function. Nat Rev Immunol (2009) 2.19
The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol (2012) 2.14
Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Am J Surg Pathol (2006) 2.08
IL-21 mediates suppressive effects via its induction of IL-10. J Immunol (2009) 2.00
Gene expression analysis of peripheral T cell lymphoma, unspecified, reveals distinct profiles and new potential therapeutic targets. J Clin Invest (2007) 1.97
SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J Exp Med (2006) 1.92
New insights into the differentiation and function of T follicular helper cells. Nat Rev Immunol (2009) 1.92
Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells. J Clin Invest (2005) 1.92
The effects of IL-6 on CD4 T cell responses. Clin Immunol (2008) 1.90
Follicular helper T cells in immunity and systemic autoimmunity. Nat Rev Rheumatol (2012) 1.89
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells. Immunity (2011) 1.83
Pathophysiology of T follicular helper cells in humans and mice. Nat Immunol (2015) 1.80
Follicular helper T cells as cognate regulators of B cell immunity. Curr Opin Immunol (2009) 1.77
Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis. Clin Dev Immunol (2012) 1.70
Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med (2012) 1.69
Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood (2008) 1.68
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1. J Exp Med (2012) 1.65
Signals that influence T follicular helper cell differentiation and function. Semin Immunopathol (2010) 1.62
Functional STAT3 deficiency compromises the generation of human T follicular helper cells. Blood (2012) 1.62
Follicular helper T cell signature in type 1 diabetes. J Clin Invest (2014) 1.61
IL-21 and T follicular helper cells. Int Immunol (2009) 1.54
The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Curr Opin Immunol (2008) 1.51
Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers. Proc Natl Acad Sci U S A (2011) 1.50
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature (2017) 1.50
The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells. Nat Immunol (2014) 1.49
BAFF regulates follicular helper t cells and affects their accumulation and interferon-γ production in autoimmunity. Arthritis Rheumatol (2015) 1.45
How diverse--CD4 effector T cells and their functions. J Mol Cell Biol (2009) 1.44
Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. J Immunol (2007) 1.42
Understanding the development and function of T follicular helper cells. Cell Mol Immunol (2010) 1.40
Macrophage Colony Stimulating Factor Derived from CD4+ T Cells Contributes to Control of a Blood-Borne Infection. PLoS Pathog (2016) 1.39
Harnessing CD4⁺ T cell responses in HIV vaccine development. Nat Med (2013) 1.39
Interleukin 21 signaling in B cells is required for efficient establishment of murine gammaherpesvirus latency. PLoS Pathog (2015) 1.38
The effects of TLR activation on T-cell development and differentiation. Clin Dev Immunol (2012) 1.33
Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc Natl Acad Sci U S A (2012) 1.32
IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans. Blood (2013) 1.31
Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new. Blood (2011) 1.30
Phenotype and functions of memory Tfh cells in human blood. Trends Immunol (2014) 1.28
Transcriptional regulation of follicular T-helper (Tfh) cells. Immunol Rev (2013) 1.28
Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity. J Leukoc Biol (2009) 1.28
Plasticity of human CD4 T cell subsets. Front Immunol (2014) 1.25
The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells. Nat Immunol (2014) 1.24
Circulating TFH subset distribution is strongly affected in lupus patients with an active disease. PLoS One (2013) 1.23
IL-21 induces in vivo immune activation of NK cells and CD8(+) T cells in patients with metastatic melanoma and renal cell carcinoma. Cancer Immunol Immunother (2008) 1.22
Hepatocyte transplantation-induced liver inflammation is driven by cytokines-chemokines associated with neutrophils and Kupffer cells. Gastroenterology (2009) 1.21
A brief history of T cell help to B cells. Nat Rev Immunol (2015) 1.21
Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells. J Virol (2013) 1.18
Multi-tasking of helper T cells. Immunology (2010) 1.17
Interleukin-23 and T helper 17-type responses in intestinal inflammation: from cytokines to T-cell plasticity. Immunology (2011) 1.17
Peripheral T cell lymphoma, not otherwise specified: the stuff of genes, dreams and therapies. J Clin Pathol (2008) 1.16
A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis. J Interferon Cytokine Res (2011) 1.12
B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis. Eur J Immunol (2010) 1.11
Development, regulation and functional capacities of Th17 cells. Semin Immunopathol (2010) 1.10
Regulatory T cells: immune suppression and beyond. Cell Mol Immunol (2010) 1.09
Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells. Lupus (2009) 1.08
Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression. J Exp Med (2014) 1.08
T cells that promote B-Cell maturation in systemic autoimmunity. Immunol Rev (2012) 1.06
Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program. J Immunol (2014) 1.03
Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome. J Exp Med (2010) 1.03
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature (2009) 8.71
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity (2009) 7.69
A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity (2008) 6.41
T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol (2008) 5.78
Follicular B helper T cells in antibody responses and autoimmunity. Nat Rev Immunol (2005) 4.99
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med (2008) 4.76
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. J Clin Invest (2002) 4.14
Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum (2010) 3.76
Diet, gut microbiota and immune responses. Nat Immunol (2011) 3.66
Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med (2005) 3.62
Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A (2007) 3.61
Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. Immunol Cell Biol (2009) 3.51
Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J Immunol (2007) 3.47
Functional roles for C5a receptors in sepsis. Nat Med (2008) 3.33
Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses. Nat Rev Drug Discov (2007) 2.97
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells. J Clin Invest (2003) 2.87
Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity (2010) 2.79
BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J Exp Med (2007) 2.70
Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. Nat Immunol (2008) 2.64
The origins, function, and regulation of T follicular helper cells. J Exp Med (2012) 2.59
B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol (2004) 2.54
Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules. Annu Rev Immunol (2007) 2.54
CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. J Immunol (2011) 2.54
SLAM family receptors and SAP adaptors in immunity. Annu Rev Immunol (2011) 2.52
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med (2010) 2.42
Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity (2013) 2.37
Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1. Nat Immunol (2006) 2.29
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol (2009) 2.29
Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes. Am J Pathol (2002) 2.28
Persistence of naive CD45RA+ regulatory T cells in adult life. Blood (2005) 2.27
Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J Immunol (2006) 2.13
Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation. Nat Immunol (2003) 2.11
Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity (2009) 2.09
Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells. J Immunol (2009) 2.09
Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity. J Immunol (2006) 1.96
Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses. Nat Immunol (2011) 1.94
Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells. J Clin Invest (2005) 1.92
IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood (2006) 1.79
MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines. Proc Natl Acad Sci U S A (2002) 1.79
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med (2011) 1.79
Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets. Blood (2010) 1.75
The functional plasticity of T cell subsets. Nat Rev Immunol (2009) 1.74
Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets. J Immunol (2005) 1.73
The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction. J Biol Chem (2009) 1.73
IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4. J Immunol (2008) 1.68
Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies. Nat Biotechnol (2006) 1.66
Functional STAT3 deficiency compromises the generation of human T follicular helper cells. Blood (2012) 1.62
Molecular and cellular pathogenesis of X-linked lymphoproliferative disease. Immunol Rev (2005) 1.57
The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. J Clin Invest (2006) 1.54
Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage. J Immunol (2005) 1.52
The role of the BAFF/APRIL system in B cell homeostasis and lymphoid cancers. Curr Opin Pharmacol (2004) 1.47
TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J Immunol (2004) 1.47
Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells. J Immunol (2008) 1.45
Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease. J Clin Invest (2006) 1.44
Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. Immunol Cell Biol (2008) 1.44
Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection. Blood (2003) 1.44
SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells. Blood (2005) 1.44
IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J Exp Med (2010) 1.41
The BAFF/APRIL system: life beyond B lymphocytes. Mol Immunol (2004) 1.41
MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol (2010) 1.41
Estimated folic acid intakes from simulated fortification of the New Zealand food supply. N Z Med J (2003) 1.40
Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses. Proc Natl Acad Sci U S A (2007) 1.38
PK1/EG-VEGF induces monocyte differentiation and activation. J Leukoc Biol (2005) 1.38
BAFF augments certain Th1-associated inflammatory responses. J Immunol (2005) 1.37
Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2. J Immunol (2006) 1.31
Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R. Proc Natl Acad Sci U S A (2003) 1.30
Hendra virus: an emerging paramyxovirus in Australia. Lancet Infect Dis (2012) 1.28
IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo. Blood (2011) 1.28
Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP. PLoS Biol (2011) 1.27
A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. J Exp Med (2005) 1.25
CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes. J Immunol (2006) 1.25
Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice. Arthritis Rheum (2011) 1.24
Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells. Blood (2009) 1.21
Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow. Blood (2003) 1.19
Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium. Proc Natl Acad Sci U S A (2002) 1.18
Autoimmunity: IL-21: a new player in Th17-cell differentiation. Immunol Cell Biol (2007) 1.18
DOCK8 is critical for the survival and function of NKT cells. Blood (2013) 1.17
Lineage specification and heterogeneity of T follicular helper cells. Curr Opin Immunol (2009) 1.14
Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J Exp Med (2013) 1.14
Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. Immunol Rev (2012) 1.13
Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis. J Infect Dis (2011) 1.12
Regulation of T follicular helper cell formation and function by antigen presenting cells. Curr Opin Immunol (2010) 1.11
STAT3 is required for IL-21-induced secretion of IgE from human naive B cells. Blood (2008) 1.11
Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody. Circulation (2005) 1.11