Published in Blood on December 04, 2003
Definitive-like erythroid cells derived from human embryonic stem cells coexpress high levels of embryonic and fetal globins with little or no adult globin. Blood (2006) 1.95
Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia. Nat Med (2013) 1.89
Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells. Blood (2007) 1.79
Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine. Haematologica (2010) 1.79
Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells. Blood (2009) 1.73
Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells. Biomaterials (2007) 1.72
VEGF induces differentiation of functional endothelium from human embryonic stem cells: implications for tissue engineering. Arterioscler Thromb Vasc Biol (2009) 1.57
Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors From AML Patients That Are Devoid of Patient-Specific Genomic Aberrations. Stem Cells (2015) 1.38
Diverse hematopoietic potentials of five human embryonic stem cell lines. Exp Cell Res (2008) 1.17
Establishment of mouse embryonic stem cell-derived erythroid progenitor cell lines able to produce functional red blood cells. PLoS One (2008) 1.15
Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells. Blood (2013) 1.14
Autologous blood cell therapies from pluripotent stem cells. Blood Rev (2009) 1.09
Scientific and clinical opportunities for modeling blood disorders with embryonic stem cells. Blood (2005) 0.88
Production of erythriod cells from human embryonic stem cells by fetal liver cell extract treatment. BMC Dev Biol (2010) 0.88
Plasticity of cells and ex vivo production of red blood cells. Stem Cells Int (2011) 0.88
Enhanced natural-killer cell and erythropoietic activities in VEGF-A-overexpressing mice delay F-MuLV-induced erythroleukemia. Blood (2006) 0.86
Generation and characterization of erythroid cells from human embryonic stem cells and induced pluripotent stem cells: an overview. Stem Cells Int (2011) 0.85
Multicolor staining of globin subtypes reveals impaired globin switching during erythropoiesis in human pluripotent stem cells. Stem Cells Transl Med (2014) 0.84
Transcriptome dynamics during human erythroid differentiation and development. Genomics (2013) 0.83
Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells. Int J Dev Biol (2010) 0.83
Hematopoietic differentiation of embryoid bodies derived from the human embryonic stem cell line SNUhES3 in co-culture with human bone marrow stromal cells. Yonsei Med J (2005) 0.81
Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co-express gamma and beta globins. Br J Haematol (2014) 0.81
Activin A promotes hematopoietic fated mesoderm development through upregulation of brachyury in human embryonic stem cells. Stem Cells Dev (2012) 0.81
Efficient commitment to functional CD34+ progenitor cells from human bone marrow mesenchymal stem-cell-derived induced pluripotent stem cells. PLoS One (2012) 0.80
The modern primitives: applying new technological approaches to explore the biology of the earliest red blood cells. ISRN Hematol (2013) 0.79
Human embryonic stem cells: a source of mast cells for the study of allergic and inflammatory diseases. Blood (2010) 0.78
In vitro large scale production of human mature red blood cells from hematopoietic stem cells by coculturing with human fetal liver stromal cells. Biomed Res Int (2013) 0.77
Placental growth factor attenuates suppression of erythroid colony formation by interferon. Transl Res (2008) 0.76
Activation of KLF1 Enhances the Differentiation and Maturation of Red Blood Cells from Human Pluripotent Stem Cells. Stem Cells (2016) 0.75
Induced Pluripotent Stem Cell for the Study and Treatment of Sickle Cell Anemia. Stem Cells Int (2017) 0.75
Direct conversion of human fibroblasts to multilineage blood progenitors. Nature (2010) 5.35
Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell (2012) 4.13
Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood (2003) 3.98
IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature (2007) 3.74
Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol (2003) 3.02
Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties. Immunity (2004) 2.89
Characterization of human embryonic stem cells with features of neoplastic progression. Nat Biotechnol (2009) 2.66
Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation. Nat Med (2005) 2.60
Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency. Nat Methods (2009) 2.51
Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression. J Exp Med (2005) 2.42
Clonal isolation of hESCs reveals heterogeneity within the pluripotent stem cell compartment. Nat Methods (2006) 2.31
Identification of growth factor conditions that reduce ex vivo cord blood progenitor expansion but do not alter human repopulating cell function in vivo. Haematologica (2005) 2.11
Prevention of amino acid conversion in SILAC experiments with embryonic stem cells. Mol Cell Proteomics (2008) 1.83
Human embryonic stem cells possess immune-privileged properties. Stem Cells (2004) 1.82
Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci U S A (2003) 1.72
Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A (2006) 1.71
The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation. Mol Cell Biol (2008) 1.67
Human embryonic stem cells maintained in the absence of mouse embryonic fibroblasts or conditioned media are capable of hematopoietic development. Blood (2005) 1.49
Cell fate potential of human pluripotent stem cells is encoded by histone modifications. Cell Stem Cell (2011) 1.30
Regional localization within the bone marrow influences the functional capacity of human HSCs. Cell Stem Cell (2013) 1.29
OP9 stroma augments survival of hematopoietic precursors and progenitors during hematopoietic differentiation from human embryonic stem cells. Stem Cells (2008) 1.24
Noncanonical Wnt signaling orchestrates early developmental events toward hematopoietic cell fate from human embryonic stem cells. Cell Stem Cell (2009) 1.20
Hematopoietic development from human embryonic stem cell lines. Exp Hematol (2005) 1.11
Analysis of the human fetal liver hematopoietic microenvironment. Stem Cells Dev (2005) 1.10
An enhanced mass spectrometry approach reveals human embryonic stem cell growth factors in culture. Mol Cell Proteomics (2008) 1.09
Distinguishing between mouse and human pluripotent stem cell regulation: the best laid plans of mice and men. Stem Cells (2010) 1.09
Hierarchical and ontogenic positions serve to define the molecular basis of human hematopoietic stem cell behavior. Dev Cell (2005) 1.05
Clonal interrogation of stem cells. Nat Methods (2011) 1.04
Smad7 alters cell fate decisions of human hematopoietic repopulating cells. Blood (2004) 1.02
Signal control of hematopoietic stem cell fate: Wnt, Notch, and Hedgehog as the usual suspects. Curr Opin Hematol (2008) 1.02
Clonal tracking of hESCs reveals differential contribution to functional assays. Nat Methods (2010) 1.01
Deconstructing human embryonic stem cell cultures: niche regulation of self-renewal and pluripotency. J Mol Med (Berl) (2008) 1.01
Retroviral transduction of hematopoietic cells differentiated from human embryonic stem cell-derived CD45(neg)PFV hemogenic precursors. Mol Ther (2004) 1.01
The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity. Blood (2010) 1.00
Molecular evidence for OCT4-induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors. Stem Cells (2014) 0.99
ID1 and ID3 represent conserved negative regulators of human embryonic and induced pluripotent stem cell hematopoiesis. J Cell Sci (2011) 0.98
Genetic manipulation of human embryonic stem cells: a system to study early human development and potential therapeutic applications. Curr Gene Ther (2005) 0.97
Inability of human induced pluripotent stem cell-hematopoietic derivatives to downregulate microRNAs in vivo reveals a block in xenograft hematopoietic regeneration. Stem Cells (2012) 0.96
Pluripotent human stem cell lines: what we can learn about cancer initiation. Trends Mol Med (2008) 0.96
Human embryonic stem cells: potential tool for achieving immunotolerance? Stem Cell Rev (2005) 0.96
Pluripotent transcription factors possess distinct roles in normal versus transformed human stem cells. PLoS One (2009) 0.96
Wnt3a activates dormant c-Kit(-) bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity. Stem Cells (2010) 0.92
Identification of T-lymphocytic leukemia-initiating stem cells residing in a small subset of patients with acute myeloid leukemic disease. Blood (2011) 0.92
Formation and hematopoietic differentiation of human embryoid bodies by suspension and hanging drop cultures. Curr Protoc Stem Cell Biol (2007) 0.91
Novel roles for Notch, Wnt and Hedgehog in hematopoesis derived from human pluripotent stem cells. Int J Dev Biol (2010) 0.91
Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells. Blood (2013) 0.90
In vivo generation of neural tumors from neoplastic pluripotent stem cells models early human pediatric brain tumor formation. Stem Cells (2012) 0.88
Multiparameter comparisons of embryoid body differentiation toward human stem cell applications. Stem Cell Res (2010) 0.88
Complement targeting of nonhuman sialic acid does not mediate cell death of human embryonic stem cells. Nat Med (2006) 0.88
Hematopoietic stem cell biology: too much of a Wnt thing. Nat Immunol (2006) 0.88
A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis. J Cell Sci (2005) 0.87
Activation of neural cell fate programs toward direct conversion of adult human fibroblasts into tri-potent neural progenitors using OCT-4. Stem Cells Dev (2014) 0.87
Intra-bone marrow transplantation facilitates pauci-clonal human hematopoietic repopulation of NOD/SCID/beta2m(-/-) mice. Exp Hematol (2005) 0.84
Engraftment potential of human fetal hematopoietic cells in NOD/SCID mice is not restricted to mitotically quiescent cells. Blood (2002) 0.84
Human ESC colony formation is dependent on interplay between self-renewing hESCs and unique precursors responsible for niche generation. Cytometry A (2010) 0.84
Derivation and characterization of hematopoietic cells from human embryonic stem cells. Methods Mol Biol (2006) 0.83
Differential gene expression of human stem progenitor cells derived from early stages of in utero human hematopoiesis. Blood (2003) 0.82
Human embryonic stem cell-derived hematopoietic cells maintain core epigenetic machinery of the polycomb group/Trithorax Group complexes distinctly from functional adult hematopoietic stem cells. Stem Cells Dev (2012) 0.82
Expansive generation of functional airway epithelium from human embryonic stem cells. Stem Cells Transl Med (2013) 0.82
Activin A promotes hematopoietic fated mesoderm development through upregulation of brachyury in human embryonic stem cells. Stem Cells Dev (2012) 0.81
Nonhematopoietic cells represent a more rational target of in vivo hedgehog signaling affecting normal or acute myeloid leukemia progenitors. Exp Hematol (2013) 0.81
Human embryonic stem cells: lessons from stem cell niches in vivo. Regen Med (2008) 0.81
Transplantation of human hematopoietic repopulating cells: mechanisms of regeneration and differentiation using human-mouse xenografts. Curr Opin Organ Transplant (2008) 0.80
Human embryonic-derived hematopoietic repopulating cells require distinct factors to sustain in vivo repopulating function. Exp Hematol (2002) 0.80
Emergence of muscle and neural hematopoiesis in humans. Blood (2002) 0.79
Human pluripotency: a difficult state to make smart choices. Cell Cycle (2012) 0.79
Brief report: ectopic expression of NUP98-HOXA10 augments erythroid differentiation of human embryonic stem cells. Stem Cells (2011) 0.78
Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis. Blood (2013) 0.78
Early cardiac development: a Wnt beat away. Proc Natl Acad Sci U S A (2007) 0.77
SDF-1 enhances the expansion and maintenance of highly purified human hematopoietic progenitors. Hematol J (2003) 0.77
Retroviral transduction of hematopoietic progenitors derived from human embryonic stem cells. Methods Mol Biol (2006) 0.77
Bone marrow localization and functional properties of human hematopoietic stem cells. Curr Opin Hematol (2014) 0.77
Identification of a novel population of human cord blood cells with hema-topoietic and chondrocytic potential. Cell Res (2004) 0.76
Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells. Stem Cells (2015) 0.76
Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells. Arch Pharm Res (2012) 0.76
Targeting LSCs: powering an old tool. Blood (2008) 0.76
Mickie Bhatia: Embryonic stem cells come of age. J Exp Med (2009) 0.75
[Human embryonic stem cell and haematopoiesis: comparison with the mouse]. Med Sci (Paris) (2006) 0.75
Characterization of retroviral gene transfer into highly purified human CD34(-) cells with primitive hematopoietic capacity. Mol Ther (2002) 0.75
Histone modification profiling in normal and transformed human embryonic stem cells using micro chromatin immunoprecipitation, scalable to genome-wide microarray analyses. Methods Mol Biol (2013) 0.75
Foundational concepts of cell fate conversion to the hematopoietic lineage. Curr Opin Genet Dev (2013) 0.75