Published in J Biol Chem on December 11, 2003
The trypanosome flagellar pocket. Nat Rev Microbiol (2009) 2.07
The developmental cell biology of Trypanosoma brucei. J Cell Sci (2005) 1.84
Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER. FEMS Microbiol Lett (2006) 1.65
Elucidation of clathrin-mediated endocytosis in tetrahymena reveals an evolutionarily convergent recruitment of dynamin. PLoS Genet (2005) 1.34
Mitochondrial outer membrane proteome of Trypanosoma brucei reveals novel factors required to maintain mitochondrial morphology. Mol Cell Proteomics (2012) 1.03
A genomic survey of the fish parasite Spironucleus salmonicida indicates genomic plasticity among diplomonads and significant lateral gene transfer in eukaryote genome evolution. BMC Genomics (2007) 1.01
An evolutionarily conserved coiled-coil protein implicated in polycystic kidney disease is involved in basal body duplication and flagellar biogenesis in Trypanosoma brucei. Mol Cell Biol (2005) 0.97
Origin and evolution of the chloroplast division machinery. J Plant Res (2005) 0.88
The endocytic activity of the flagellar pocket in Trypanosoma brucei is regulated by an adjacent phosphatidylinositol phosphate kinase. J Cell Sci (2014) 0.85
The double-edged sword in pathogenic trypanosomatids: the pivotal role of mitochondria in oxidative stress and bioenergetics. Biomed Res Int (2014) 0.85
Mitochondrial shape and function in trypanosomes requires the outer membrane protein, TbLOK1. Mol Microbiol (2013) 0.84
The cell biology of the endocytic system from an evolutionary perspective. Cold Spring Harb Perspect Biol (2014) 0.84
Stem-loop silencing reveals that a third mitochondrial DNA polymerase, POLID, is required for kinetoplast DNA replication in trypanosomes. Eukaryot Cell (2008) 0.83
Ancient dynamin segments capture early stages of host-mitochondrial integration. Proc Natl Acad Sci U S A (2015) 0.82
Identification and characterization of an unusual class I myosin involved in vesicle traffic in Trypanosoma brucei. PLoS One (2010) 0.81
Identification and partial characterization of a dynamin-like protein, EhDLP1, from the protist parasite Entamoeba histolytica. Eukaryot Cell (2009) 0.80
Proteomics on the rims: insights into the biology of the nuclear envelope and flagellar pocket of trypanosomes. Parasitology (2012) 0.79
Toxoplasma gondii Syntaxin 6 is required for vesicular transport between endosomal-like compartments and the Golgi complex. Traffic (2013) 0.79
Interaction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteins. Cell Logist (2014) 0.78
New insights into the molecular mechanisms of mitosis and cytokinesis in trypanosomes. Int Rev Cell Mol Biol (2014) 0.77
Glycolysis in the african trypanosome: targeting enzymes and their subcellular compartments for therapeutic development. Mol Biol Int (2011) 0.77
A dynamin-related protein contributes to Trichomonas vaginalis hydrogenosomal fission. FASEB J (2013) 0.77
An Interactome-Centered Protein Discovery Approach Reveals Novel Components Involved in Mitosome Function and Homeostasis in Giardia lamblia. PLoS Pathog (2016) 0.76
Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression. Nucleic Acids Res (2016) 0.76
Conservation and divergence within the clathrin interactome of Trypanosoma cruzi. Sci Rep (2016) 0.76
Mitochondrial Proteomics of Antimony and Miltefosine Resistant Leishmania infantum. Proteomes (2015) 0.75
Constriction by Dynamin: Elasticity versus Adhesion. Biophys J (2016) 0.75
Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum. BMC Biol (2017) 0.75
Mitochondrial growth during the cell cycle of Trypanosoma brucei bloodstream forms. Sci Rep (2016) 0.75
The proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion. Mol Microbiol (2017) 0.75
The genome of the African trypanosome Trypanosoma brucei. Science (2005) 11.48
IFITM3 restricts the morbidity and mortality associated with influenza. Nature (2012) 4.66
Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. PLoS Pathog (2012) 3.81
Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts. Infect Immun (2009) 3.36
The genome of Naegleria gruberi illuminates early eukaryotic versatility. Cell (2010) 2.93
Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion. Science (2010) 2.77
High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature (2012) 2.55
RNAit: an automated web-based tool for the selection of RNAi targets in Trypanosoma brucei. Mol Biochem Parasitol (2003) 2.55
A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics (2011) 2.34
Clathrin-mediated endocytosis is essential in Trypanosoma brucei. EMBO J (2003) 2.11
Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection. Proc Natl Acad Sci U S A (2012) 2.09
Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites. J Biol Chem (2002) 2.08
A Plasmodium calcium-dependent protein kinase controls zygote development and transmission by translationally activating repressed mRNAs. Cell Host Microbe (2012) 2.06
Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores. J Bacteriol (2009) 1.96
Evolution of the multivesicular body ESCRT machinery; retention across the eukaryotic lineage. Traffic (2008) 1.86
Control systems for membrane fusion in the ancestral eukaryote; evolution of tethering complexes and SM proteins. BMC Evol Biol (2007) 1.82
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest (2002) 1.81
Evolution of the eukaryotic membrane-trafficking system: origin, tempo and mode. J Cell Sci (2007) 1.81
Evidence for a shared nuclear pore complex architecture that is conserved from the last common eukaryotic ancestor. Mol Cell Proteomics (2009) 1.74
The trypanosome transcriptome is remodelled during differentiation but displays limited responsiveness within life stages. BMC Genomics (2008) 1.56
Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8. Mol Biol Cell (2003) 1.53
Chromosome-wide analysis of gene function by RNA interference in the african trypanosome. Eukaryot Cell (2006) 1.47
A cyclic GMP signalling module that regulates gliding motility in a malaria parasite. PLoS Pathog (2009) 1.46
Endocytosis of a glycosylphosphatidylinositol-anchored protein via clathrin-coated vesicles, sorting by default in endosomes, and exocytosis via RAB11-positive carriers. Mol Biol Cell (2003) 1.46
Rab5 and Rab11 mediate transferrin and anti-variant surface glycoprotein antibody recycling in Trypanosoma brucei. Biochem J (2003) 1.45
Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity. Mol Microbiol (2004) 1.45
The size of the synaptic cleft and distinct distributions of filamentous actin, ezrin, CD43, and CD45 at activating and inhibitory human NK cell immune synapses. J Immunol (2003) 1.39
Molecular paleontology and complexity in the last eukaryotic common ancestor. Crit Rev Biochem Mol Biol (2013) 1.39
Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis. Cell Host Microbe (2012) 1.38
Phylogeny of endocytic components yields insight into the process of nonendosymbiotic organelle evolution. Proc Natl Acad Sci U S A (2008) 1.35
Use of purified Clostridium difficile spores to facilitate evaluation of health care disinfection regimens. Appl Environ Microbiol (2010) 1.32
A novel genetic switch controls phase variable expression of CwpV, a Clostridium difficile cell wall protein. Mol Microbiol (2009) 1.30
Functional analysis of TbARL1, an N-myristoylated Golgi protein essential for viability in bloodstream trypanosomes. J Cell Sci (2005) 1.30
Molecular and physiological analysis of three Pseudomonas aeruginosa phages belonging to the "N4-like viruses". Virology (2010) 1.30
Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei. J Cell Sci (2011) 1.29
Differential endocytic functions of Trypanosoma brucei Rab5 isoforms reveal a glycosylphosphatidylinositol-specific endosomal pathway. J Biol Chem (2001) 1.29
New approaches to the microscopic imaging of Trypanosoma brucei. Microsc Microanal (2004) 1.27
Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases. J Cell Sci (2012) 1.25
A conserved acetyl esterase domain targets diverse bacteriophages to the Vi capsular receptor of Salmonella enterica serovar Typhi. J Bacteriol (2010) 1.24
Activation of endocytosis as an adaptation to the mammalian host by trypanosomes. Eukaryot Cell (2007) 1.24
Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species. Proc Natl Acad Sci U S A (2012) 1.22
The Swedish new variant of Chlamydia trachomatis: genome sequence, morphology, cell tropism and phenotypic characterization. Microbiology (2010) 1.21
Both of the Rab5 subfamily small GTPases of Trypanosoma brucei are essential and required for endocytosis. Mol Biochem Parasitol (2004) 1.15
Rab protein evolution and the history of the eukaryotic endomembrane system. Cell Mol Life Sci (2010) 1.15
A suggested new bacteriophage genus: "Viunalikevirus". Arch Virol (2012) 1.15
Evolution of specificity in the eukaryotic endomembrane system. Int J Biochem Cell Biol (2008) 1.14
NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions. PLoS Biol (2012) 1.12
The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences. Trends Parasitol (2002) 1.12
Evolution of modular intraflagellar transport from a coatomer-like progenitor. Proc Natl Acad Sci U S A (2013) 1.11
TbVps34, the trypanosome orthologue of Vps34, is required for Golgi complex segregation. J Biol Chem (2006) 1.11
A cell-surface phylome for African trypanosomes. PLoS Negl Trop Dis (2013) 1.09
Molecular characterization of the Salmonella enterica serovar Typhi Vi-typing bacteriophage E1. J Bacteriol (2008) 1.08
The single ENTH-domain protein of trypanosomes; endocytic functions and evolutionary relationship with epsin. Traffic (2009) 1.08
Genome and transcriptome adaptation accompanying emergence of the definitive type 2 host-restricted Salmonella enterica serovar Typhimurium pathovar. MBio (2013) 1.06
Ubiquitylation is required for degradation of transmembrane surface proteins in trypanosomes. Traffic (2008) 1.05
The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system. Trends Parasitol (2002) 1.05
Citrobacter rodentium is an unstable pathogen showing evidence of significant genomic flux. PLoS Pathog (2011) 1.05
Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates. Genes Dev (2013) 1.04
Rab4 is an essential regulator of lysosomal trafficking in trypanosomes. J Biol Chem (2004) 1.04
Implications of the new eukaryotic systematics for parasitologists. Parasitol Int (2007) 1.03
Interaction of enteric bacterial pathogens with murine embryonic stem cells. Infect Immun (2008) 1.03
Ubiquitylation and developmental regulation of invariant surface protein expression in trypanosomes. Eukaryot Cell (2011) 1.03
Cytoplasmic targeting signals in transmembrane invariant surface glycoproteins of trypanosomes. J Biol Chem (2004) 1.03
Adaptin evolution in kinetoplastids and emergence of the variant surface glycoprotein coat in African trypanosomatids. Mol Phylogenet Evol (2013) 1.02
Developmental variation in Rab11-dependent trafficking in Trypanosoma brucei. Eukaryot Cell (2005) 1.02
Refinement of the hamster model of Clostridium difficile disease. Methods Mol Biol (2010) 1.02
A bioinformatic analysis of the RAB genes of Trypanosoma brucei. Mol Biochem Parasitol (2005) 1.02
High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis. PLoS Pathog (2011) 1.01
The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation. Blood (2011) 1.01
A generalized transducing phage for the murine pathogen Citrobacter rodentium. Microbiology (2007) 1.00
Identification of a very large Rab GTPase family in the parasitic protozoan Trichomonas vaginalis. Mol Biochem Parasitol (2005) 1.00
RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet (2012) 1.00
Dileucine signal-dependent and AP-1-independent targeting of a lysosomal glycoprotein in Trypanosoma brucei. Mol Biochem Parasitol (2007) 0.99
TbRAB1 and TbRAB2 mediate trafficking through the early secretory pathway of Trypanosoma brucei. Mol Biochem Parasitol (2004) 0.97
The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals. PLoS Pathog (2009) 0.97
A Salmonella Typhimurium-Typhi genomic chimera: a model to study Vi polysaccharide capsule function in vivo. PLoS Pathog (2011) 0.97
An evolutionarily conserved coiled-coil protein implicated in polycystic kidney disease is involved in basal body duplication and flagellar biogenesis in Trypanosoma brucei. Mol Cell Biol (2005) 0.97
ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome. Hum Mol Genet (2005) 0.97
The mechanism of oxidative stress stabilization of the thromboxane receptor in COS-7 cells. J Biol Chem (2003) 0.96
Paternal effect of the nuclear formin-like protein MISFIT on Plasmodium development in the mosquito vector. PLoS Pathog (2009) 0.96
Proteomic analysis of clathrin interactions in trypanosomes reveals dynamic evolution of endocytosis. Traffic (2013) 0.95
The alveolin IMC1h is required for normal ookinete and sporozoite motility behaviour and host colonisation in Plasmodium berghei. PLoS One (2012) 0.95
An automated graphics tool for comparative genomics: the Coulson plot generator. BMC Bioinformatics (2013) 0.95
The agr locus regulates virulence and colonization genes in Clostridium difficile 027. J Bacteriol (2013) 0.95
Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines. Mol Pharmacol (2012) 0.94
Evolution of the karyopherin-β family of nucleocytoplasmic transport factors; ancient origins and continued specialization. PLoS One (2011) 0.93
Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism. BMC Genomics (2014) 0.93
Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia. Cerebellum (2010) 0.91
Leishmania RAB7: characterisation of terminal endocytic stages in an intracellular parasite. Mol Biochem Parasitol (2002) 0.90
Evidence for a non-LDL-mediated entry route for the trypanocidal drug suramin in Trypanosoma brucei. Mol Biochem Parasitol (2002) 0.89
Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite. Exp Parasitol (2004) 0.89
Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control. Cell Microbiol (2013) 0.89