Published in Biochemistry on December 23, 2003
Model of human low-density lipoprotein and bound receptor based on cryoEM. Proc Natl Acad Sci U S A (2009) 1.27
Molecular structure of low density lipoprotein: current status and future challenges. Eur Biophys J (2008) 1.17
Three-dimensional cryoEM reconstruction of native LDL particles to 16Å resolution at physiological body temperature. PLoS One (2011) 0.92
Lipid composition influences the shape of human low density lipoprotein in vitreous ice. Lipids (2005) 0.91
Enhancing the contrast of ApoB to locate the surface components in the 3D density map of human LDL. J Mol Biol (2010) 0.90
Human LDL core cholesterol ester packing: three-dimensional image reconstruction and SAXS simulation studies. J Lipid Res (2010) 0.88
Low density lipoproteins as circulating fast temperature sensors. PLoS One (2008) 0.85
Characterization of antibiotic peptide pores using cryo-EM and comparison to neutron scattering. Biophys J (2009) 0.84
Human low density lipoprotein: the mystery of core lipid packing. J Lipid Res (2010) 0.84
High hydrostatic pressure specifically affects molecular dynamics and shape of low-density lipoprotein particles. Sci Rep (2017) 0.75
Lipoproteins: When size really matters. Curr Opin Colloid Interface Sci (2006) 0.75
Association of an intensive lifestyle intervention with remission of type 2 diabetes. JAMA (2012) 5.15
Outcome of the first electron microscopy validation task force meeting. Structure (2012) 4.35
Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus. Nature (2006) 3.73
Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med (2012) 3.54
Backbone structure of the infectious epsilon15 virus capsid revealed by electron cryomicroscopy. Nature (2008) 3.54
De novo backbone trace of GroEL from single particle electron cryomicroscopy. Structure (2008) 3.41
EMDataBank.org: unified data resource for CryoEM. Nucleic Acids Res (2010) 3.32
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14
Protein structure fitting and refinement guided by cryo-EM density. Structure (2008) 3.12
Refinement of protein structures into low-resolution density maps using rosetta. J Mol Biol (2009) 2.94
The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state. Cell (2003) 2.89
Structural basis of pore formation by the bacterial toxin pneumolysin. Cell (2005) 2.87
Mechanism of folding chamber closure in a group II chaperonin. Nature (2010) 2.85
Coat protein fold and maturation transition of bacteriophage P22 seen at subnanometer resolutions. Nat Struct Biol (2003) 2.76
Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Nat Mater (2011) 2.71
Common ancestry of herpesviruses and tailed DNA bacteriophages. J Virol (2005) 2.60
Identification of secondary structure elements in intermediate-resolution density maps. Structure (2007) 2.60
Structural framework for DNA translocation via the viral portal protein. EMBO J (2007) 2.58
Remotely triggered liposome release by near-infrared light absorption via hollow gold nanoshells. J Am Chem Soc (2008) 2.56
Structure of the Escherichia coli ribosomal termination complex with release factor 2. Nature (2003) 2.54
Seeing GroEL at 6 A resolution by single particle electron cryomicroscopy. Structure (2004) 2.50
Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions. J Struct Biol (2010) 2.48
The pore structure of the closed RyR1 channel. Structure (2005) 2.42
Structure of a type IV secretion system core complex. Science (2009) 2.36
Outcome of a workshop on archiving structural models of biological macromolecules. Structure (2006) 2.32
Experimental verification of conformational variation of human fatty acid synthase as predicted by normal mode analysis. Structure (2004) 2.30
Cryo-EM asymmetric reconstruction of bacteriophage P22 reveals organization of its DNA packaging and infecting machinery. Structure (2006) 2.26
The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature (2010) 2.23
4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement. Proc Natl Acad Sci U S A (2010) 2.17
Structural changes in a marine podovirus associated with release of its genome into Prochlorococcus. Nat Struct Mol Biol (2010) 2.12
Refinement of protein structures by iterative comparative modeling and CryoEM density fitting. J Mol Biol (2006) 2.06
An expanded conformation of single-ring GroEL-GroES complex encapsulates an 86 kDa substrate. Structure (2006) 2.04
Structural basis for scaffolding-mediated assembly and maturation of a dsDNA virus. Proc Natl Acad Sci U S A (2011) 2.03
Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance. Circ Res (2006) 1.95
Direct electron detection yields cryo-EM reconstructions at resolutions beyond 3/4 Nyquist frequency. J Struct Biol (2012) 1.94
Structure of Halothiobacillus neapolitanus carboxysomes by cryo-electron tomography. J Mol Biol (2006) 1.90
Averaging tens to hundreds of icosahedral particle images to resolve protein secondary structure elements using a Multi-Path Simulated Annealing optimization algorithm. J Struct Biol (2007) 1.90
Structure of bacteriophage SPP1 tail reveals trigger for DNA ejection. EMBO J (2007) 1.81
The molecular architecture of the eukaryotic chaperonin TRiC/CCT. Structure (2012) 1.80
DNA packaging and delivery machines in tailed bacteriophages. Curr Opin Struct Biol (2007) 1.79
A digital atlas to characterize the mouse brain transcriptome. PLoS Comput Biol (2005) 1.78
4.4 Å cryo-EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus. EMBO J (2011) 1.77
Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proc Natl Acad Sci U S A (2013) 1.75
Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure. Structure (2011) 1.71
Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography. J Mol Biol (2010) 1.71
A 9 angstroms single particle reconstruction from CCD captured images on a 200 kV electron cryomicroscope. J Struct Biol (2004) 1.70
Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proc Natl Acad Sci U S A (2008) 1.68
Troglitazone antagonizes tumor necrosis factor-alpha-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kappaB. J Biol Chem (2003) 1.67
Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins. Nat Struct Mol Biol (2007) 1.67
Structural characterization of components of protein assemblies by comparative modeling and electron cryo-microscopy. J Struct Biol (2005) 1.67
Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation. Mol Cell (2005) 1.65
JADAS: a customizable automated data acquisition system and its application to ice-embedded single particles. J Struct Biol (2008) 1.62
Assessing the capabilities of a 4kx4k CCD camera for electron cryo-microscopy at 300kV. J Struct Biol (2006) 1.61
Zernike phase contrast cryo-electron microscopy and tomography for structure determination at nanometer and subnanometer resolutions. Structure (2010) 1.60
Structure of the acrosomal bundle. Nature (2004) 1.59
Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation. Blood (2002) 1.59
Cryo-EM of macromolecular assemblies at near-atomic resolution. Nat Protoc (2010) 1.58
Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients. J Lipid Res (2002) 1.56
Structure of bacteriophage SPP1 head-to-tail connection reveals mechanism for viral DNA gating. Proc Natl Acad Sci U S A (2009) 1.56
Topologies of a substrate protein bound to the chaperonin GroEL. Mol Cell (2007) 1.52
3D volume reconstruction of a mouse brain from histological sections using warp filtering. J Neurosci Methods (2006) 1.51
Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT. Nat Struct Mol Biol (2008) 1.51
Applications of a bilateral denoising filter in biological electron microscopy. J Struct Biol (2003) 1.50
Mitochondrial ATP synthasome: three-dimensional structure by electron microscopy of the ATP synthase in complex formation with carriers for Pi and ADP/ATP. J Biol Chem (2004) 1.47
Recognition and separation of single particles with size variation by statistical analysis of their images. J Mol Biol (2004) 1.45
Interprotofilament interactions between Alzheimer's Abeta1-42 peptides in amyloid fibrils revealed by cryoEM. Proc Natl Acad Sci U S A (2009) 1.45
Detection and separation of heterogeneity in molecular complexes by statistical analysis of their two-dimensional projections. J Struct Biol (2007) 1.45
Electron cryotomography reveals the portal in the herpesvirus capsid. J Virol (2006) 1.40
Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration. Cell (2012) 1.40
Challenges at the frontiers of structural biology. Nat Struct Biol (2002) 1.39
Genome sequence, structural proteins, and capsid organization of the cyanophage Syn5: a "horned" bacteriophage of marine synechococcus. J Mol Biol (2007) 1.37
Mitochondrial ATP synthasome. Cristae-enriched membranes and a multiwell detergent screening assay yield dispersed single complexes containing the ATP synthase and carriers for Pi and ADP/ATP. J Biol Chem (2003) 1.35
Automated segmentation of molecular subunits in electron cryomicroscopy density maps. J Struct Biol (2006) 1.34
Structure of the herpesvirus major capsid protein. EMBO J (2003) 1.33
Modeling protein structure at near atomic resolutions with Gorgon. J Struct Biol (2011) 1.29
Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein. Nat Chem Biol (2012) 1.27
Model of human low-density lipoprotein and bound receptor based on cryoEM. Proc Natl Acad Sci U S A (2009) 1.27
Structure of Ca2+ release channel at 14 A resolution. J Mol Biol (2005) 1.27
The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity. EMBO J (2006) 1.26
Structure of the type 1 inositol 1,4,5-trisphosphate receptor revealed by electron cryomicroscopy. J Biol Chem (2003) 1.26
Dual action of ATP hydrolysis couples lid closure to substrate release into the group II chaperonin chamber. Cell (2011) 1.25
Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis. J Biol Chem (2005) 1.24
Shear-induced disulfide bond formation regulates adhesion activity of von Willebrand factor. J Biol Chem (2007) 1.24
Flexible architecture of IP3R1 by Cryo-EM. Structure (2011) 1.24
Direct three-dimensional visualization of membrane disruption by amyloid fibrils. Proc Natl Acad Sci U S A (2012) 1.24
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils. J Mol Biol (2009) 1.21
Visualizing virus assembly intermediates inside marine cyanobacteria. Nature (2013) 1.20
Serum opacity factor unmasks human plasma high-density lipoprotein instability via selective delipidation and apolipoprotein A-I desorption. Biochemistry (2007) 1.18
Metabolic basis of HIV-lipodystrophy syndrome. Am J Physiol Endocrinol Metab (2002) 1.18
Learning-based segmentation framework for tissue images containing gene expression data. IEEE Trans Med Imaging (2007) 1.17
Visualizing GroEL/ES in the act of encapsulating a folding protein. Cell (2013) 1.16
Determination of icosahedral virus structures by electron cryomicroscopy at subnanometer resolution. Adv Protein Chem (2003) 1.16
A geometric database for gene expression data. Symp Geom Process (2003) 1.15
Validation of cryo-EM structure of IP₃R1 channel. Structure (2013) 1.15
Visualizing the structural changes of bacteriophage Epsilon15 and its Salmonella host during infection. J Mol Biol (2010) 1.15
Removal of divalent cations induces structural transitions in red clover necrotic mosaic virus, revealing a potential mechanism for RNA release. J Virol (2006) 1.14
Cryo-EM model validation using independent map reconstructions. Protein Sci (2013) 1.13
Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle. EMBO J (2011) 1.12