Published in JAMA on December 19, 2012
Look AHEAD: Action for Health in Diabetes (LookAHEAD) | NCT00017953
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med (2013) 15.58
Nutrition therapy recommendations for the management of adults with diabetes. Diabetes Care (2013) 4.85
Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study. Obesity (Silver Spring) (2014) 3.10
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet (2013) 2.66
Diabetes: Looking back at Look AHEAD--giving lifestyle a chance. Nat Rev Cardiol (2013) 1.49
Durable change in glycaemic control following intensive management of type 2 diabetes in the ACCORD clinical trial. Diabetologia (2014) 1.42
Surgical vs medical treatments for type 2 diabetes mellitus: a randomized clinical trial. JAMA Surg (2014) 1.40
Diabetes Remission after Nonsurgical Intensive Lifestyle Intervention in Obese Patients with Type 2 Diabetes. J Diabetes Res (2015) 1.39
Impact of an intensive lifestyle intervention on use and cost of medical services among overweight and obese adults with type 2 diabetes: the action for health in diabetes. Diabetes Care (2014) 1.38
Lifestyle Intervention for Weight Loss and Cardiometabolic Changes in the Setting of Glucokinase Regulatory Protein Inhibition: Glucokinase Regulatory Protein-Leu446Pro Variant in Look AHEAD. Circ Cardiovasc Genet (2015) 1.38
Diabetes and weight in comparative studies of bariatric surgery vs conventional medical therapy: a systematic review and meta-analysis. Obes Surg (2014) 1.12
Long-term impact of behavioral weight loss intervention on cognitive function. J Gerontol A Biol Sci Med Sci (2014) 0.98
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Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: implications of new evidence upon optimizing cardiovascular patient outcomes. Vasc Health Risk Manag (2013) 0.94
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Improved acylated ghrelin suppression at 2 years in obese patients with type 2 diabetes: effects of bariatric surgery vs standard medical therapy. Int J Obes (Lond) (2013) 0.94
A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice. Nutr Diabetes (2016) 0.94
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Pancreatic β-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity. J Clin Endocrinol Metab (2013) 0.91
Patients' Future Expectations for Diabetes and Hypertension Treatments: "Through the Diet… I Think This is Going to Go Away." J Gen Intern Med (2016) 0.90
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Knowledge, Attitudes, and Current Practices of Canadian Physiotherapists in Preventing and Managing Diabetes. Physiother Can (2016) 0.87
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The influence of hyperglycemia on the therapeutic effect of exercise on glycemic control in patients with type 2 diabetes mellitus. JAMA Intern Med (2013) 0.86
Is physical exercise a core therapeutical element for most patients with type 2 diabetes? Diabetes Care (2013) 0.86
Remission of recently diagnosed type 2 diabetes mellitus with weight loss and exercise. J Cardiopulm Rehabil Prev (2015) 0.84
Restoring Insulin Secretion (RISE): design of studies of β-cell preservation in prediabetes and early type 2 diabetes across the life span. Diabetes Care (2013) 0.84
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Is Bariatric Surgery an Effective Treatment for Type II Diabetic Kidney Disease? Clin J Am Soc Nephrol (2015) 0.83
Short-term weight loss patterns, baseline predictors, and longer-term follow-up within a randomized controlled trial. Obesity (Silver Spring) (2013) 0.82
A Mathematical Model of the Pathogenesis, Prevention, and Reversal of Type 2 Diabetes. Endocrinology (2015) 0.82
The Look AHEAD Trial: Implications for Lifestyle Intervention in Type 2 Diabetes Mellitus. Prog Cardiovasc Dis (2015) 0.82
Challenges in the management of type 2 diabetes mellitus and cardiovascular risk factors in obese subjects: what is the evidence and what are the myths? Int J Endocrinol (2013) 0.82
Current and emerging medications for overweight or obesity in people with comorbidities. Diabetes Obes Metab (2015) 0.82
Physical activity and pre-diabetes-an unacknowledged mid-life crisis: findings from NHANES 2003-2006. PeerJ (2014) 0.82
A lifestyle program of exercise and weight loss is effective in preventing and treating type 2 diabetes mellitus: Why are programs not more available? Prev Med (2015) 0.82
A look ahead at the future of diabetes prevention and treatment. JAMA (2012) 0.82
Development and demonstration of a state model for the estimation of incidence of partly undetected chronic diseases. BMC Med Res Methodol (2015) 0.81
Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle. Adv Physiol Educ (2014) 0.81
Treating Diabetes with Exercise - Focus on the Microvasculature. J Diabetes Metab (2013) 0.80
ACP Journal Club. An intensive lifestyle intervention increased remission from type 2 diabetes in overweight adults. Ann Intern Med (2013) 0.80
Intensive lifestyle intervention including high-intensity interval training program improves insulin resistance and fasting plasma glucose in obese patients. Prev Med Rep (2015) 0.80
Implications of Look AHEAD for clinical trials and clinical practice. Diabetes Obes Metab (2014) 0.80
The rise of mitochondria in medicine. Mitochondrion (2016) 0.80
The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial. BMC Fam Pract (2016) 0.79
Timing of bariatric surgery in people with obesity and diabetes. Ann Transl Med (2015) 0.79
Improving Adiponectin Levels in Individuals With Diabetes and Obesity: Insights From Look AHEAD. Diabetes Care (2015) 0.79
Challenging obesity: Patient, provider, and expert perspectives on the roles of available and emerging nonsurgical therapies. Obesity (Silver Spring) (2015) 0.79
Impact of Education on Weight in Newly Diagnosed Type 2 Diabetes: Every Little Bit Helps. PLoS One (2015) 0.78
Previous experiences and emotional baggage as barriers to lifestyle change - a qualitative study of Norwegian Healthy Life Centre participants. BMC Fam Pract (2015) 0.78
Insulin Resistance and Diabetes Mellitus in Contemporary Cardiac Rehabilitation. J Cardiopulm Rehabil Prev (2016) 0.78
Metabolic disease puts up a fight: are diet and exercise helpful for the heart? Nat Med (2013) 0.76
Importance of Beta Cell Function for the Treatment of Type 2 Diabetes. J Clin Med (2014) 0.76
Current status of intragastric balloon for obesity treatment. World J Gastroenterol (2016) 0.76
Lessons from the look action for health in diabetes study. Indian J Endocrinol Metab (2013) 0.76
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. Curr Atheroscler Rep (2014) 0.76
Mitochondrial Epigenetic Changes Link to Increased Diabetes Risk and Early-Stage Prediabetes Indicator. Oxid Med Cell Longev (2016) 0.76
Physician perspectives on de-intensifying diabetes medications. Medicine (Baltimore) (2016) 0.75
The Role of Healthy Lifestyle in the Implementation of Regressing Suboptimal Health Status among College Students in China: A Nested Case-Control Study. Int J Environ Res Public Health (2017) 0.75
Diabetes: T2DM--will tertiary prevention solve the problem? Nat Rev Endocrinol (2013) 0.75
Cost of intervention delivery in a lifestyle weight loss trial in type 2 diabetes: results from the Look AHEAD clinical trial. Obes Sci Pract (2017) 0.75
Relationship of Lifestyle with Academic Achievement in Nursing Students. J Clin Diagn Res (2017) 0.75
[Lifestyle intervention in type 2 diabetes: is remission possible? Overcoming thinking barriers--lifestyle interventions have great benefits!]. Dtsch Med Wochenschr (2013) 0.75
The Look AHEAD Trial: A Review and Discussion Of Its Outcomes. Curr Nutr Rep (2014) 0.75
Gray matter alterations and correlation of nutritional intake with the gray matter volume in prediabetes. Medicine (Baltimore) (2016) 0.75
Using multi-year national survey cohorts for period estimates: an application of weighted discrete Poisson regression for assessing annual national mortality in US adults with and without diabetes, 2000-2006. Popul Health Metr (2016) 0.75
Meta-analysis of bariatric surgery versus non-surgical treatment for type 2 diabetes mellitus. Oncotarget (2016) 0.75
Diabetes diagnosis and exercise initiation among older Americans. Prev Med (2014) 0.75
Changes in Hepatic Venous Pressure Gradient Induced by Physical Exercise in Cirrhosis: Results of a Pilot Randomized Open Clinical Trial. Clin Transl Gastroenterol (2016) 0.75
Impact of intensive lifestyle intervention on preference-based quality of life in type 2 diabetes: Results from the Look AHEAD trial. Obesity (Silver Spring) (2016) 0.75
Remission of pre-diabetes to normal glucose tolerance in obese adults with high protein versus high carbohydrate diet: randomized control trial. BMJ Open Diabetes Res Care (2016) 0.75
Sedentary Patterns, Physical Activity, and Cardiorespiratory Fitness in Association to Glycemic Control in Type 2 Diabetes Patients. Front Physiol (2017) 0.75
One-Year Results of a Synthetic Intervention Model for the Primary Prevention of T2D among Elderly Individuals with Prediabetes in Rural China. Int J Environ Res Public Health (2017) 0.75
Standard and Novel Treatment Options for Metabolic Syndrome and Diabetes Mellitus. Curr Treat Options Cardiovasc Med (2013) 0.75
George A. Bray, MD: Progress in Obesity-Multidisciplinary Research, Multidimensional Man. Diabetes Care (2016) 0.75
Exercise and Regulation of Carbohydrate Metabolism. Prog Mol Biol Transl Sci (2015) 0.75
Impact of a behavioral weight loss intervention on comorbidities in overweight and obese breast cancer survivors. Support Care Cancer (2016) 0.75
The Role of Metabolic Surgery in Non-alcoholic Steatohepatitis Improvement. Curr Atheroscler Rep (2017) 0.75
Long-term impact of intensive lifestyle intervention on cognitive function assessed with the National Institutes of Health Toolbox: The Look AHEAD study. Alzheimers Dement (Amst) (2017) 0.75
Initial Weight Loss Response as an Indicator for Providing Early Rescue Efforts to Improve Long-term Treatment Outcomes. Curr Diab Rep (2017) 0.75
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med (2002) 101.79
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med (2001) 56.11
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Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med (2012) 13.59
Bariatric surgery versus conventional medical therapy for type 2 diabetes. N Engl J Med (2012) 11.25
Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Control Clin Trials (2003) 9.97
Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Intern Med (2010) 8.77
Emergency hospitalizations for adverse drug events in older Americans. N Engl J Med (2011) 8.75
The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it. Obesity (Silver Spring) (2006) 8.25
Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Popul Health Metr (2010) 7.70
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Effect of intensive diabetes management on macrovascular events and risk factors in the Diabetes Control and Complications Trial. Am J Cardiol (1995) 4.83
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Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial. Lancet (2011) 4.35
Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study. Lancet (2012) 4.33
How do we define cure of diabetes? Diabetes Care (2009) 3.59
Bariatric surgery and reduction in morbidity and mortality: experiences from the SOS study. Int J Obes (Lond) (2008) 1.79
Effects of weight loss with orlistat on glucose tolerance and progression to type 2 diabetes in obese adults. Arch Intern Med (2000) 1.51
The development and description of the comparison group in the Look AHEAD trial. Clin Trials (2011) 1.46
Behavioral strategies in diabetes prevention programs: a systematic review of randomized controlled trials. Diabetes Res Clin Pract (2010) 1.39
Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes: A 1-year randomized controlled trial. Diabetes Care (2002) 1.35
Analysis of incomplete longitudinal binary data using multiple imputation. Stat Med (2006) 1.22
Screening for type 2 diabetes and dysglycemia. Epidemiol Rev (2011) 1.16
Clinical outcomes after bariatric surgery: a five-year matched cohort analysis in seven US states. Obes Surg (2012) 1.07
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA (2002) 80.37
Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA (2004) 23.69
A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med (2015) 19.14
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med (2013) 15.58
Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care (2007) 14.35
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA (2006) 12.44
Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med (2006) 12.09
Stromal gene expression predicts clinical outcome in breast cancer. Nat Med (2008) 10.68
Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med (2003) 10.06
Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Control Clin Trials (2003) 9.97
Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab (2002) 8.90
Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Intern Med (2010) 8.77
Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med (2006) 8.73
Outcomes ascertainment and adjudication methods in the Women's Health Initiative. Ann Epidemiol (2003) 8.64
Exemestane for breast-cancer prevention in postmenopausal women. N Engl J Med (2011) 8.19
Comparative effectiveness of weight-loss interventions in clinical practice. N Engl J Med (2011) 7.81
Association of weight status with mortality in adults with incident diabetes. JAMA (2012) 7.49
Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. JAMA (2010) 7.12
Effect of weight loss with lifestyle intervention on risk of diabetes. Diabetes Care (2006) 7.09
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Examining a bidirectional association between depressive symptoms and diabetes. JAMA (2008) 6.83
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Disparities in stroke incidence contributing to disparities in stroke mortality. Ann Neurol (2011) 4.61
Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol (2014) 4.30
Pioglitazone for diabetes prevention in impaired glucose tolerance. N Engl J Med (2011) 4.28
Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study. JAMA Intern Med (2013) 4.25
One-year weight losses in the Look AHEAD study: factors associated with success. Obesity (Silver Spring) (2009) 4.08
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet (2011) 3.92
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Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest (2007) 3.63
Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity (Silver Spring) (2011) 3.62
Calcium plus vitamin D supplementation and the risk of breast cancer. J Natl Cancer Inst (2008) 3.60
Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology (2010) 3.55
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Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause. Am J Epidemiol (2009) 3.33
Consistent self-monitoring of weight: a key component of successful weight loss maintenance. Obesity (Silver Spring) (2007) 3.30
A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the Sleep AHEAD study. Arch Intern Med (2009) 3.27
Validity of diabetes self-reports in the Women's Health Initiative: comparison with medication inventories and fasting glucose measurements. Clin Trials (2008) 3.24
Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study. Am J Gastroenterol (2008) 3.16
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Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study. Obesity (Silver Spring) (2014) 3.10
Race, ethnicity, socioeconomic position, and quality of care for adults with diabetes enrolled in managed care: the Translating Research Into Action for Diabetes (TRIAD) study. Diabetes Care (2005) 3.09
Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA (2006) 2.97
Obstructive sleep apnea among obese patients with type 2 diabetes. Diabetes Care (2009) 2.95
Fetuin-A and incident diabetes mellitus in older persons. JAMA (2008) 2.92
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Classification of heart failure in the atherosclerosis risk in communities (ARIC) study: a comparison of diagnostic criteria. Circ Heart Fail (2012) 2.88
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Calcium plus vitamin D supplementation and health outcomes five years after active intervention ended: the Women's Health Initiative. J Womens Health (Larchmt) (2013) 2.81
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Fast food consumption and breakfast skipping: predictors of weight gain from adolescence to adulthood in a nationally representative sample. J Adolesc Health (2006) 2.74
Novel metabolic risk factors for incident heart failure and their relationship with obesity: the MESA (Multi-Ethnic Study of Atherosclerosis) study. J Am Coll Cardiol (2008) 2.74
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Measurement of human daily physical activity. Obes Res (2003) 2.62
Neighborhood resources for physical activity and healthy foods and incidence of type 2 diabetes mellitus: the Multi-Ethnic study of Atherosclerosis. Arch Intern Med (2009) 2.61
Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes. Arch Intern Med (2009) 2.59
Racial differences in the impact of elevated systolic blood pressure on stroke risk. JAMA Intern Med (2013) 2.55