Published in J Mol Biol on January 23, 2004
De novo computational design of retro-aldol enzymes. Science (2008) 7.62
Laboratory-directed protein evolution. Microbiol Mol Biol Rev (2005) 1.69
Designing artificial enzymes by intuition and computation. Nat Chem (2009) 1.37
Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation. Proc Natl Acad Sci U S A (2013) 1.21
Structure-function analysis of Friedreich's ataxia mutants reveals determinants of frataxin binding and activation of the Fe-S assembly complex. Biochemistry (2011) 1.04
Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. J Mol Biol (2011) 1.04
Development of a small peptide tag for covalent labeling of proteins. Bioconjug Chem (2007) 1.00
Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. J Mol Biol (2013) 0.86
Comparison of designed and randomly generated catalysts for simple chemical reactions. Protein Sci (2012) 0.80
Rational approaches for engineering novel functionalities in carbon-carbon bond forming enzymes. Comput Struct Biotechnol J (2012) 0.78
Rosetta:MSF: a modular framework for multi-state computational protein design. PLoS Comput Biol (2017) 0.75
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol (2013) 11.58
De novo computational design of retro-aldol enzymes. Science (2008) 7.62
The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci U S A (2003) 6.37
Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies. Proc Natl Acad Sci U S A (2008) 4.67
Engineering polydactyl zinc-finger transcription factors. Nat Biotechnol (2002) 4.40
Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases. Nucleic Acids Res (2006) 3.95
A rare-cell detector for cancer. Proc Natl Acad Sci U S A (2004) 3.95
Crystal structure of a bacterial cocaine esterase. Nat Struct Biol (2002) 3.06
Custom zinc-finger nucleases for use in human cells. Mol Ther (2005) 3.04
Scanning the human genome with combinatorial transcription factor libraries. Nat Biotechnol (2003) 2.75
Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem (2005) 2.69
Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases. J Mol Biol (2010) 2.65
Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science (2002) 2.51
Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature (2012) 2.44
Designing transcription factor architectures for drug discovery. Mol Pharmacol (2004) 2.44
Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins. Biochemistry (2003) 2.33
Evidence for ozone formation in human atherosclerotic arteries. Science (2003) 2.22
Targeted gene knockout by direct delivery of zinc-finger nuclease proteins. Nat Methods (2012) 2.07
Synthesis of programmable integrases. Proc Natl Acad Sci U S A (2009) 1.94
Enamine-based organocatalysis with proline and diamines: the development of direct catalytic asymmetric Aldol, Mannich, Michael, and Diels-alder reactions. Acc Chem Res (2004) 1.92
Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA. J Mol Biol (2006) 1.91
Modular system for the construction of zinc-finger libraries and proteins. Nat Protoc (2010) 1.87
Rapid, stable, chemoselective labeling of thiols with Julia-Kocieński-like reagents: a serum-stable alternative to maleimide-based protein conjugation. Angew Chem Int Ed Engl (2013) 1.85
Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. Science (2008) 1.79
Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst. Proc Natl Acad Sci U S A (2003) 1.78
Expression and assembly of a fully active antibody in algae. Proc Natl Acad Sci U S A (2003) 1.61
Biochemical characterization and structural analysis of a highly proficient cocaine esterase. Biochemistry (2002) 1.60
Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nat Chem Biol (2006) 1.60
Metabolite-initiated protein misfolding may trigger Alzheimer's disease. Proc Natl Acad Sci U S A (2004) 1.55
Enthalpy arrays. Proc Natl Acad Sci U S A (2004) 1.52
Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries. PLoS Pathog (2010) 1.46
Chimeric TALE recombinases with programmable DNA sequence specificity. Nucleic Acids Res (2012) 1.38
A general method for greatly improving the affinity of antibodies by using combinatorial libraries. Proc Natl Acad Sci U S A (2005) 1.37
Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector. Int J Cancer (2006) 1.37
Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors. Proc Natl Acad Sci U S A (2002) 1.34
In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase. J Am Chem Soc (2007) 1.33
Structure-guided reprogramming of serine recombinase DNA sequence specificity. Proc Natl Acad Sci U S A (2010) 1.31
Exploring strategies for the design of artificial transcription factors: targeting sites proximal to known regulatory regions for the induction of gamma-globin expression and the treatment of sickle cell disease. J Biol Chem (2004) 1.30
Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display. J Mol Biol (2003) 1.30
Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices. J Med Chem (2004) 1.29
Evolution of programmable zinc finger-recombinases with activity in human cells. J Mol Biol (2007) 1.28
Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation. Biochemistry (2005) 1.26
Breaking the one antibody-one target axiom. Proc Natl Acad Sci U S A (2006) 1.26
Direct asymmetric alpha-fluorination of aldehydes. Angew Chem Int Ed Engl (2005) 1.25
Instant immunity through chemically programmable vaccination and covalent self-assembly. Proc Natl Acad Sci U S A (2009) 1.25
Libraries against libraries for combinatorial selection of replicating antigen-antibody pairs. Proc Natl Acad Sci U S A (2009) 1.24
Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. J Biol Chem (2004) 1.24
Chemical generation of bispecific antibodies. Proc Natl Acad Sci U S A (2010) 1.24
Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies. Bioorg Med Chem Lett (2006) 1.22
Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis. Proc Natl Acad Sci U S A (2004) 1.21
Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites. J Virol (2004) 1.20
Directed evolution of recombinase specificity by split gene reassembly. Nucleic Acids Res (2010) 1.19
A method for the generation of combinatorial antibody libraries using pIX phage display. Proc Natl Acad Sci U S A (2002) 1.18
The chemistry of the antibody molecule. Angew Chem Int Ed Engl (2002) 1.15
Core-structure-motivated design of a phosphine-catalyzed [3+2] cycloaddition reaction: enantioselective syntheses of spirocyclopenteneoxindoles. J Am Chem Soc (2011) 1.15
Towards organo-click chemistry: development of organocatalytic multicomponent reactions through combinations of aldol, Wittig, Knoevenagel, Michael, Diels-Alder and Huisgen cycloaddition reactions. Chemistry (2004) 1.14
Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase. Nucleic Acids Res (2011) 1.13
Development of small designer aldolase enzymes: catalytic activity, folding, and substrate specificity. Biochemistry (2005) 1.12
Organocatalytic asymmetric domino knoevenagel/diels-alder reactions: a bioorganic approach to the diastereospecific and enantioselective construction of highly substituted spiro[5,5]undecane-1,5,9-triones. Angew Chem Int Ed Engl (2003) 1.12
Integrin alpha(v)beta3 targeted therapy for Kaposi's sarcoma with an in vitro evolved antibody. FASEB J (2002) 1.11
A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy. J Mol Biol (2003) 1.11
An efficient chemical approach to bispecific antibodies and antibodies of high valency. Bioorg Med Chem Lett (2009) 1.11
Small molecule oxidation products trigger disease-associated protein misfolding. Acc Chem Res (2006) 1.11
Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells. Proc Natl Acad Sci U S A (2013) 1.11
Preparation of integrin alpha(v)beta3-targeting Ab 38C2 constructs. Nat Protoc (2007) 1.10
The origin of enantioselectivity in aldolase antibodies: crystal structure, site-directed mutagenesis, and computational analysis. J Mol Biol (2004) 1.10
A modular assembly strategy for improving the substrate specificity of small catalytic peptides. J Am Chem Soc (2002) 1.09
Tyrosine bioconjugation through aqueous ene-type reactions: a click-like reaction for tyrosine. J Am Chem Soc (2010) 1.08
Directed evolution of the TALE N-terminal domain for recognition of all 5' bases. Nucleic Acids Res (2013) 1.08
Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site. J Virol (2006) 1.07
Genetic reprogramming of tumor cells by zinc finger transcription factors. Proc Natl Acad Sci U S A (2005) 1.07
{gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice. J Biol Chem (2005) 1.06
Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies. Acc Chem Res (2014) 1.06
Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections. Proc Natl Acad Sci U S A (2013) 1.05
A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells. Nucleic Acids Res (2013) 1.04
Phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody reduces tumor growth and angiogenesis in vivo. Proc Natl Acad Sci U S A (2005) 1.04
Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation. Proc Natl Acad Sci U S A (2007) 1.04
Immunochemical termination of self-tolerance. Proc Natl Acad Sci U S A (2008) 1.03
Beta-lactam-based approach for the chemical programming of aldolase antibody 38C2. Bioorg Med Chem Lett (2009) 1.03
A highly enantioselective route to either enantiomer of both alpha- and beta-amino acid derivatives. J Am Chem Soc (2002) 1.03
A highly enantioselective amino acid-catalyzed route to functionalized alpha-amino acids. J Am Chem Soc (2002) 1.03
In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for ICAM-1 provides new insights into gene regulation. J Mol Biol (2004) 1.02
Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries. Proc Natl Acad Sci U S A (2012) 1.02
The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles. J Org Chem (2003) 1.02
Development of a small peptide tag for covalent labeling of proteins. Bioconjug Chem (2007) 1.00
Synthesis of beta-hydroxyaldehydes with stereogenic quaternary carbon centers by direct organocatalytic asymmetric aldol reactions. Angew Chem Int Ed Engl (2004) 1.00
Human/mouse cross-reactive anti-VEGF receptor 2 recombinant antibodies selected from an immune b9 allotype rabbit antibody library. J Immunol Methods (2004) 1.00