Published in Nat Protoc on April 01, 2010
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High-frequency homologous recombination in plants mediated by zinc-finger nucleases. Plant J (2005) 3.45
Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38
Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem (2001) 3.35
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Scanning the human genome with combinatorial transcription factor libraries. Nat Biotechnol (2003) 2.75
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Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA. J Mol Biol (2006) 1.91
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Site-directed transposon integration in human cells. Nucleic Acids Res (2007) 1.74
Phenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors. Nat Biotechnol (2003) 1.65
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Engineered zinc finger proteins for controlling stem cell fate. Stem Cells (2003) 1.36
Chimeric recombinases with designed DNA sequence recognition. Proc Natl Acad Sci U S A (2003) 1.35
Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors. Proc Natl Acad Sci U S A (2002) 1.34
In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase. J Am Chem Soc (2007) 1.33
Chemically regulated zinc finger transcription factors. J Biol Chem (2000) 1.29
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Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase. Proc Natl Acad Sci U S A (2006) 1.22
A bacterial one-hybrid selection system for interrogating zinc finger-DNA interactions. Comb Chem High Throughput Screen (2006) 1.21
Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method. Nucleic Acids Res (2007) 1.17
Direct detection of double-stranded DNA: Molecular methods and applications for DNA diagnostics. Mol Biosyst (2006) 1.17
Phenotypic alteration and target gene identification using combinatorial libraries of zinc finger proteins in prokaryotic cells. J Bacteriol (2005) 1.13
Sequence-enabled reassembly of beta-lactamase (SEER-LAC): a sensitive method for the detection of double-stranded DNA. Biochemistry (2006) 1.12
Specific targeting of cytosine methylation to DNA sequences in vivo. Nucleic Acids Res (2006) 1.12
Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors. Cancer Res (2003) 1.09
Genetic reprogramming of tumor cells by zinc finger transcription factors. Proc Natl Acad Sci U S A (2005) 1.07
In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for ICAM-1 provides new insights into gene regulation. J Mol Biol (2004) 1.02
Induction and characterization of taxol-resistance phenotypes with a transiently expressed artificial transcriptional activator library. Nucleic Acids Res (2004) 1.01
Site-specific detection of DNA methylation utilizing mCpG-SEER. J Am Chem Soc (2006) 0.98
Promoter-targeted phage display selections with preassembled synthetic zinc finger libraries for endogenous gene regulation. J Mol Biol (2004) 0.98
Selective inhibition of P-glycoprotein expression in multidrug-resistant tumor cells by a designed transcriptional regulator. J Pharmacol Exp Ther (2002) 0.97
Design of artificial transcription factors to selectively regulate the pro-apoptotic bax gene. Nucleic Acids Res (2003) 0.97
One-step selection of artificial transcription factors using an in vivo screening system. Mol Cells (2006) 0.97
Modulation of drug resistance by artificial transcription factors. Mol Cancer Ther (2008) 0.91
Cell-free selection of zinc finger DNA-binding proteins using in vitro compartmentalization. J Mol Biol (2005) 0.90
Engineering zinc finger protein transcription factors to downregulate the epithelial glycoprotein-2 promoter as a novel anti-cancer treatment. Mol Carcinog (2007) 0.89
Positive selection of DNA-protein interactions in mammalian cells through phenotypic coupling with retrovirus production. Nat Struct Mol Biol (2009) 0.88
In vitro selection of zinc finger DNA-binding proteins through ribosome display. Biochem Biophys Res Commun (2006) 0.85
Employing libraries of zinc finger artificial transcription factors to screen for homologous recombination mutants in Arabidopsis. Plant J (2006) 0.81
[Construction of a SV40 promoter specific artificial transcription factor]. Sheng Wu Gong Cheng Xue Bao (2003) 0.79
Controlling gene expression in Drosophila using engineered zinc finger protein transcription factors. Biochem Biophys Res Commun (2006) 0.79
Selective transcription of p53 target genes by zinc finger-p53 DNA binding domain chimeras. Biochim Biophys Acta (2004) 0.78
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol (2013) 11.58
De novo computational design of retro-aldol enzymes. Science (2008) 7.62
The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci U S A (2003) 6.37
Engineering polydactyl zinc-finger transcription factors. Nat Biotechnol (2002) 4.40
Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases. Nucleic Acids Res (2006) 3.95
Custom zinc-finger nucleases for use in human cells. Mol Ther (2005) 3.04
Scanning the human genome with combinatorial transcription factor libraries. Nat Biotechnol (2003) 2.75
Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem (2005) 2.69
Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases. J Mol Biol (2010) 2.65
Designing transcription factor architectures for drug discovery. Mol Pharmacol (2004) 2.44
Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins. Biochemistry (2003) 2.33
Targeted gene knockout by direct delivery of zinc-finger nuclease proteins. Nat Methods (2012) 2.07
Synthesis of programmable integrases. Proc Natl Acad Sci U S A (2009) 1.94
Enamine-based organocatalysis with proline and diamines: the development of direct catalytic asymmetric Aldol, Mannich, Michael, and Diels-alder reactions. Acc Chem Res (2004) 1.92
Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA. J Mol Biol (2006) 1.91
Rapid, stable, chemoselective labeling of thiols with Julia-Kocieński-like reagents: a serum-stable alternative to maleimide-based protein conjugation. Angew Chem Int Ed Engl (2013) 1.85
Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst. Proc Natl Acad Sci U S A (2003) 1.78
Biochemical characterization and structural analysis of a highly proficient cocaine esterase. Biochemistry (2002) 1.60
Chimeric TALE recombinases with programmable DNA sequence specificity. Nucleic Acids Res (2012) 1.38
Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector. Int J Cancer (2006) 1.37
Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors. Proc Natl Acad Sci U S A (2002) 1.34
In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase. J Am Chem Soc (2007) 1.33
Structure-guided reprogramming of serine recombinase DNA sequence specificity. Proc Natl Acad Sci U S A (2010) 1.31
Evolution of aldolase antibodies in vitro: correlation of catalytic activity and reaction-based selection. J Mol Biol (2004) 1.30
Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display. J Mol Biol (2003) 1.30
Exploring strategies for the design of artificial transcription factors: targeting sites proximal to known regulatory regions for the induction of gamma-globin expression and the treatment of sickle cell disease. J Biol Chem (2004) 1.30
Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices. J Med Chem (2004) 1.29
Evolution of programmable zinc finger-recombinases with activity in human cells. J Mol Biol (2007) 1.28
Breaking the one antibody-one target axiom. Proc Natl Acad Sci U S A (2006) 1.26
Direct asymmetric alpha-fluorination of aldehydes. Angew Chem Int Ed Engl (2005) 1.25
Instant immunity through chemically programmable vaccination and covalent self-assembly. Proc Natl Acad Sci U S A (2009) 1.25
Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. J Biol Chem (2004) 1.24
Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies. Bioorg Med Chem Lett (2006) 1.22
Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites. J Virol (2004) 1.20
Directed evolution of recombinase specificity by split gene reassembly. Nucleic Acids Res (2010) 1.19
Core-structure-motivated design of a phosphine-catalyzed [3+2] cycloaddition reaction: enantioselective syntheses of spirocyclopenteneoxindoles. J Am Chem Soc (2011) 1.15
Towards organo-click chemistry: development of organocatalytic multicomponent reactions through combinations of aldol, Wittig, Knoevenagel, Michael, Diels-Alder and Huisgen cycloaddition reactions. Chemistry (2004) 1.14
Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase. Nucleic Acids Res (2011) 1.13
Organocatalytic asymmetric domino knoevenagel/diels-alder reactions: a bioorganic approach to the diastereospecific and enantioselective construction of highly substituted spiro[5,5]undecane-1,5,9-triones. Angew Chem Int Ed Engl (2003) 1.12
Development of small designer aldolase enzymes: catalytic activity, folding, and substrate specificity. Biochemistry (2005) 1.12
Integrin alpha(v)beta3 targeted therapy for Kaposi's sarcoma with an in vitro evolved antibody. FASEB J (2002) 1.11
A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy. J Mol Biol (2003) 1.11
An efficient chemical approach to bispecific antibodies and antibodies of high valency. Bioorg Med Chem Lett (2009) 1.11
Preparation of integrin alpha(v)beta3-targeting Ab 38C2 constructs. Nat Protoc (2007) 1.10
The origin of enantioselectivity in aldolase antibodies: crystal structure, site-directed mutagenesis, and computational analysis. J Mol Biol (2004) 1.10
A modular assembly strategy for improving the substrate specificity of small catalytic peptides. J Am Chem Soc (2002) 1.09
Tyrosine bioconjugation through aqueous ene-type reactions: a click-like reaction for tyrosine. J Am Chem Soc (2010) 1.08
Directed evolution of the TALE N-terminal domain for recognition of all 5' bases. Nucleic Acids Res (2013) 1.08
Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site. J Virol (2006) 1.07
Genetic reprogramming of tumor cells by zinc finger transcription factors. Proc Natl Acad Sci U S A (2005) 1.07
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{gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice. J Biol Chem (2005) 1.06
A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells. Nucleic Acids Res (2013) 1.04
Phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody reduces tumor growth and angiogenesis in vivo. Proc Natl Acad Sci U S A (2005) 1.04
Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation. Proc Natl Acad Sci U S A (2007) 1.04
A highly enantioselective route to either enantiomer of both alpha- and beta-amino acid derivatives. J Am Chem Soc (2002) 1.03
Beta-lactam-based approach for the chemical programming of aldolase antibody 38C2. Bioorg Med Chem Lett (2009) 1.03
A highly enantioselective amino acid-catalyzed route to functionalized alpha-amino acids. J Am Chem Soc (2002) 1.03
The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles. J Org Chem (2003) 1.02
In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for ICAM-1 provides new insights into gene regulation. J Mol Biol (2004) 1.02
Development of a small peptide tag for covalent labeling of proteins. Bioconjug Chem (2007) 1.00
Synthesis of beta-hydroxyaldehydes with stereogenic quaternary carbon centers by direct organocatalytic asymmetric aldol reactions. Angew Chem Int Ed Engl (2004) 1.00
Human/mouse cross-reactive anti-VEGF receptor 2 recombinant antibodies selected from an immune b9 allotype rabbit antibody library. J Immunol Methods (2004) 1.00
Design and use of fluorogenic aldehydes for monitoring the progress of aldehyde transformations. J Am Chem Soc (2004) 0.99
Promoter-targeted phage display selections with preassembled synthetic zinc finger libraries for endogenous gene regulation. J Mol Biol (2004) 0.98
Direct asymmetric anti-Mannich-type reactions catalyzed by a designed amino acid. J Am Chem Soc (2006) 0.98
Thiourea-catalyzed highly enantio- and diastereoselective additions of oxindoles to nitroolefins: application to the formal synthesis of (+)-physostigmine. J Am Chem Soc (2009) 0.97
Controlling gene expression in plants using synthetic zinc finger transcription factors. Plant J (2002) 0.97
Highly enantio- and diastereoselective Mannich reactions of glycine Schiff bases with in situ generated N-Boc-imines catalyzed by a cinchona alkaloid thiourea. Org Lett (2010) 0.96
Regulation of transgene expression in plants with polydactyl zinc finger transcription factors. Proc Natl Acad Sci U S A (2002) 0.96
Proline-catalyzed one-step asymmetric synthesis of 5-hydroxy-(2E)-hexenal from acetaldehyde. J Org Chem (2002) 0.96
Expanding the concept of chemically programmable antibodies to RNA aptamers: chemically programmed biotherapeutics. Angew Chem Int Ed Engl (2010) 0.95
Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody. Cancer Res (2005) 0.95
Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst. Nat Chem (2011) 0.95
Organocatalytic direct asymmetric aldol reactions in water. J Am Chem Soc (2006) 0.95
Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors. ACS Synth Biol (2013) 0.94
Catalysis of 3-pyrrolidinecarboxylic acid and related pyrrolidine derivatives in enantioselective anti-Mannich-type reactions: importance of the 3-acid group on pyrrolidine for stereocontrol. J Am Chem Soc (2007) 0.94
Direct observation of an enamine intermediate in amine catalysis. J Am Chem Soc (2009) 0.94
Small-molecule switches for zinc finger transcription factors. J Am Chem Soc (2003) 0.94
Monoclonal antibody therapeutics with up to five specificities: functional enhancement through fusion of target-specific peptides. MAbs (2013) 0.93
Improving the serum stability of site-specific antibody conjugates with sulfone linkers. Bioconjug Chem (2014) 0.93
Direct asymmetric organocatalytic Michael reactions of alpha,alpha-disubstituted aldehydes with beta-nitrostyrenes for the synthesis of quaternary carbon-containing products. Org Lett (2004) 0.92
Expanding the scope of site-specific recombinases for genetic and metabolic engineering. Biotechnol Bioeng (2013) 0.92
Asymmetric synthesis of quaternary alpha- and beta-amino acids and beta-lactams via proline-catalyzed mannich reactions with branched aldehyde donors. Org Lett (2004) 0.92
Isolation of human prostate cancer cell reactive antibodies using phage display technology. J Immunol Methods (2004) 0.92
Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors. J Biol Chem (2003) 0.92
Modulation of drug resistance by artificial transcription factors. Mol Cancer Ther (2008) 0.91
Direct catalytic asymmetric synthesis of anti-1,2-amino alcohols and syn-1,2-diols through organocatalytic anti-Mannich and syn-aldol reactions. J Am Chem Soc (2007) 0.91
Reactive immunization: a unique approach to catalytic antibodies. J Immunol Methods (2002) 0.91
Facile and stabile linkages through tyrosine: bioconjugation strategies with the tyrosine-click reaction. Bioconjug Chem (2013) 0.90
Potent inhibition of HIV-1 entry with a chemically programmed antibody aided by an efficient organocatalytic synthesis. Chembiochem (2010) 0.90
Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis. MAbs (2012) 0.89
Assembly of spirooxindole derivatives containing four consecutive stereocenters via organocatalytic Michael-Henry cascade reactions. Org Lett (2012) 0.89
Quantitation of DNA and RNA. CSH Protoc (2007) 0.89
Highly enantioselective organocatalytic α-amination reactions of aryl oxindoles: developing designer multifunctional alkaloid catalysts. Org Lett (2010) 0.88