Published in Arterioscler Thromb Vasc Biol on December 29, 2003
Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr (2006) 2.83
Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load. Am J Clin Nutr (2005) 1.66
Choline and betaine in health and disease. J Inherit Metab Dis (2010) 1.61
Epigenetic mechanisms for nutrition determinants of later health outcomes. Am J Clin Nutr (2009) 1.28
The association between betaine and choline intakes and the plasma concentrations of homocysteine in women. Am J Clin Nutr (2007) 1.16
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Nutrients (2013) 1.04
Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline. IUBMB Life (2007) 1.03
Adequate Intake levels of choline are sufficient for preventing elevations in serum markers of liver dysfunction in Mexican American men but are not optimal for minimizing plasma total homocysteine increases after a methionine load. Am J Clin Nutr (2008) 0.97
Effects of orange juice and proline betaine on glycine betaine and homocysteine in healthy male subjects. Eur J Nutr (2007) 0.93
Betaine and secondary events in an acute coronary syndrome cohort. PLoS One (2012) 0.90
Are dietary choline and betaine intakes determinants of total homocysteine concentration? Am J Clin Nutr (2010) 0.85
Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses: an observational study. Cardiovasc Diabetol (2012) 0.84
Associations among objectively measured physical activity, fasting plasma homocysteine concentration, and MTHFR C677T genotype. Eur J Appl Physiol (2011) 0.82
High homocysteine induces betaine depletion. Biosci Rep (2015) 0.80
Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males. J Nutr (2012) 0.80
Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes. Clin Epigenetics (2015) 0.80
Choline supplementation alters some amino acid concentrations with no change in homocysteine in children with cystic fibrosis and pancreatic insufficiency. Nutr Res (2015) 0.77
The contrasting relationships between betaine and homocysteine in two clinical cohorts are associated with plasma lipids and drug treatments. PLoS One (2012) 0.77
Maternal Folate Status and the BHMT c.716G>A Polymorphism Affect the Betaine Dimethylglycine Pathway during Pregnancy. Nutrients (2016) 0.75
Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med (2010) 6.48
450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect (2012) 4.89
Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. JAMA (2008) 4.49
Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem (2004) 4.31
Effects of exemestane administered for 2 years versus placebo on bone mineral density, bone biomarkers, and plasma lipids in patients with surgically resected early breast cancer. J Clin Oncol (2005) 3.72
Is folic acid good for everyone? Am J Clin Nutr (2008) 3.05
Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA (2009) 2.66
Screening for vitamin B-12 and folate deficiency in older persons. Am J Clin Nutr (2003) 2.47
Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals. Lancet (2013) 2.37
A randomized trial of low-dose tamoxifen on breast cancer proliferation and blood estrogenic biomarkers. J Natl Cancer Inst (2003) 2.25
The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr (2006) 2.15
Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom (2009) 1.96
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One (2010) 1.92
Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr (2006) 1.91
Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study. Age Ageing (2006) 1.86
Randomized double-blind 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in high-risk premenopausal women. J Clin Oncol (2009) 1.85
Folate and depression. Psychother Psychosom (2003) 1.71
Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clin Chem (2003) 1.70
Vitamin B12 deficiency and hyperhomocysteinemia in rural and urban Indians. J Assoc Physicians India (2006) 1.69
Genotype-guided tamoxifen therapy: time to pause for reflection? Lancet Oncol (2009) 1.65
Changes in lifestyle and plasma total homocysteine: the Hordaland Homocysteine Study. Am J Clin Nutr (2004) 1.65
Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry (2011) 1.60
Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years. Clin Chem (2003) 1.58
Effect of vorapaxar on myocardial infarction in the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome (TRA·CER) trial. Eur Heart J (2013) 1.56
Dietary fat and plasma total homocysteine concentrations in 2 adult age groups: the Hordaland Homocysteine Study. Am J Clin Nutr (2007) 1.55
Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia. Nutrition (2010) 1.53
Mid-pregnancy cotinine and risks of orofacial clefts and neural tube defects. J Pediatr (2008) 1.52
Tamoxifen and metabolite concentrations in serum and breast cancer tissue during three dose regimens in a randomized preoperative trial. Clin Cancer Res (2004) 1.50
Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. Arch Gen Psychiatry (2003) 1.50
The other side of the coin: perceived positive effects of illness in women following acute myocardial infarction. Eur J Cardiovasc Nurs (2007) 1.48
Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance. J Nutr (2008) 1.47
Effect of vitamin B12 treatment on haptocorrin. Clin Chem (2006) 1.46
Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci U S A (2013) 1.46
Coronary reperfusion and clinical outcomes after thrombus aspiration during primary percutaneous coronary intervention: findings from the HORIZONS-AMI trial. Catheter Cardiovasc Interv (2013) 1.44
Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev (2010) 1.40
Poor folate status predicts persistent diarrhea in 6- to 30-month-old north Indian children. J Nutr (2011) 1.40
Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study. Am J Clin Nutr (2007) 1.38
Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women. J Nutr (2008) 1.37
Patterns and predictors of folic acid supplement use among pregnant women: the Norwegian Mother and Child Cohort Study. Am J Clin Nutr (2006) 1.37
Low vitamin B-12 status and risk of cognitive decline in older adults. Am J Clin Nutr (2007) 1.32
Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring. J Nutr (2007) 1.23
Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC. Cancer Epidemiol Biomarkers Prev (2011) 1.21
Multianalyte quantification of vitamin B6 and B2 species in the nanomolar range in human plasma by liquid chromatography-tandem mass spectrometry. Clin Chem (2005) 1.21
Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. Circulation (2007) 1.21
Serum B vitamin levels and risk of lung cancer. JAMA (2010) 1.20
Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. Arch Intern Med (2005) 1.19
Cobalamin and folate status in infants and young children in a low-to-middle income community in India. Am J Clin Nutr (2007) 1.19
Choline and risk of neural tube defects in a folate-fortified population. Epidemiology (2009) 1.18
Plasma homocysteine, folate, and vitamin B 12 and the risk of hip fracture: the hordaland homocysteine study. J Bone Miner Res (2007) 1.18
Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation. J Nutr (2011) 1.18
Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status. Clin Chem (2009) 1.14
Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study. Am J Clin Nutr (2009) 1.13
Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. J Lipid Res (2010) 1.12
Associations between maternal methylenetetrahydrofolate reductase polymorphisms and adverse outcomes of pregnancy: the Hordaland Homocysteine Study. Am J Med (2004) 1.11
Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition study. Cancer Epidemiol Biomarkers Prev (2008) 1.10
Vitamin B12 status of pregnant Indian women and cognitive function in their 9-year-old children. Food Nutr Bull (2008) 1.10
Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study. Arch Intern Med (2006) 1.09
MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis. Circulation (2009) 1.09
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr (2013) 1.08
Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. Ann Neurol (2005) 1.07
One-carbon metabolism and prostate cancer risk: prospective investigation of seven circulating B vitamins and metabolites. Cancer Epidemiol Biomarkers Prev (2009) 1.07
Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism? Am J Clin Nutr (2008) 1.07
Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer. BMC Cancer (2010) 1.06
Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy. Am J Clin Nutr (2005) 1.05
The vitamin D receptor gene is associated with Alzheimer's disease. Neurosci Lett (2011) 1.05
Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation. Cancer Epidemiol Biomarkers Prev (2008) 1.05
Folic acid and multivitamin supplement use and risk of placental abruption: a population-based registry study. Am J Epidemiol (2008) 1.04
Kinetic modeling of storage effects on biomarkers related to B vitamin status and one-carbon metabolism. Clin Chem (2011) 1.03
Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels. Am J Med Genet B Neuropsychiatr Genet (2008) 1.02
Birth prevalence of homocystinuria. J Pediatr (2004) 1.01
Determination of vitamins A, D and E in a small volume of human plasma by a high-throughput method based on liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom (2011) 1.01
Do we need to reconsider the desirable blood level of vitamin B12? J Intern Med (2011) 1.01
Maternal total homocysteine concentration and neonatal size in India. Asia Pac J Clin Nutr (2005) 1.01
Dietary patterns, food groups, and nutrients as predictors of plasma choline and betaine in middle-aged and elderly men and women. Am J Clin Nutr (2008) 1.00
Functional inference of the methylenetetrahydrofolate reductase 677C > T and 1298A > C polymorphisms from a large-scale epidemiological study. Hum Genet (2006) 1.00
Predictors of serum ferritin and serum soluble transferrin receptor in newborns and their associations with iron status during the first 2 y of life. Am J Clin Nutr (2007) 1.00
Systemic markers of interferon-γ-mediated immune activation and long-term prognosis in patients with stable coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 0.99