Published in Cardiovasc Diabetol on July 11, 2012
Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study. PLoS One (2014) 1.23
Metabolic profiling in Maturity-onset diabetes of the young (MODY) and young onset type 2 diabetes fails to detect robust urinary biomarkers. PLoS One (2012) 0.85
Assessment of urinary betaine as a marker of diabetes mellitus in cardiovascular patients. PLoS One (2013) 0.80
Listening to Our Gut: Contribution of Gut Microbiota and Cardiovascular Risk in Diabetes Pathogenesis. Curr Diab Rep (2015) 0.78
Relationship between blood levels of methyl donor and folate and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study. J Clin Biochem Nutr (2014) 0.78
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53
Concentrations of choline-containing compounds and betaine in common foods. J Nutr (2003) 4.12
Cellular response to hyperosmotic stresses. Physiol Rev (2007) 3.58
Choline and betaine in health and disease. J Inherit Metab Dis (2010) 1.61
Long-term effect of betaine on risk factors associated with the metabolic syndrome in healthy subjects. Eur J Clin Nutr (2010) 1.54
The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem (2010) 1.43
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem (2011) 1.40
Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women. J Nutr (2008) 1.37
Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene. J Biol Chem (1999) 1.15
Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr (2003) 1.13
Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. J Nutr (2006) 1.07
Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation. Arterioscler Thromb Vasc Biol (2003) 1.06
A whole-grain cereal-rich diet increases plasma betaine, and tends to decrease total and LDL-cholesterol compared with a refined-grain diet in healthy subjects. Br J Nutr (2011) 1.03
Post-methionine load hyperhomocysteinemia in persons with normal fasting total plasma homocysteine: initial results from the NHLBI Family Heart Study. Atherosclerosis (1995) 1.00
Tissue-specific alterations of methyl group metabolism with DNA hypermethylation in the Zucker (type 2) diabetic fatty rat. Diabetes Metab Res Rev (2012) 0.97
Plasma dependent and independent accumulation of betaine in male and female rat tissues. Physiol Res (2008) 0.96
Homocysteine, glycine betaine, and N,N-dimethylglycine in patients attending a lipid clinic. Metabolism (2005) 0.96
Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutr Res (2010) 0.95
The cellular hydration state: a critical determinant for cell death and survival. Biol Chem (2002) 0.94
Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans. J Nutr (2006) 0.92
Consumption of wheat aleurone-rich foods increases fasting plasma betaine and modestly decreases fasting homocysteine and LDL-cholesterol in adults. J Nutr (2010) 0.92
High sodium chloride intake decreases betaine-homocysteine S-methyltransferase expression in guinea pig liver and kidney. Am J Physiol Regul Integr Comp Physiol (2004) 0.92
Dietary and supplementary betaine: acute effects on plasma betaine and homocysteine concentrations under standard and postmethionine load conditions in healthy male subjects. Am J Clin Nutr (2008) 0.92
Short and long-term variation of plasma glycine betaine concentrations in humans. Clin Biochem (2004) 0.90
Elevated glycine betaine excretion in diabetes mellitus patients is associated with proximal tubular dysfunction and hyperglycemia. Diabetes Res Clin Pract (1999) 0.89
Abnormal glycine betaine content of the blood and urine of diabetic and renal patients. Clin Chim Acta (1994) 0.89
Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int (2002) 0.87
Inter- and intra-individual variations in normal urinary glycine betaine excretion. Clin Biochem (2007) 0.87
Separation of cationic aracyl derivatives of betaines and related compounds. J Chromatogr A (2005) 0.87
Measurement of the formation of betaine aldehyde and betaine in rat liver mitochondria by a high pressure liquid chromatography-radioenzymatic assay. Biochim Biophys Acta (1992) 0.85
Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells. Am J Physiol Gastrointest Liver Physiol (2007) 0.85
Methionine loading test is necessary for detection of hyperhomocysteinemia. J Lab Clin Med (1998) 0.83
Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic. Clin Biochem (2007) 0.82
An abnormal urinary excretion of glycine betaine may persist for years. Clin Biochem (2007) 0.81
Betaine excretion correlates with plasma homocysteine when plasma lipids are elevated. Clin Biochem (2011) 0.80
Glycine betaine excretion is not directly linked to plasma glucose concentrations in hyperglycaemia. Diabetes Res Clin Pract (2001) 0.79
Low diagnostic value of fasting and post-methionine load homocysteine tests. A study in Dutch subjects with homocysteine test indications. Clin Chim Acta (2003) 0.77
Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study. Arch Intern Med (2009) 7.82
A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): a prospective observational validation study. Lancet (2011) 5.61
Meta-analysis: vitamin D compounds in chronic kidney disease. Ann Intern Med (2007) 4.23
Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney Int (2010) 3.37
Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney Int (2011) 3.05
Impact of routine systematic polymerase chain reaction testing on case finding for Legionnaires' disease: a pre-post comparison study. Clin Infect Dis (2013) 2.28
Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial. JAMA (2012) 2.27
A comparison between two strategies for monitoring hepatic function during antituberculous therapy. Am J Respir Crit Care Med (2011) 2.22
Vitamin D compounds for people with chronic kidney disease not requiring dialysis. Cochrane Database Syst Rev (2009) 1.88
Use of ethanol locks to prevent recurrent central line sepsis. J Infect (2004) 1.69
Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine. Cardiovasc Drugs Ther (2009) 1.49
Peritonsillar infection in Christchurch 2006-2008: epidemiology and microbiology. N Z Med J (2011) 1.46
Differential identification of a rare form of platelet-type (pseudo-) von Willebrand disease (VWD) from Type 2B VWD using a simplified ristocetin-induced-platelet-agglutination mixing assay and confirmed by genetic analysis. Br J Haematol (2007) 1.43
The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem (2010) 1.43
Evaluation of a PCR assay for detection of Streptococcus pneumoniae in respiratory and nonrespiratory samples from adults with community-acquired pneumonia. J Clin Microbiol (2003) 1.41
Prospective validation of cerebrospinal fluid bilirubin in suspected subarachnoid haemorrhage. Ann Clin Biochem (2007) 1.40
CAPD in sheep following bilateral nephrectomy. Perit Dial Int (2006) 1.40
Cutaneous myiasis due to Dermatobia hominis (the human botfly) in a New Zealand traveller returned from South America. N Z Med J (2009) 1.39
Coenzyme Q10: an independent predictor of mortality in chronic heart failure. J Am Coll Cardiol (2008) 1.35
Effect of coenzyme Q(10) supplementation on simvastatin-induced myalgia. Am J Cardiol (2007) 1.31
The scent of Mycobacterium tuberculosis--part II breath. Tuberculosis (Edinb) (2009) 1.27
Antibiotic resistance in uncomplicated urinary tract infection: problems with interpreting cumulative resistance rates from local community laboratories. N Z Med J (2002) 1.23
Contamination of Qiagen DNA extraction kits with Legionella DNA. J Clin Microbiol (2003) 1.22
Cystatin C--a paradigm of evidence based laboratory medicine. Clin Biochem Rev (2008) 1.17
Recurrent breast abscess caused by Gordonia bronchialis in an immunocompetent patient. J Clin Microbiol (2005) 1.17
Double complex mutations involving F8 and FUNDC2 caused by distinct break-induced replication. Hum Mutat (2007) 1.15
Trimethylaminuria: causes and diagnosis of a socially distressing condition. Clin Biochem Rev (2011) 1.12
Mutant fibrinogen cleared from the endoplasmic reticulum via endoplasmic reticulum-associated protein degradation and autophagy: an explanation for liver disease. Am J Pathol (2006) 1.09
The scent of Mycobacterium tuberculosis. Tuberculosis (Edinb) (2008) 1.08
Detection of factor VIII gene mutations by high-resolution melting analysis. Clin Chem (2007) 1.08
Vitamin D compounds for people with chronic kidney disease requiring dialysis. Cochrane Database Syst Rev (2009) 1.06
The relative effects of fat versus muscle mass on cystatin C and estimates of renal function in healthy young men. Ann Clin Biochem (2012) 1.06
Investigation into the production of 2-Pentylfuran by Aspergillus fumigatus and other respiratory pathogens in vitro and human breath samples. Med Mycol (2008) 1.06
2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung. BMC Pulm Med (2010) 1.05
Vitamin D receptor genotypes influence the success of calcitriol therapy for recurrent vertebral fracture in osteoporosis. Pharmacogenet Genomics (2005) 1.05
Identification and characterization of two non-secreted PCSK9 mutants associated with familial hypercholesterolemia in cohorts from New Zealand and South Africa. Atherosclerosis (2007) 1.02
Interventions for preventing bone disease in kidney transplant recipients: a systematic review of randomized controlled trials. Am J Kidney Dis (2005) 1.01
Plasma lipids and betaine are related in an acute coronary syndrome cohort. PLoS One (2011) 0.97
Homocysteine, glycine betaine, and N,N-dimethylglycine in patients attending a lipid clinic. Metabolism (2005) 0.96
Coenzyme Q10: is there a clinical role and a case for measurement? Clin Biochem Rev (2008) 0.95
Novel fibrinogen gamma375 Arg-->Trp mutation (fibrinogen aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia. Hepatology (2002) 0.94
Outpatient intravenous treatment for infective endocarditis: safety, effectiveness and one-year outcomes. J Infect (2009) 0.93
Effects of orange juice and proline betaine on glycine betaine and homocysteine in healthy male subjects. Eur J Nutr (2007) 0.93
Use of fully denaturing HPLC for UGT1A1 genotyping in Gilbert syndrome. Clin Chem (2005) 0.92
Dietary and supplementary betaine: acute effects on plasma betaine and homocysteine concentrations under standard and postmethionine load conditions in healthy male subjects. Am J Clin Nutr (2008) 0.92
Proteome-wide analysis and CXCL4 in systemic sclerosis. N Engl J Med (2014) 0.92
Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity. Pharmacogenet Genomics (2008) 0.90
Short and long-term variation of plasma glycine betaine concentrations in humans. Clin Biochem (2004) 0.90
Betaine and secondary events in an acute coronary syndrome cohort. PLoS One (2012) 0.90
Successful antimicrobial therapy and implant retention for streptococcal infection of prosthetic joints. ANZ J Surg (2004) 0.88
Benefits of knowledge-based interprofessional communication skills training in medical undergraduate education. JRSM Short Rep (2011) 0.88
Free and total cefazolin plasma and interstitial fluid concentrations at steady state during continuous infusion. J Antimicrob Chemother (2002) 0.88
Protein binding of cefazolin is saturable in vivo both between and within patients. Br J Clin Pharmacol (2007) 0.87
Inter- and intra-individual variations in normal urinary glycine betaine excretion. Clin Biochem (2007) 0.87
Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate. J Lipid Res (2012) 0.87
Biomarkers of cardiac dysfunction and mortality from community-acquired pneumonia in adults. PLoS One (2013) 0.87
Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int (2002) 0.87
Comparison of galactomannan detection, PCR-enzyme-linked immunosorbent assay, and real-time PCR for diagnosis of invasive aspergillosis in a neutropenic rat model and effect of caspofungin acetate. Clin Diagn Lab Immunol (2005) 0.86
Effect of atorvastatin on plasma levels of asymmetric dimethylarginine in patients with non-ischaemic heart failure. Eur J Heart Fail (2008) 0.86
Evaluation of high-resolution melting analysis for screening the LDL receptor gene. Clin Biochem (2008) 0.86
Campylobacter fetus-associated epidural abscess and bacteremia. J Clin Microbiol (2009) 0.86
Betaine analogues alter homocysteine metabolism in rats. Int J Biochem Cell Biol (2004) 0.85
Performance of Xpert MTB/RIF in the diagnosis of tuberculous mediastinal lymphadenopathy by endobronchial ultrasound. Ann Am Thorac Soc (2014) 0.85
Hypertension as a determinant of survival for patients treated with home dialysis. Kidney Int (2002) 0.84
Endothelium-ameliorating effects of statin therapy and coenzyme Q10 reductions in chronic heart failure. Atherosclerosis (2004) 0.84
Biological variation of coenzyme Q10. Clin Chem (2005) 0.83
Plasma and urine betaine and dimethylglycine variation in healthy young male subjects. Clin Biochem (2009) 0.83
Comparison of SSCP and DHPLC for the detection of LDLR mutations in a New Zealand cohort. Hum Mutat (2002) 0.82
Coenzyme Q10; an adjunctive therapy for congestive heart failure? N Z Med J (2009) 0.82
Real-time detection of common microbial volatile organic compounds from medically important fungi by Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS). J Microbiol Methods (2005) 0.82
Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic. Clin Biochem (2007) 0.82
The sialic acid content of fibrinogen decreases during pregnancy and increases in response to fibrate therapy. Thromb Res (2005) 0.82
A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the metabolic syndrome. Am J Hypertens (2011) 0.81
Fibrinogen B beta polymorphisms do not directly contribute to an altered in vitro clot structure in humans. Thromb Haemost (2003) 0.81
An abnormal urinary excretion of glycine betaine may persist for years. Clin Biochem (2007) 0.81
Role of genetic testing in retinoblastoma management at a tertiary referral centre. Clin Experiment Ophthalmol (2010) 0.81
Folate and vitamin B12 status of women of reproductive age living in Hanoi City and Hai Duong Province of Vietnam. Public Health Nutr (2008) 0.81