Published in Genes Dev on December 15, 2003
MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision. Proc Natl Acad Sci U S A (2005) 3.69
Linking asymmetric cell division to the terminal differentiation program of postmitotic neurons in C. elegans. Dev Cell (2009) 1.35
Stochastic mechanisms of cell fate specification that yield random or robust outcomes. Annu Rev Cell Dev Biol (2010) 1.32
Similar requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in diverse cell types. Dev Biol (2007) 1.22
A "FLP-Out" system for controlled gene expression in Caenorhabditis elegans. Genetics (2008) 1.16
The C. elegans Twist target gene, arg-1, is regulated by distinct E box promoter elements. Mech Dev (2007) 0.91
Otx-dependent expression of proneural bHLH genes establishes a neuronal bilateral asymmetry in C. elegans. Development (2010) 0.90
Spatial regulation of lag-2 transcription during vulval precursor cell fate patterning in Caenorhabditis elegans. Genetics (2011) 0.87
Delta activity independent of its activity as a ligand of Notch. BMC Dev Biol (2005) 0.86
C. elegans HLH-2/E/Daughterless controls key regulatory cells during gonadogenesis. Dev Biol (2009) 0.86
The transcription factor HLH-2/E/Daughterless regulates anchor cell invasion across basement membrane in C. elegans. Dev Biol (2011) 0.84
Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling. Genes Dev (2013) 0.84
Stochastic variation: from single cells to superorganisms. HFSP J (2009) 0.84
The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway. PLoS Genet (2015) 0.83
Different cell fates from cell-cell interactions: core architectures of two-cell bistable networks. Biophys J (2012) 0.82
Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans. Proc Natl Acad Sci U S A (2013) 0.82
C. elegans twist gene expression in differentiated cell types is controlled by autoregulation through intron elements. Dev Biol (2010) 0.80
Transcriptional regulation of gene expression in C. elegans. WormBook (2013) 0.79
EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Genetics (2006) 0.78
Dimerization-driven degradation of C. elegans and human E proteins. Genes Dev (2015) 0.77
Caenorhabditis elegans histone deacetylase hda-1 is required for morphogenesis of the vulva and LIN-12/Notch-mediated specification of uterine cell fates. G3 (Bethesda) (2013) 0.77
Distinct Caenorhabditis elegans HLH-8/twist-containing dimers function in the mesoderm. Dev Dyn (2012) 0.77
LIN-12/Notch regulates lag-1 and lin-12 expression during anchor cell/ventral uterine precursor cell fate specification. Mol Cells (2013) 0.75
UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans. G3 (Bethesda) (2016) 0.75
Of plasticity and specificity: dialectics of the micro- and macro-environment and the organ phenotype. Wiley Interdiscip Rev Membr Transp Signal (2014) 0.75
Influences of LIN-12/Notch and POP-1/TCF on the Robustness of Ventral Uterine Cell Fate Specification in Caenorhabditis elegans Gonadogenesis. G3 (Bethesda) (2015) 0.75
Linking the environment, DAF-7/TGFβ signaling and LAG-2/DSL ligand expression in the germline stem cell niche. Development (2017) 0.75
The genetics of Caenorhabditis elegans. Genetics (1974) 102.14
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol (1977) 19.51
An efficient recombination system for chromosome engineering in Escherichia coli. Proc Natl Acad Sci U S A (2000) 17.30
Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell (1989) 14.24
Noise in eukaryotic gene expression. Nature (2003) 13.01
Specific interference by ingested dsRNA. Nature (1998) 11.82
Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene (2001) 11.09
Signalling downstream of activated mammalian Notch. Nature (1995) 11.08
Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol (2000) 8.89
The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans. Dev Biol (1979) 8.31
A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans. Gene (1990) 5.27
Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell (1994) 4.95
Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev (1995) 4.47
RNAi in C. elegans: soaking in the genome sequence. Science (1998) 4.39
The lin-12 locus specifies cell fates in Caenorhabditis elegans. Cell (1983) 3.87
LIN-12/Notch signaling: lessons from worms and flies. Genes Dev (1998) 3.75
The choice of cell fate in the epidermis of Drosophila. Cell (1991) 3.71
A new kind of informational suppression in the nematode Caenorhabditis elegans. Genetics (1989) 3.69
Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans. Dev Biol (1981) 3.61
The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Genes Dev (1995) 3.24
The taxonomy of developmental control in Caenorhabditis elegans. Science (1998) 2.80
lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans. Development (1994) 2.66
The basic helix-loop-helix protein family: comparative genomics and phylogenetic analysis. Genome Res (2001) 2.47
Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions. Development (1991) 2.30
The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes. Development (1991) 2.03
Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc Natl Acad Sci U S A (1997) 2.00
The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans. Genes Dev (1999) 1.97
Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation. Genes Dev (1994) 1.95
Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila. Nature (1994) 1.90
Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development (1996) 1.86
A C. elegans E/Daughterless bHLH protein marks neuronal but not striated muscle development. Development (1997) 1.81
Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision. Cell (1994) 1.79
The Groucho-like transcription factor UNC-37 functions with the neural specificity gene unc-4 to govern motor neuron identity in C. elegans. Development (1997) 1.77
A dual function of the Notch gene in Drosophila sensillum development. Dev Biol (1990) 1.75
Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. EMBO J (2003) 1.73
An Organ-Specific Differentiation Gene, pha-1, from Caenorhabditis elegans. Science (1990) 1.63
Cell autonomy of lin-12 function in a cell fate decision in C. elegans. Cell (1989) 1.62
Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila. Development (1990) 1.60
Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling. Genes Dev (1998) 1.59
The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins. Development (2003) 1.57
Notch signaling induces rapid degradation of achaete-scute homolog 1. Mol Cell Biol (2002) 1.51
bHLH proteins encoded by the Enhancer of split complex of Drosophila negatively interfere with transcriptional activation mediated by proneural genes. Mol Gen Genet (1994) 1.49
Decoding vectorial information from a gradient: sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye. Development (1999) 1.48
Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells. Development (1999) 1.44
Analysis of dominant-negative mutations of the Caenorhabditis elegans let-60 ras gene. Genes Dev (1991) 1.42
cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans. Development (1996) 1.41
Cell-cell interactions prevent a potential inductive interaction between soma and germline in C. elegans. Cell (1990) 1.32
A cell-specific enhancer that specifies lin-3 expression in the C. elegans anchor cell for vulval development. Development (2003) 1.28
The Caenorhabditis elegans NK-2 homeobox gene ceh-22 activates pharyngeal muscle gene expression in combination with pha-1 and is required for normal pharyngeal development. Development (1997) 1.27
The daughterless gene product in Drosophila is a nuclear protein that is broadly expressed throughout the organism during development. Mech Dev (1993) 1.20
Lateral inhibition mediated by the Drosophila neurogenic gene delta is enhanced by proneural proteins. Proc Natl Acad Sci U S A (1994) 1.18
The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage. Development (2000) 1.15
Genesis of an organ: molecular analysis of the pha-1 gene. Development (1994) 1.10
The role of lin-22, a hairy/enhancer of split homolog, in patterning the peripheral nervous system of C. elegans. Development (1997) 1.06
LIN-12 protein expression and localization during vulval development in C. elegans. Development (1998) 1.03
Interpretation of X chromosome dose at Sex-lethal requires non-E-box sites for the basic helix-loop-helix proteins SISB and daughterless. Mol Cell Biol (2001) 0.98
The Drosophila daughterless gene autoregulates and is controlled by both positive and negative cis regulation. Development (2001) 0.96
Spatial and temporal patterns of lin-12 expression during C. elegans hermaphrodite development. Genetics (1995) 0.91
LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans. Science (2005) 4.28
Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Science (2004) 3.03
OrthoList: a compendium of C. elegans genes with human orthologs. PLoS One (2011) 2.05
The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins. Dev Cell (2004) 1.93
Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans. Nature (2002) 1.66
SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans. Dev Cell (2006) 1.61
LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans. Development (2005) 1.34
lin-35 Rb acts in the major hypodermis to oppose ras-mediated vulval induction in C. elegans. Dev Cell (2005) 1.32
Endocytosis function of a ligand-gated ion channel homolog in Caenorhabditis elegans. Curr Biol (2005) 1.25
A Caenorhabditis elegans model for epithelial-neuronal transdifferentiation. Proc Natl Acad Sci U S A (2008) 1.23
Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans. Genes Dev (2002) 1.18
SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells. Development (2007) 1.06
Wnt signal from multiple tissues and lin-3/EGF signal from the gonad maintain vulval precursor cell competence in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.04
Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE. Dev Biol (2005) 1.00
Multiple roles for the E/Daughterless ortholog HLH-2 during C. elegans gonadogenesis. Dev Biol (2004) 0.96
LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning. Curr Biol (2010) 0.96
New positive regulators of lin-12 activity in Caenorhabditis elegans include the BRE-5/Brainiac glycosphingolipid biosynthesis enzyme. Genetics (2005) 0.94
A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells. Proc Natl Acad Sci U S A (2010) 0.94
Spatial regulation of lag-2 transcription during vulval precursor cell fate patterning in Caenorhabditis elegans. Genetics (2011) 0.87
SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron. Genes Dev (2012) 0.83
Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans. Proc Natl Acad Sci U S A (2013) 0.82
sel-7, a positive regulator of lin-12 activity, encodes a novel nuclear protein in Caenorhabditis elegans. Genetics (2004) 0.80
sel-11 and cdc-42, two negative modulators of LIN-12/Notch activity in C. elegans. PLoS One (2010) 0.79
EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Genetics (2006) 0.78
Cluster Analyzer for Transcription Sites (CATS): a C++-based program for identifying clustered transcription factor binding sites. Bioinformatics (2004) 0.76
WormBook: WormBiology for the 21st Century. Genetics (2016) 0.75