Published in Proc Natl Acad Sci U S A on March 10, 2010
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. J Cell Biol (2012) 1.07
Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene (2011) 1.03
Protease regulation: the Yin and Yang of neural development and disease. Neuron (2011) 1.00
Downregulation of Notch modulators, tetraspanin 5 and 10, inhibits osteoclastogenesis in vitro. Calcif Tissue Int (2014) 0.91
Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans. PLoS Genet (2012) 0.89
TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics. Mol Psychiatry (2016) 0.86
TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization. Cell Mol Life Sci (2015) 0.84
Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol (2015) 0.79
Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids. PLoS Genet (2015) 0.77
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Tetraspanin (TSP-17) protects dopaminergic neurons against 6-OHDA-induced neurodegeneration in C. elegans. PLoS Genet (2014) 0.76
Genetic and biochemical changes of the serotonergic system in migraine pathobiology. J Headache Pain (2017) 0.75
Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans. PLoS Genet (2017) 0.75
Identifying genetic interactions associated with late-onset Alzheimer's disease. BioData Min (2014) 0.75
Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments. Mol Neurodegener (2017) 0.75
Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer. Oncotarget (2016) 0.75
The Emerging Role of Tetraspanins in the Proteolytic Processing of the Amyloid Precursor Protein. Front Mol Neurosci (2016) 0.75
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
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LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway. Nature (2000) 2.17
The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J Cell Biol (2002) 1.99
Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors. Development (1997) 1.94
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NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL. Blood (2008) 1.84
Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila. Proc Natl Acad Sci U S A (2001) 1.74
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Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans. Nature (1990) 1.62
Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions. Mol Cell Biol (2000) 1.44
Notch signaling in the C. elegans embryo. WormBook (2005) 1.34
Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila. Nat Cell Biol (2001) 1.30
Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein. FASEB J (2009) 1.28
LIN-12/Notch signaling in C. elegans. WormBook (2005) 1.27
Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat Cell Biol (2009) 1.25
A regulatory role for CD37 in T cell proliferation. J Immunol (2004) 1.20
Tetraspanin protein (TSP-15) is required for epidermal integrity in Caenorhabditis elegans. J Cell Sci (2004) 1.20
Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr virus nuclear antigen 2. J Virol (1998) 1.15
SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2000) 1.07
Origin of the tetraspanin uroplakins and their co-evolution with associated proteins: implications for uroplakin structure and function. Mol Phylogenet Evol (2006) 1.02
Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Proc Natl Acad Sci U S A (2002) 1.02
Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE. Dev Biol (2005) 1.00
MicroRNA expression profiles classify human cancers. Nature (2005) 69.12
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A (2006) 6.80
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med (2007) 6.55
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc Natl Acad Sci U S A (2007) 5.44
LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans. Science (2005) 4.28
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med (2007) 4.04
Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat Med (2008) 3.98
Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell (2003) 3.86
Myc-induced T cell leukemia in transgenic zebrafish. Science (2003) 3.15
Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Science (2004) 3.03
Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia. Cancer Cell (2011) 2.89
Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias. Blood (2004) 2.60
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science (2009) 2.51
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell (2002) 2.48
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet (2011) 2.32
OrthoList: a compendium of C. elegans genes with human orthologs. PLoS One (2011) 2.05
The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins. Dev Cell (2004) 1.93
The TLX1 oncogene drives aneuploidy in T cell transformation. Nat Med (2010) 1.93
ETV6 mutations in early immature human T cell leukemias. J Exp Med (2011) 1.88
Genetic loss of SH2B3 in acute lymphoblastic leukemia. Blood (2013) 1.87
In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci U S A (2004) 1.85
NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL. Blood (2008) 1.84
The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia. Cell Cycle (2008) 1.83
HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. Blood (2012) 1.76
WT1 mutations in T-ALL. Blood (2009) 1.75
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. Nat Genet (2010) 1.68
Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans. Nature (2002) 1.66
ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes. Proc Natl Acad Sci U S A (2008) 1.65
SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans. Dev Cell (2006) 1.61
Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL. Nat Med (2012) 1.56
Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Nat Immunol (2010) 1.49
CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia. J Exp Med (2009) 1.47
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med (2005) 1.46
LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans. Development (2005) 1.34
lin-35 Rb acts in the major hypodermis to oppose ras-mediated vulval induction in C. elegans. Dev Cell (2005) 1.32
Endocytosis function of a ligand-gated ion channel homolog in Caenorhabditis elegans. Curr Biol (2005) 1.25
A Caenorhabditis elegans model for epithelial-neuronal transdifferentiation. Proc Natl Acad Sci U S A (2008) 1.23
Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans. Genes Dev (2003) 1.23
Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol. J Clin Oncol (2009) 1.22
Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans. Genes Dev (2002) 1.18
Decreased expression of peroxisome proliferator activated receptor gamma in cftr-/- mice. J Cell Physiol (2004) 1.17
Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. Blood (2006) 1.17
Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia. J Clin Oncol (2010) 1.14
Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia. Blood (2013) 1.13
IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL. Blood (2003) 1.10
Recent advances on NOTCH signaling in T-ALL. Curr Top Microbiol Immunol (2012) 1.09
Preclinical analysis of the γ-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia. Mol Cancer Ther (2012) 1.09
Early T-cell precursor acute lymphoblastic leukaemia. Curr Opin Hematol (2013) 1.08
SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells. Development (2007) 1.06
Wnt signal from multiple tissues and lin-3/EGF signal from the gonad maintain vulval precursor cell competence in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.04
Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE. Dev Biol (2005) 1.00
Multiple roles for the E/Daughterless ortholog HLH-2 during C. elegans gonadogenesis. Dev Biol (2004) 0.96
LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning. Curr Biol (2010) 0.96
The NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy. Ther Adv Hematol (2013) 0.94
New positive regulators of lin-12 activity in Caenorhabditis elegans include the BRE-5/Brainiac glycosphingolipid biosynthesis enzyme. Genetics (2005) 0.94
Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia. Genes Chromosomes Cancer (2004) 0.92
Spatial regulation of lag-2 transcription during vulval precursor cell fate patterning in Caenorhabditis elegans. Genetics (2011) 0.87
ParMap, an algorithm for the identification of small genomic insertions and deletions in nextgen sequencing data. BMC Res Notes (2010) 0.84
SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron. Genes Dev (2012) 0.83
Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans. Proc Natl Acad Sci U S A (2013) 0.82
sel-7, a positive regulator of lin-12 activity, encodes a novel nuclear protein in Caenorhabditis elegans. Genetics (2004) 0.80
sel-11 and cdc-42, two negative modulators of LIN-12/Notch activity in C. elegans. PLoS One (2010) 0.79
TLX1-induced T-cell acute lymphoblastic leukemia. Clin Cancer Res (2011) 0.79
The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo. Blood (2012) 0.79
EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Genetics (2006) 0.78
Cluster Analyzer for Transcription Sites (CATS): a C++-based program for identifying clustered transcription factor binding sites. Bioinformatics (2004) 0.76
WormBook: WormBiology for the 21st Century. Genetics (2016) 0.75
An oncogenic enhancer enemy (N-Me) in T-ALL. Cell Cycle (2015) 0.75
Cutaneous vesicostomy for palliative management of hemorrhagic cystitis and urinary clot retention. Urology (2010) 0.75
Extranodal nasal-type natural killer T-cell lymphoma in an adolescent from Bangladesh. J Am Acad Dermatol (2006) 0.75