Published in Genes Dev on November 01, 1995
Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs. Genes Dev (2005) 5.78
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev (1998) 4.78
Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell (2008) 3.09
The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Mol Cell Biol (1996) 3.06
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci U S A (1999) 2.81
Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. Mol Cell Biol (2000) 2.80
Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol Cell Biol (1998) 2.75
Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol Cell Biol (2001) 2.74
p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol Cell Biol (2001) 2.64
SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Site clustering over random expectation. Proc Natl Acad Sci U S A (2002) 2.51
The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc Natl Acad Sci U S A (1996) 2.35
Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis. Genes Dev (2001) 2.32
p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol Cell Biol (2002) 2.29
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol (2000) 2.27
Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins. EMBO Rep (2002) 2.21
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers. Genes Dev (2007) 2.19
Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol (1997) 2.12
Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol (1998) 1.99
The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa). J Virol (1996) 1.97
LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein. Mol Cell Biol (1998) 1.96
RBP-L, a transcription factor related to RBP-Jkappa. Mol Cell Biol (1997) 1.89
Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. Genes Dev (2000) 1.87
Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. Genes Dev (2002) 1.87
Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos. Genes Dev (1998) 1.82
Senseless acts as a binary switch during sensory organ precursor selection. Genes Dev (2003) 1.79
Notch signaling in Drosophila long-term memory formation. Proc Natl Acad Sci U S A (2004) 1.63
Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J (1999) 1.61
Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. Mol Cell Biol (2002) 1.59
Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling. Genes Dev (1998) 1.59
EBNA-2 and EBNA-3C extensively and mutually exclusively associate with RBPJkappa in Epstein-Barr virus-transformed B lymphocytes. J Virol (1996) 1.58
Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation. J Virol (1997) 1.56
Notch inhibitors for cancer treatment. Pharmacol Ther (2013) 1.55
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. Mol Cell (2011) 1.55
Inhibition of granulocytic differentiation by mNotch1. Proc Natl Acad Sci U S A (1996) 1.54
A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. Genetics (2000) 1.52
Transcriptional control of stem cell maintenance in the Drosophila intestine. Development (2010) 1.48
The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription. Genes Dev (1998) 1.47
Notch signaling directly controls cell proliferation in the Drosophila wing disc. Proc Natl Acad Sci U S A (2000) 1.38
VEGF and Notch in tip and stalk cell selection. Cold Spring Harb Perspect Med (2013) 1.38
The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression. Mol Cell Biol (1997) 1.32
Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex. Mol Cell Biol (2001) 1.31
Analysis of dominant enhancers and suppressors of activated Notch in Drosophila. Genetics (1996) 1.29
Target specificities of Drosophila enhancer of split basic helix-loop-helix proteins. Mol Cell Biol (1999) 1.26
Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development. Proc Natl Acad Sci U S A (2001) 1.24
Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor. EMBO J (1996) 1.23
Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans. Genes Dev (2003) 1.23
Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase. J Cell Biol (2004) 1.21
Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo. Mol Cell Biol (1998) 1.19
The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression. Mol Cell Biol (2007) 1.17
The notch pathway intermediate HES-1 silences CD4 gene expression. Mol Cell Biol (1998) 1.14
Notch and wingless regulate expression of cuticle patterning genes. Mol Cell Biol (1999) 1.13
The nuclear protein encoded by the Drosophila neurogenic gene mastermind is widely expressed and associates with specific chromosomal regions. Genetics (1996) 1.12
Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of notch signaling. Genetics (1998) 1.12
Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway. J Virol (2006) 1.11
Synergy between suppressor of Hairless and Notch in regulation of Enhancer of split m gamma and m delta expression. Mol Cell Biol (1997) 1.11
Genes required for Drosophila nervous system development identified by RNA interference. Proc Natl Acad Sci U S A (2004) 1.10
Notchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activity. EMBO J (1998) 1.09
Concomitant requirement for Notch and Jak/Stat signaling during neuro-epithelial differentiation in the Drosophila optic lobe. Dev Biol (2010) 1.09
Activated mouse Notch1 transactivates Epstein-Barr virus nuclear antigen 2-regulated viral promoters. J Virol (1999) 1.08
A functional analysis of Notch mutations in Drosophila. Genetics (1997) 1.07
Snail is required for Delta endocytosis and Notch-dependent activation of single-minded expression. Dev Genes Evol (2003) 1.04
Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes. PLoS Genet (2013) 1.03
Dominant enhancers of Egfr in Drosophila melanogaster: genetic links between the Notch and Egfr signaling pathways. Genetics (1997) 1.02
Functional characterization of PAS and HES family bHLH transcription factors during the metamorphosis of the red flour beetle, Tribolium castaneum. Gene (2009) 0.99
phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development. Proc Natl Acad Sci U S A (2004) 0.99
Notch and the awesome power of genetics. Genetics (2012) 0.99
Mutual inhibition among postmitotic neurons regulates robustness of brain wiring in Drosophila. Elife (2013) 0.98
Role of glycans and glycosyltransferases in the regulation of Notch signaling. Glycobiology (2010) 0.97
Complex interplay of three transcription factors in controlling the tormogen differentiation program of Drosophila mechanoreceptors. Dev Biol (2009) 0.96
Activated Notch1 can transiently substitute for EBNA2 in the maintenance of proliferation of LMP1-expressing immortalized B cells. J Virol (2001) 0.96
Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates Notch transcriptional activity. J Biol Chem (2011) 0.95
The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestine. Development (2013) 0.94
Serpent, suppressor of hairless and U-shaped are crucial regulators of hedgehog niche expression and prohemocyte maintenance during Drosophila larval hematopoiesis. Development (2010) 0.94
The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila. Mol Genet Genomics (2006) 0.93
putzig is required for cell proliferation and regulates notch activity in Drosophila. Mol Biol Cell (2007) 0.92
Genome-wide identification of cis-regulatory motifs and modules underlying gene coregulation using statistics and phylogeny. Proc Natl Acad Sci U S A (2010) 0.92
Amino acids of Epstein-Barr virus nuclear antigen 3A essential for repression of Jkappa-mediated transcription and their evolutionary conservation. J Virol (2001) 0.92
lin-12 Notch functions in the adult nervous system of C. elegans. BMC Neurosci (2005) 0.92
Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development. Mech Dev (2007) 0.92
Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development. EMBO J (2011) 0.91
A novel Pzg-NURF complex regulates Notch target gene activity. Mol Biol Cell (2010) 0.90
Regulation of Notch signaling by a novel mechanism involving suppressor of hairless stability and carboxyl terminus-truncated notch. Mol Cell Biol (2003) 0.90
Tarsal-less peptides control Notch signalling through the Shavenbaby transcription factor. Dev Biol (2011) 0.90
Residues 231 to 280 of the Epstein-Barr virus nuclear protein 2 are not essential for primary B-lymphocyte growth transformation. J Virol (1998) 0.90
Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis. Development (2010) 0.90
Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers. Dev Dyn (2011) 0.88
BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Development (2013) 0.88
CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster. J Cell Sci (2012) 0.87
Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin. Dev Dyn (2011) 0.86
Non-canonical Notch signaling represents an ancestral mechanism to regulate neural differentiation. Evodevo (2014) 0.86
Ancestral and conserved cis-regulatory architectures in developmental control genes. Dev Biol (2011) 0.84
Ligand-Independent Mechanisms of Notch Activity. Trends Cell Biol (2015) 0.84
Sequence conservation and combinatorial complexity of Drosophila neural precursor cell enhancers. BMC Genomics (2008) 0.84
Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta. Dev Biol (2009) 0.84
A murine homologue of the Drosophila brainiac gene shows homology to glycosyltransferases and is required for preimplantation development of the mouse. Mol Cell Biol (2001) 0.84
A genetic screen for novel components of the notch signaling pathway during Drosophila bristle development. Genetics (1998) 0.84
Self-modulation of Notch signaling during ommatidial development via the Roughened eye transcriptional repressor. Development (2008) 0.82
Tools and methods for studying Notch signaling in Drosophila melanogaster. Methods (2014) 0.82
Development of the embryonic and larval peripheral nervous system of Drosophila. Wiley Interdiscip Rev Dev Biol (2014) 0.81
Modeling polarity buildup and cell fate decision in the fly eye: insight into the connection between the PCP and Notch pathways. Dev Genes Evol (2008) 0.81
Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell. Development (1999) 2.12
Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless. Genes Dev (1994) 2.08
Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division. Nat Cell Biol (2001) 1.96
Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. Genes Dev (2000) 1.87
The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila. Cell (2001) 1.85
Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila. Nature (1998) 1.79
Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila. Curr Biol (2001) 1.78
Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling. J Cell Biol (2001) 1.77
Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos. Curr Biol (1998) 1.76
Covalent modification of the transcriptional repressor tramtrack by the ubiquitin-related protein Smt3 in Drosophila flies. Mol Cell Biol (2000) 1.36
Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling. Development (1996) 1.34
Engineered secreted T-cell receptor alpha beta heterodimers. Proc Natl Acad Sci U S A (1991) 1.30
Relationship between expression of serendipity alpha and cellularisation of the Drosophila embryo as revealed by interspecific transformation. Development (1993) 0.90
Lineage, cell polarity and inscuteable function in the peripheral nervous system of the Drosophila embryo. Development (2001) 0.89
Lineage diversity in the Drosophila nervous system. Curr Opin Genet Dev (2001) 0.81
Role of suppressor of hairless in the delta-activated Notch signaling pathway. Perspect Dev Neurobiol (1997) 0.78
Evolutionarily conserved positive and negative cis-acting elements control the blastoderm-specific expression of the Drosophila serendipity alpha cellularisation gene. Mech Dev (1995) 0.77