Published in Proc Natl Acad Sci U S A on January 02, 2004
Deep sequencing analysis of small noncoding RNA and mRNA targets of the global post-transcriptional regulator, Hfq. PLoS Genet (2008) 5.23
Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory system. PLoS Biol (2008) 4.34
Genome-wide identification of mRNAs associated with the translational regulator PUMILIO in Drosophila melanogaster. Proc Natl Acad Sci U S A (2006) 3.27
RNA immunoprecipitation and microarray analysis show a chloroplast Pentatricopeptide repeat protein to be associated with the 5' region of mRNAs whose translation it activates. Plant Cell (2005) 2.68
Post-transcriptional gene regulation: from genome-wide studies to principles. Cell Mol Life Sci (2008) 2.18
Experimental approaches to identify non-coding RNAs. Nucleic Acids Res (2006) 1.80
Global identification of noncoding RNAs in Saccharomyces cerevisiae by modulating an essential RNA processing pathway. Proc Natl Acad Sci U S A (2006) 1.64
Conserved and divergent features of the structure and function of La and La-related proteins (LARPs). Biochim Biophys Acta (2010) 1.58
Functional specificity of shuttling hnRNPs revealed by genome-wide analysis of their RNA binding profiles. RNA (2005) 1.58
A comprehensive analysis of the La-motif protein superfamily. RNA (2009) 1.44
Protein expression regulation under oxidative stress. Mol Cell Proteomics (2011) 1.34
C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis. RNA (2008) 1.32
Systems biology of the clock in Neurospora crassa. PLoS One (2008) 1.27
Genome-wide analysis of mRNAs bound to the histone stem-loop binding protein. RNA (2006) 1.25
Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf. PLoS Genet (2013) 1.21
The La protein functions redundantly with tRNA modification enzymes to ensure tRNA structural stability. RNA (2006) 1.18
Genome-wide search for yeast RNase P substrates reveals role in maturation of intron-encoded box C/D small nucleolar RNAs. Proc Natl Acad Sci U S A (2008) 1.16
Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein. Structure (2008) 1.14
Role of the unfolded protein response pathway in secretory stress and regulation of INO1 expression in Saccharomyces cerevisiae. Genetics (2004) 1.12
CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism. Mol Cell Biol (2004) 1.12
Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain. RNA (2006) 1.06
Stress puts TIA on TOP. Genes Dev (2011) 1.00
Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Nucleic Acids Res (2010) 1.00
Conservation of a masked nuclear export activity of La proteins and its effects on tRNA maturation. Mol Cell Biol (2007) 0.98
Metabolic engineering in the -omics era: elucidating and modulating regulatory networks. Microbiol Mol Biol Rev (2005) 0.97
Functionally related transcripts have common RNA motifs for specific RNA-binding proteins in trypanosomes. BMC Mol Biol (2008) 0.95
The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells. Mol Cell Biol (2006) 0.95
An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors. Proc Natl Acad Sci U S A (2011) 0.95
Noncoding RNAs binding to the nucleoid protein HU in Escherichia coli. J Bacteriol (2012) 0.93
Nonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesis. Mol Cell Biol (2004) 0.92
Conservation of RNA chaperone activity of the human La-related proteins 4, 6 and 7. Nucleic Acids Res (2013) 0.90
A bona fide La protein is required for embryogenesis in Arabidopsis thaliana. Nucleic Acids Res (2007) 0.84
La-motif-dependent mRNA association with Slf1 promotes copper detoxification in yeast. RNA (2012) 0.83
RNA integrity as a quality indicator during the first steps of RNP purifications : a comparison of yeast lysis methods. BMC Biochem (2004) 0.79
Exploring the metabolic and genetic control of gene expression on a genomic scale. Science (1997) 60.15
Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell (2000) 36.09
Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature (2003) 29.16
Dissecting the regulatory circuitry of a eukaryotic genome. Cell (1998) 23.62
Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. Nature (2001) 21.55
Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science (2003) 16.49
Characterization of the yeast transcriptome. Cell (1997) 11.33
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell (1993) 9.84
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell (1996) 8.17
Identification of novel small RNAs using comparative genomics and microarrays. Genes Dev (2001) 7.65
A computational screen for methylation guide snoRNAs in yeast. Science (1999) 6.43
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell (1997) 6.26
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. J Virol (1993) 5.89
Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier. Science (2000) 4.95
tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell (1996) 4.93
Eukaryotic mRNPs may represent posttranscriptional operons. Mol Cell (2002) 4.39
Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol Biol Cell (1999) 4.34
Precursor molecules of both human 5S ribosomal RNA and transfer RNAs are bound by a cellular protein reactive with anti-La lupus antibodies. Cell (1982) 3.76
Synthesis of the translational apparatus is regulated at the translational level. Eur J Biochem (2000) 3.73
Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response. Cell (2001) 3.45
The La protein. Annu Rev Biochem (2001) 3.32
Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery. Nat Genet (2003) 3.25
Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii. Genome Biol (2003) 3.03
Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response. Mol Biol Cell (1997) 2.91
The yeast La protein is required for the 3' endonucleolytic cleavage that matures tRNA precursors. Cell (1997) 2.86
Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. EMBO J (1999) 2.84
Analysis of the yeast genome: identification of new non-coding and small ORF-containing RNAs. Nucleic Acids Res (1997) 2.40
A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase III transcripts. EMBO J (1998) 2.31
Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translation. Mol Cell Biol (2000) 2.22
Computational identification of non-coding RNAs in Saccharomyces cerevisiae by comparative genomics. Nucleic Acids Res (2003) 2.15
The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p. Proc Natl Acad Sci U S A (2000) 2.09
La proteins from Drosophila melanogaster and Saccharomyces cerevisiae: a yeast homolog of the La autoantigen is dispensable for growth. Mol Cell Biol (1994) 2.04
DNA-binding requirements of the yeast protein Rap1p as selected in silico from ribosomal protein gene promoter sequences. Bioinformatics (1999) 2.02
Precursors to the U3 small nucleolar RNA lack small nucleolar RNP proteins but are stabilized by La binding. Mol Cell Biol (2000) 1.90
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. Nature (1997) 1.89
Regulation of ribosome synthesis in yeast. Yeast (1997) 1.63
GCD14p, a repressor of GCN4 translation, cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae. Mol Cell Biol (1999) 1.59
A La protein requirement for efficient pre-tRNA folding. EMBO J (2003) 1.55
Human La antigen is required for the hepatitis C virus internal ribosome entry site-mediated translation. J Biol Chem (2000) 1.54
U snRNP assembly in yeast involves the La protein. EMBO J (2000) 1.44
Transcript leader regions of two Saccharomyces cerevisiae mRNAs contain internal ribosome entry sites that function in living cells. Proc Natl Acad Sci U S A (2001) 1.43
La autoantigen enhances translation of BiP mRNA. Nucleic Acids Res (2001) 1.33
La protein has a positive effect on the translation of TOP mRNAs in vivo. Nucleic Acids Res (2000) 1.31
Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs. Mol Cell (2003) 1.25
Lsm proteins are required for normal processing of pre-tRNAs and their efficient association with La-homologous protein Lhp1p. Mol Cell Biol (2002) 1.20
La protein is associated with terminal oligopyrimidine mRNAs in actively translating polysomes. J Biol Chem (2003) 1.19
Role of the unfolded protein response pathway in regulation of INO1 and in the sec14 bypass mechanism in Saccharomyces cerevisiae. Genetics (2002) 1.12
The effect of a single, temperature-sensitive mutation on global gene expression in Escherichia coli. RNA (2003) 1.11
Binding of the La autoantigen to the 5' untranslated region of a chimeric human translation elongation factor 1A reporter mRNA inhibits translation in vitro. Biochim Biophys Acta (2001) 0.98
A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell (2008) 2.96
Transcript specificity in yeast pre-mRNA splicing revealed by mutations in core spliceosomal components. PLoS Biol (2007) 2.60
Rapid, transcript-specific changes in splicing in response to environmental stress. Mol Cell (2007) 2.58
Reciprocal intronic and exonic histone modification regions in humans. Nat Struct Mol Biol (2010) 2.20
The Glc7p nuclear phosphatase promotes mRNA export by facilitating association of Mex67p with mRNA. Mol Cell (2004) 1.99
The DEAD-box protein Dbp5p is required to dissociate Mex67p from exported mRNPs at the nuclear rim. Mol Cell (2005) 1.98
Hierarchical modularity and the evolution of genetic interactomes across species. Mol Cell (2012) 1.88
From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II. Cell (2013) 1.87
Functional specificity of shuttling hnRNPs revealed by genome-wide analysis of their RNA binding profiles. RNA (2005) 1.58
The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing. Genes Dev (2005) 1.51
ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8. Nat Struct Mol Biol (2008) 1.50
Expression of the essential mRNA export factor Yra1p is autoregulated by a splicing-dependent mechanism. RNA (2002) 1.46
Spliceosomal snRNAs: Mg(2+)-dependent chemistry at the catalytic core? Cell (2002) 1.45
Conformational dynamics of single pre-mRNA molecules during in vitro splicing. Nat Struct Mol Biol (2010) 1.45
Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. RNA (2006) 1.43
Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2. Nat Struct Mol Biol (2009) 1.40
A single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast. Mol Cell (2008) 1.36
A conserved Lsm-interaction motif in Prp24 required for efficient U4/U6 di-snRNP formation. RNA (2002) 1.34
Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation. Genetics (2005) 1.30
Computational and experimental approaches double the number of known introns in the pathogenic yeast Candida albicans. Genome Res (2007) 1.24
Autoregulation of the mRNA export factor Yra1p requires inefficient splicing of its pre-mRNA. RNA (2006) 1.16
Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing. Nat Struct Mol Biol (2013) 1.11
Evolution of yeast noncoding RNAs reveals an alternative mechanism for widespread intron loss. Science (2010) 1.08
Diverse environmental stresses elicit distinct responses at the level of pre-mRNA processing in yeast. RNA (2011) 1.08
Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain. RNA (2006) 1.06
Alternative 3' pre-mRNA processing in Saccharomyces cerevisiae is modulated by Nab4/Hrp1 in vivo. PLoS Biol (2007) 1.04
The yeast SR-like protein Npl3 links chromatin modification to mRNA processing. PLoS Genet (2012) 1.01
Autoregulation of Npl3, a yeast SR protein, requires a novel downstream region and serine phosphorylation. Mol Cell Biol (2008) 0.94
Evolution of small nuclear RNAs in S. cerevisiae, C. albicans, and other hemiascomycetous yeasts. RNA (2007) 0.89
Preparation of fluorescent pre-mRNA substrates for an smFRET study of pre-mRNA splicing in yeast. Methods Enzymol (2010) 0.87
Diverse forms of RPS9 splicing are part of an evolving autoregulatory circuit. PLoS Genet (2012) 0.87
Modifications target spliceosome dynamics. Nat Struct Mol Biol (2008) 0.86
Regulation of the Dbp5 ATPase cycle in mRNP remodeling at the nuclear pore: a lively new paradigm for DEAD-box proteins. Genes Dev (2011) 0.86
An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8. RNA (2013) 0.83
The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing. RNA (2014) 0.82
H2B ubiquitylation modulates spliceosome assembly and function in budding yeast. Biol Cell (2014) 0.81
Getting to the gate: crystallization of a Sac3(CID):Sus1:Cdc31 complex. Mol Cell (2009) 0.79
Colony PCR. Methods Enzymol (2013) 0.77
Chemical transformation of yeast. Methods Enzymol (2013) 0.76
Molecular biology. Accurate RNA siting and splicing gets help from a DEK-hand. Science (2006) 0.75
SnapShot: Formation of mRNPs. Cell (2009) 0.75
Yeast-gene replacement using PCR products. Methods Enzymol (2013) 0.75